Building Blocks

<p>Applications A substrate for the determination of lactate dehydrogenase isoenzymes.This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Hegeman, G., et al.: J. Bacteriol., 91, 1155 (1966), Dobritzsch, D., et al.: J. Biol. Chem., 273, 20196 (1998), Chang, A., et al.: Biochem. J., 339, 255 (1999),<br></p>

<p>Applications Hydrazine derivative.<br></p>

<p>Applications Asiatic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Asiatic Acid is a neuroprotectant and induces of apoptosis in HepG2 human hepatoma cells.<br>References Zhou, J. et al.: Jiang. Dax. Xueb. Yixueb., 19, 475 (2009); Hsu, Y.L. et al.: J. Pharmacol. Exp. Ther., 313, 333 (2005);<br></p>

<p>Applications 2'-Chloroacetophenone (cas# 2142-68-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Very Very Moisture Sensitive<br>Applications Dichlorotriphenylphosphorane is a reagent used in the synthetic preparation of sulfonamides. Also used to prepare O-alkylated benzamides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Y. et al.: RSC. Adv., 5, 4171 (2015); Prabhakaran, P. et al.: Tetrahedron, 68, 4485 (2012);<br></p>

<p>Applications 2-METHOXY-4-METHYLANILINE (cas# 39538-68-6) is a useful research chemical.<br></p>

<p>Applications It can be degraded efficiently by the QL-degrading bacteria.<br>References Shukla, O., et al.: Microbios., 59, 47 (1989), Oh, Y; Biotechnol Bioeng 1994, 44, 533,,,<br></p>

<p>Applications 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Motoyama, N., et al.: Rev. Pestic. Toxicol., 1, 173 (1991)<br></p>

<p>Stability Hygroscopic<br>Applications 1,6-Anhydrohexopyranoses have proven to be valuable synthons for the preparation of biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.The chemical/physical/toxicological properties have not been thoroughly investigated. Since it is known to be a minor component of certain food materials it may be regarded as of relatively low toxicity.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987); Fresnos, J.N. and Swenton, J.S. , J. Chem. Soc., Chem. Commun. 658, (1985); Kochetkov, N.K. et al., Tetrahedron Lett. 22, 4315, 4319 (1981); Georges, M. et al., Carbohydr. Res. 130, 115 (1984); Paulsen, et al., Chem. Ber. 114, 322 (1981).<br></p>

<p>Applications 2,4-Thioxylenol is a building block that has been used as a reactant for the preparation of Dibenzothiophene derivatives via palladium catalyzed aryl(alkyl)thiolation of unactivated arenes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Saravanan, P., Anbarasan, P.: Org. Lett., 16, 848 (2014)<br></p>

<p>Applications 2-Chloroethylamine Hydrochloride is used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs. Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sancineto, L., et al.: Bioorg. Med. Chem., 22, 4658 (2014); Mori, R., et al.: Eur. J. Med. Chem., 82, 16 (2014)<br></p>

<p>Applications 2-chloro-3-hydrazinylpyrazine (cas# 63286-28-2) is a useful research chemical.<br></p>

<p>Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,3',5,5'-Tetramethylbenzidine is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA). Dyes and metabolites, Environmental Testing.<br>References Josephy, P. David., et al.: J. Biol. Chem., 257, 3669 (1982);<br></p>

<p>Applications 4-Chlorophenyl Phenyl Sulfone is an impurity of Dapson (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Dong, X.W., et al.: Bioorg. Med. Chem., 16, 8151 (2008); Schafer, E., et al.: Arch. Environ. Contamin. Toxicol., 12, 355 (1983);<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Applications A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(ab’)2 fragments to ß-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms<br>References Maham, D.G., et al.: Anal. Biochem., 162, 163 (1987), Yoshitake, S., et al.: Eur. J. Biochem., 101, 395 (1979), Freytag, J.W., et al.: Clin. Chem., 30(9), 1494 (1984), Mahan, D.E., et al.: Anal. Biochem., 162, 163 (1987), Peeters, J.M., et al.: J. Immunol. Meth., 120, 133 (1989),<br></p>