Antibiotiques

Anhydrooxytetracycline hydrochloride is a useful research chemical. Buy Anhydrooxytetracycline hydrochloride from Cymit Quimica for a variety of research applications.

Ceftaroline fosamil is an antibacterial agent used to treat various bacterial infections such as pneumonia. Ceftaroline fosamil binds to the ribosomal RNA of bacteria, preventing the formation of proteins necessary for cell division. Ceftaroline fosamil has been shown to be highly active against Mycobacterium tuberculosis, Mycobacterium avium complex, and fungi such as Candida species.

Nadifloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase to inhibit DNA synthesis and is used for treating acne vulgaris and bacterial skin infections.

Amicoumacin B is a potent antibiotic, which is isolated from the bacterial species Bacillus pumilus. It acts by inhibiting protein synthesis, targeting the ribosomal 30S subunit and disrupting translational fidelity in bacterial cells. This interference in protein production leads to the effective elimination of various Gram-positive and certain Gram-negative bacteria.

9-Erythromycin 9-oxime is an activty inpurity, binding to the 50S ribosomal subunit of bacteria.

Ceftazidime is a broad-spectrum beta-lactam antibiotic that inhibits bacterial growth by inhibiting penicillin-binding proteins (PBPs). It is used to treat many bacteria infections including pneumonia and septicaemia. It has shown to be effective against some treatment-resistant bacteria such as Pseudomonas aeruginosa.

Bacitracin is a polypeptide antibiotic and is used for the treatment of bacterial infections, particularly skin infections. It interferes with bacterial cell wall synthesis by inhibiting the dephosphorylation of bactoprenol.

Amicetin is a type of antibiotic, which is derived from bacterial sources, specifically from Streptomyces species. It functions primarily by inhibiting protein synthesis in susceptible bacteria, achieved through interfering with the aminoacyl-tRNA binding process on the ribosome. This mechanism disrupts the translation process, thereby preventing bacterial growth and replication.

Roxithromycin is a macrolide antibiotic with action on bacterial protein synthesis by binding to the 50S ribosomal subunit and is used for treating respiratory, skin, and soft tissue infections.

Inhibitor of protein synthesis; macrolide class

Cefiderocol is a siderophore cephalosporin antibiotic with action on bacterial cell wall synthesis, particularly targeting multidrug-resistant gram-negative bacteria and is used for treating complicated urinary tract infections and hospital-acquired pneumonia.

A broad-spectrum antibiotic of cephalosporin class, which inhibits bacterial cell wall synthesis by targeting the penicillin-binding protein, involved in peptidoglycan synthesis. This third-generation cephalosporin is very active against Pseudomonas species and can also be used to treat bacterial meningitis as it penetrates in the cerebrospinal fluid.

Pefloxacin is a mesylate prodrug that is converted to pefloxacin in the body. The optimum concentration for pefloxacin is 2 µg/mL, and it has been shown to be active against gram-positive bacteria such as Streptococcus pneumoniae, group A beta-hemolytic streptococci, and Enterococcus faecalis. Pefloxacin has also been shown to inhibit the growth of human leukemia cells (HL-60) and drug interactions have been documented with this drug. Pefloxacin is not active against Mycobacterium tuberculosis or Mycobacterium avium complex.

Anthracycline is a class of chemotherapy drugs, which are anthraquinone antibiotics derived from the bacterial genus Streptomyces. They exert their therapeutic effects primarily through intercalation into DNA, disrupting the function of enzymes such as topoisomerase II, thus preventing the transcription and replication processes in rapidly dividing cancer cells. Furthermore, they generate free radicals, leading to oxidative stress and subsequent cell damage. These mechanisms collectively result in apoptosis of malignant cells. Anthracyclines are utilized extensively in oncology for the treatment of various malignancies, including leukemias, lymphomas, breast cancer, and sarcomas. The efficacy of anthracyclines in inhibiting tumor growth must be balanced against their cardiotoxic potential, which is a significant consideration in their clinical use. This dual nature makes them both pivotal and challenging in chemotherapy regimens, necessitating careful management and monitoring throughout treatment.

Puromycin is active against both prokaryotic and eukaryotic cells. Puromycin resistance gene (pac) is a common choice for the selection of mammalian cells since its first application in 1988, especially for therapeutic proteins in mammalian cells where it was used to produce high levels of protein of interest. Puromycin can also be used as a selection marker for Archea.

Inhibitor of protein synthesis; glycylcycline class

Maduramicin ammonium is an anticoccidial agent with action on protozoal parasites by disrupting ion gradients and is used for preventing coccidiosis in poultry.