Building Blocks

<p>Applications Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates.<br>References Erkelenz, M. et al.: J. Am. Chem. Soc., 133, 16111 (2011);<br></p>

<p>Applications trans-Campestanyl Ferulate is used for synthesis of trans-feruloyl-β-sitostanol.<br>References Condo, A., et al.: J. Agric. Food Chem., 49, 4961 (2001);<br></p>

<p>Applications A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kubinyi, H., et al.: J. Cancer Res. Clin. Oncol., 116, 529 (1990), Sheridan, R., et al.: J. Med. Chem., 50, 3173 (2007), Sahu, R.P., et al.: Carcinogenesis, 30, 1744 (2009),<br></p>

<p>Applications A sulfonate ester as potential genotoxic impurity in drug substances. It may exert genotoxic effects in bacterial and mammalian cell systems.<br>References Eder, E., et al.: Xenobiotica, 12, 831 (1982), Li, W., et al.: J. Chromatogr., 1046, 297 (2004), Glowienke, S., et al.: Mutat. Res., 581, 23 (2005), Colon, I., et al.: J. Pharm. Biomed. Anal., 39, 477 (2005),<br></p>

<p>Applications BENZYL CINNAMATE (cas# 103-41-3) is a useful research chemical.<br></p>

<p>Applications Pentaerythritol is a compound most commonly used in cosmetics (in its rosinate form). It is used as a skin conditioning agent (used as part of a cream base in lotions), and is also used to increase viscosity of cosmetic formulations.<br>References Andersen, F.: J. Am. Coll. Toxicol., 13, 395 (1994); Dhanorkar, V., et al.: J. Cosm. Sci., 53, 199 (2002); Lanigan, R.: Int. J. Toxicol., 17, 83 (1998)<br></p>

<p>Applications 3-Azidopropionic Acid is a mutagenic substance.<br>References LaVelle, J. M., et al.: Mutat. Res., 177, 27 (1987); Carlsson, L., et al.: J. Chem. Inf. Model., 49, 2551 (2009)<br></p>

<p>Applications (3-Azidopropyl)triphenylphosphonium Bromide (cas# 127611-39-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Parabanic acid appears to be an important marker of free radical reactions in vivo and may be used to monitor free radical activity and to evaluate pharmacological therapy with radical scavengers.<br>References Koumoto, Y., et al.: J. Biol. Chem., 276, 29688 (2001), Gibon, Y., et al.: Plant Cell, 16, 3304 (2004), Kaplan, F., et al.: Plant J., 44, 730 (2005), Ishii, N., et al.: Science, 316, 593 (2007),<br></p>

<p>Stability Very Hygroscopic<br>Applications Oxidation of 5-Hydroxymethyl-2-furancarboxylic Acid is used for green synthesis of 2,​5-​Furandicarboxylic Acid (F863750), one of the most important chemical building blocks from biomass.<br>References Gupta, N., et al.: Green Chem., 13, 824 (2011);<br></p>

<p>Applications An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lattova, E. et al.: Meth. Mol. Biol., 534, 65 (2009); Anderson, L.B. et al.: J. Biol. Chem., 275, 4920 (2000);<br></p>

<p>Impurity Anastrozole Monoacid Impurity<br>Applications Anastrozole Mono Acid is an impurity of Anastrozole (A637435), an aromatase enzyme inhibitor and antineoplastic agent. Anastrozole Monoacid Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications 1,2-Ethanedithiol is used in the synthesis of pH-sensitive biodegradable micelles. Also used in the preparation of biarsenical cyanine probes for imaging and tagging cytosolic bacterial proteins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, N. et al.: Bioconj. Chem., 24, 251 (2013); Chen, J. et al.: ACS. App. Mat. Int., 5, 3108 (2013);<br></p>