Anneaux à 6 chaînons

<p>Applications (3,5-Dimethoxyphenyl)acetonitrile (cas# 13388-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis[2-​(1-​methylethyl)​phenyl] Ester Phosphorochloridic Acid is an intermediate in the synthesis of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.<br>References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);<br></p>

<p>Applications Phenyl Tosylate is an intermediate in synthesizing Diclofenac-13C6 Sodium Salt (D436453), which is a labelled analogue of Diclofenac Sodium Salt (D436450).<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>

<p>Applications N-BENZYLBENZAMIDE (cas# 1485-70-7) is a useful research chemical.<br></p>

<p>Applications Geranylgeranyltriphenylphosphonium Bromide (cas# 57784-37-9 ) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Formylbenzenesulfonic Acid is used in preparation method for 3-Phenyl-L-serine derivatives.<br>References Xu, W., et al.:PCT Int. Appl., (2020):<br></p>

<p>Applications (2S,3S,4R,5R)-2-(6-Amino-9H-purin-9-yl)-5-(((3-aminophenyl)thio)methyl)tetrahydrofuran-3,4-diol is an enantiomer of (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-(((3-aminophenyl)thio)methyl)tetrahydrofuran-3,4-diol (A577286), which an intermediate used in the synthesis of S-adenosylhomocysteine analogs with biological activities.<br>References Lawrence, F., et al.: Biochem. S-Adenosylmethionine Relat. Compd., Proc. Conf., 637 (1982); Shire, D., et al.: Nucleosides &amp; Nucleotides, 2, 21 (1983)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-phenyl-2-[(trimethylsilyl)oxy]acetonitrile (cas# 25438-37-3) is a useful research chemical.<br></p>

<p>Applications 4-benzylcyclohexan-1-one (cas# 35883-77-3) is a useful research chemical.<br></p>

<p>Applications Methyl-2-bromo-4-bromomethylbenzoate<br></p>

<p>Applications m-Xylene-2,4,6-triol is a reagent used to synthesize a series of flavanone derivatives that show anti-tumor activities.<br>References Shi, L., et al.: Biorgan. Med. Chem. Lett., 20, 5466 (2010)<br></p>

<p>Applications o-Iodochlorobenzene is a building block that has been used as a reactant for the synthesis of biaryl derivatives of seasamol used for their antioxidant activity against DPPH radical.<br>References Rodriguez, S.A., et. al.: Australian J. Chem., 66, 1334 (2013)<br></p>

<p>Applications 2-cyclohexylpropan-1-amine (cas# 103254-49-5) is a useful research chemical.<br></p>

<p>Applications (±)-trans-1,2-Diaminocyclohexane is a reagent used in the thyroid receptor agonists for treatment of androgenetic alopecia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, J. J., et al.: Bioorg. Med. Chem. Lett., 20, 306 (2010)<br></p>

<p>Applications 1,5-Diphenylcarbazone compound with 1,5-Diphenylcarbazide (cas# 538-62-5) is a useful research chemical.<br></p>

<p>Applications [4-(Cyclopropylmethyl)phenyl]methanamine Hydrochloride is a useful research chemical for organic synthesis.<br></p>

<p>Applications 2-PHENOXYBENZOIC ACID (cas# 2243-42-7) is a useful research chemical.<br></p>

<p>Applications 1,4-Cyclohexanediamine<br></p>

<p>Applications An intermediate in the preparation of Digallic Acid<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications 2-tert-Butylbenzenesulfonamide can be used as reactant in preparation of benzimidazole derivatives for inhibiting neoplastic cells.<br>References Sperl, G., et al.: U.S., US 6348032 B1 20020219 (2002)<br></p>

<p>Applications Monobenzyl Miglustat is a useful synthetic intermediate.<br></p>

<p>Applications Methyl 2-Phenoxybenzoylformate is an intermediate in the synthesis of (Z)-Metominostrobin (M338758), a fungicide for rice plants.<br></p>

<p>Applications Bis(2,4,5-tribromophenyl)iodonium Hydrogen Sulfate is an intermediate in the synthesis of 2,2',4,4',5,6'-Hexabromodiphenyl ether (H290745), which is a hepatotoxic polybrominated diphenyl ester (PBDE) that is commonly used as a flame retardant. 2,2',4,4',5,6'-Hexabromodiphenyl ether is also sometimes found in food and meats as well, posing a significant risk to humans (especially during pregnancy) and/or animals that consume it. One of the new POPs under the Stockholm Convention<br>References Johnson, P., et al.: Sci. Total Environ., No vol. given, 445 (2013); Scott, L., et al.: Organo. Comp., 74, 1109 (2012); Zhao, Y., et al.: Env. Sci. Tech., 47, 5939 (2013)<br></p>

<p>Applications (E)-N-(2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)ethyl)-4-oxo-4-phenylbut-2-enamide is a useful research chemical.<br></p>

<p>Applications (2S,3R,4E)-3-Benzoyl-2-tert-butyloxycarbonylamino-4-octadecen-1,3-diol (cas# 299172-59-1) is a compound useful in organic synthesis.<br>References Kinjo, Y., et al.: Chem. Biol., 15, 654 (2008),<br></p>

<p>Applications 3-(1-(Ethylamino)cyclohexyl)phenol is a useful synthesis intermediate.<br></p>

<p>Impurity Ketoprofen EP Impurity G<br>Applications 3-​(2-Hydroxyethyl)​benzoic Acid (Ketoprofen EP Impurity G) is an impurity in the synthesis of Ketoprofen (K200800), anti-inflammatory (1,2); analgesic.<br>References 1. Ueno, K. et al.: J Med Chem. 1976 Jul;19(7):941-6. 2. Jamali, F. et al.: Clin Pharmacokinet. 1990 Sep;19(3):197-217.<br></p>

<p>Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.<br></p>

<p>Applications 3-(Phenylmethoxy)cyclobutanemethanol is a compound useful in organic synthesis.<br></p>

<p>Applications (24,28),(25,27)-Bis-[8,9(3,4-dimethyl)benzo-crown-6]calix[4]arene is a metal chelator and intercalator.<br></p>

<p>Applications Trimethylphenylammonium Iodide (cas# 98-04-4) is a compound useful in organic synthesis.<br>References Dorweiler, J., et al.: Biochem., 42, 14653 (2003),<br></p>

<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>

<p>Applications 1,2-O-Cyclohexylidene myo-Inositol (cas# 6763-47-9) is a compound useful in organic synthesis.<br></p>

<p>Applications methyl 3-chloro-4-hydroxyphenylacetate (cas# 57017-95-5) is a useful research chemical.<br></p>

<p>Applications Ethyl (pentafluorobenzoyl)acetate (cas# 3516-87-8) is a useful research chemical.<br></p>

<p>Applications 7,8-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-one (cas# 75187-63-2) is a useful research chemical.<br></p>

<p>Applications 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents.<br>References Ye, X. et al.: Zhong. Yao. Xuax. Zaz., 20, 106 (2010);<br></p>

<p>Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.<br></p>

<p>Applications Methyl 2,​5-​Dihydroxybenzoate is a general reagent used in the synthesis of angiogenesis inhibitors that display anti-tumor activity.<br>References Marin-Ramos, N. et al.: J. Med. Chem, 58, 3757 (2015);<br></p>

<p>Applications Methyl 2-Amino-3,4,5-trimethoxybenzoate could be a constituent contributing to the aroma of green tea leaves.<br>References Hasegawa, T., et al.: J. Food Eng., 4, 10 (2014)<br></p>

<p>Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl<br></p>

<p>Applications 4,5,6,7-Tetrahydro-7-oxo-benzo[b]thiophene-4-carbonitrile is a useful synthetic intermediate.<br></p>

<p>Applications 1,4-Benzodioxan-2-carbonitrile (cas# 1008-92-0) is a compound useful in organic synthesis.<br></p>

<p>Applications m-Xylene is an organic solvent used in histology. It is also used after tissue sections have been stained to make them hydrophobic so a coverslip may be applied with a resin in solvent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Watanabe, M., et al.: Stain Technol., 50, 239 (1975); Wishe, H., et al.: Anat. Rec., 197, 283 (1980); Wolf, E.: Acta Histochem. Suppl., 35, 179 (1988); Dykewicz, M.: J. Allergy Clin. Immunol., 87 (1991)<br></p>

<p>Stability Hygrscopic<br>Applications N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide is an intermediate used to prepare Ranolazine (R122500), an antianginal agent.<br>References Aalla, S., et al.: Org. Proc. Res. Dev.,16, 748 (2012)<br></p>

<p>Applications Methyl 4-(trifluoromethoxy)benzoate<br></p>

<p>Applications Methyl 3-(Hydroxymethyl)benzoate is used in the synthetic preparation of N-acylhydrazone derivatives as lactate dehydrogenase A inhibitors.<br>References Rupiani, S., et al.: J. Med. Chem., 101, 70 (2015)<br></p>

<p>Applications 3-Phenylpropyne is a useful synthetic intermediate. It is an intermediate used to synthesize carlina oxide. It can also be used to prepare triazole substituted pyrazolopyrimidinamide derivatives via click chemistry as potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klein, M., et al.: Org. Biomol. Chem., 7, 3421 (2009)<br></p>

<p>Applications 5-(Benzyloxy)-2-((benzyloxy)carbonyl)-3-hydroxy-5-oxopentanoic Acid is an intermediate used in the synthesis of 2-[2-[(5-carboxypentyl)amino]-2-oxoethyl]-2-hydroxybutanedioic Acid (C181175), which is derived from Methyl 6-Aminohexanoate Hydrochloride (M287100), which is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Applications (S)-(+)-Z-4-Amino-2-hydroxybutyric Acid is used in the synthesis of aminoglycoside antibiotics.<br>References Rai, R. et al.: Org. Lett., 8, 887 (2006); Li, Jie. et al.: J. org. Chem., 72, 4055 (2007);<br></p>

<p>Applications 1-​(3-​Hydroxyphenyl)​-​1-​propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity.<br>References Zheng, L., et al.: J. Org. Chem., 81, 8911-8919 (2016)<br></p>

<p>Applications A hydroxy derivative of dibenzothiophene. Coal model compound used in chemical coal cleaning studies with molten hydroxides.<br>References Nowak, M.A. et al.: Coal Prep., 7, 29 (1989); Nishioka, M. et al.: Anal. Chem., 57, 1327 (1985);<br></p>

<p>Applications N-{2-[(4-Hydroxyphenyl)sulfanyl]ethyl}acetamide (cas# 91281-32-2) is a useful compound for use as a skin-lightening agent; cosmetic applications.<br>References Parvez, S., et al.: Phytother. Res., 20, 921 (2006)<br></p>

<p>Applications ETHYL 4-ETHOXYBENZOATE (cas# 23676-09-7) is a useful research chemical.<br></p>

<p>Applications 3-O-tert-Butyldimethylsilyl-cholest-5-ene-3-ol 24-(2-hydroxyisopropyl) 24-Phenyl Sulfinate is an intermediate in the preparation of Campesterol (C155360).<br></p>

<p>Applications 5-chloro-2,1,3-benzoxadiazol-4-amine (cas# 80277-04-9) is a useful research chemical.<br></p>

<p>Applications Used for preparation of Terfenadine (T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications (1,2-Dioxoethylene)bis(iminoethylene) bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) (cas# 70331-94-1) is a useful research chemical.<br></p>

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Applications 1,1'-[Oxybis(3,1-propanediyloxymethylene)]bis-benzene is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.<br>References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)<br></p>

<p>Stability Volatile<br>Applications 2,3-Dihydropyran is used in the synthesis of potent and selective myeloperoxidase inhibitors useful as antimicrobial oxidants. Also is used to synthesize novel and selective σ1 receptor ligands.<br>References Soubhye, J. et al.: J. Med. Chem., 56, 3943 (2013); Diaz, J. et al.: J. Med. Chem., 56, 3656 (2013);<br></p>