Anneaux à 6 chaînons

Ethyl 3-cyclopropyl-2-oxopropanoate

Applications Isopropyl Benzoate (cas# 939-48-0) is a useful research chemical.

Stability Hygroscopic
Applications Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
References Bhat, S. et al.: J. Hetero. Chem., 52, 1253 (2015); Xu, R. et al.: J. Labelled. Comp. Radiopharm., 58, 308 (2015);

Impurity Iohexol USP Related Compound C
Applications N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is used in the preparation of X-ray contrast agents.
References Haavaldsen, J. et al.: Acta Pharmac. Sue., 20, 219 (1983);

Applications m-Aminophenyl Tosylate is a reactant used in the synthesis of 2-methyl-5-(2,3,4,5,6-pentafluorophenyl)benzothiazole and 4-[(2',3',4',5',6'-pentafluoro-1,1'-biphenyl-3-yl)amino]benzonitrile.
References Lee, D.S., et. al.: RSC Advances, 2, 9179 (2012)

Applications 2,2-Diphenylpentanoic Acid (cas# 841-32-7) is a compound useful in organic synthesis.

Applications 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol is used in protection measures in the prevention of tick-born diseases. Acaricide.
References Cisak, E. et al.: Annals Agri. Env. Med., 19, 625 (2012); Gbenou, J. et al.: Mol. Biol. Rep., 40, 1127 (2013);

Applications 4-​tert-​Butylbenzoic Acid is a general chemical reactant/reagent used in the synthesis of Arylboronic Acids as dual-action FAAH and TRPV1 ligands. As well, used in the preparation of cellular chemical probes targetting PRC1 (polycomb repressive complex 1) for prostate cancer cells.
References Morera, E. et al.: Bioorg. Med. Chem. Lett., 26, 1401 (2016); Stuckey, J. et al.: Nat. Chem. Biol., 12, 180 (2016);

Applications 2-Benzothiazolethiol is an intermediate used to synthesize benzothiazole derivatives as cyclooxygenase inhibitors. It is also used to prepare pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Paramashivappa, R., et al.: Bioorg. Med. Chem. Lett., 13, 657 (2003); Dolle, V., et al.: J. Med. Chem., 38, 4679 (1995)

Applications alpha-D-Glucoheptose (cas# 6946-18-5) is a useful research chemical.

Applications 2-(Morpholinothio)Benzothiazole (cas# 102-77-2) is a useful research chemical.

Applications 3,4-dihydro-2H-1-benzopyran (cas# 493-08-3) is a useful research chemical.

Applications 4-octylbenzoic acid (cas# 3575-31-3) is a useful research chemical.

Stability Very Very Moisture Sensitive
Applications Dichlorotriphenylphosphorane is a reagent used in the synthetic preparation of sulfonamides. Also used to prepare O-alkylated benzamides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, Y. et al.: RSC. Adv., 5, 4171 (2015); Prabhakaran, P. et al.: Tetrahedron, 68, 4485 (2012);

Applications o-tert-Butyl-α-chlorotoluene is a useful research reagent for the competitive chloromethylation of alkylbenzenes.
References Takezawa, T., et al.: Nippon Kagaku Kaishi 6, 1047 (1989); Hu, Y. L., et al.: J. Chil. Chem. Soc., 55, 97 92 (2010); Pinnell, R. P., et al.: Tetrahedron Lett., 25, 3511 (1984)

Applications Methyl 1,4-Benzodioxan-2-carboxylate is an intermediate used to prepare 2,3-dihydrobenzo[b|[1,4|dioxin- and indolealkylamine derivatives as potential antidepressants.
References Wang, S., et al.: Archiv der Pharmazie (Weinheim, Germany), 347, 32 (2014); Wang, S., et al.: Bioorg. Med. Chem. Lettt., 24, 1766 (2014)

Stability Hygroscopic
Applications 3,4-DIHYDROXYBENZYL ALCOHOL (cas# 3897-89-0) is a useful research chemical.

Applications tert-Butylbenzene is a component of the model diesel fuel.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xiao, Jing, et al.: Indus. & Eng. Chem. Res., 51(8), 3436-3443 (2012)

Applications 4,4'-Dithiobisbenzoic Acid, Technical Grade (cas# 1155-51-7) is a compound useful in organic synthesis.

Applications 1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethanone (cas# 14035-33-7) is a useful research chemical.

Applications N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.
References Harada, H., et al.: Bioorg. Med. Chem., 9, 2709 (2001); Tully, D., et al.: Bioorg. Med. Chem. Lett., 16, 5112 (2006)

Applications benzo[b]fluoren-11-one (cas# 3074-03-1) is a useful research chemical.

Applications Dibenzothiophene is commonly used in microbial studies as a sole, organic sulfur and carbon source for growth. Research concerning the biodegradation of dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful polycyclic hydrocarbons (PAH) as well. This may prove to be a very practical method in removing PAH’s from soils, sludge and crude oils.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bastiaens, L., et al.: Appl. Environ. Microb., 66, 1834 (2000); Gunam, I., et al.: J. Microbiol. Biotechn., 23, 473 (2013); Omori, T., et al.: Appl. Environ. Microb., 58, 911 (1992)

Applications Propyl 4-aminobenzoate (cas# 94-12-2) is a useful research chemical.

Applications 4-Benzoylbiphenyl is a reagent used in the synthesis of multicolored mechanochromic luminogen molecules.
References Zhao, Z. et al.: J. Mat. Chem. C. Mat. Opt. Elec. Dev., 4, 4800 (2016);

Applications N-Diethylaminoethyl-p-[2-(-n-octyloxy)-benzoyl]aminobenzoate (cas# 26090-29-9) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 2-Hydroxy-1-phenyl-1-propanone is a reagent used in the synthesis of heterocycles via heterocyclization of α-hydroxyarylketones.
References Li, G. et al.: Org. Lett., 18, 4526 (2016);

Impurity Quetiapine EP Impurity G; Quetiapine Impurity G; Quetiapine USP-G
Applications Dibenzo[b,f][1,4]thiazepine-11-[10H]one (Quetiapine EP Impurity G; Quetiapine Impurity G; Quetiapine USP-G) is an intermediate in the synthesis of quetiapine (Q510000).

Applications Decafluorobiphenyl is used for step−growth polymers synthesis (1).
References (1) Deck, P. A. and Maiorana, C. R. Macromolecules 34, 9 (2001)

Applications 3-(1-Cyanoethyl)benzoic Acid is an intermediate for the synthetic preparation of various pharmaceutical compounds. 3-(1-Cyanoethyl)benzoic Acid was used in studies examining the enantioselectivity of nitrile hydratases.
References Rzeznicka, K., et al.: App. Microbiol. Biotechnol., 85, 1417 (2010); Van Pelt. S., et al.: Org. Biomole. Chem., 9, 3011 (2011);

Applications Hydrochloride salt of benzyltriethylammonium which acts as a phase-transfer catalyst in chemical reactions.
References Shi, Z. et al.: Chem. Sci., 4, 829 (2013); Landeros, J. et al.: J. Mol. Struct., 1037, 412 (2013);

Stability Moisture Sensitive
Applications 3A-METHYLHEXAHYDROISOBENZOFURAN-1,3-DIONE (cas# 25550-51-0) is a useful research chemical.

Applications 3-Hydroxyphenylacetic Acid (cas# 621-37-4) is a compound useful in organic synthesis.

Stability Store Under Argon; Air Sensitive
Applications 4-Mercaptobenzoic Acid, Technical Grade (cas# 1074-36-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);

Impurity Oxybutynin USP Related Compound A
Applications An intermediate in the synthesis of oxybutynin (O868525). Oxybutynin USP Related Compound A.

Stability Moisture Sensitive
Applications 4,4'-Bis(isocyanatophenyl)oxide is a reagent used in the synthesis of lipid-conjugated Smac analogs with antitumor activity against human breast cancer cell lines.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Micewicz, E et al.: Bioorg. Med. Chem. Lett., 25, 4419 (2015);

Applications 3-hydroxycyclohexan-1-one (cas# 823-19-8) is a useful research chemical.

Applications 1-Cyclohexenylcarboxylic Acid is a reagent used in the synthesis and optimization of small-molecule HIV-1 entry inhibitors. Also used in the stereoselective synthesis of diazabicyclic β-lactams for antimicrobial activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tuyishime, M. et al.: Bioorg. Med. Chem. Lett., 24, 5439 (2014); Zhang, S. et al.: J. Org. Chem., 81, 956 (2016);

Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.
References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)

Applications (2E)-3-Phenyl-2-propenoic Acid is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.
References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);

Applications Phenyl(9H-purin-6-yl)amine (cas# 1210-66-8) is a compound useful in organic synthesis.

Applications Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form α and β pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boettecher, B. & Meister, A.: Anal. Biochem., 138, 449 (1984); Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112); Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006); Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994); Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)

Applications p,p'-Dimethoxytriphenylcarbinol, can be used in Amberlyst-15 catalyzed regioselective tritylation of sugar-based diols.
References Valeru, A., et al.: J. Carbohydrate Chem., 37, 318-326 (2018);

Applications o-Acetyltoluene can be used as a reagent to prepare diaryl dihydropyrazoles as inhibitors of mitotic kinesin spindle protein (1). It is also used to synthesize aryl- and indolyl-cyanoaminopyridines with anti-inflammatory, analgesic, and antipyretic activities (2).
References (1) Cox, C., et al.: Bioorg. Med. Chem. Lett. (2005) 15, 2041 (2) Manna, F., et al.: Eur. J. Med. Chem. (1999) 34, 245-54

Applications 2-[Methyl(phenylmethyl)amino]ethanol is used in the preparation of dihydropyrimidinones as sodium iodide symporter inhibitors used to regulate the accumulation of iodide in the thyroid gland. Also used in the synthesis of new class of pseudopeptides as potential inhibitors of β-sheet aggregation.
References Lacotte, P. et al.: ChemMedChem, 8, 104 (2013); Klein, J. et al.: Org. Lett., 14, 330 (2012);

Applications 5-phenylbenzene-1,3-diol (cas# 7028-41-3) is a useful research chemical.

Applications Reagent used to prepare poly-substituted benzenes.
References Grady, R., et al.: J. Cell. Biochem., 25, 15 (1984), Powis, G., et al.: Cancer Res., 47, 2363 (1987), Zeiger, E., et al.: Environ. Mol. Mut., 11, 1 (1988),

Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 3,5-Dihydroxytoluene is found in lichen fungi and can improve functional properties of lysozyme.
References Martirosova, E. I., et al.: Pharmaceutical and Medical Biotechnology, no vol., 45 (2013); Joergensen, S.H., et al.: Fungal Genet. Biol., 70, 24 (2014)

Applications Triphenylacetonitrile is used as a reactant in the rhodium-catalyzed reductive cleavage of carbon-cyano bonds with hydrosilane.
References Tobisu, M., et al.: JACS., 131, 3174 (2009)

Applications 4-((4-(Allyloxy)phenyl)sulfonyl)phenol is an additive to enhance the flame-retardation of unsaturated polyester resin (FR-UPR).
References Dai, K., et. al.: Ind. Eng. Chem. Res., 51, 15918 (2012)

Applications 1,3-Dinitrobenzene is used as an analyte to detect explosive environments (1), including those containing picric acid (2). Neurotoxic agent (3). Drinking water contaminant candidate (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. ÄŒapka, L. et al.: J. Chromatogr. A. 2015 Apr 3;1388:167-73.2. Sanda, S. et al.: Chem. Commun. (Camb) 2015 Apr 18;51(30):6576-93. Maurer, L. et al.: Neurotoxicology. 2016 Mar;53:74-84

Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.
References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)

Applications 2,4-Dioxo-4-phenylbutanoic acid

Applications 3-Carboxyphenylboronic Acid is used in phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration.
References Wang, X., et al.: Nanotechnology, 27, 385101 (2016); Wang, X., et al.: Eur. J. Pharm. Biopharm., 113, 168 (2017)

Applications 2-aminobenzene-1,4-disulfonic acid (cas# 98-44-2) is a useful research chemical.

Applications 1,4-Cyclohexanedimethanol is extensively used as cross-linking reagent in polymer industry. It has been used in the synthesis of polyketal copolymers. It was used as diol comonomer during the synthesis of polyester-carbonates based on 1,3-propylene-co-1,4-cyclohexanedimethylene succinate.
References Yang, S., et al.: Bioconjugate Chem., 19, 1164 (2008); Liu, Y., et al.: J. Polym. Sci. A Polym. Chem., 39, 2508 (2011); Hungria, A., et al.: Angewandte Chemie, 45, 4782 (2006)

Applications 2,6-Dimethylcyclohexanol (cas# 5337-72-4) is a useful research chemical.

Applications 3,5-Di-tert-butyl-4-hydroxybenzoic acid

Applications KAR3 is a compound in smoke responsible for promoting the seed germination of a wide range of plant species. The researchers named the compounds “the karrikins”, for “karrik”, an aboriginal word for smoke.
References Sakuma, H., et al.: .Agric Biol. Chem., 45, 443 (1981), Stevens, J., et al.: Plant Soil, 298, 113 (2007), Nelson, D., et al.: Plant Physiol., 149, 863 (2009),

Applications Aminophenyltrimethoxysilane is a useful intermediate for the preparation of aromatic silanes as high thermal stability coupling agents.
References Pan, Y., et al.: Adv. Mat. Res., 690, 1483 (2013)

Applications 6-Benzyl-2-thiouracil (cas# 6336-50-1) is a useful research chemical.

Applications 5-Bromo-1,2,3-trichlorobenzene is a useful intermediate in the preparation of isoxazole derivatives for controlling parasites, such as Rhipicephalus sanguineous nymphs.
References Gauvry, Noelle., et al.: PCT Int. Appl., WO 2012120135 A1 20120913. (2012);

Applications Bis(4-hydroxyphenyl) Sulfone is commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.
References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);

Applications N-Undecylbenzenesulfonic Acid is an anionic surfactant.
References Mottaleb, M. A.: Anal. Sci., 15, 1137 (1999), Kolb, M., et al.: LaborPraxis, 22, 56 (1998); Ferrer D., et al.: Tenside, Surfact., Det., 34, 278 (1997)

Applications 2-(Acetylamino)-3-(phenylthio)propanoic acid is a useful chemical in research.

Applications 1-(2H-1,3-benzodioxol-5-yl)propan-2-ol (cas# 6974-61-4) is a useful research chemical.

Applications 2,5-Dinitrotoluene, is a building block used in various chemical synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Impurity Ketoprofen EP Impurity A; Ketoprofen USP Related Compound D
Applications 3-Acetylbenzophenone (Ketoprofen EP Impurity A) is a Ketoprofen intermediate. Ketoprofen USP Related Compound D.
References Dvorak, J., et al.: J. Pharm. Biomed. Anal., 36, 625 (2004), Zhang, X., et al.: Bioorg. Med. Chem. Lett., 14, 1205 (2004),

Applications 4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.
References Eren, G., et al.: Bioorg. Med. Chem., 18, 6467 (2010); Weber, V., et al.: Bioorg. Med. Chem., 13, 4552 (2005)

Applications 2-Sulfobenzoic Anhydride (cas# 81-08-3) is a useful research chemical.

Applications 1-​Ethyl-​4-​vinylbenzene is a pollutant that comes from pyrolysis and combustion of waste lubricant oil from diesel cars.
References Fuentes, M., et al.: J. Anal. Appl. Pyrolysis, 79, 215 (2007); Molto, J., et al.: J. Anal. Appl. Pyrolysis, 84, 68 (2009);

Applications Ethyl 4-Phenylacetoacetate is a useful synthetic intermediate. It is used to prepare pyrazolone derivatives as antiprion compounds. It is also used to prepare pyrrolinylaminopyrimidine analogs as inhibitors of AP-1 and NF-κB mediated gene expression.
References Kimata, A., et al.: J. Med. Chem., 50, 5053 (2007); Palanki, M., et al.: Bioorg. Med. Chme. Lett., 12, 2573 (2002)

Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.

Applications Pyribenzoxim can be used in biological study of production of acetolactate synthase inhibitor herbicide tolerant Brassica napus mutants.
References Ruiter, R., et al.: U.S. Pat. Appl. Publ., US 20150089682 A1 20150326 (2015)

Stability Store in a Cool Dry Area.
Applications A metabolite of 1,4-diethenylbenzene.
References Linhart, I., et al.: Xenobiotica, 19, 645 (1989),

Applications 1,3-Divinylbenzene is a useful research chemical, a metabolites of diethenylbenzene in rat.
References Linhart, I., et al.: Xenobiotica, 22, 335 (1992)