Étalons pharmaceutiques

Applications CMPD101 is a potent and selective GRK2/3 inhibitor.
References Lowe, J.D., et al.: Mol. Pharmacol., 88, 347 (2015); Ikeda, S., et al.: PCT Int. Appl. WO 2007034846 A1 20070329. Mar 29, 2007

Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Applications 2,4'-Dibromoacetophenone-2-13C (CAS# 335081-05-5) is a useful isotopically labeled research compound.

Applications Diethyl 2,2'-((((6-chloroquinoxaline-2,3-diyl)bis(oxy))bis(4,1-phenylene))bis(oxy))dipropanoate is an intermediate used in the preparation of ethyl 2-[4-(3-fluoro-2-quinoxalinyloxy)phenoxy]propanoate, a new fluoro analog of the herbicide quizalofopethyl.
References Makino, K., et al.: J. Fluorine Chem., 37, 119 (1987)

Applications cis-Chrysanthemic Acid is an intermediate in synthesizing (+)-cis-Phenothrin (P318100), an isomer of Phenothrin (P318095), which is a pesticide used in the control of pests and insects.
References Wang, Y. et al.: Chemopshere, 90, 848 (2013); Hirahara, Y. et al.: Japan. J. Toxicol. Env. Health, 44, 451 (1998)

Applications 4-Chloro-3-cyclohexene-1-carboxylic Acid Methyl Ester (cas# 27705-05-1) is a compound useful in organic synthesis.

Applications The minor metabolite of Deflazacort.
References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),

Applications 3,3'-Bis(methylthio)-2,2'-bithiophene is a useful reagent for organic synthesis and other chemical processes.
References Smie, A., et al.: J. Electroanal. Chem., 452, 87 (1998), Di C. N., et al.: Chem. Phys. Lett., 275, 533 (1997),

Applications rac Isopropyl (±)-10-camphorsulfate-d7 is the isotope analog of rac Isopropyl (±)-10-camphorsulfate. rac Isopropyl (±)-10-camphorsulfate is an Impurity from the synthesis of Frovatriptan Succinate (F768500) and a chiral derivative of Camphor.
References Parsons, A.A., et al.: J. Cardiovasc. Pharmacol., 30, 136 (1997); Siow, C.H., et al.: Cephalalgia, 24, 1045 (2004); Poolsup, N., et al.: J. Clin. Pharm. Ther., 30, 521 (2005); Peng, R., et al.: Biochem. Pharmacol., 35, 1391 (1986), Tanaka, E., et al.: Biochem. Pharmacol., 41, 472 (1991),

Applications Labelled 3-(3,4-Dimethoxyphenyl)propanoic Acid (D460730), one of the novel circulating coffee metabolites in human plasma.
References Clifford, M., et al.: J. Sci. Food Agric., 80, 1033 (2000), Mateos, R., et al.: J. Agric. Food Chem., 54, 8724 (2006), Wong, C., et al.: J. Nutr. Biochem., 21, 1060 (2010),

Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).

Applications Benzyl 4-Nitrophenyl Carbonate is used as a reagent in the synthesis of Janus PEG-based dendrimers for use in combination therapy by controlled multi-drug loading and sequential release. Benzyl 4-Nitrophenyl Carbonate is also used as a reagent in the synthesis of Norfloxacin analogs which can exhibit antibacterial and antifungal activities under visible and UV light.
References Acton, A.L., et al.: Biomacromolecules, 14, 564 (2013); Bakhotmah, D.A., et al.: ISRN Org. Chem., 184754, 11 (2011)

Applications BIS(4-NITROPHENYL) SULFONE (cas# 1156-50-9) is a useful research chemical.

Applications Isotope labelled δ-Valerolactone used in the synthesis of various antibiotics including the ionophore antibiotic X-14547A. Also used in the preparation of polyesters via copolymerization.
References Nicolaou, K. et al.: J. Org. Chem., 50, 1440 (1985); Parrish, B. et al.: J. Polym. Sci. Polym, Chem., 40, 1983 (2002);

Applications 9-Bromononanoic Acid is an intermediate in synthesizing Rumenic Acid (R701590), a trans fatty acid that may potentially reduce the risk of cancer and cardiovascular diseases. It may also prevent disease processes that lead to chronic inflammation, atherosclerosis, and diabetes.
References Baer, D. J.: Am J Clin Nutr 95, 267 (2012); Gebauer, S. K., et al.:  Adv Nutr 2, 332 (2011); Duffy, P. E., et al.: Tetrahedron 62, 4838 (2006)

Applications The R-enantiomer of Baclofen (B108000) metabolite.

Applications α-(Bromomethyl)-α-butyl-4-chlorobenzeneacetonitrile-d9 is an intermediate used in the synthesis of Myclobutanil-d9 (M831402), which is the labeled analogue of Myclobutanil (M831400), an fungicide used on a wide range of food crops. Myclobutanil inhibits the biosynthesis of ergosterol, a critical component of fungal membranes.
References Kumar, A., et al.: J. Mycol. Plant. Pathnol., 42, 443 (2012); An, Y.R., et al.: Toxicol., 303, 94 (2013); Keinath, A.P., et al.: Crop. Protect., 42, 338 (2012);

Applications Bis(carboxyethylgerm​anium) Sesquioxide is a reagent used in the synthesis of carbon nanotubes.
References She, X. et al.: ACS App. Mat. Inter., 8, 10383 (2016);

Applications Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.
References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),

Applications (+)-Pinanediol-2-O-(hydrogen Sulfate) is a reactant used in studies on formation of organosulfates from reactive uptake of monoterpene oxides on neutral and acidic sulfate particles.
References Iinuma, Y., et al.: Phys. Chem. Chem. Phys., 11, 7985 (2009);

Applications (4-Chloro-3-nitrophenyl)-(2-thienyl)methanone (cas# 31431-18-2) is a compound useful in organic synthesis.

Applications 2',5'-Dideoxyuridine (cas# 35959-50-3) is a useful research chemical.

Applications 4-tert-Butyldimethylsiloxyacetophenone is an intermediate in the synthesis of 1-(4-(2-Cyclobutoxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol (C988245), which is a derivative of Betaxolol (B328000).
References Philippe, M.M., et. al.: Am. Chem. Soc., 30, 1003 (1987)

Applications Dihydronaftazone-d4 O-β-D-Glucuronide is labelled Dihydronaftazone O-β-D-Glucuronide (D450330) which is a metabolite of Naftazone (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011)

Applications 6β-Hydroxy Betamethasone can be used as analyte in analytical study for detecting betamethasone metabolites in human urine using liquid chromatography coupled to tandem mass spectrometry.
References Matabosch, X., et al.: Drug Testing and Analysis, 7, 663-672 (2015)

Applications Olodaterol is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).
References Cazzola, M., et al.: Pharmacol. Rev., 64, 450 (2012); Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);

Applications 3,4-Dihydro-1H-indolo[2,3-b][1,8]naphthyridin-2(10H)-one, is a derivative of 6,7,8,9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3’,2’:4,5]imidazo[1,2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metaboism. Created through the heat processing of food.
References Vanhaecke, L.. et al.: Food Chem. Toxicol., 46, 140 (2008);

Applications Methyl trans-Cinnamate is one of the odour active compounds of Tahitian vanilla flavour and basil oil. Methyl trans-Cinnamate is naturally found in Magnolia liliflora oil, which is used to create a variety of nematicides. Methyl trans-Cinnamate also inhibits mushroom tyrosinase and has antimicrobial effects against Escherechia coli in food.
References Adams, A., et al.: J. Am. Oil Chem. Soc., 88, 201 (2011); Blank, A., et al.: Ind. Crop. Prod., 38, 93 (2012); Brunschwig, C., et al.: Food Res. Int., 46, 148 (2012); Huang, Q., et al.: J. Agr. Food Chem., 57, 2565 (2009)

Stability Temperature and Moisture Sensitive
Applications 5-Trifluoromethyl-2-pyridinesulfonyl Chloride, 95%, 10% in Benzene (cas# 174485-72-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Phenindione is a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010);

Impurity Duloxetine Phthalamide Impurity
Applications (S)-Duloxetine Phthalamide is an impurity of (S)-Duloxetine present with enteric polymer hydroxypropylmethylcellulose phthalate (HPMCP) in dosage formulations.
References Jansen, P.J., et al.: J. Pharmaceut. Sci., 87, 81 (1998),

Applications 2,4-Bis(trimethylsilyl)cytosine is an intermediate used in the synthesis of 1’-Epi Gemcitabine Hydrochloride (E588510), which is an α-Anomer of Gemcitabine.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),