Glycosciences

Applications Verbascose (CAS# 546-62-3) is an α-galactooligosaccharide with immunomodulatory activity in mouse macrophage RAW264.7 cells.
References Dai, Z.; et al.: J. Agric. Food. Chem., 66, 9070 (2018);

2-Azido-2-deoxy-3,5-O-benzylidene-D-xylono-1,4-lactone is a synthetic sugar that is used in the synthesis of glycosylation, methylation and click modification reactions. It has been shown to be a potential precursor for polysaccharides and fluorinated saccharides. This product can be custom synthesized and is available at high purity.

Fleetamine is a piperidine compound that has been shown to be an inhibitor of the enzyme glycosylation. Inhibitors of glycosylation are useful for treating diseases such as diabetes and Alzheimer's disease. It is thought that Fleetamine may inhibit human glycosylating enzymes, such as glucosyl transferase, which catalyzes the addition of a glucose molecule to a protein. This inhibition prevents the formation of oligosaccharides and glycoconjugates, which are necessary for proper functioning of cells.

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. It has been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

GDP-D-mannose diammonium salt is a custom synthesis. It has been modified with fluorination, methylation, and monosaccharide substitution. The structure of this compound consists of a glucose molecule bonded to a D-mannose molecule by an oxygen linkage at the 1-position. This product has been synthetically modified to include a click modification and oligosaccharides. GDP-D-mannose diammonium salt is used for the production of polysaccharides as well as glycosylation reactions.

Methyl α-D- glucopyranoside is a methylated sugar used as an inhibitor of lectin-conjugate binding. Methyl α-D- glucopyranoside is commonly used in protein purification for eluting glycoproteins and other glycoconjugates from affinity chromatography columns of agarose lectin. Methyl α-D- glucopyranoside is also known as Methyl alpha-D-glucoside or alpha-Methyl-glucoside.

D-Allose pentaacetate is a modified oligosaccharide that can be used as a synthetic intermediate in the production of complex carbohydrates. It has been shown to have high purity and is easily synthesized in a laboratory setting. D-Allose pentaacetate is a monosaccharide with five acetate groups that can be methylated or glycosylated, which makes it an ideal candidate for modification. D-Allose pentaacetate has CAS No. 144071-49-8 and can be found on PubChem CID: 1215965.

1,2-O-Benzylidene -beta- L- idofuranuronic acid gamma-lactone is a custom synthesis of a fluorinated monosaccharide. The modification of the sugar is accomplished by methylation and click chemistry. The monosaccharide can be used as a building block for oligosaccharides and polysaccharides. It is also used as an intermediate in the glycosylation process that produces complex carbohydrates.

6-O-Benzyl-1-(-)-carboxymenthyl-2,3:4,5-di-O-cyclohexylidene-L-myo-inositol is a synthetic oligosaccharide with the chemical formula C9H14FNO5. It is a monosaccharide composed of a single sugar unit, inositol, which has been modified with benzyl groups on the 6th and 1st positions of the inositol ring. This compound is used as an intermediate in the synthesis of other saccharides.

2-Azido-2-deoxy-2-C-methyl-D-ribono-1,5-lactone is a custom synthesized carbohydrate. It is an oligosaccharide that is modified by methylation and glycosylation. The carbohydrate has been fluorinated to provide the desired properties of this product. 2-Azido-2-deoxy-2-C-methyl-Dribono1,5 -lactone is a high purity product that is synthesized in a controlled environment with strict quality control measures. It has been synthesized using Click chemistry and is available for purchase in bulk quantities.

D-Galactosamine (GalN) is an aldohexose (2-Amino-2-deoxygalactose) in which the hydroxyl group at position 2 is replaced by an amino group (Collins, 2006). Galactosamine (as the N-Acetyl derivative) forms a key part of both N- and O-linked glycoproteins, glycolipids and glycosaminoglycans. Treatment of experimental animals with D-galactosamine / lipopolysaccharide causes lethal liver injury characterized by apoptosis of the hepatocyte and it is used as a laboratory model to study the effect of therapeutic agents (Hirono, 2001).

Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside is a carbohydrate that has been custom synthesized. It has a molecular weight of 614.4 g/mol and the chemical formula C30H50O8. This compound is an oligosaccharide with a polysaccharide backbone. Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside is soluble in water and ethanol, but insoluble in hexane or ether. It has CAS No. 19308-45-3 and can be modified by methylation or glycosylation. The molecule contains three sugar residues that have been linked through glycosidic bonds to form a triose sugar (a sugar containing three carbon atoms). The molecule also contains an acetal group at the C1 position of the mannose moiety that can be fluorinated with b

Simvastatin acyl-b-D-glucuronide is a modification of simvastatin that has been synthesized and modified to provide high purity. It is a white, crystalline solid with a melting point of about 200°C. This compound can be used as an intermediate in the synthesis of oligosaccharides, polysaccharides, or other carbohydrate derivatives.

L-Fucose is a monosaccharide that is an important component of glycoproteins and glycolipids. L-Fucose is also found in the cell wall of bacteria. The most abundant sources of L-fucose are from the hydrolysis of lactose or sucrose by bacteria, or as a result of intestinal microbial fermentation. L-Fucose has been shown to be involved in the regulation of many metabolic processes, including the glomerular filtration rate and sephadex g-100 binding capacity in the kidney. It has also been shown to improve growth in infant rats with protein malnutrition. The enzyme that catalyzes the conversion of D-arabinose to L-fucose is known as fucokinase.

2-Azido-((R)-3,5-O-benzylidene)-2,6-dideoxy-L-manno-hexitol is a methylated sugar that can be custom synthesized. It has CAS number of 4783-79-8. The chemical formula for this compound is C12H22N2O11 and the molecular weight is 538.3 g/mol. This product is a white to off white crystalline powder with a melting point of 200 degrees Celsius and an assay of 98%. This product is not soluble in water or alcohol. In addition, this product does not contain any heavy metals or toxic residues.

Trehalose is a naturally occurring disaccharide found in many organisms.Its role in nature is as versatile as its applications in the laboratory. Trehalose is synthesized by cells in response to stress and helps retaining the cellular integrity under tough conditions: An important function of Trehalose is to stabilize protein structures and to prevent proteins from their degradation. Researchers use Trehalosefor instance as a carbon source in selective microbiological media, as desiccation protectant and for cryoprotection.