Glycosciences

Dyed and soluble azo-xyloglucan (tamarind) is used for the measurement of enzyme activity, research, biochemical enzyme assays and in vitro diagnostic analysis.  It is a soluble chromogenic substrate for the assaying of endo-cellulase.

N-Nonanoyl-N-methylglucamine is a nonionic surfactant that has been shown to be effective in the treatment of some inherited blood disorders. N-Nonanoyl-N-methylglucamine is used as a red cell membrane stabilizer and has been shown to increase the proton concentration in human serum. It also increases the transfer rate of p-nitrophenyl phosphate from erythrocytes to plasma. This drug has been found to have enzyme activity on soybean trypsin, model system, and epoxidase activity. N-Nonanoyl-N-methylglucamine has shown to be an effective protective agent against sodium citrate induced hemolysis and monoclonal antibody mediated cytotoxicity. It also shows kinetic data for protein synthesis and gene expression at different concentrations.

MW of BSA approx 65000

1,2,3,5-Tetra-o-acetyl-D-xylofuranose is a fatty acid that is found in human red blood cells. It is used as a biochemical marker to diagnose the activity index of fatty acids in the red cell membrane. The activity index can be used to determine whether an individual has metabolic disorders such as hepatic steatosis or lc-ms/ms method. 1,2,3,5-Tetra-o-acetyl-D-xylofuranose also has antimicrobial effects against bacteria and fungi and can be used for the treatment of infectious diseases.

Raltegravir b-D-glucuronide is a synthetic, fluorinated analog of raltegravir. It is a potent HIV-1 integrase inhibitor that has been shown to be active against the majority of HIV-1 strains. Raltegravir b-D-glucuronide is less potent than the parent compound and exhibits reduced antiviral activity in vitro. Raltegravir b-D-glucuronide is metabolized to raltegravir and eliminated in urine as the glucuronide conjugate.

1,4:3,6-Dianhydro-2-O-methyl-D-glucitol is a modified sugar that belongs to the group of carbohydrates. It is synthesized by the modification of 1,4:3,6-dianhydro-2,5-diO-methyl D glucitol with methyl iodide and sodium methoxide. The compound is used in pharmaceuticals as an excipient and in cosmetics as a moisturizer. It has been shown to be effective against influenza A virus.

4-Glucopyranosylmannose is a disaccharide compound, which is a synthetic carbohydrate derived from the enzymatic or chemical glycosylation processes. It consists of glucose and mannose units linked through a glycosidic bond. The compound is sourced through advanced synthetic methodologies involving specific glycosyltransferases or chemical catalysts that facilitate the precise attachment of these sugar moieties.

Complex glucan (a 1-6) from Leuconostoc spp.; extender in blood transfusions.

6-O-Benzyl-D-glucose is an aglycon of 6-O-benzylglycosides, which are synthesized from glucose by alkaline hydrolysis in the presence of silver oxide. The benzyl group can be removed by a variety of methods, including treatment with hydrogen chloride gas. 6-O-Benzyl-D-glucose has been used in research to demonstrate that carbohydrates have a common structural feature that can be identified by looking at their molecular structure. This molecule has also been used to study the synthesis and reactivity of benzyl groups.

1,4-b-Xylobiose hexaacetate is a sugar that is used in the glycosylation of complex carbohydrates. It can be synthesized from xylose and acetaldehyde by Methylation and Click modification. 1,4-b-Xylobiose hexaacetate has been fluorinated to give a stable product. This product is soluble in water, ethanol, acetone, DMF, DMSO and other organic solvents. It can also be used for methylation or polysaccharide synthesis. The CAS number for this compound is 58024-20-7.

1,5-α-L-Arabinohexaose is a carbohydrate. It is a nonreducing sugar that can be found in plants. 1,5-α-L-Arabinohexaose has an optimum pH of 5 and an ethanol concentration of 0.02%. The enzyme form of 1,5-α-L-Arabinohexaose is α-(1→6)-glycosidase. This enzyme hydrolyzes the α-(1→6) glycosidic bond between two glucose residues in a polysaccharide chain to produce β-(1→4) bonds. It also hydrolyzes the β-(1→4) glycosidic bond between two galactose residues to produce β-(1→2) bonds and oxidizes the terminal carbon atom to produce aldehyde products.
A structural analysis of this carbohydrate was conducted using marine microorganisms and it was found that they contain galacturonic acid and sugar residues

Psicose diacetonide is a synthetic, custom-synthesized carbohydrate. It is a complex carbohydrate that is made of saccharides and has been modified to have a fluorinated monosaccharide. Psicose diacetonide is an oligosaccharide with a high purity and has been methylated and glycosylated.

A disaccharide

1,4-Dideoxy-1,4-imino-D-xylitol HCl (DDX) is a potent inhibitor of the enzyme carboxypeptidase A2. DDX has been shown to inhibit the growth of HIV in vitro and in vivo. DDX also inhibits the production of proinflammatory cytokines and neurotrophic factors from HL60 cells. It has been shown to be a potential drug target for the treatment of infectious diseases such as alphaviruses, which produce a severe neuroinvasive disease in humans. DDX binds to dna with high affinity and specificity, but does not bind to RNA or proteins. DDX inhibits mitochondrial membrane potential by binding to ATP synthase and blocking the synthesis of ATP. DDX has also been shown to have an anti-oxidative injury effect on mitochondria, which may contribute to its inhibition of viral replication.

1-Deoxy-L-ribose is a metabolite of acetone. It is a monosaccharide that contains one less oxygen atom than its parent compound. 1-Deoxy-L-ribose is found in the urine and blood of humans and animals. In animals, it can be synthesized from glucose by the enzyme ribose 1-phosphate reductase. This reaction requires an energy source such as ATP or NADH to reduce ribose 1,5-bisphosphate to 1,4-dihydroxyacetone phosphate, which then undergoes spontaneous dehydration to form 1-deoxy-D-ribose.

2-Acetonyl-1,3,4,6-tetra-O-acetyl-2-deoxy-b-D-galactopyranoside is a synthetic sugar that has been modified to contain an acetyl group at the C2 position. The synthesis of this compound is based on the modification of galactose with acetic anhydride. This product has been shown to be resistant to hydrolysis by esterases or glucuronidases and can also inhibit bacterial growth in culture. It is a monosaccharide with a CAS number of 85583-40-7. It is also used as a precursor for the synthesis of complex carbohydrates.

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).

Methyl 2,3,4-tri-O-acetyl-b-L-thiofucopyranoside is a ferrite that is important for the growth of cells. It can be used as a growth factor to promote the growth of cells. Covid®-19 pandemic A/Aureus strain is resistant to this drug and it has been shown to inhibit cellular transformation in human epidermal cells. The drug also reduces the size and number of cancerous lesions in mice by inhibiting tumor angiogenesis. Methyl 2,3,4-tri-O-acetyl-b-L-thiofucopyranoside can cause an overload of Ca2+ ions in the cell, which may lead to apoptosis or necrosis.

3-Amino-2,3-dideoxy-D-myo-inositol (3ADMI) is a gene product that belongs to the class of chemical biology. It is an actuator that has been shown to be able to bind and activate enzymes. 3ADMI is used as a substrate in the calibration of enzyme kinetics and as an analog for aminoglycosides. The conjugates of 3ADMI have been shown to prevent viral replication by inhibiting the synthesis of DNA or RNA.