Flavonoïdes

<p>Dihydrogenistein 4'-methyl ether is a phytoestrogen compound, which is derived from botanical sources such as Leguminosae plants. Its molecular structure consists of a flavonoid backbone, specifically modified with a methyl ether group at the 4' position. This structural modification imparts unique biological properties to the compound.</p>

<p>7-Hydroxyflavone-beta-D-glucoside is a glucoside compound, which is a type of natural flavonoid derivative. This compound is derived from plant sources, particularly those rich in flavonoids, where it is a metabolite formed through the glycosylation of 7-hydroxyflavone. The mode of action of 7-Hydroxyflavone-beta-D-glucoside involves interacting with cellular antioxidative pathways. It potentially offers protection against oxidative stress by scavenging free radicals and modulating enzyme activities related to oxidative metabolism.</p>

<p>5-Hydroxyflavanone is a naturally occurring flavonoid compound, which is predominantly sourced from various plant species, including fruits, vegetables, and certain herbs. These plants synthesize flavonoids as part of their secondary metabolism, aiding in defense mechanisms against pathogens and contributing to their pigmentation.</p>

<p>Isoastilbin is a bioactive flavonoid, which is a naturally occurring compound found primarily in certain plant species, such as the Chinese herb Smilax glabra and Engelhardtia roxburghiana Wall leaf. As a derivative of astilbin, it possesses a unique mechanism that involves the modulation of cellular redox states. Isoastilbin's mode of action is primarily through its antioxidant properties, where it scavenges free radicals and thus, mitigates oxidative stress at a cellular level. Additionally, it exhibits anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines.The applications of Isoastilbin are diverse and promising in scientific research. It is extensively studied for its potential therapeutic benefits in combating diseases associated with oxidative stress and inflammation, such as cardiovascular diseases, neurodegenerative disorders, and certain metabolic syndromes. Furthermore, its role in cell signaling and apoptosis makes it a candidate for cancer research, offering insights into the molecular pathways that can be targeted for therapeutic intervention. Isoastilbin’s multifunctional properties make it a compelling subject for ongoing pharmacological and biomedical research.</p>

<p>5-Hydroxy-7,4'-dimethoxy-6,8-dimethylflavone is a bioactive flavonoid compound, which is naturally derived from certain plant sources. As a type of flavone, this compound is notable for its polyphenolic skeleton that contributes to notable biological properties. Its mode of action primarily involves modulating various enzymatic pathways and cellular signaling processes due to its structural ability to interact with biomolecules like enzymes and receptors. This interaction can lead to a range of biological effects, including antioxidant and anti-inflammatory activities.</p>

<p>Isoaloeresin D is a natural compound product, which is derived from the Aloe plant, specifically containing up to 20% Aloeresin D. It is a phytochemical extracted from the leaves of Aloe species, renowned for its inclusion of various bioactive compounds. The primary mode of action of Isoaloeresin D involves its potential antioxidant properties, which may contribute to the neutralization of free radicals and reduction of oxidative stress within biological systems.</p>

<p>5-Hydroxy-7,2',3',4',5'-pentamethoxyflavone is a flavone that can be found in coffee. It has been shown to inhibit the enzyme arabinose isomerase and psiadiarabin, which are involved in the conversion of sugar into energy in plants. 5-Hydroxy-7,2',3',4',5'-pentamethoxyflavone also inhibits the plant enzyme phytase, which breaks down phytic acid. Phytic acid is a naturally occurring substance that binds to minerals such as calcium and zinc, preventing their absorption by the body. This compound has not shown any significant activity against bacterial DNA gyrase or topoisomerase IV or human DNA gyrase or topoisomerase II.</p>

<p>Dihydroisoformononetin is an isoflavonoid compound, which is a type of phytoestrogen derived primarily from plant sources, such as legumes and certain medicinal herbs. This compound is of significant interest due to its structural similarity to estrogen, which allows it to interact with estrogen receptors in the body. Its mode of action involves modulating estrogenic activity by acting either as an agonist or antagonist, depending on the tissue context. Such dual behavior makes it an intriguing subject of study in endocrine research.</p>

<p>8-Hydroxygenistein-5,7,8,4'-tetramethyl ether is a natural product with bioactive properties. It is an 8-hydroxy derivative of genistein that is found in soybeans and other legumes. The purity of this compound is confirmed by HPLC standards and it has been isolated from the plant source. This compound can be used as a reference material for analytical purposes or for quality control testing.</p>

<p>4,7-Dihydroxy-2'-methoxyisoflavan is a naturally occurring isoflavan compound, which is typically extracted from various plant sources known for their medicinal properties. These sources include legumes and other plant families rich in phytoestrogens and related secondary metabolites.</p>

<p>Quercetin 3-rhamnoside 7-glucoside is a naturally occurring flavonoid glycoside, which is derived from various plant sources, particularly those rich in flavonoids like fruits, vegetables, and leaves. This compound is characterized by its complex structure that includes quercetin linked to sugar moieties, specifically rhamnose and glucose, at the 3 and 7 positions.</p>

<p>7,8-Dihydroxyflavanone is a naturally occurring flavonoid compound, which is typically sourced from various plant species. This compound is structurally characterized by two hydroxyl groups, which are crucial for its biochemical activity. Its mode of action primarily involves the modulation of cellular signaling pathways, including those related to oxidative stress and enzyme inhibition. By interfering with these pathways, 7,8-Dihydroxyflavanone exerts antioxidant and possibly anti-inflammatory effects.</p>

<p>5-Hydroxy-7-methoxyisoflavone is an isoflavone compound, a type of naturally occurring organic substance usually derived from plant sources such as soybeans and other legumes. These compounds are known for their significant role in the plant kingdom, often contributing to the plant's resistance against pathogens and environmental stresses. The mode of action of 5-Hydroxy-7-methoxyisoflavone involves its potential antioxidant properties, where it may neutralize free radicals, thereby reducing oxidative stress and cellular damage. This activity arises primarily from its chemical structure, enabling it to donate electrons to unstable molecules.</p>

<p>Hesperidin is a bioflavonoid compound, which is naturally sourced from citrus fruits, primarily found in the peels of oranges and lemons. Its mode of action involves acting as a potent antioxidant by scavenging free radicals and reducing oxidative stress. Hesperidin also exhibits anti-inflammatory effects by modulating various signaling pathways and inhibiting the release of pro-inflammatory cytokines.In scientific applications, hesperidin is extensively studied for its potential therapeutic benefits. Its antioxidant properties make it a candidate for mitigating oxidative damage in various tissues, while its anti-inflammatory effects are explored in the context of chronic inflammatory conditions. Research has shown potential cardiovascular benefits, including the improvement of endothelial function and lipid profiles. Additionally, hesperidin is investigated for its neuroprotective effects and potential in managing metabolic disorders. These diverse applications highlight the significance of hesperidin in pharmacological research, aiming to leverage its natural properties for health benefits.</p>

<p>2',6-Dihydroxyflavone is a natural flavonoid compound, which is derived from various plant sources. This compound is known for its interaction with cellular pathways and has been studied extensively for its potential neuroprotective effects. 2',6-Dihydroxyflavone acts as an agonist for the TrkB receptor, which is the high-affinity catalytic receptor for the brain-derived neurotrophic factor (BDNF). By activating this receptor, it plays a crucial role in neuronal survival, development, and plasticity.</p>

<p>Scutellarein 7-methyl ether is a naturally occurring flavone derivative, which is primarily sourced from various plant species within the genus Scutellaria. These plants are rich in flavonoids and have been studied extensively for their diverse biochemical properties. The mode of action of Scutellarein 7-methyl ether involves its ability to act as an antioxidant, neutralizing free radicals and reducing oxidative stress at the cellular level. This compound has been observed to interfere with various enzymatic pathways, contributing to its potential therapeutic effects.</p>

<p>Hesperetin 7-O-beta-D-glucuronide is a flavonoid metabolite, which is a derivative of hesperetin commonly found in citrus fruits. This compound is produced through the biotransformation of hesperetin, involving conjugation with glucuronic acid in the liver, and is integral to the metabolism of flavonoids in humans. Hesperetin 7-O-beta-D-glucuronide exhibits potential antioxidant properties, making it of interest in scientific research aimed at exploring its bioactivity and potential therapeutic benefits.</p>

<p>7-O-Methyl-liquiritigenin is a flavonoid that has been shown to have anticarcinogenic properties. It has been studied in human studies and shown to be safe for use in cancer patients. 7-O-Methyl-liquiritigenin inhibits the growth of cancer cells by inhibiting cell proliferation, inducing apoptosis, and arresting the cell cycle at G2/M phase. 7-O-Methyl-liquiritigenin also inhibits the production of cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2), which have been linked to tumor promotion. 7-O-Methyl-liquiritigenin has been shown to inhibit the growth of human colon cancer cells in vitro, as well as in vivo when injected into mice. This compound also inhibits PIM1, an oncogene that regulates cellular proliferation, differentiation, tumor progression, angiogenesis, and metast</p>

<p>Rhodiosin is a bioactive compound, which is a polyphenolic glycoside derived from the plant Rhodiola rosea. This compound is primarily sourced through extraction processes that isolate active constituents from the roots of Rhodiola, a perennial plant native to cold regions and known for its traditional medicinal uses. Rhodiosin exhibits its mode of action through various molecular pathways, particularly influencing the central nervous system and enhancing cellular resistance to stress. It acts as an adaptogen, a class of metabolic regulators that promote homeostasis and increase the body's resilience to environmental and physical stressors.</p>

<p>8-Prenylnaringenin is a flavonoid compound, which is a naturally occurring phytoestrogen. It is primarily found in hops (Humulus lupulus), a plant commonly used in brewing beer. The compound is known for its high estrogenic activity, which is attributed to its ability to bind to estrogen receptors, particularly the estrogen receptor alpha.</p>

<p>Isogentisin is a specific type of biochemical compound that falls under the category of xanthones, which are naturally occurring polyphenolic compounds. It is typically sourced from certain medicinal plants, where it is found in the roots or other plant parts. The mode of action of isogentisin is primarily related to its antioxidant properties, which involve neutralizing free radicals and reducing oxidative stress within biological systems. This action can potentially protect cells and tissues from damage that may lead to various diseases.</p>

<p>Puerarin is a bioactive isoflavone, which is extracted from the root of Pueraria lobata, commonly known as kudzu. It functions as a phytoestrogen and exhibits multiple pharmacological activities. The mode of action of puerarin involves interacting with various biological pathways, including antioxidant, anti-inflammatory, and neuroprotective mechanisms. It modulates enzyme activities and influences cell signaling pathways, making it a versatile compound for therapeutic research.</p>

<p>Deguelin is a rotenoid, which is a naturally occurring compound derived primarily from the roots of plants in the Leguminosae family, such as Mundulea sericea and Derris species. It functions as a potent inhibitor of mitochondrial complex I, interfering with cellular respiration by blocking electron transport within the mitochondrial electron transport chain. This action leads to the inhibition of ATP production, which is essential for cellular energy.</p>

<p>Orobol 7,3',4'-trimethyl ether is a synthetic flavonoid compound, which is derived from the chemical modification of natural flavonoids. These modifications involve methylation, specifically at the 7, 3', and 4' positions of the flavone structure. This chemical derivation allows for enhanced stability and solubility compared to its natural counterparts.</p>

Natural glycoside

<p>Aureusidin is a flavonoid pigment, which is a type of plant-derived compound. It is primarily sourced from various flowering plants, where it contributes to the coloration of petals. Aureusidin is synthesized through the enzymatic oxidation of chalcones, which involves flavonoid oxidase activity.</p>

<p>Applications 5α-Pregnane-3-one-20α-ol, is a steroid metabolome, that can be used for in studies of a possible tool for laboratory diagnosis of schizophrenia. It is also a metabolite of Progesterone (P755900) in adipose cells.<br>References Bicikova, M., et al.: J. Steriod Biochem. Mol. Bio., 77, 133 (2013); Zhang, Y., et al.: Mol. Cell. Endocrinology, 298, 76 (2009);<br></p>

<p>Applications 8,9-Di-O-methyl-urolithin D is a derivative of Urolithin D (U847020) which is used in biological studies to evaluate DNA gyrase inhibitory activity of ellagic acid derivatives.<br>References Weidner-Weels, M. A., et al: Bioorg. Med. Chem. Lett., 8, 97 (1998)<br></p>

<p>Applications Typhaneoside is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.<br>References Shulan S. et al.: Am. J. Chin. Med., 38, 777 (2010); Huang, X. et al.: J. Chrom. B. Anal. Tech. Biomed. Life Sci., 962, 75 (2014);<br></p>

<p>Applications O-Methylated metabolite of the flavanoid Quercertin (Q509500) with antioxidant activity.<br>References Soobrattee, M.A. et al.: Mut. Res. Fund. Mol. Mech. Mutagen., 579, 200 (2005); Yamamoto, N. et al.: Arch. Biochem. Biophys., 372, 347 (1999);<br></p>

<p>2,3-Dehydrokievitone is a phytoalexin, which is a naturally occurring antimicrobial compound. It is derived from leguminous plants, such as those in the Fabaceae family. Phytoalexins are synthesized de novo by plants in response to pathogen attack, and 2,3-Dehydrokievitone plays a role in the plant’s defense mechanisms.</p>

<p>Aromadendrin 7-O-methyl ether is a flavonoid compound, which is a type of bioactive molecule. It is sourced primarily from plant materials, where it occurs naturally as a secondary metabolite. The mode of action of Aromadendrin 7-O-methyl ether involves interaction with various biological pathways, potentially affecting enzyme activity and cell signaling mechanisms. Such interactions may contribute to its reported antioxidant and anti-inflammatory properties.</p>

<p>5,7-Dihydroxy-3',4',5'-trimethoxyflavanone is a flavanone compound, which is a type of polyphenolic compound found predominantly in the plant kingdom. This compound can be sourced from various plants, where it often occurs as part of the natural defense mechanisms to protect the organism from environmental stressors.</p>

<p>5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methoxylated flavonoid, which is a type of polyphenolic compound. This compound is typically sourced from certain plant species known for their high antioxidant content. Flavonoids are widely studied for their diverse biological activities and are often isolated from traditional medicinal plants.</p>

<p>Petanin is a natural compound isolated from the fruit of Lycium barbarum. It has been shown to have anti-inflammatory and antioxidant properties, as well as protective effects against UV radiation. Petanin is used in dietary supplements and works in synergy with other nutrients to help protect cells and repair skin damage.</p>

<p>3'-Methoxydaidzein is an isoflavone compound, which is typically isolated from soybean sources. This compound belongs to a class of phytoestrogens, naturally occurring plant-derived compounds with estrogenic activity. 3'-Methoxydaidzein exhibits various biological activities due to its structural similarity to human estrogens, allowing it to bind to estrogen receptors. Its mode of action primarily involves modulating estrogen receptor activity, potentially influencing gene expression in estrogen-responsive tissues.</p>

<p>7-Hydroxy-5-methoxyflavanone is a naturally occurring flavanone compound, which is derived from various plant sources. These sources often include fruits, vegetables, and certain medicinal herbs, known for their rich flavonoid content. The mode of action of 7-Hydroxy-5-methoxyflavanone primarily involves its role as an antioxidant. It helps in scavenging free radicals and reducing oxidative stress, which is a common pathway in cellular protection against damage.</p>

<p>3',4',7-Trihydroxyflavanone is a natural flavonoid compound, which is predominantly found in various plant sources, such as flowers, fruits, and leaves. This compound is known for its significant antioxidative properties, attributed to its polyphenolic structure. The mechanism of action involves the scavenging of free radicals, thereby reducing oxidative stress within biological systems. Additionally, its molecular configuration allows it to interact with various cellular pathways that modulate inflammation and cellular signaling.</p>

<p>6,7,2',3',4'-Pentamethoxyisoflavone is a naturally occurring flavonoid compound, which is derived from certain plant sources known for their rich polyphenolic content. As part of the isoflavone family, this compound is structurally similar to estrogen, allowing it to potentially interact with estrogen receptors in the body. Its mode of action includes modulating various biochemical pathways, including antioxidant and anti-inflammatory pathways, due to its ability to influence enzyme activities and cell signaling processes.</p>

<p>3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone, (2R,3S)- is a naturally occurring prenylated flavanone, which is primarily sourced from various plant species. This compound is part of the larger flavonoid family and is often found in certain medicinal plants known for their wide range of therapeutic properties. Its structure comprises a flavanone backbone, modified by hydroxyl, methoxy, and prenyl groups that contribute to its distinctive chemical profile.</p>

<p>Sideritoflavone is a flavonoid compound, which is a type of secondary metabolite derived from the *Sideritis* plant species. These plants, commonly found in the Mediterranean region, are traditionally used in herbal remedies. The compound is known for its potential biological and pharmacological activities, which stem from its interaction with various biochemical pathways.</p>

<p>6,2',4'-Trimethoxyflavone is a flavonoid compound, which is a type of phytochemical found in various plant species. It is derived from natural sources, including certain medicinal herbs and plants known for their bioactive properties. This specific flavone is characterized by its three methoxy groups attached at distinct positions on the flavonoid backbone, which confer unique chemical properties and biological activities.</p>

<p>Phytoestrogen; estrogen receptor agonist; PPARγ ligand</p>

<p>Cuneatin-7-methyl ether is a naturally occurring compound, classified as a flavonoid derivative. It is primarily sourced from certain plant species known for producing bioactive flavonoids. These plants are typically found in specific geographical regions, and the compound can be extracted through meticulous phytochemical methods.</p>

<p>3'-Hydroxyflavanone is a naturally occurring flavanone, which is a type of polyphenolic compound found in various plants and fruits. Known for its presence in citrus fruits and certain herbal sources, 3'-Hydroxyflavanone is characterized by its unique structural configuration, featuring a hydroxyl group that is crucial for its bioactivity.</p>

<p>Kaempferol-3-rutinoside-7-rhamnoside is a flavonoid glycoside, which is an organic compound derived from specific plant species like tea, onions, and broccoli. It primarily exists as a complex molecule formed by the bonding of kaempferol with sugar moieties—rutinoside and rhamnoside. This compound functions by modulating various cellular signaling pathways, including those involved in oxidation-reduction processes, apoptosis, and inflammation. It combats oxidative stress by scavenging free radicals, thereby providing a protective effect against cellular damage.</p>

<p>Daidzein diacetate is a synthetic derivative of the isoflavone daidzein, which is a bioactive compound found primarily in soybeans and other legumes. The acetylation process enhances the compound's stability and solubility, potentially improving its bioavailability compared to its parent compound. Daidzein itself is naturally occurring and has been studied for its various health-promoting properties, including estrogenic and antioxidant activities.</p>

<p>4'-O-Hexanoyldaidzein is a chemically modified isoflavone, which is a derivative of daidzein. This compound is sourced from soybeans, renowned for being rich in naturally occurring isoflavones. The modification entails the addition of a hexanoyl group to the daidzein molecule, altering its physicochemical properties and potentially enhancing its biological activity.</p>

<p>Retusin TLC is a flavonoid compound, which is derived from natural plant sources. Flavonoids are known for their diverse biological activities, primarily due to their antioxidant properties. The mode of action of Retusin TLC involves its ability to scavenge free radicals, thereby reducing oxidative stress at the cellular level. This activity plays a crucial role in modulating various biochemical pathways, potentially leading to anti-inflammatory and anti-cancer effects.</p>