Étalons pharmaceutiques

Stability Unstable in Solution
Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.
References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);

Applications 4,4’-Dithiobis[2-(1,1-dimethylethyl)-phenol is used as a reactant for the fabrication of coatings based on epoxy resins for environmental protection of microelectronics.
References Krysin, A. P., et al.: Russ. J. Appl. Chem., 86, 997-1000 (2013)

Applications 1-Amino-7-naphthalenesulfonic Acid is used as an analyte in the development of several detection and analytical methods.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pyrzynska, Krystyna: Analy. Sci., 13(4),  629-632 (1997);Hong, S. P., et al.: Chromatographia, 54(1/2), 83-86 (2001)

Applications 1,3-Diethyl-2-thiourea (cas# 105-55-5) is a useful research chemical.

Applications (S)-(4-Nitrophenyl)oxirane is used as a reagent in the enantioconvergent synthesis of the β-blocker (R)-Nifenalol which is based on a combined chemoenzymic approach.
References Paedragosa-Moreau, S., et al.: Tetrahedron, 53, 9707 (1997)

Applications 6-Fluoro-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (cas# 885269-59-0) is a useful research chemical.

Applications 2-Iodo Adenosine 2’,3’-Acetonide (cas# 141018-25-9) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of 3,4-Methylenedioxymethamphetamine and its metabolites.
References Pizarro, N., et al.: Bioorg. Med. Chem., 10, 1085 (2002), Milhazes, N., et al.: Chem. Res. Toxicol., 19, 1294 (2006),

Applications Tris(4-nitrophenyl)phosphate (cas# 3871-20-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-BENZYL-3,3'-IMINODIPROPIONIC ACID (cas# 6405-28-3) is a useful research chemical.

Applications 9-Methylanthracene-d12 (CAS# 6406-97-9) is a useful isotopically labeled research compound.

Applications (3-Nitrophenyl)acetic Acid is a useful synthetic intermediate.
References Strazzolini, P., et al.: J. Org. Chem., 63, 952 (1998)

Applications B-1-Naphthalenyl-boronic Acid is a useful synthetic intermediate. It is a reagent used to synthesize potassium aryltrifluoroborates which is a convenient precursor of arylboron difluoride lewis acids. It can also be used to prepare high yields of biaryls via Suzuki coupling.
References Vedejs, E., et al.: J. Org. Chem., 60, 3020 (1995); Larhed, M., et al.: Tetrahedron Lett., 37, 8219 (1996); Singh, R., et al.: 7, 1829 (2005)

Stability Hygroscopic
Applications 6-(dimethylamino)naphthalene-2-carboxylic Acid (cas# 5043-05-0) is a useful research chemical.

Applications N-Des-tetrahydrofuran N-(6,7-Dimethoxy-4,4a-dihydroquinazolin-4-amine) Alfuzosin-d3 is an isotopic analog of N-Des-tetrahydrofuran N-(6,7-Dimethoxy-4,4a-dihydroquinazolin-4-amine) Alfuzosin (D297955), a dimer impurity of Alfuzosin (A532000).
References Ramage, A.G., et al.: Eur. J. Pharmacol., 129, 307 (1986); Deering, A.H.,: Brit. J. Clin. Pharmacol., 25, 417 (1988); Priolo, L.D., et al.: Eur. J. Clin. Pharmacol., 35, 25 (1988);

Applications α-2’-Deoxyguanosine is a reagent that forms a β-furanose anomer of imidazolone when photosensitized in the presence of benzophenone.
References Vialas, C., et al.: J. Chem. Soc. Perkin Trans. I, 1201-1206 (1999)

Applications An impurity of Docetaxel (D494420).
References Zamir, L., et al.: Tetrahedron Lett., 33, 5173 (1992), Gueritte-Voegelein, F., et al.: J. Med. Chem., 34, 992 (1993), Volk, K., et al.: J. Chromatogr., 696, 99 (1997),

Applications 6-methyl-2-oxo-4-[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]-1,2-dihydropyridine-3-carboxylic acid (cas# 1239521-17-5) is a useful research chemical.

Applications Curcumin β-D-Glucuronide Triacetate Methyl Ester-d3 is an intermediate used in the synthesis of Curcumin β-D-Glucuronide-d3 (C838512), which is a labelled analogue of Curcumin β-D-Glucuronide, a metabolite of Curcumin (C838510) in hepatic tissue and portal blood.
References Sharma, O., et al.: Biochem. Pharmacol., 25, 1811 (1976); Colletti, L., et al.: J. Clin. Invest., 85, 1936 (1990); Sharma, R., et al.: Clin. Cancer Res., 7, 1894 (2001);

Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.
References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);

Applications Tetramethylthiourea (cas# 2782-91-4) is a useful research chemical.

Applications Stavudine-alpha,alpha,alpha,6-d4 (CAS# 1219803-67-4) is a useful isotopically labeled research compound.

Stability Moisture Sensitive
Applications 2-Bromo-4’-isopropylacetophenone (cas# 51012-62-5) is a compound useful in organic synthesis.

Applications 1,3-Dicyclohexyl-2-phenyl-pseudourea is an intermediate in the synthesis of [R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid (D454455) which is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is an intermediate in the synthesis of [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (A611565), another Fosfomycin (F727500) impurity.
References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.

Stability Moisture Sensitive
Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)

Applications A metabolite of Nabumetone.
References Nobilis, M., et al.: J., Pharm., Biomed., Anal., 32, 641 (2003),

Stability Moisture Sensitive
Applications Labelled Phosphoric Acid, used in various chemical processes as a phosphorylating compound. It is involved in the hydrolysis via phosphorylation of nanocrystals to obtain high-aspect-ratio cellulose nanocrystals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Camarero E. et al.: Biomacromol., 14, 1223 (2013);

Applications N-Descyclopropyl N-Allyl Buprenorphine, is the metabolite of Buprenorphine (B689570), an Analgesic that demonstrates narcotic agonist-antagonist properties.
References Martin, W.R., et al.: J. Pharmacol. Exp. Ther., 197, 517 (1976), Rance, M.J., Biochem. Pharmacol., 25, 735 (1976), Heel, R.C., et al.: Drugs, 17, 81 (1979),

Applications 5,8-Dibromo-2-naphthalenecarboxylic Acid is bromo substituted naphthalene carboxylic acid which is a useful research reagent.
References Wang, X., et al.: Ultrasound Sonochemistry, 47,57 (2018)

Applications 4,5,6,7-Tetrahydro-7-oxo-benzo[b]thiophene-4-carboxylic Acid methyl Ester is a useful synthetic intermediate.