Étalons pharmaceutiques

Stability Moisture Sensitive
Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)

Applications Intermediate in the preparation of Caffeic Acid metabolties.

Applications (2,2',3,3',4',5,5',6,6'-d9-[1,1'-Biphenyl]-4-yl)boronic Acid acts as a reagent in the preparation of anthracene derivatives used as organic electroluminescent materials.
References Kim, T. H., et al.: From Repub. Korean Kongkae Taeho Kongbo (2013), KR 2013124775 A 20131115

Applications tert-Butyl 5-Iodovalerate is used as a reactant in the labeling of site-specific cell surface proteins with biophysical probes using biotin ligase.
References Chen, I., et al.: Nat. Methods, 2, 99 (2005);

Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.

Applications 2-[(4-Nitrophenyl)thio]-acetic Acid Octyl Ester is an intermediate in the synthesis of labelled Sodium Trifluoroacetate which is a compound used as an intermediate for various pharmaceutical, agricultural and chemical applications.

Applications Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.
References Namikoshi, M., et al.: Chem. Pharm. Bull., 35, 2761 (1987); Foroumadi, A., et al.: Bioorg. Med. Chem. Lett., 17, 6764 (2007);

Applications 2-[[[[1-(Methyl-d3)ethyl-1,2,2,2-d4]amino]sulfonyl]amino]-benzoic Acid Methyl Ester is an intermediate in the synthesis of Bentazon-d7 (B120583). Bentazon-d7 is deuterium labelled Bentazon (B120580), which is a herbicide.
References Ghirardello, D., et al.: Environ. Sci. Technol., 44, 9010 (2010); Frihauf, J., et al.: Weed Technol., 24, 262 (2010); Rotroff, D., et al.: Toxicol. Sci., 117, 348 (2010)

Applications 1,3-Dicyclohexyl-2-phenyl-pseudourea is an intermediate in the synthesis of [R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid (D454455) which is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is an intermediate in the synthesis of [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (A611565), another Fosfomycin (F727500) impurity.
References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Applications (+)-β-Eudesmol-7,7,8a,8’8’-D5 is an isotope labeled analog of (+)-β-Eudesmol (E938600), which is a sesquiterpenoid molecule that affects the central nervous system (CNS). It is known to induce neurite outgrowth. Antiangiogenic activity.
References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);

Applications 1,8-Dimethylnaphthalene-d12 (CAS# 104489-29-4) is a useful isotopically labeled research compound.