Glycosciences

<p>4-Methoxyphenyl 3-O-allyl-2-O-benzyl-4,6-O-benzylidene-2-deoxy-b-D galactopyranoside is a fluorinated monosaccharide that is synthesized from allose. It has been modified with click chemistry to introduce a benzyl group at the C2 position and an allyl group at the C4 position. This compound has been glycosylated with glucose and methylated with methanol to produce a complex carbohydrate that can be used as a control for glycosylation reactions. The compound was purified to high purity using column chromatography.</p>

Tolmetin acyl-b-D-glucuronide is a nonsteroidal anti-inflammatory drug that is metabolized to the active form, tolmetin, in the liver. The major route of elimination is through the kidneys as an inactive conjugate with glucuronic acid and excreted in urine. Tolmetin acyl-b-D-glucuronide has been shown to react with lysines on proteins in biological fluids by forming covalent adducts. This reaction can lead to allergic reactions and other problems.

<p>1,2,3,4,6-Penta-O-benzoyl-a-D-galactopyranose is a custom synthesis of an oligosaccharide with a glycosylation site that can be modified by the addition of other sugars. It has been fluorinated and methylated at the 6 position. The CAS number for this compound is 41545-55-5.</p>

<p>Methyl-O-b-D-glucopyranosyl-(1-3)-S-b-D-glucopyranosyl-(1-4)-O-4-thio-b-D-glucopyranosyl-(1,4)-b-D-[2] glucopyranoside is a synthetic saccharide with a single modification of 4'-fluoro substitution on the O6 position. This modification provides an increased stability to acid hydrolysis. Methylation and saccharide synthesis is performed in our lab and custom modifications are available upon request.</p>

<p>3,4-O-Isopropylidene-D-galactal is a modified form of galactal. This compound is a methylated derivative of D-galactal that has been synthesized by the click reaction. It can be used in the synthesis of oligosaccharides and polysaccharides. 3,4-O-Isopropylidene-D-galactal is a high purity compound with a CAS number of 124477-12-9.</p>

<p>3-O-Acetyl-1,6-anhydro-2-azido-2',3'-di-O-benzyl-4',6'-O-benzylidene-2-deoxy-b,D cellobiose is a fluorinated oligosaccharide that can be customized for a variety of applications. The sugar unit contains an acetyl group on the C1 position and an azido group at the C2 position. This compound has been subjected to click chemistry in order to form a covalent bond with 4,6'-O-benzylidene 2,3'-dideoxy b,D cellobiose.</p>

<p>a-D-Galactopyranosyl-(1-1)-a-D-galactopyranoside is a complex carbohydrate that belongs to the saccharides. It is an oligosaccharide that contains both a monosaccharide and a disaccharide. This compound is synthesized from sugar, which is obtained from sucrose. The sugar molecule has been modified with fluorination, methylation, glycosylation, and click chemistry. This product has high purity and can be custom synthesized for any specific requirements.</p>

<p>GalNAca1-3(Fuca1-2)Galb1-3GlcNAc</p>

<p>(2S- trans)-4-Hydroxy-N-methyl 2-pyrrolidinecarboxamide is a modification of the sugar molecule. It is a complex carbohydrate that belongs to the group of oligosaccharides. It has CAS number 143035-54-5 and can be synthesized in high purity with a glycosylation process. This chemical can also be fluorinated and saccharide substituted to create a wide range of products with different properties.</p>

<p>Phosphoric acid mono-((2R,3R,4S,5R)-2,3,4,5,7-pentahydroxy-6-hydroxyimino-heptyl) ester disodium salt (compound H) is a high purity compound that can be custom synthesized to suit the customer's needs. It is a synthetically modified sugar with Click modification. This product has been fluorinated and glycosylated. Modification and methylation are also available on request.</p>

<p>2,6-Di-O-acetyl-3,4-di-O-benzyl-a-D-mannopyranosyl trichloroactimidate is a synthetic, glycosylate sugar that can be used in the synthesis of oligosaccharides and polysaccharides. This molecule has been fluorinated to increase its lipophilicity and stability. It has been modified with methyl groups to improve its reactivity with other molecules. The purity of 2,6-Di-O-acetyl-3,4-di-O-benzyl-a-D-mannopyranosyl trichloroactimidate is greater than 98%.</p>

<p>Main metabolite of antiretroviral drug Abacavir with potent activity against human immunodeficiency virus type 1 (HIV-1). Abacavir is eliminated by hepatic metabolism to two major metabolites: 5’-glucuronide formed by uridine diphosphate glucuronyl transferase and 5’-carboxylate formed by cytosolic alcohol dehydrogenase.</p>

<p>4-Methoxyphenyl 4-O-(2,3,6-tri-O-benzyl-b-D-galactopyranosyl)-2,3,6-tri-O-benzyl-b-D-glucopyranoside is a sugar that is custom synthesized. It is fluorinated and modified with saccharides. The molecular weight of this compound is 582.06 g/mol and the CAS number for it is 15041281.</p>

<p>(R)-Ketoprofen b-D-glucuronide is a synthetic modified sugar that is produced by the glucuronidation of ketoprofen, a nonsteroidal anti-inflammatory drug. The modification of ketoprofen with glucuronic acid can be achieved through an enzymatic process, which is catalyzed by UDP-glucuronyltransferase. This modification increases the solubility of ketoprofen and its ability to penetrate cells. (R)-Ketoprofen b-D-glucuronide has been shown to have antibacterial properties against Gram positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. It has also shown antiviral activity against HIV-1 due to its inhibition of reverse transcriptase, which is an enzyme important for viral replication.</p>

<p>The major gel forming component in agar, agarose, consists of a linear chain of sequences of 1,3 linked β-D-galactopyranosyl units and 1,4 linkages to 3,6-anhydro-α-L-galactopyranosyl units. Gelation is done via the formation of double helices (Arnott, 1974). Agar's properties are similar to gelatin as it is primarily used as a plating gel for microbial cultures (Lahaye, 1991). However, agar is a good substitute for animal-based gelatin in vegetarian foods and is easy to use in food gels in a similar way to the carrageenans. Common food applications of agar include: puddings, custards, and soft candies. Agar improves the texture of processed cheese and frozen desserts, and is also added to baked goods to inhibit staling. A creative food application uses agar-based gel cubes that are infused with fruit extract or wine to make a vegetable-based aspic (Armisén, 2009).<br>Agar contains two polysaccharides Agarobiose and Agaropectin. Both Gelidium latifolium and Gelidium amansii are sources of both Agar and Agarose. The images were kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.<br>Agaropectin<br>Agaropectin is a sulphated non-gelling galactan comprising about 30% of Agar. Half ester sulphate is present in varying amounts plus D-glucuronic acid and small amounts of pyruvic acid. As with Agarose the main chain has alternating residues of D-galactose and L-galactose heavily modified with acidic side-groups which are usually sulfate, glucuronate, and pyruvate. Pyruvic acid is possibly attached in an acetal form to the D-galactose residues of the agarobiose skeleton. No formal structure of Agaropectin appears to have been published.<br>Agarose<br>Agarose is a linear gelling polysaccharide of (1-3) linked β-D-galactopyranose residues linked to 3,6-anhydro-α-L-galactopyranose via 1-4 bonds. Agar contains about 60% Agarose.</p>

<p>Intermediate in the production of biosynthetic antibiotics</p>

<p>3,5-Bis-O-(2,4-Dichlorobenzyl)-2-C-methyl-a-D-ribofuranose is a custom synthesis that can be modified by fluorination, methylation, and monosaccharide or oligosaccharide addition. This sugar has a molecular weight of 476.28 g/mol and CAS No. 94629-04-0. It is a polysaccharide that is glycosylated with sugar at carbons 1 and 2. 3,5-Bis-O-(2,4-Dichlorobenzyl)-2-C-methyl-a-D-ribofuranose is used as an intermediate in the synthesis of complex carbohydrates such as Glycogenin A (CAS No. 94629 04 0), which has been shown to have antihyperglycemic effects.</p>

<p>Neocarratetraose-41-O-sulfate sodium salt is a high purity, synthetic oligosaccharide with a CAS number of 108321-78-4. It is an oligosaccharide that has been modified with methylation, saccharide, and Click modification. Neocarratetraose-41-O-sulfate sodium salt is used in the synthesis of complex carbohydrates and glycosylations. <br>Neocarratetraose-41-O-sulfate sodium salt is synthesized by reacting the sugar neocarratetraose with sulfuryl chloride to form the corresponding sulfonic acid chloride. The resulting compound is then treated with sodium hydroxide to produce its sodium salt form.</p>

<p>Octyl D-galactofuranoside tetraacetate is a fluorinated monosaccharide that is synthesized from octyl galactopyranoside. It is a synthetic oligosaccharide with a molecular weight of 806. Octyl D-galactofuranoside tetraacetate has been modified for glycosylation, methylation, and click modification. The chemical name is 4-O-(2-deoxy-beta-D-glucopyranosyl)galactopyranose 1,2,3,4,6-pentaacetate and it has CAS No. 223412-29-1. This product can be custom synthesized to order in high purity as per the customer's requirements.</p>

<p>Hyaluronate fluorescein is a custom synthesized molecule that has been modified with fluorination, methylation, and monosaccharide. This product is a synthetic oligosaccharide saccharide that has a molecular weight of 10kDa. It's CAS number is <br>Hyaluronate fluorescein is a complex carbohydrate that is synthesized through the modification of glycosylation. It contains sugar and carbons.</p>