Étalons pharmaceutiques

Applications (2-Fosfomycinyl-1-(hydroxy)propyl)phosphonic Acid is an impurity of Fosfomycin (F727500); an antibiotic compound used in the treatment of urinary tract infections.
References Liu, H., et al.: Zhongguo Kangshengsu Zazhi, 36, 765 (2011); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981); Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013)

Applications 6'-Amino-1,6-dihydro-2-methyl-6-oxo[3,3'-bipyridine]-5-carbonitrile is a reagent used in the preparation of cardiotonic agents.
References Yamanaka, M. et al.: Chem. Pharm. Bull., 40, 666 (1992);

Applications 3-Bromo-4-nitrophenol (cas# 5470-65-5) is a compound useful in organic synthesis.

Applications 2-[1-(2-Naphthyl)ethyl]benzoic Acid (cas# 904236-46-0) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-[[4-[2-[(5-Chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl Ester is an impurity in the synthesis of Gyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic.
References Mizukami, et al.: Arzneimittel-Forsch., 19, 1413 (1969); Efendic, S., et al.: Proc. Nat. Acad. Sci. USA, 76, 5901 (1979); Feldman, J.M.: Pharmacotherapry, 5, 43 (1985);

Applications trans-Caffeic Acid is a useful synthetic intermediate. It was used as a reactant to synthesize N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. It is also used to prepare caffeic acid phenethyl ester analogs with antitumor structures.
References Michalet, S., et al.: Bioorg. Med. Chem. Lett., 17, 1755 (2007); Nagaoka, T., et al.: Bioorg. Med. Chem., 10, 3351 (2002)

Applications C-18 Silica Gel for reverse phase flash chromatography.- 35-70 micron particles, capped with TMS
References J. Org. Chem., 48, 3589 (1983)

Applications Jatrorrhizine iodide, is an alkaloid extract from the Berberidaceae family of plants displaying antioxidant activity.
References Ruiz, A. et al.: J. Agri. Food Chem., 62, 12407 (2014); Kim, J. et al.: Bioorg. Med. Chem., 22, 6047 (2014);

Applications 2,2'-(2-hydroxypropane-1,3-diyldisulfonyl)diethanol (cas# 67006-34-2) is a useful research chemical.

Applications N-Descarbo(1,4-benzodioxine), N-Acetyl Doxazosin-d8 Hydrochloride is the isotope analog of N-Descarbo(1,4-benzodioxine), N-Acetyl Doxazosin Hydrochloride. N-Descarbo(1,4-benzodioxine), N-Acetyl Doxazosin Hydrochloride is an impurity of doxazosin, which is used in biological studies to evaluate the structure activity or prazosin pharmacophore for Transport-P inhibition.
References Zunszain, P.A., et al.: Bioorg. Med. Chem., 13, 3681 (2005); Al-Damluji, S., et al.: J. Pharmacol., 124, 693 (1998)

Applications L-Methionine methyl ester is a protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.
References Forbes, J. & Shariatmadari, F.: World. Poul. Sci. J., 50, 7 (24); Kozak, M.: J. Cell. Biol., 108, 229 (1989); Müntz, K., et al.: Food/Nahrung, 42, 125 (1998); Wright, L., et al.: Amer. J. Physiol., 149, 130 (1947)

Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.
References Demetriou, A., et al.: Science, 233, 1190 (1986); Aebischer, P., et al.: Nat. Med., 2, 696(1996); Prakash, S., et al.: Biotechnol. Bioeng., 46, 621(1995);

Applications 3a,4,5,6-Tetrahydro-1H,3H-naphtho[1,8-cd]pyran-1-one is an intermediate in the synthesis of (S,S)-Palonosetron Acid which is an impurity in the synthesis of (S,S) Palonosetron (P165800), serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Applications N-(2-Chloroethyl)-N'-(4-pyridinyl)urea (cas# 62491-96-7) is a useful research chemical.

Applications β-Cyclogeraniol (cas# 472-20-8) is a compound useful in organic synthesis.

Applications α,α,2-Trimethylcyclohexanemethanol is a volatile constituent found in leaves of Eucalyptus citriodora.
References Tian, Y., et al.: Sepu, 23, 651-54 (2005);

Applications Labelled analogue of Crotonobetaine Hydrochloride, a trimethylammonium compound that can be converted into L-Carnitine by Escherichia coli via stereoselective hydration.
References Seim, H. et al.: Eur. Congr. Biotechnol., 1, 481 (1984); Seim, H. et al.: Appl. Microbiol. Biotechnol., 27, 538 (1988);

Applications Benzyl-2,3,4,5,6-d5 trans-Cinnamate (CAS# 347840-02-2) is a useful isotopically labeled research compound.

Applications 4,5,6,7-Tetrahydro-7-oxo-benzo[b]thiophene-4-carboxylic Acid methyl Ester is a useful synthetic intermediate.

Stability Moisture Sensitive
Applications Labelled Phosphoric Acid, used in various chemical processes as a phosphorylating compound. It is involved in the hydrolysis via phosphorylation of nanocrystals to obtain high-aspect-ratio cellulose nanocrystals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Camarero E. et al.: Biomacromol., 14, 1223 (2013);

Applications A metabolite of Nabumetone.
References Nobilis, M., et al.: J., Pharm., Biomed., Anal., 32, 641 (2003),

Stability Moisture Sensitive
Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.
References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)

Applications 1,3-Dicyclohexyl-2-phenyl-pseudourea is an intermediate in the synthesis of [R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid (D454455) which is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is an intermediate in the synthesis of [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (A611565), another Fosfomycin (F727500) impurity.
References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Stability Moisture Sensitive
Applications 2-Bromo-4’-isopropylacetophenone (cas# 51012-62-5) is a compound useful in organic synthesis.

Applications Curcumin β-D-Glucuronide Triacetate Methyl Ester-d3 is an intermediate used in the synthesis of Curcumin β-D-Glucuronide-d3 (C838512), which is a labelled analogue of Curcumin β-D-Glucuronide, a metabolite of Curcumin (C838510) in hepatic tissue and portal blood.
References Sharma, O., et al.: Biochem. Pharmacol., 25, 1811 (1976); Colletti, L., et al.: J. Clin. Invest., 85, 1936 (1990); Sharma, R., et al.: Clin. Cancer Res., 7, 1894 (2001);

Applications An impurity of Docetaxel (D494420).
References Zamir, L., et al.: Tetrahedron Lett., 33, 5173 (1992), Gueritte-Voegelein, F., et al.: J. Med. Chem., 34, 992 (1993), Volk, K., et al.: J. Chromatogr., 696, 99 (1997),

Stability Hygroscopic
Applications 6-(dimethylamino)naphthalene-2-carboxylic Acid (cas# 5043-05-0) is a useful research chemical.

Applications (3-Nitrophenyl)acetic Acid is a useful synthetic intermediate.
References Strazzolini, P., et al.: J. Org. Chem., 63, 952 (1998)

Applications N-BENZYL-3,3'-IMINODIPROPIONIC ACID (cas# 6405-28-3) is a useful research chemical.