Antifongiques

Dactylfungins A: antifungal from Dactylaria Parvispora, effective against fungi like Candida pseudotropicalis, MIC < 10 µg/ml.

Picarbutrazox: potent pesticide/fungicide for corn/soybean against Pythium/Phytophthora.

Syringomycin E: antifungal lipopeptide, inhibits yeast growth, alters membrane potential, affects ion flow.

CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. It effectively eradicates Candida auris biofilms and significantly enhances cellular uptake in accumulation studies. Moreover, CYP51-IN-26 provides protection against Candida auris infection in both G. mellonella and D. melanogaster models. It is applicable for research on fungal infections.

Dermaseptin-S3 is an antimicrobial peptide originating from frog skin with activity against filamentous fungi [1].

Laccase-IN-2 is a potent laccase inhibitor demonstrating excellent antifungal activity against Magnaporthe oryzae both in vitro and in vivo [1].

Protoneogracillin: anti-fungal vs. P.oryzae (MMDC=94.0μM), cytotoxic on K562 cells (IC50=6.6μM).

Pecilocin is a fungicidal antibiotic generated by Paecilomyces varioti Bainier var. antibioticus.

Compound 3a (Antifungal agent 62) exhibits potent fungicidal properties, particularly against Fusarium oxysporum f.sp.

Succinate dehydrogenase-IN-9 (Compound Iik) is an inhibitor of succinate dehydrogenase with an IC50 of 3.6 μM. It demonstrates strong inhibitory activity against various fungi, such as S. sclerotiorum, with an EC50 of 1.14 μg/mL. Additionally, Succinate dehydrogenase-IN-9 enhances nitrate reductase activity, promoting plant growth.

Cymoxanil is a fungicidal against plant diseases caused by fungi belonging to the Perenosporales[1].

Latrunculin B: alkaloid, inhibits actin polymerization, antifungal, antiprotozoal, modulates heart rhythm, studied in glaucoma.

(E)-Ajoene, found in A. sativum, fights bacteria (MICs: 10-500 μg/ml), fungi (MICs: 15-50 μg/ml), cancer cells, and protects neurons in ischemia.

L-Diguluronic acid disodium: a linear polysaccharide forming alginate, used in antifungal delivery research.

<p>Amycolatopsin B, from Amycolatopsis, inhibits lung (NCI H460) and colon (SW620) cancer cells, with IC50s of 0.28 μM and 0.14 μM.</p>

Compound A19 is a potent antifungal, effective against Fluconazole-resistant Candida with MIC 0.5-2 μg/mL; outperforms Miconazole.

Diclobutrazol: potent systemic fungicide against rusts, mildews, and crop diseases.

Trichodecenin II is a peptaibol isolated from Trichoderma viride.

Efungumab, a monoclonal antibody exhibiting antifungal properties, specifically targets HSP 90 to inhibit a conformational alteration crucial for fungal

<p>Rimocidin is a macrolide antifungal compound isolated from Streptomyces rimosus.</p>

<p>Amphotericin B methyl ester: a cholesterol-binding antifungal derivative of Amphotericin B; inhibits HIV-1.</p>

Antifungal 14: potent, broad-spectrum, low-minimum inhibitory concentration.

Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.

L 685818 is the C18-hydroxy, C21-ethyl of FK-506 analog.

6-Prenylindole, from Streptomyces, is antifungal/antimalarial, active against A. brassicicola, F. oxysporum, and resistant P. falciparum.

CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).

Fumigaclavine A, a clavine alkaloid mycotoxin produced by Aspergillus fumigatus, can be isolated from mold-contaminated silage [1].

Amphotericin B methyl ester hydrochloride, an antifungal and anti-HIV cholesterol binder, is a methyl ester of Amphotericin B.

Dendryphiellin D from Septoria rudbeckiae fungus inhibits NO production.

Amphocil is used to treat patients with invasive fungal infection.

<p>Antifungal agent 18 is a novel antifungal agent for the treatment of fungal infection.</p>

Toonaciliatin M is a useful organic compound for research related to life sciences and the catalog number is T123902.

<p>Compound 1 (Ys-II) is a spirostanol glycoside extracted from the stem of Yucca elephantipes, exhibiting antifungal properties by inhibiting Candida albicans and</p>

NK 1971 is a bioactive chemical.

Solasodine hydrochloride (90 μM; 2 days) treatment induced significant budding in P19 cells. This compound strongly stimulated the expression of various neuronal markers, including βIII-tubulin, synaptophysin, MAP2, ChAT, and the neural progenitor marker doublecortin. Predominantly, Solasodine hydrochloride directed the differentiation of P19 cells towards neuronal pathways.

Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.

<p>Mg silicate (MgO &amp; SiO2) used in antacids, deodorizing, decolorizing &amp; as antifungal.</p>

<p>Ibrexafungerp citrate: a triterpenoid antifungal inhibiting 1,3-β-d-glucan synthesis, with activity against fluconazole-resistant Candida.</p>

Harzianic acid is a useful organic compound for research related to life sciences and the catalog number is T125719.

Antifungal 53 inhibits Candida CYP51, blocks biofilms, and is safe.

Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.

Compound 3i (Antifungal agent 63) is a fungicidal agent displaying potent activity against Fusarium oxysporum f.sp.

Xanthobaccin A is a useful organic compound for research related to life sciences and the catalog number is T125282.

Rolusafine is an antifungal agent [1] .

Y12196, a newly developed succinate dehydrogenase inhibitor (SDHI), demonstrates potent fungicidal effects specifically targeting F. graminearum.

Compound A07, effective against Fluconazole-resistant fungi, outperforms Miconazole, inhibits Candida at 0.25-1 μg/mL MIC.

Triadimenol (UK 199) is a triazole fungicide that is cardiotoxic and promotes reactive oxygen species (ROS) production and apoptosis in zebrafish.

Anisocoumarin H is a useful organic compound for research related to life sciences. The catalog number is T126178 and the CAS number is 123237-86-5.

β-Cedrene ((+)-β-Cedrene), a sesquiterpene isolated from both Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibits a broad range of biological activities, including antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal properties. Additionally, β-Cedrene acts as a potent competitive inhibitor of the CYP2B6-mediated bupropion hydroxylase activity, demonstrating a K i value of 1.6 μM [1] [2].

Mepartricin, a polyene macrolide, exhibits both antifungal and antiprotozoal activities and is extensively utilized in studies related to benign prostatic hyperplasia.

Cyclo(Arg-Pro) TFA, also known as Cyclo(Pro-Arg) TFA, serves as an inhibitor of chitinase. This compound impedes the cell separation of Saccharomyces cerevisiae without affecting its growth. Additionally, Cyclo(Arg-Pro) TFA inhibits the morphological transition of Candida albicans from a yeast form to a filamentous form.

SDH-IN-10 is a potent inhibitor of succinate dehydrogenase (SDHI) that exhibits antifungal activity [1].

Deacetylsclerotiorin is a chloroazaphilones produced by the fungus Bartalinia robillardoides strain LF550.

Endo-1,3-β-glucanase (Lyticase) is a glucanase from fungi and Chlamydomonas reinhardtii that displays lytic activity on fungal cells.

Guignardone K, a meroterpene compound extracted from solid cultures of the endophytic fungus Guignardia sp., exhibits antifungal activity [1].

Compound A09: potent vs fluconazole-resistant fungi; stronger than miconazole; MIC 0.03-0.25 μg/mL for C. albicans.

Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via

Antifungal agent 78 (compound 25am) exhibits potent activity, with an EC50 of 13.46 μM against Fusarium graminearum [1].

2,2-Dibromopropanoic acid, with two bromines, is a propionic acid derivative used as a mold inhibitor and food preservative.

Akrobomycin is an anthracycline antibiotic.

Aureonitol, a fungal metabolite with antiviral properties, hinders influenza A (H3N2 and H1N1) replication and hemagglutination.

Kievitone, an isoflavanone from Phaseolus vulgaris, has antifungal and antitumor properties.

(–)-Voacangarine, an indole alkaloid isolated from V. africana, exhibits cytotoxicity towards various cell lines including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 values of 20 µg/ml. Additionally, it demonstrates cytostatic effects on wild-type S. cerevisiae and is cytotoxic to Δrad3-e5 and Δrad6-1 mutant strains of S. cerevisiae, which have defects in DNA strand break repair and the mutagenic repair pathway, respectively.

Compound Fr13414, with CAS No. 13114-72-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13414 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Benalaxyl, (+)- is a fungicide agent.

N-563 promotes resistance to Candida albicans infection in mice

Sodium formate has antiviral and antifungal properties, can inhibit carbonic anhydrase, and can also be used as a biochemical buffer.

Ethyl 4-bromocrotonate ((E)-Ethyl 4-bromobut-2-enoate) is an antimicrobial compound belonging to the ester group. As an important pharmaceutical intermediate, it has been used as a substrate for enzyme-catalyzed reactions, and as a tool for studying enzyme kinetics. It has also been found to have anti-inflammatory and analgesic properties.

3,5-Dimethoxybenzaldehyde is an aromatic aldehyde, widely used in biochemical experiments and drug synthesis research.

Ibrexafungerp (MK 3118) is a β-1,3-glucan synthase inhibitor with antifungal activity.

Propoxur (Standard) is the standard substance of Propoxur, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Propoxur (Propoxure) is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholinesterase inhibition of red blood cells, with mild cholinergic symptoms including blurred vision, nausea, vomiting, sweating, and tachycardia; however, the effects are transient. Chronic (long-term) inhalation exposure has resulted in depressed cholinesterase levels, headaches, vomiting, and nausea in humans. Chronic ingestion studies in animals have reported depressed cholinesterase levels, depressed body weight, effects to the liver and bladder, and a slight increase in neuropathy. No information is available on the reproductive, developmental, or carcinogenic effects of propoxur in humans. Mixed results are available from cancer studies of propoxur in animals. EPA has not classified propoxur for carcinogenicity.

Thymol iodide is a compound of Iodide and Thymol. It is mostly used as mild antiseptic and fungicide.

3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.

2-Phenylethyl b-D-glucopyranoside is a useful organic compound for research related to life sciences.

Piperanine is a useful organic compound for research related to life sciences. The catalog number is T125252 and the CAS number is 23512-46-1.

<p>Metalaxyl (CGA 48988) is a fungicide that inhibits protein synthesis in fungi and interferes with skeletal development in zebrafish embryos.</p>

Phenamacril (Standard) is the standard substance of Phenamacril, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum. Phenamacril is a specific Fusarium myosin I inhibitor.

Procymidone (Standard) is the standard substance of Procymidone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Procymidone is a broad-spectrum fungicide that inhibits fungal glycerol triester synthesis, thereby disrupting hyphal growth. It is primarily used for grey mould and sclerotium rot and can also act as a competitive androgen receptor (AR) antagonist, interfering with sexual differentiation in male rats.

Amisulbrom is classified under the triazole group of fungicides.

Lanoconazole is an antifungal imidazole that is potent and orally available and acts by inhibiting the synthesis of ergosterol in fungal cell membranes.

Fludioxonil (Standard) is the standard substance of Fludioxonil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.

D-Gluconic acid (D-Gluco-hexonic acid) is a carboxylic acid that has antiseptic and chelating properties through oxidation.

Mepronil (Standard) is the standard substance of Mepronil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Mepronil is a compound of pesticide.

Ticlatone (landromil) is a synthetic antifungal used to research pathogenic fungal infections.

<p>Posaconazole-D5, a deuterium-labeled variant of Posaconazole, is a second-generation, broad-spectrum triazole compound with antifungal activity.</p>

Antifungal agent 1 is an effective antifungal agent.