Antimicrobiens

Stability Light Sensitive
Applications Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.
References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990);

Applications N-Octylpyridin-4-amine is used in the synthesis of antimicrobial agent Octenidine (O239150), as chelating agent.
References Bailey, D.M., et al.: J. Med. Chem., 27, 1457 (1984),

Stability Hygroscopic
Applications Sanguinarium Chloride is a natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Sanguinarium Chloride has antiproliferative, pro-apoptosis effects in some cancer cell lines.
References Ahmad, N., et al.: Clin. Cancer Res., 6, 1524 (2000), Adhami, V., et al.: Mol. Cancer Ther., 3, 933 (2004),

Applications Protected amino acid with antimicrobial activity.
References Oancea, S. et al.: J. Med. Biochem. 3, 239 (1999)

Applications Combinations of Bis(trichloromethyl)sulfone, (Hexachlorodimethyl sulfone) and 1,2-Dibromo-2,4-dicyanobutane are shown to have synergistic antimicrobial properties. The synergistic compounds may be used together with a third microbiocide to enhance the compound’s effectiveness against a wide variety of bacteria, molds, and yeasts and other microorganisms.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pearl, G., et al.: Curr. Top Med. Chem., 1, 247 (2001), Casalegno, M., et al.: Chem. Res. Toxicol., 18, 740 (2005), Toropov, A., et al.: Bioorg. Med. Chem., 14, 2779 (2006),

Applications Fungisterol is used in the improvement of the measuring methods of composition and total contents of sterols in vegetable oils, study on the antioxidant and antimicrobial activities of supercritical fluid extract of Agaricus brasiliensis.
References Zhu, L., et al.: Zhongguo Liangyou Xuebao, 27, 109 (2012); Mazzutti, S., et al.: J. Supercrit. Fluids, 70, 48 (2012)

Applications (+)-Phytone is an constituent of leaf essential oil of Lawsonia Inermis growing in Nepal with potential anti-microbial activities.
References Satyal, P., et al.: Pharmacol., 1, 31 (2012);

Applications A reagent used in the preparation of agrochemicals and antimicrobial agents.

Applications TNP-470 is a synthetic analog of Fumagillin (F862650); a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis and shows promise as both an anti-infective and antiangiogenic agent.
References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990)

Applications 2,2,4-Trimethyl-1,2,3,4-tetrahydroquinoline is a reagent in the synthesis of tetrahydroquinoline sensitizers used for dye-sensitized solar cells. 2,2,4-Trimethyl-1,2,3,4-tetrahydroquinoline is also a reagent in the preparation of tetra- and pentacyclic derivatives of phenothiazinium photosensitizers which are used as photoantimicrobial agents.
References Hao, Y., et al.: Tetrahedron, 68, 552 (2012); Wainwright, M., et al.: Dyes Pigments, 91, 1 (2011)

Applications α-Selinine is a natural product found in essential oils from variety of plants. It is a functional antioxidant with antiradical and antimicrobial properties.
References Sacchetti, G., et al.: Food Chem., 91, 621 (2005); Bozin, B., et al.: J. Agric. Food Chem., 54, 1822 (2006); Kiralan, M., et al.: Nat. Prod. Res., 26, 132 (2012);

Applications An intermediate in the synthesis of biotin. Pimeloyl-CoA is transformed into AOP in the presence of L-alanine by the enzyme AOP synthase. The catalytic mechanism of AOP synthase has been studied for the elucidation of inhibitors as potential antimicrobial agents.
References Ohsugi, M., et al.: J. Nutr. Sci. Vitaminol., 34 (4), 343 (1985), Pearson, B.M., et al.: Lett. Appl. Microbiol., 10 (2), 89 (1990), Ploux, O., et al.: Biochem. J., 283, 327 (1992)

Stability Hygroscopic
Applications Formic Acid-d is the isotope labelled analog of Formic Acid (F692900). Formic Acid is used as a potential energy source in the preparation of fuel cells. Also used in chemical synthesis of various anti-inflammatory and anti-microbial agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yu, X. et al.: J. Power Source., 182, 124 (2008); Bekhit, A. et al.: Bioorg. Med. Chem., 12, 1935 (2004);

Applications 5-Methylfurfural is a common chemical reagent used in a wide variety of chemical reactions and organic synthesis. Polycyclic pyridazine based derivatives are synthesized with this compound to form antimicrobial agents. Also used in the preparation of antiinflammatory diarylpentanoid analogues.
References Deeb, A. et al.: Eur. Chem. Bull., 3, 897 (2014); Leong, S. et al.: Molecules, 19, 16058 (2014);

Applications 4,5-Dichloro-2-methylisothiazol-3-one is an methylisothiazolinone derivative and a potential antimicrobial agent for the inhibition of PCAF activity.
References Morley, J.O. et al.: Org. Biomolec. Chem., 3, 3713 (2005); Briski, F., et al.: Chem. Biochem. Engineer. Quater., 13, 27 (1999);

Stability Hygroscopic
Applications (+)-ar-Turmerone is an anti-tumor and immune activating agent, which maintains a cytotoxic effect in cancer cells. Antimicrobial agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, D. et al.: Int. J. Mol. Med., 31, 386 (2013); Dehghanzadeh, N. et al.: Asian. J. Exp. Biol. Sci., 3, 767 (2012);

Stability Hygroscopic
Applications Atractyloside A is known to inhibit mitochondrial ADP transportation resulting in necrosis. Antimicrobial.
References Stewart, M. et al.: Ther. Drug. Monit., 22, 641 (2000); Federico, B. et al.: J. Nat. Prod., 75 1070 (2012);

Applications Methyl dehydroabietate is used as an adhesive in food packaging. It is also used in the preparation of antimicrobial carbazoles.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aznar, M. et al.: J. Mat. Chem., 21, 4358 (2011); Gu, W. et al.: Eur. J. Med. Chem., 45, 4692 (2010);

Applications Isopregnanolone is used in the preparation of antimicrobial and anti-leukemic steroids. Intermediate.
References Shingate, B. et al.: Chem. Biol. Int., 1, 198 (2011); Jegham, H. et al.: Steroids., 77, 1403 (2012);

Applications Taurinamide is a derivative of Taurolidine; a drug with antimicrobial and antiendotoxic properties.
References Stendel, Ruediger., et al.: Clin. Pharmacokinet., 46(6), 513-524 (2007); Gong, Li., et al.: J. Clin. Pharmacol., 47(6), 697-703 (2007)

Stability Volatile
Applications (S)-ar-Curcumene is used in the study and the characterization of the antioxidant and antimicrobial compounds of cinnamon and ginger essential oils, also in the phytochemical and biological studies of the flower and fruits of Pongamia pinnata.
References El-Baroty, G. S., et al.: Afr. J. Biochem. Res., 4, 167 (2010); El-Shabrawy, A. O, et al.: Egyptian J. Biomed. Sci., 23, 1 (2007)

Applications Diethyl 3-Oxopentanedioate is a reactant used in the synthesis of 2-(3-benzoylthioureido)-thiophene-3-carbonitrile derivatives with antimicrobial activity.
References Prabhu, P.J., et. al.: Int. J. Chem., 3, 91 (2014)

Impurity Nitrofurazone USP Related Compound A
Applications 5-Nitro-2-furfuraldazine is an impurity in the synthesis of Nitrofurazone (N493880), anti-infective (topical). Antimicrobial. Nitrofurazone USP Related Compound A
References Morris, et al.: Cancer Res., 29, 2145 (1969), Sanderson, H., et al.: Toxicol. Lett., 144, 383 (2003),

Anthelmintic; inhibitor of tubulin polymerization

Fungicide

Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.

Inhibitor of protein synthesis; aminoglycoside