Produits biochimiques et réactifs

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Melanoma associated antigen antibody was raised in mouse using melanoma associated antigen Isolated from human melanoma cells as the immunogen.</p>

<p>Peptide H-AVAANIVL^TV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-AHQLAIDTYQEFEETYIPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AHQLAIDTYQEFEETYIPK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AHQLAIDTYQEFEETYIPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AHQLAIDTYQEFEETYIPK-OH at the technical inquiry form on this page</p>

<p>Peptide H-VDATEESDLAQQYGVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>γ-secretase inhibitor; reduces amyloid-β in brainÂ</p>

<p>5-HT1B/1D serotonin receptor agonist; anti-migraine agent; vasoconstrictive</p>

<p>OSU 6162 hydrochloride is a research chemical classified as a dopamine stabilizer, derived synthetically. It primarily acts as a dopamine receptor antagonist, targeting both D2 and D3 dopaminergic receptors in the central nervous system. By modulating dopamine receptor activity, OSU 6162 hydrochloride can help balance dopaminergic signaling, which is crucial in various neurological and psychiatric conditions.</p>

<p>Purified Mouse IgG1 FITC conjugate</p>

<p>Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.</p>

<p>Phenobarbital antibody was raised in rabbit using Phenobarbital-BSA as the immunogen.</p>

<p>Purified recombinant Human IL18BP protein (His tag)</p>

<p>Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerative</p>

<p>H-WMVLPWLPGTLDGGSGC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-WMVLPWLPGTLDGGSGC-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-WMVLPWLPGTLDGGSGC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-WMVLPWLPGTLDGGSGC-OH at the technical inquiry form on this page</p>

<p>Peptide derived from vitronectin, the mammalian glycoprotein which plays a key role in tissue repair and remodelling. Its properties as an adhesive protein allow mammalian cells in serum to interact with culture vessels.</p>

<p>Opiorphin is a naturally occurring peptide, which is derived from human bodily secretions, particularly from saliva. It acts as an endogenous inhibitor of enkephalin-degrading enzymes, thus enhancing the activity of endogenous opioid peptides by preventing their breakdown. This stabilization of enkephalins contributes to the body's natural pain regulation processes.</p>

<p>Inhibitor of glutaminase; glutamine analogue</p>

<p>Fmoc-Ser(tBu)-Wang resin is a versatile building block that is used in the synthesis of complex compounds. It has a CAS number and is available as a fine chemical or reagent. Fmoc-Ser(tBu)-Wang resin is an intermediate for research chemicals, reaction components, and speciality chemicals. This material can be used as an important building block in the synthesis of many useful compounds and has high quality.</p>

<p>Acid Black 26 is a polyphenol with antioxidant properties. It has been shown to have an inhibitory effect on the oxidation of basic dyes and control agents. Acid Black 26 has also been used in biological treatment to remove organic matter from wastewater. The thermodynamic data for Acid Black 26 are complex, but it displays a high reactivity toward particle surfaces and functional groups. Immobilized Acid Black 26 can be used as a surface methodology for the production of activated carbon filters, which removes reactive substances from air streams.</p>

<p>Histamine (H2) receptor antagonist; treats ulcers and acid reflux</p>

<p>Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is an RNA-binding protein (RBP) which recognises two related GGC-core elements (GGCA and CGGC) and is of particular interest in tumorigenesis and tumour progression.RBPs play a major role in regulating the RNA life cycle via directing nuclear export, translation and degradation rates, and in the intracellular localisation of RNA transcripts. IGF2BP3 has been implicated in various aspects of human tumour progression including cell growth, migration, and the response to drugs, depending on cellular context. IGF2BP3 is able to bind and segregate oncogene transcripts into granules (locasomes). Once in these granules they are protected from let-7-dependent silencing and other miRNAs and therefore offer a safe house from degradation. However in other contexts IGF2BP3 can also promote the association between mRNAs and RISC, to favour mRNA degradation.IGF2BP3 is expressed in mouse embryos in neural cells, intestine, thymus, pancreas, and kidney epithelial germ layers where it plays a general role in neural development and organogenesis. IGF2BP3 is also detected in the placenta, lymph nodes, tonsils, and testes in adult humans. The lysine residue at position 1 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.</p>

<p>H-DYAEVGR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DYAEVGR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DYAEVGR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DYAEVGR-OH at the technical inquiry form on this page</p>

<p>HIV-1 replication is rapid and error prone which is beneficial to the virus as it allows mutations to arise that aid evasion of the host immune system and resistance to drug treatment. RT is the key target for most anti-HIV drugs and therefore conserved sequences are useful to aid further research into new less toxic antiviral treatments.  HIV-1 reverse transcriptase (RT) converts the RNA genome into DNA during retroviral replication. HIV-1 RT is a heterodimer composed of 2 subunits, p66 and p51. HIV-1 RT heterodimer has 2 enzymatic functions, DNA polymerase and Rnase H resulting in nucleic acid translation to a linear DNA duplex. Complete inhibition of viral replication is the only known method of preventing HIV-1 drug resistance and disease progression.HIV RT epitopes have become a useful research tool as an in vitro antigenic challenge to study cytotoxic T lymphocyte (CTL) responses to retroviruses. The HIV-1 RT A2-YI9 sequence has been shown to be an effective epitope for CTL recognition leading to lysis of HIV-infected T cells. The A2-YI9 is also considered a potential for vaccine development due to it being a well conserved sequence. Synthesised HIV-1 RT A2-YI9 is provided here with N-terminal acetylation to mimic the charge of the native peptide more closely. The epitope is also available without acetylation from our catalogue.</p>

<p>CBL-B (22-37) is derived from the CBL-B E3 ubiquitin ligase which targets receptor tyrosine kinases to lysosome degradation. CBL-B and its family member CBL are expressed in hematopoietic cells and as E3 ubiquitin ligases they contain a tyrosine kinase domain and an RF domain joined by a linker domain. The function of the RF domain is to transfer ubiquitin from E2 ubiquitin-conjugating enzymes onto the target protein which is often phosphorylated. Consequently the ubiquitinated substrate, the receptor tyrosine kinases, are ultimately targeted to the lysosome for degradation.EGFR is an example of a receptor tyrosine kinase whose activation is prevented by CBL and CBL-B when they bind and recruit GRb2, the adapter protein to EGFR. Consequently the ubiquitinylation of EGFR occurs and targets it for recognition by the endosomal protein complex and then lysosome degradation.It has also been found that the CBL family can negatively regulate through ubiquitinylation, PI 3-kinases, Rap G-protein guanine nucleotide exchange factor (GEF), C3G and Rho GTPase GEF Vav which are all non-receptors.If CBL or CBL-B becomes non-functional it can be associated with malignancies such as acute mye-loid leukemia and myelodysplastic syndrome.The lysine residue at position 16 is isotopically labelled with carbon-13 (6) and nitrogen-15 (2).</p>

<p>Peptide H-VVSEDFLQDVSASTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Fmoc-ACC-Resin is a resin for the synthesis of peptides that has been used for the synthesis of Fmoc-protected amino acids and peptides. The resin is a solid support that can be used in automated peptide synthesizers. It can be used in the synthesis of peptides with N-terminal amine or carboxylic acid groups, such as Fmoc-amino acids, Fmoc-NHS esters, and side chain protected amino acids.</p>

<p>MLN-3897 is a new small molecule that has potent inhibitory activity against chemokine receptors. MLN-3897 blocks chemotaxis of immune cells and viral replication, and is therefore a potential treatment for autoimmune diseases and other inflammatory diseases. It also inhibits the expression of surface proteins on activated T cells, which may be due to its ability to block leukotriene receptor antagonist activity. This drug is currently in preclinical development, but could potentially be deployed as an anti-inflammatory agent in the future.</p>

<p>Cyclic AC253 is an antagonist of the amylin receptor with neuroprotective effects against Aβ toxicity. Cyclic AC253 eliminates Aβ-induced impairment of hippocampal long-term potentiation and is able to penetrate the blood-brain barrier.</p>

<p>SIRT1 activator</p>

Purified recombinant FUT3 protein (His tag)

<p>The cyclic tridecapeptide Compstatin, binds to and selectively inhibits the interaction between C3 and convertase, hence preventing the formation of C3a and C3b and activation of the complement system. Compstatin has the ability to form β-turns and hydrophobic clusters which are crucial for its inhibitory properties. When binding between C3 MG4 and MG5 domains, located within the MG-ring of the β-chain, Compstatin undergos a conformational change which is believed to prevent C3 from binding to C3 convertase through steric hindrance. Consequently the complement cascade is inhibited.The complement cascade is an important feature of the immune system. C3b, produced from the interaction of C3 and C3 convertase, binds to pathogens and somatic cells and signals for their removal from the body. However the increased activation of the complement system can result in diseases, associated with Alzheimers, strokes, heart attacks and autoimmune diseases. Therefore Compstatin can be used as a therapeutic agent within medicine.</p>

<p>Encequidar is a small-molecule inhibitor, which is a synthetic chemical compound with the ability to modulate the activity of efflux transporters. It specifically targets P-glycoprotein (P-gp), an ATP-binding cassette transporter widely expressed in tissues such as the intestine, kidney, liver, and blood-brain barrier. By inhibiting P-gp, Encequidar enhances the oral bioavailability of co-administered therapeutic agents that are typically P-gp substrates, thereby improving their systemic absorption and therapeutic efficacy.</p>

<p>Itk is a protein that is involved in the immune system and is a member of the TNF receptor superfamily. It has been shown to have immunomodulatory effects, which may be due to its ability to inhibit epidermal growth factor-induced signaling pathways and cell proliferation. The Itk active rat has been found to have an increased susceptibility to radiation-induced skin injury, as well as an increased susceptibility to chemical carcinogen-induced skin cancer. Sorafenib has been shown to inhibit Itk expression in vivo, leading to decreased tumor size and prolonged survival in mice with melanoma.</p>

<p>GPR68 PAM, bioavailable in mice and with excellent brain penetration</p>

<p>Endothelin A receptor antibody was raised in sheep using C-terminal peptide QEQNHNTERSSHK residues 410 - 422 of rat ET(A) Receptor conjugated to KLH as the immunogen.</p>

<p>Monoclonal antibody against VEGF</p>

<p>Polyclonal Bacillus anthracis antibody (Edema Factor), Anti-Bacillus anthracis antibody (Edema Factor), Bacillus anthracis EF antibody, Anthrax EF antibody, Bacillus anthracis Edema Factor antibody, Anthrax Edema Factor antibody</p>

<p>H-LHLILDYINGGELFTHLSQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LHLILDYINGGELFTHLSQR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LHLILDYINGGELFTHLSQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LHLILDYINGGELFTHLSQR-OH at the technical inquiry form on this page</p>

<p>Adenovirus antibody was raised in mouse using hexon group antigen of many ADV serotypes as the immunogen.</p>

<p>A highly potent antagonist of group II metabotropic glutamate receptors (IC50 values = 21 nM and 14 nM at human mGluR2 and mGluR3 respectively). LY 341495 also inhibits group I and III mGluRs with lower potencies (IC50 values = 0.17, 7.8 and 8.2 µM at mGluR8, mGluR1a and mGluR5a respectively). There has been contradicting findings on the antidepressant and anxiolytic activities of this compound. Enhanced cognitive function and locomotor activity have also been described for LY 341495.</p>

<p>This C-terminal Sortagging peptide acts as a (oligo)glycine nucleophile in the final steps of a sortagging protein labelling reaction. This reaction results in the [Cys(AF488)] fluorescent moiety being attached to the C-terminus of the target protein or peptide.A substrate peptide containing the LPXTG motif is recognised and cleaved by the enzyme Sortase A (SrtA) from Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA, serves as a nucleophile to cleave the peptide bond between threonine and glycine of the substrate peptide. Cleavage results in the formation of a thioacyl intermediate between the substrate peptide and SrtA. This intermediate is then resolved by the N-terminus of this (oligo)glycine nucleophile peptide, resulting in the creation of a new peptide bond that links the substrate peptide to this peptide and its fluorescent dye.  This method of protein labelling is known as sortagging.This peptide contains the AF488 fluorescent dye AF488 is a bright green dye with excitation at 488 nm, it is water soluble and stable from pH 4 to pH 10.</p>

<p>H-ISQGTSGGAT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ISQGTSGGAT-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ISQGTSGGAT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ISQGTSGGAT-OH at the technical inquiry form on this page</p>

<p>Portion of Influenza NP</p>

<p>Tetanus Toxin (1174-1189) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani. The neurotoxins produced by Clostridium tetani are among the most potent molecules known to humankind. Once in the body, the toxin binds to the basal lamina at the neuromuscular junction. From here, the toxin is transported to inhibitory interneurons in the spinal cord, where it prevents the release of neurotransmitters, which causes spastic paralysis.</p>

<p>HDL protein is a crucial component of the body's immune system. It plays a vital role in preventing and combating various diseases. HDL protein is known for its ability to produce autoantibodies, which are essential for neutralizing harmful substances and inhibiting the growth of pathogens. Additionally, HDL protein can act as an inhibitor by blocking the activity of certain enzymes or molecules that contribute to disease progression.</p>

<p>Fmoc-Cys(Xan)-Wang Resin (100-200 mesh) 1% DVB is a research tool used in the synthesis of peptides. It is an inhibitor that blocks the activity of the protein tyrosine phosphatase, which plays a role in the regulation of cell proliferation and differentiation. This resin can be used to produce peptides with cysteine residues that are important for binding to receptors or ion channels. Fmoc-Cys(Xan)-Wang Resin (100-200 mesh) 1% DVB can also be used as a ligand to activate receptors or ion channels. The resin has a purity of 99% and contains less than 0.1% water, so it is suitable for use in research on proteins and cells.</p>

<p>Stabilizer for Alkaline Phosphatase antibody and antigen conjugates</p>

<p>DDOST (71-77) (heavy) is derived from dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST). Congenital disorders of glycosylation are associated with functionally inactive DDOST. The arginine residue at position 11 is isotopically labelled with carbon-13 (6) and nitrogen-15 (4).</p>

<p>Portion of EBV EBNA 3C</p>

<p>Inhibits FGFR family of kinases; antineoplastic; anti-angiogenic</p>