Produits biochimiques et réactifs

<p>NGF</p>

<p>ApoB protein is a biomolecule that plays a crucial role in the transport of lipids, particularly low-density lipoprotein (LDL) cholesterol, in the bloodstream. It contains a carbonyl group and an amino group, which are activated during the lipid transport process. The ApoB protein interacts with various molecules, including alpha-synuclein and trastuzumab, to regulate lipid metabolism and cellular functions.</p>

<p>Inhibitor of the Bruton tyrosine kinase</p>

<p>Transparent Violet RR is a white powder that is soluble in organic solvents and water. It is an oxidant, surfactant, and coating for paper. Transparent Violet RR can be used as a pigment in paints, lacquers, and printing inks.</p>

<p>Peptide Ac-CTETVKAEKMETD-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Galanin is a neuropeptide synthesised and released by the brainstem locus coeruleus (LC). Galanin is expressed in most LC neurons in rodents and humans. Galanin has been shown to inhibit LC activity by hyperpolarising LC neurons, suppressing their spontaneous firing rate, and enhancing alpha2-adrenergic receptor-mediated negative feedback. Galanin is also a potent trophic and neuroprotective factor throughout the nervous system.Galanin is widely distributed from the central nervous system, peripheral regions and endocrine system. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes GalR1-3 which are G protein-coupled receptors and are inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway but unlike GalR1 there is detectable inositol phosphate production. GalR3 is associated with the Gα pathway, activation of the receptor leads to cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin protects against a variety of physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied in relation to Alzheimer's disease and galaninergic neurons have been shown to be spared in late-stage Alzheimer's relative to non-galaninergic neurones.</p>

<p>Cell-penetrating peptides  (CPP) conjugated to biomolecular cargo can provide targeted molecular treatments. This could be revolutionary for numerous conditions such as cancer, muscular dystrophy and many more. CPP often use the endosomal system to enter the cell. Still, they vary in their ability to escape the endosome allowing the cargo to reach its intended area within the cell. Most CPP activity escaping the endosome is weak, and the method is unclear.Dimeric fluorescent TAT (dfTAT) is a CPP composed of 2 TAT peptides with an N-terminal fluorophore tetramethylrhodamine. When incubated with cells, it shows a cytosolic localisation. A simple co-incubation method of dfTAT with a cargo results in efficient endosomal leakage and release of the cargo to the cytosol. dfTAT has been shown to efficiently deliver a wide variety of cargos to the cell, including transcription factors, antibodies, and metal-organic framework (MOF) nanoparticles. One of the significant advantages of using dfTAT is that the co-incubation method of delivery allows dfTAT, and the cargo can be added as separate entities. This enables the controlled titration of material into cells through the modulation of cargo concentration independent of dfTAT.</p>

<p>Ac-WQTSII-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-WQTSII-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-WQTSII-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-WQTSII-OH at the technical inquiry form on this page</p>

<p>Rotavirus antibody was raised in mouse using Intact virus of strains RRV, WA and bovine as the immunogen.</p>

<p>Inhibitor of BCR-ABL1 kinase</p>

<p>GLAST/ EAAT-1 (glutamate-aspartate transporter/ excitatory amino acid transporter 1) (rodent/human nomenclature) is a sodium-dependent plasma membrane glutamate transporter expressed exclusively by astrocytes in the cerebellum and present at high densities near excitatory synapses. The cerebellum is the region of the brain essential for maintaining postural control and coordination of voluntary muscle movement. Glutamate transporters regulate glutamate receptors and limit glutamate accumulation to prevent neurotoxicity whilst ensuring accurate synaptic communication. GLAST is the major transporter expressed during development. Loss of GLAST/EAAT-1 has been linked to the pathogenesis of several disorders affecting the motor system including several subtypes of spinocerebellar ataxia (SCA); SCA1, SCA5, SCA7, episodic ataxia type 6, spinal muscular atrophy and fragile X associated tremor/ataxia syndrome. Furthermore, disrupted GLAST/EAAT-1 has been associated with schizophrenia and cerebellar dysfunction and also is linked to the pathophysiology of Alzheimer's disease, autism and other cognitive and neuropsychiatric disorders. This antibody has AF488 conjugated to it. AF488 is a popular bright green fluorescent dye with high PH-stability.</p>

<p>Promestriene is a synthetic estrogen derivative, which is sourced from modifications of the natural hormone estradiol. It functions by binding to estrogen receptors, primarily focusing on the mucosal and epithelial tissues. This interaction stimulates cellular proliferation and increases the thickness of the epithelial layers, thereby promoting tissue regeneration and hydration.</p>

<p>ELISA kit for detection of Free Cortisol in Saliva in the research laboratory</p>

<p>Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions._x000D_<br>_x000D_<br>Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, Homer._x000D_<br>_x000D_<br>mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber-Purkinje cell synapses critical for cerebellar motor learning._x000D_<br>_x000D_<br>This antibody is conjugated to Alexa Fluor® 488, a popular bright green fluorescent dye with high pH-stability.</p>

<p>GLG1</p>

<p>The FPR1 antibody is a highly specialized monoclonal antibody that has the ability to neutralize and inhibit the activity of leukemia inhibitory factor (LIF). It is colloidal in nature and has been shown to effectively bind to autoantibodies present in human serum. The FPR1 antibody is activated upon binding to its target, resulting in a cascade of biochemical reactions that lead to the inhibition of LIF. This monoclonal antibody can be used in various research applications, such as electrode-based assays or immunoassays, to study the role of LIF in different biological processes. Additionally, the FPR1 antibody has shown cytotoxic effects on certain cell types, making it a valuable tool for studying hormone peptides and growth factors involved in cellular signaling pathways. With its specificity and high affinity for its target, the FPR1 antibody offers researchers a reliable tool for investigating LIF-related mechanisms and potential therapeutic applications.</p>

<p>Benzoylecgonine COOH Conjugate for use in immunoassays</p>

<p>HAMA blocking reagent is an essential component for various Life Sciences applications. It is specifically designed to prevent interference in assays caused by human anti-mouse antibodies (HAMA). This blocking reagent contains buffers that create an acidic environment, which effectively inhibits the binding of HAMA to target molecules. By neutralizing the presence of HAMA, this reagent ensures accurate and reliable results in experiments involving antibodies, such as monoclonal antibody-based assays. Additionally, it has been proven effective in preventing hemolysis and reactive effects when used with human serum or other biological samples. With its ability to block HAMA interference, this reagent is a valuable tool for researchers in the field of Life Sciences.</p>

<p>Streptavidin antibody (HRP) was raised in rabbit using streptavidin as the immunogen.</p>

<p>H-KVLVEVLADPLDHR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KVLVEVLADPLDHR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KVLVEVLADPLDHR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KVLVEVLADPLDHR-OH at the technical inquiry form on this page</p>

<p>Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics the GLP-1 hormone, released in the gut in response to eating.  Semaglutide can enhance insulin secretion and suppress glucagon section in a glucose-dependent manner. It also increases gastric emptying time and reduces intestinal motility. This combination leads to a decrease in appetite. Semaglutide has a long half-life allowing weekly subcutaneous application. Semaglutide also has positive effects on heart, liver, and lung function. Semalgutide also slows the progression of the effects of Alzheimer’s disease.<br>This is a heavy isotype-labelled version of semaglutide that is suited to peptide quantification by mass spectrometry. This allows it to be used as an internal standard for quantification of semaglutide. There are two phenylalanine residues isotopically labelled with carbon-13 (9) and nitrogen-15 (1); one valine is labelled with carbon-13 (5) and nitrogen-15 (1); two leucine residues labelled with carbon-13 (6) and nitrogen-15 (1). This semaglutide peptide has a mass increase of 40 compared to the unlabelled peptide.25nmol = 0.1mg</p>

<p>Thyroglobulin (Tg) is a widely used biomarker of various differentiated thyroid cancer (DTC)- Tg is a substrate for thyroid hormone production. Detection and quantification of serum thyroglobulin levels remain challenging due to Tg's size, heterogeneity, and thyroglobulin autoantibodies (TgAb). Immunoassays offer the opportunity to tailor DTC treatments, but many patients are TgAb positive, excluding them from analysis during regression.Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can overcome immunoassay issues by digestion of Tg to a tryptic peptide removing the interference from TgAbs.</p>

<p>Peptide H-TSLAVLGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>The AMPK antibody is a highly effective growth factor that targets specific proteins involved in cellular metabolism. It is particularly effective against Helicobacter infections and has been shown to inhibit the growth of glycoproteins associated with these bacteria. The AMPK antibody is a polyclonal antibody that specifically neutralizes the activated form of the protein, preventing its harmful effects on the body. This antibody is formulated with excipients to ensure stability and potency. In addition to its antimicrobial properties, the AMPK antibody has demonstrated cytotoxic effects against cancer cells, making it a valuable tool in oncology research. With its high specificity and efficacy, this monoclonal antibody is an essential component in life sciences research.</p>

<p>14-3-3 proteins are highly conserved from yeast to plants and mammals where they are found in various organs and tissues. 14-3-3 proteins regulate numerous signalling pathways via direct binding to proteins carrying phosphorylated 14-3-3-binding motifs, several hundred binding partners have been identified for 14-3-3 proteins. Their functions include a role in viral infections and innate immunity, protein trafficking, cell-cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. There are seven 14-3-3 subtypes (alpha/β,γ, ε,η, σ, τ [also called θ] and ζ/δ) in mammals. 14-3-3 ζ has been shown to interact with Hepatitis B virus (HBV) protein X (HBx), E6 oncoprotein, Caspase-2: a protease involved in apoptosis, and to be is involved in the subcellular localisation of the FOXO forkhead transcription factor. 14-3-3 ζ acts as a molecular block that covers the DNA-binding site of FOXO4, thus blocking its interaction with the target DNA. 14-3-3 ζ also participates in the TLR3-TICAM-1 signalling pathway by promoting multimerization of TICAM-1 to form a signalosome. 14-3-3 ζ isoform may also be the target of SARS-CoV-2 in the nervous system.</p>

<p>H-Arg-Leu-Leu-Phe-Thr-NH2 is a peptide that has been shown to inhibit the proliferation of cancer cells by interfering with the calcium signaling pathway. It also inhibits the production of pro-inflammatory cytokines and growth factors, which are important in inflammatory diseases. This peptide can be used as a therapeutic agent for ganglia disease, such as human immunodeficiency virus (HIV) infection or diabetes. H-Arg-Leu-Leu-Phe-Thr-NH2 has an inhibitory effect on nociceptors, which are nerve cells that transmit pain signals to the brain. It may also potentiate the effects of other drugs used to treat inflammation.</p>

<p>Inhibitor of CDK2, JAK2 and FLT3; anticancer</p>

<p>Portion of Influenza NP</p>

<p>SAMS peptide was originally designed as a selective substrate for mammalian 5' adenosine monophosphate-activated protein kinase (AMPK) for use in kinase assays. However it is also able to be phosphorylated by the yeast AMP homologue- sucrose non-fermenting 1 kinase (SNF1) and SNF1-related kinases (SnRK1) in plants.The conserved family of kinases containing SnRK1, SNF1 and AMPK plays an important role in regulating cellular energy homeostasis.</p>

<p>H-PYLFWLAAI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PYLFWLAAI-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PYLFWLAAI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PYLFWLAAI-OH at the technical inquiry form on this page</p>

<p>Substrate peptide for adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase (PKA) and related kinases, for use in kinase assays. The peptide sequence is based on the cAMP-dependent protein kinase inhibitor alpha (amino acid 15-23).Protein kinase A (PKA) also known as cAMP-dependent protein kinase is a family of serine/threonine protein kinase enzymes whose activity is regulated by cyclic AMP (cAMP). PKA is involved in a plethora of roles within the cell including: regulation of glycogen, sugar and lipid metabolism and roles within adipocytes and hepatocytes, nucleus accumbens neurons, skeletal muscle, cardiac muscle and in memory formation.</p>

<p>Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.</p>

<p>Icatibant M1 [M+6] Heavy</p>

<p>KOR antibody was raised in rabbit using residues 366-380 DPAYLRDIDGMNLPV of the human KOR-1 protein as the immunogen.</p>

<p>Alanine transaminase antibody was raised in sheep using porcine alanine transaminase as the immunogen.</p>

<p>Control immune goat serum was raised in goat using a proprietary peptide as the immunogen.</p>

<p>Thyroxine antibody was raised in mouse using T4-BSA as the immunogen.</p>

<p>SCO-267 is a highly purified chemical compound used as a selective enzyme inhibitor, which is derived from synthetic sources. This compound acts by specifically binding to the active site of its target enzyme, effectively inhibiting its biological activity. Through competitive inhibition, SCO-267 modulates enzymatic pathways, facilitating research into metabolic processes and enzyme kinetics.</p>

<p>Memantine is an NMDA receptor antagonist that is an effective therapeutic agent for Alzheimer’s disease and other neurodegenerative diseases. This drug inhibits the NDMA receptor preventing glutamate from carrying out its function thus helping with the symptoms associated with Alzheimer’s.</p>

<p>TORC-2</p>

<p>SARS-CoV-2 NSP7 (21-35)</p>

<p>H-Glu(Glu-OH)-OH is a synthetic amino acid that is currently being investigated as a diagnostic agent for the detection of intracellular protein degradation by matrix metalloproteinase-9 (MMP-9). H-Glu(Glu-OH)-OH is taken up by cells in a concentration and time dependent manner, with an uptake rate of approximately 1.6 x 10^6 molecules per cell per hour. The uptake mechanism is not yet known, but has been hypothesized to be due to receptor binding. H-Glu(Glu-OH)-OH binds to cerebellar granule cells and alters mitochondrial metabolism, which may be related to its effects on the ubiquitin proteasome pathway. This compound also has diagnostic potential for atherosclerosis and glutamate transport disorders.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Intracellular Sigma peptide is a membrane-permeable peptide mimetic of protein tyrosine phosphatase sigma (PTPσ) wedge. PTPσ is a neural receptor that binds with very high affinity to chondroitin sulfate proteoglycans (CSPGs). Inhibition of this interaction has been shown to promote regeneration of damaged nerves and improve nerve function in animal models. ISP has a protein transduction domain from HIV's trans-activating regulatory protein (Tat). This domain allows facilitates membrane-penetration.</p>

<p>Interferon alpha 2b is a recombinant protein that belongs to the family of interferons. It is a glycoprotein that has been modified with polyethylene glycol (PEG) to increase its stability and prolong its half-life in the body. Interferon alpha 2b has a wide range of biological activities, including antiviral, antiproliferative, and immunomodulatory effects. It can neutralize superoxide radicals and inhibit the growth of various viruses by interfering with their replication process. This protein has been used in the field of life sciences for research purposes, as well as in medical applications for the treatment of certain diseases, such as hepatitis C and some types of cancer. Interferon alpha 2b can also enhance the activity of other therapeutic agents, such as monoclonal antibodies like trastuzumab, or antibiotics like ofloxacin. Its ability to inhibit angiogenesis and stimulate immune responses makes it a promising candidate for future developments</p>

<p>Peptide H-YPIPPPDAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Ghrelin is involved in several physiological processes, including feeding and lipid accumulation, stress response, anxiety, cardiac performance, immunity and inflammation, taste sensation, reward-seeking behaviour, regulation of glucose metabolism and thermogenesis, memory, motivation and learning.Ghrelin is a peptide hormone that typically has a serine at the third residue and relies on modification with a fatty acid to give ghrelin its functional activity. In its modified form, ghrelin is an endogenous ligand for the pituitary gland's growth hormone receptor (GHS-R) and stimulates growth hormone release. Rat/mouse ghrelin differs from the human form at positions 11 and 12 (RV) in rats to (KA) in humans.Ghrelin acts on the hypothalamic arcuate nucleus as an orexigenic agent to stimulate appetite. Ghrelin is produced in the stomach as a precursor peptide preproghrelin, cleaved to ghrelin. Ghrelin circulates in the blood and can cross the blood-brain barrier. Levels of ghrelin respond to fasting conditions and allow signals about the energy status to be transmitted from the peripheral organs to the central nervous system to maintain energy homeostasis.Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.</p>

<p>Peptide Ac-CY-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>IRF5 antibody was raised in Rabbit using Human IRF5 as the immunogen</p>

<p>H-DGDFAIVKFTKVLLDYTGHI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DGDFAIVKFTKVLLDYTGHI-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DGDFAIVKFTKVLLDYTGHI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DGDFAIVKFTKVLLDYTGHI-OH at the technical inquiry form on this page</p>