Anticorps d'immunologie

Goat IgG (Fc) is a purified immunoglobulin that has various characteristics and applications in the field of life sciences. This antibody is known for its anti-MERTK activity, which makes it a valuable tool for studying the role of MERTK in different biological processes. Additionally, Goat IgG (Fc) has been shown to interact with colony-stimulating factors, steroids, glucagon, transferrin, and other molecules involved in cellular signaling pathways.

Purified Rat IgG FITC conjugate

Purified Human IgG Fab protein

<p>C5A is an anaphylatoxin produced along with C5b, by the cleavage of complement C5, a fundamental factor of the complement system pathways.</p>

<p>Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (324-338) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.</p>

<p>Ara h 1 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins.Ara h 1 is a member of the 7/8 S globulin (vicilin) family of seed storage proteins belonging to the cupin superfamily and is the most abundant allergen present in the peanut kernel. Ara h 1 plays an important role in the allergy sensitising procedure and can be recognised by 90% of patients with a peanut allergy.This peptide represents a tryptic peptide of Ara h 1.</p>

Purified Goat IgG (Fab)

<p>Cilengitide is a cyclic arginine-glycine-aspartic acid (RGD) motif containing peptide that selectively inhibits the integrin alphav subunit. Integrins are cell adhesion molecules which mediate cell-cell and cell-matrix interactions and creating a scaffold for tissue organisation. Integrins also act to regulate cell attachment, proliferation, differentiation, apoptosis and motility.Integrin alphav can form heterodimers with integrin subunits subunits β1, β3, β5, β6, or β8. Cilengitide is a highly specific antagonist of alphavβ3 and alphavβ5 integrins. It also and shows anti-angiogenic effects and inhibits growth and promotes apoptosis of tumour cells that express integrins, such as glioblastoma.Cilengitide has gone on to phase II trials for cancers such as glioblastoma, melanoma, prostate, breast, lung and head and neck cancers.</p>

<p>alpha 1 Antitrypsin antibody (biotin) was raised in goat using human alpha-1-anti-Trypsin as the immunogen.</p>

<p>The cyclic tridecapeptide Compstatin, binds to and selectively inhibits the interaction between C3 and convertase, hence preventing the formation of C3a and C3b and activation of the complement system. Compstatin has the ability to form β-turns and hydrophobic clusters which are crucial for its inhibitory properties. When binding between C3 MG4 and MG5 domains, located within the MG-ring of the β-chain, Compstatin undergos a conformational change which is believed to prevent C3 from binding to C3 convertase through steric hindrance. Consequently the complement cascade is inhibited.The complement cascade is an important feature of the immune system. C3b, produced from the interaction of C3 and C3 convertase, binds to pathogens and somatic cells and signals for their removal from the body. However the increased activation of the complement system can result in diseases, associated with Alzheimers, strokes, heart attacks and autoimmune diseases. Therefore Compstatin can be used as a therapeutic agent within medicine.</p>

<p>Purified native IgG3 protein</p>

<p>Fibrinogen b43-63 Human is derived from Fibrinogen, which is a large plasma glycoprotein with a complex structure, and one of the most abundant proteins in blood. Fibrinogen is important in fibrin clot formation, haemostasis, and inflammatory responses. Increased plasma fibrinogen indicates a proinflammatory state and is a risk factor for vascular inflammatory diseases including hypertension and atherosclerosis. Fibrinogen cleavage products act as inflammatory activators in the pathophysiology of allergic asthma.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to fibrinogen and catalyses cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB). Fibrinopeptide B is protected from modifications such as carbamylation by pyroglutamination of the N-terminal amino acid.</p>

<p>Latent TGF-β is a non-lysosomal glycoprotein with mannose 6-phosphate (Man-6-P) residues on its N-glycans. When it is released, latent TGF-β is bound to its latency-associated peptide (LAP), it must then be activated and released from LAP before it can bind to its cell surface-localised Man-6-P receptors and exert its biological activity. Activation can occur by various mechanisms in vivo, including those governed by integrins and thrombospondin. Mannose phosphorylation has also been implicated in this activation process. Man-6-P has been proposed as an anti-scarring therapy due to its ability to directly block the activation of latent TGF-β.</p>

Nangibotide, also referred as LR12, is an antagonist of triggering receptor expressed on myeloid cells (TREM)-1, and was derived from residues 94 to 105 of TREM-like transcript-1 (TLT-1).TREM-1 plays a crucial role in the onset of sepsis by amplifying the host immune response. TLT-1- and TLT-1-derived peptides therefore exhibit anti-inflammatory properties by dampening TREM-1 signalling.  LR12 blocks TREM-1 by binding to the TREM-1 ligand and provides protective effects during sepsis such as inhibiting hyper-responsiveness, organ damage, and death, without causing deleterious effects. The protective effects of modulating TREM-1 signalling are also evident in other models of inflammation such as: pancreatitis- haemorrhagic shock- inflammatory bowel diseases and inflammatory arthritis.

<p>Human IgE is a hormone peptide that plays a crucial role in immune response and allergic reactions. It is a protein that belongs to the immunoglobulin family and is involved in the activation of various immune cells. Human IgE specifically recognizes and binds to antigens, triggering an immune response against them. Monoclonal antibodies targeting human IgE have been developed for therapeutic purposes. These antibodies can neutralize the effects of IgE, reducing allergic reactions and symptoms associated with allergies such as asthma, hay fever, and hives. They work by blocking the binding of IgE to its receptors on immune cells, preventing the release of inflammatory mediators. In addition to their therapeutic applications, human IgE and its monoclonal antibodies are widely used in research and diagnostic laboratories. They are valuable tools for studying immune responses, identifying specific allergens, and detecting the presence of autoantibodies or infections caused by microorganisms like Mycoplasma genitalium. Our purified human IgE products are carefully</p>

<p>Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (323-339) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.</p>

Pack contains 100 vials.  Peptide sequences: H5N1 native seq1  H-IQIIPK-OHH5N1 native seq2  H-LVLATGLR-OHH5N1 native seq3  H-EFNNLER-OHH5N1 native seq4  H-TLDFHDSNVK-OHH5N1 native seq5  H-EEISGVK-OH1nmol/peptide/vial and provided as dry aliquots

<p>Blocks the Wnt pathway and inhibits the expression of TGFb1 in CT26 colon carcinoma cells, leading to the reduction of CCL20 and CCL22, two TGF-b- dependent chemokines critical for Treg cell recruitment into the tumour microenvironment.  hsBCL9CT-24 shows robust antitumour efficacy across multiple in vivo models.</p>