Stéroïdes

DHED is a neuroactive steroid precursor, specifically a bioprecursor prodrug of estradiol, which is derived from chemical synthesis pathways. It is unique in its targeted mode of action, as it selectively converts to the active hormone estradiol within the brain via enzymatic processes that occur in situ. This specificity is facilitated by 17β-hydroxysteroid dehydrogenase type 1, which catalyzes the conversion of DHED to estradiol exclusively in the brain, minimizing peripheral estrogenic effects.

3,9-Di-O-methylcoumestrol is a synthetic coumestan derivative, which is primarily derived or synthesized from various plant sources that produce isoflavonoids and related compounds. As a type of phytoestrogen, it exhibits selective estrogen receptor modulating activity, interacting with estrogen receptors in a manner similar to endogenous hormones but with distinctive affinity and specificity. This mode of action suggests it could influence estrogen-responsive pathways, making it of particular interest in fields like endocrinology and pharmacology.