Réactifs synthétiques

Applications AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
References Zarrinkar, P., et al.: Blood, 114, 2984 (2009); Sato, T., et al.: Blood, 117, 3286 (2011)

Applications ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.
References Liang, Y., et al.: Sci. Translational Med., 5, 167ra5 (2013)

Applications N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.
References Obreque, B., et al.: Eur. J. Med. Chem., 109, 124 (2016); Rodriguez-Hernandez, D., et al.: Eur. J. Med. Chem., 105, 57 (2015);

Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.
References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)

Applications Adenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3).
References (1) Jones, K. R., et al.: Sci Rep. 7, 44816 (2017) (2) Hutchison, A. J., et al.: J. Pharm. Exp. Ther. 251, 47 (1989) (3) Hasko, G., et al.: Nat. Rev. Drug Discov. 7, 759 (2008)

Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression
References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)

Stability Hygroscopic
Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).
References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),