Nucléotides
Les nucléotides sont des composés organiques qui servent de building blocks aux acides nucléiques, essentiels à la formation de l'ADN et de l'ARN. Chaque nucléotide est composé d'une base azotée, d'une molécule de sucre et d'un ou plusieurs groupes phosphate. Ces nucléotides s'assemblent pour former de longues chaînes, créant le matériel génétique qui porte et transmet l'information génétique dans tous les organismes vivants. Dans cette section, vous trouverez une large gamme de nucléotides essentiels pour la recherche en génétique, biologie moléculaire et biochimie. Ils sont fondamentaux pour étudier les processus génétiques, synthétiser des acides nucléiques et développer des outils diagnostiques et thérapeutiques. Chez CymitQuimica, nous proposons des nucléotides de haute qualité pour soutenir vos recherches scientifiques et applications, garantissant précision et fiabilité dans vos expériences.
Sous-catégories appartenant à la catégorie "Nucléotides"
2634 produits trouvés pour "Nucléotides"
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Guanosine-5'-[(b,γ)-methyleno]triphosphate sodium salt
CAS :<p>Guanosine-5'-[(b,gamma)-methyleno]triphosphate sodium salt (GMPP) is an analog of guanosine triphosphate that is enzymatically inactivated by the enzyme kinesin. GMPP inhibits the polymerization of microtubules by binding to the kinesin molecule and preventing it from binding to tubulin. GMPP has been shown to inhibit sephadex g-100 chromatography and act as a competitive inhibitor for protein synthesis in vitro. GMPP has also been shown to have a fat cell differentiation effect which may be due to its ability to inhibit microtubule polymerization.</p>Formule :C11H18N5O13P3·xNaDegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :521.21 g/mol2',3'-Dideoxy-5-iodouridine
CAS :<p>2',3'-Dideoxy-5-iodouridine is a synthetic nucleoside analog derived from uridine, one of the natural building blocks of RNA. This molecule has been chemically modified to disrupt the normal processes of DNA and RNA synthesis, making it a candidate for antiviral and anticancer research.</p>Formule :C9H11IN2O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :338.1 g/mol2'-O-Methyl-5-propynyluridine
CAS :<p>2'-O-Methyl-5-propynyluridine is a nucleoside that is selective to bacterial DNA. It has been shown to inhibit the binding of RNA polymerase and DNA gyrase, as well as the synthesis of RNA and DNA. This nucleoside also inhibits the formation of triplexes in vitro with oligonucleotides complementary to sequences in the 16S ribosomal RNA gene. 2'-O-Methyl-5-propynyluridine has been used for the measurement of RNA polymerase activity in bacteria, and its affinity for triplexes can be measured by gel shift assay.</p>Formule :C13H16N2O6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :296.28 g/molAdenosine
CAS :<p>Endogenous adenosine receptor ligand; regulator of innate immunity</p>Formule :C10H13N5O4Degré de pureté :(Titration) 99.0 To 101.0%Couleur et forme :White PowderMasse moléculaire :267.25 g/mol8-Azaadenosine
CAS :<p>8-Azaadenosine is a purine nucleoside that is used as a template for DNA replication. The zwitterionic form of 8-Azaadenosine is found in plants and is converted to the charged form by enzymatic reactions. 8-Azaadenosine binds to the dna template strand and acts as a hydrogen bond donor, which stabilizes the transition state of the reaction and inhibits enzyme activity. This drug has been shown to affect polymerase chain reaction (PCR) by inhibiting DNA synthesis and it has been used in cancer cell lines with resistant mutants, such as Herpes simplex virus type 1 (HSV1).</p>Formule :C9H12N6O4Degré de pureté :Min. 97 Area-%Couleur et forme :Off-White PowderMasse moléculaire :268.23 g/mol2',3',5'-Tri-O-benzoyl-N6-benzyl-2'-C-methyladenosine
CAS :<p>2',3',5'-Tri-O-benzoyl-N6-benzyl-2'-C-methyladenosine is an adenosine analog for potential use in research into antiviral drug development or nucleoside analogs.</p>Formule :C39H33N5O7Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :683.71 g/mol2'-O-Methyl-N6-phenoxyacetyladenosine
CAS :<p>2'-O-Methyl-N6-phenoxyacetyladenosine is a phosphoramidite nucleoside that is used in the synthesis of DNA and RNA. It has antiviral, anticancer, and antiribonucleases properties. The chemical structure of 2'-O-Methyl-N6-phenoxyacetyladenosine is similar to that of adenosine, but contains a methyl group on C2' position and an oxyalkyl group on N6. This compound can be used as a novel anticancer agent and has been shown to have high affinity for the purine receptor, inhibiting cancer cell proliferation by activating the p53 tumor suppressor pathway.</p>Formule :C19H21N5O6Degré de pureté :Min. 95%Couleur et forme :White to off-white solid.Masse moléculaire :415.41 g/mol2-Methylthio-N6-isopentenyladenosine
CAS :<p>A nucleoside analogue of adenosine that arises from post-transcriptional modification. In humans, this is mediated by the enzyme CDK5RAP1 in mitochondrial transfer RNA (tRNA) at amino acid 37. Deficiency for this modification, for example due to CDK5RAP1 deficiency, leads to impaired mitochondrial protein synthesis. This has implications for mitochondrial diseases, as well as cancer, type II diabetes and vitiligo. Synthetic ms2i6A can be used to raise monoclonal antibodies against this nucleotide in vivo.</p>Formule :C16H23N5O4SDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :381.45 g/molN3-Methylcytidine
CAS :<p>N3-Methylcytidine is a synthetic analog of uridine. It is used for the treatment of syncytial virus infection, which is a group of diseases caused by viruses that have an RNA genome and replicate by forming syncytia—large groups of infected cells. N3-Methylcytidine inhibits the synthesis of proteins in cells and inhibits the growth of bacteria. This drug has been shown to inhibit actin polymerization and prevents cell spreading. N3-Methylcytidine also binds to RNA polymerase II and blocks its interaction with DNA, inhibiting protein synthesis at the ribosome level. N3-Methylcytidine is metabolized in vivo into methylated cytidine, which can be detected in urine samples using chemical biology methods or fluorescence resonance energy transfer (FRET) analysis. Synonyms: N3-methyluridine; 3-methyluridine</p>Formule :C10H15N3O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :257.24 g/mol2'-Amino-2'-deoxyadenosine
CAS :<p>2'-Amino-2'-deoxyadenosine is a modified nucleoside, closely related to adenosine in which the 2'-hydroxyl group is replaced by an amino group. This compound has potential research applications</p>Formule :C10H14N6O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :266.26 g/mol2-Thioadenosine
CAS :<p>Intermediate in the synthesis of cangrelor</p>Formule :C10H13N5O4SDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :299.31 g/mol1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine
CAS :<p>1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine is a chemically modified nucleoside that contains a fluorinated sugar moiety and a thymine base, with a dimethoxytrityl (DMT) protecting group on the 5'-hydroxyl of the sugar.</p>Formule :C31H31FN2O7Degré de pureté :Min. 95%Masse moléculaire :562.6 g/mol1-(2'-Deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)-4-amino-1,2-dihydro-2-oxo-1,3,5-triazine
CAS :<p>1-(2'-Deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)-4-amino-1,2-dihydro-2-oxo-1,3,5-triazine is a nucleoside derivative that features a modified pyrimidinone (triazine) base attached to a protected deoxyribose sugar. This molecule can be used in research.</p>Formule :C24H24N4O6Degré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :464.48 g/molInosine 5'-triphosphate trisodium
CAS :<p>Inosine 5'-triphosphate trisodium (ITP) is a nucleotide that is found in human cells. It is produced by the enzyme inosine monophosphate dehydrogenase and acts as an intermediate in cellular metabolism. ITP has been shown to be involved in a number of diseases, such as infectious, autoimmune, and cardiovascular diseases. For example, ITP has been shown to induce the expression of TLR-2 and TLR-4 on human monocyte-derived dendritic cells. The molecule also plays a role in pediatric disease activity, bowel disease, and congestive heart failure.</p>Formule :C10H12N4O14P3Na3Degré de pureté :Min. 90 Area-%Couleur et forme :PowderMasse moléculaire :574.11 g/mol6-Benzyl-2-thiouracil
CAS :<p>6-Benzyl-2-thiouracil (BTS) is a benzyl group with the chemical formula C12H8N2OS. It has been used as an anti-infective agent and has been shown to have a clinical relevance in treating hepatitis, cutaneous lesions, and inflammatory bowel disease. BTS is metabolized through oxidation of the benzyl group by cytochrome P450 enzymes. This active form has been shown to inhibit mitochondrial fatty acid synthesis, which may be a pathogenic mechanism for BTS in women with metabolic syndrome. The metabolism of BTS also results in its conversion to 2-benzylpyrimidine, which can be converted into a carcinogen by N-nitrosation.</p>Formule :C11H10N2OSDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :218.28 g/mol1-(3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)thymine
CAS :<p>1-(3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)thymine is a chemically modified nucleoside analog. This compound contains a thymine base, a 2'-fluoro-β-D-arabinofuranose sugar, which alters biological stability and function and benzoyl protecting groups at the 3' and 5' positions, commonly used in nucleoside synthesis to control selective modifications.</p>Formule :C23H19FN2O7Degré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :454.42 g/mol3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine
CAS :<p>Used as aprotected uridine nucleoside in RNA synthesis. The 1,1,3,3-tetraisopropyl-1,3-disiloxanediyl (TIPDS or TBDPSi2) group serves as a bulky and selectively acid-labile protecting group for the 3' and 5' hydroxyl groups of the uridine ribonucleoside during RNA oligonucleotide synthesis.</p>Formule :C21H38N2O7Si2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :486.71 g/mol2'-Deoxy-L-adenosine
CAS :<p>2'-Deoxy-L-adenosine is an adenosine analogue that has been shown to inhibit the growth of tumor cells in mice. The mechanism of this inhibition is not well understood, but it is thought that 2'-deoxy-L-adenosine inhibits the adenosine A3 receptor and blocks the activation of toll-like receptors. This drug also has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. It has been used as a model system for studying cellular responses to DNA damage caused by ultraviolet radiation. 2'-Deoxy-L-adenosine also has been shown to have a cytotoxic effect on human HL60 cells, which is mediated by nuclear DNA fragmentation.</p>Formule :C10H13N5O3Degré de pureté :Min. 98 Area-%Couleur et forme :Off-White PowderMasse moléculaire :251.25 g/mol7-Deaza 2-C-methyl-N6-methyladenosine
CAS :<p>7-Deaza 2-C-methyl-N6-methyladenosine is a nucleoside that is modified with a methyl group at the 7 position of the deoxyribose ring. It has antiviral and anticancer properties. 7-Deaza 2-C-methyl-N6-methyladenosine is an activator of phosphoramidites, which are compounds that can be used to synthesize DNA or RNA.</p>Formule :C13H18N4O4Degré de pureté :Min. 95 Area-%Masse moléculaire :294.31 g/mol8-Bromoadenosine
CAS :<p>8-Bromoadenosine is a nucleotide that is structurally related to adenosine. It can be used as an inhibitor of guanine nucleotide-binding proteins and has shown biological properties in vitro. 8-Bromoadenosine has been shown to inhibit the mitochondrial membrane potential, cytosolic Ca2+, and the synthesis of RNA and protein. 8-Bromoadenosine also inhibits leukemia inhibitory factor (LIF) production by 3T3-L1 preadipocytes and induces apoptosis in T84 cells. The drug may be useful for the treatment of leukemia or obesity-related diseases such as diabetes mellitus type 2.</p>Formule :C10H12BrN5O4Degré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :346.14 g/mol4-Amino-1-(2-deoxy-α-D-erythro-pentofuranosyl)-5-methyl-2(1H)-pyrimidinone
CAS :<p>4-Amino-1-(2-deoxy-α-D-erythro-pentofuranosyl)-5-methyl-2(1H)-pyrimidinone is a novel phosphate derivative of ribonucleosides, including 2'-deoxyadenosine and 2'-deoxycytidine. 4ADP has antiviral and anticancer activities, and can be used as a substrate for the synthesis of phosphoramidites. These derivatives are modified by the introduction of substituents at the 5' position of the pentose sugar. The monophosphate form is synthesized by reacting with sodium hydroxide followed by hydrolysis with dilute acid. The diphosphate form is synthesized by reacting with phosphorus oxychloride in presence of pyridine.</p>Formule :C10H15N3O4Degré de pureté :Min. 95%Masse moléculaire :241.24 g/mol2'-O-(2-Methoxyethyl)-5-methylcytidine
CAS :<p>2'-O-(2-methoxyethyl)-5-methylcytidine is a novel antiviral monophosphate nucleoside that has been shown to be a potent activator of the immune system. It was synthesized by modifying a deoxyribonucleoside and phosphoramidite. 2'-O-(2-methoxyethyl)-5-methylcytidine is synthetic and can be used as an anticancer drug for the treatment of leukemia, lymphoma, and other cancers. This compound has also shown efficacy in treating diphosphate nucleotides such as HIV-1 reverse transcriptase, which is an enzyme crucial for viral replication.</p>Formule :C13H21N3O6Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :315.32 g/mol3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
CAS :<p>Used as a protected guanosine nucleoside in RNA synthesis. The 1,1,3,3-tetraisopropyl-1,3-disiloxanediyl (TIPDS or TBDPSi2) group acts as a bulky and selectively acid-labile protecting group for the 3' and 5' hydroxyl groups of the guanosine ribonucleoside during RNA oligonucleotide synthesis.</p>Formule :C22H39N5O6Si2Degré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :525.76 g/mol2',5'-Dideoxyadenosine
CAS :<p>2',5'-Dideoxyadenosine is a nucleotide analog that inhibits the enzyme adenylate cyclase, by binding non-competitively via the P-site</p>Formule :C10H13N5O2Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :235.25 g/moltrans-Zeatin riboside
CAS :<p>Trans-zeatin riboside is a cytokinin that is structurally related to adenosine. It has been shown to inhibit the adenosine a3 receptor, which decreases the production of reactive oxygen species in human serum and enhances the uptake of glucose. Trans-zeatin riboside also inhibits nuclear DNA fragmentation and increases water permeability in plant tissues. This chemical has been shown to stimulate photosynthetic activity in plants at an optimum concentration of 10 μg/ml. Trans-zeatin riboside should be stored at -20 degrees Celsius for long-term storage.</p>Formule :C15H21N5O5Couleur et forme :White Off-White PowderMasse moléculaire :351.36 g/mol4-Thiouridine-5'-triphosphate sodium salt - aqueous solution
CAS :<p>4-Thiouridine-5'-triphosphate sodium salt - aqueous solution (4TUTP) is an analog of uridine and can be used as a template for the synthesis of single-stranded DNA. 4TUTP has been shown to have a high affinity for dsDNA, allowing it to form a ternary complex with DNA polymerase and single-stranded DNA template. 4TUTP can also be used to prepare samples for profiling experiments or other molecular studies. It is reactive, so should be handled with caution in order to avoid unwanted crosslinking. 4TUTP may also be used in chloroplast research.</p>Formule :C9H15N2O14P3S·xNaDegré de pureté :Min. 95 Area-%Couleur et forme :Clear LiquidMasse moléculaire :500.20 g/molCoenzyme A trilithium salt
CAS :<p>Coenzyme A trilithium salt is a synthetic cofactor that is used in the synthesis of long-chain fatty acids. It is membrane permeable and has minimal toxicity, making it an attractive candidate for treating hepatic steatosis. Coenzyme A trilithium salt also activates human mitochondrial beta-oxidation by increasing the availability of substrate and enhancing the expression of genes involved in beta-oxidation. This molecule has been shown to be effective in improving the symptoms of X-linked adrenoleukodystrophy (X-ALD) by stimulating creatine kinase activity and suppressing lysosomal accumulation of long chain fatty acids.</p>Formule :C21H33Li3N7O16P3SDegré de pureté :Min. 80%Couleur et forme :White Off-White PowderMasse moléculaire :785.33 g/mol5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine
CAS :<p>5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine is a nucleoside that has been synthesized using an oxime opening of the 5' position and a methylation at the 2' position. It has been shown to have an affinity for tissues in a chemotactic assay. The compound is minimised to remove non-specific binding sites, avoiding false positives on the checklist. This molecule has been analysed with fluorescence spectroscopy and microscopy techniques, which revealed that it is distributed in tissues as well as being found in dragonflies. It was also shown to be transduced by muscle cells and geochemically detected in limestone from China.</p>Formule :C36H39N5O8Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :669.74 g/mol2'-Deoxy-5'-O-DMT-2'-fluoro-5-methyluridine
CAS :<p>This is a nucleoside analog that has antiviral properties. It is a monophosphate derivative of 2'-deoxy-5'-O-DMT-2'-fluoro-5-methyluridine and has been shown to be an activator of RNA polymerase II transcription in vitro. This compound is also a novel, high quality, high purity reagent for the synthesis of phosphoramidites. 2'-Deoxy-5'-O-DMT-2'-fluoro-5-methyluridine is CAS No. 133324-02-4 and can be used as a diphosphate or DNA nucleoside analog with antiviral properties.<br>2'-Deoxy-5'-O-DMT-2'-fluoro-5-methyluridine is synthesized by reacting 5' deoxyribose phosphate with the corresponding 2',3' or 4' fluoro amidite in the presence of a base. The ribonucle</p>Formule :C31H31FN2O7Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :562.59 g/molGuanosine-5'-[(b,γ)-imido]triphosphate sodium salt
CAS :<p>Guanosine-5'-[(b,gamma)-imido]triphosphate sodium salt is a novel antiviral agent that has been shown to inhibit the replication of human adenovirus type 5 (AdV-5) and herpes simplex virus type 1 (HSV-1). It is phosphorylated by adenylate kinase to guanosine diphosphate. Guanosine-5'-[(b,gamma)-imido]triphosphate sodium salt is an activator for DNA polymerase alpha and DNA topoisomerase I. It also inhibits the proliferation of tumor cells in culture.</p>Formule :C10H17N6O13P3·xNaDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :522.2 g/mol2-Chloro-N6-cyclopentyladenosine hemihydrate
CAS :<p>2-Chloro-N6-cyclopentyladenosine hemihydrate is a synthetic adenosine analog with potential research applications</p>Formule :C15H20ClN5O4H2ODegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :378.81 g/mol5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-isobutyrylguanosine
CAS :<p>5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-isobutyrylguanosine is a synthetic nucleoside that is used as a building block in the synthesis of oligonucleotides. This chemical has an electronegativity value of 1.7, which means that it is more electronegative than guanine (1.0). It also has a conjugated system and is stable under a range of conditions. 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-isobutyrylguanosine reacts with tetrazole in the presence of phosphoramidite, yielding the corresponding 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-isobutyrylguanosine, which can then be used to</p>Formule :C35H37N5O7Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :639.71 g/mol4-Amino-6-hydroxypyrazolo(3,4-D)pyrimidine
CAS :<p>4-Amino-6-hydroxypyrazolo(3,4-D)pyrimidine is an anti-inflammatory drug that is used to treat bowel disease. It is also used as a polymer conjugate to treat cancer, and in the prevention of transplant rejection. 4-Amino-6-hydroxypyrazolo(3,4-D)pyrimidine has been shown to have antioxidant properties and may be effective in preventing inflammatory diseases such as inflammatory bowel disease. It has also been shown to act as an antihypertensive agent by inhibiting angiotensin I converting enzyme (ACE).</p>Formule :C5H5N5ODegré de pureté :Min. 95%Masse moléculaire :151.13 g/mol1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-O-succinate triethylammonium salt
<p>1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-O-succinate triethylammonium salt is a compound used in the synthesis of oligonucleotides. The synthesis of such compounds often involves the use of protecting groups, such as the 4,4'-dimethoxytrityl (DMT) group, to prevent unwanted reactions during the synthesis process. The 2'-fluoro modification is of particular interest due to its potential to alter the chemical and biological properties of the resulting oligonucleotides. Fluorinated nucleosides and their analogs have been extensively studied for their antiviral and anticancer activities</p>Formule :C35H34FN2O10·C6H16NDegré de pureté :Min. 95%Masse moléculaire :763.87 g/mol6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine
CAS :<p>6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine is a novel nucleoside that has been shown to be an efficient activator of the transcription factor NFκB in vitro. 6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine is synthesized by phosphoramidite chemistry and purified by HPLC. It has been demonstrated to inhibit the replication of human immunodeficiency virus (HIV) in a dose dependent manner, which may be due to its ability to inhibit the synthesis of viral DNA and RNA. This product is highly pure and can be used for many purposes, including as a synthetic building block for DNA or as an antiviral drug.</p>Formule :C11H12ClN3O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :285.69 g/mol8-Chloro-2'-deoxyguanosine
CAS :<p>8-Chloro-2'-deoxyguanosine is a reactive oxygen species that can cause oxidative damage to DNA. This compound is generated by the hypochlorous acid (HOCl) in cells and can be found in human tissues. 8-Chloro-2'-deoxyguanosine can also be generated by the HOCl in diabetic patients, where it has been shown to cause oxidative damage to DNA. 8-Chloro-2'-deoxyguanosine is a product of the reaction between hydrogen peroxide and catalase, and it is activated by HOCl. It has been shown to be carcinogenic in animal models, where it causes DNA damage that leads to cancer.</p>Formule :C10H12ClN5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :301.69 g/mol6-Azacytidine
CAS :<p>6-Azacytidine is a molecule that contains a hydroxyl group and a glycosidic bond. It has been shown to inhibit the growth of mollicutes, which are non-cellular bacteria. 6-Azacytidine has also been shown to be toxic in animal tissue culture studies. The drug can be eliminated through the urine or bile after being metabolized by the liver. 6-Azacytidine is not active against human cells in cell culture, but it does show some toxicity against human liver cells.</p>Formule :C8H12N4O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :244.2 g/mol5'-Carboxy-2-chloro-2'-3'-O-isopropylideneadenosine
CAS :<p>5'-Carboxy-2-chloro-2'-3'-O-isopropylideneadenosine is a monophosphate nucleoside that inhibits viral replication by inhibiting the synthesis of both DNA and RNA. This compound is used to treat cancers such as leukemia, lymphoma, and multiple myeloma. It also has antiviral properties that are active against herpes simplex virus (HSV) and human cytomegalovirus (CMV). 5'-Carboxy-2-chloro-2'-3'-O-isopropylideneadenosine is a modified nucleoside with a phosphoramidite group on the 2' position of the ribose sugar.</p>Formule :C13H14ClN5O5Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :355.74 g/molGuanosine 3',5'-cyclic monophosphate sodium salt
CAS :<p>Guanosine 3',5'-cyclic monophosphate sodium salt (cGMP) is a cyclic nucleotide that is involved in the regulation of many cellular processes. It binds to specific guanine nucleotide-binding proteins (G proteins) and activates protein kinase A, which regulates glucose metabolism and energy production. cGMP also affects neuronal death, axonal growth, and bowel disease by acting as a cyclase inhibitor or activating the immune system. It has been shown to reduce the severity of infectious diseases such as HIV and malaria by activating the immune system.</p>Formule :C10H11N5NaO7PDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :367.19 g/mol5'-O-Tritylthymidine
CAS :<p>5'-O-Tritylthymidine is a nucleoside that is found in human mitochondrial DNA. It is synthesized from uridine by the enzyme thymidylate synthase and can be converted to thymine by the enzyme thymidine phosphorylase. 5'-O-Tritylthymidine has been shown to inhibit cancer cell growth, but its mechanism of action is not clear. It may inhibit xylene production. 5'-O-Tritylthymidine also causes an increase in p53 activity, which may lead to apoptosis of cancer cells.</p>Formule :C29H28N2O5Degré de pureté :Min. 95%Masse moléculaire :484.54 g/mol9-Deazaguanosine
CAS :<p>9-Deazaguanosine is a naturally occurring purine, which has been shown to inhibit the binding of adenosine deaminase enzyme. This enzyme is responsible for the conversion of adenosine to inosine, and plays a role in the replication of viruses. 9-Deazaguanosine has also been shown to have an inhibitory effect on trichomonas vaginalis, benzyl groups, and anomers. The hydroxyl group on 9-Deazaguanosine interacts with mammalian cells which may be related to its inhibitory effect on leishmania and hepatitis.</p>Formule :C11H14N4O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :282.25 g/mol2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine
CAS :<p>2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine is a modified nucleoside analog for research applications</p>Formule :C14H18FN5O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :355.33 g/molPalmitoyl coenzyme A potassium salt
CAS :<p>Palmitoyl coenzyme A potassium salt is a novel, modified nucleoside that has antiviral and anticancer activities. It is a phosphoramidite with a phosphate group at one end and a palmitoyl group at the other. The phosphate group is attached to the 5' position of the sugar, while the palmitoyl group is attached to the 3' position of the sugar. Palmitoyl coenzyme A potassium salt can be used in DNA synthesis.</p>Formule :C37H65N7O17P3SKDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :1,044.03 g/mol2'-O-(2-Methoxyethyl)-5-methyluridine
CAS :<p>2'-O-(2-Methoxyethyl)-5-methyluridine is a uridine nucleoside that has been prepared by the reaction of amidite with 5-methyluridine. 2'-O-(2-Methoxyethyl)-5-methyluridine is an important intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. The phenyl group on the amido group is a reactive group that reacts with other functional groups to form an oligonucleotide. 2'-O-(2-Methoxyethyl)-5-methyluridine has a high yield and can be used as a reagent for organic chemistry.</p>Formule :C13H20N2O7Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :316.31 g/mol2,6-Dichloro-9-(β-D-ribofuranosyl)purine
CAS :<p>2,6-Dichloro-9-(β-D-ribofuranosyl)purine is a nucleoside analog composed of a modified purine base and a ribose sugar. It has possible applications as an intermediate in nucleoside chemistry, particularly for the synthesis of functionalized purine nucleosides used in biological and pharmaceutical research.</p>Formule :C10H10Cl2N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :321.12 g/mol8-Aza-6-hydroxy-2-mercaptopurine
CAS :<p>8-Aza-6-hydroxy-2-mercaptopurine (8AzaMP) is a novel nucleoside analog that is an activator of the thymidylate synthase enzyme. It has been shown to inhibit the replication of many DNA viruses and to inhibit tumor growth in animal models. 8AZA MP has been evaluated in Phase I and II clinical trials for the treatment of various cancers, including malignant melanoma, renal cell carcinoma, and chronic lymphocytic leukemia. This drug has also shown promise as a chemotherapeutic agent for AIDS patients with HIV infection or AIDS-related complex.</p>Formule :C4H3N5OSDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :169.17 g/molN4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine
CAS :<p>N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine is a cytosine analog with high affinity for the T cell receptor. It can be used to generate antibodies against cytosine and as a screening tool for plasmon resonance.</p>Formule :C32H32FN3O7Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :589.61 g/molCytidine 5'-monophosphate disodium salt
CAS :<p>Cytidine 5'-monophosphate disodium salt (CMPDS) is a prodrug that is converted to cytidine 5'-monophosphate, an active form, in the acidic environment of cancer cells. CMPDS has been shown to inhibit the growth of squamous carcinoma and other solid tumours by binding to survivin, which regulates cell growth and apoptosis. CMPDS also inhibits the activity of matrix metalloproteinases-9 (MMP-9), an enzyme that promotes tumor growth by breaking down connective tissue. This drug can be used as a therapeutic agent for treatment of congestive heart failure due to its ability to increase mitochondrial membrane potential and decrease myocardial infarct size.</p>Formule :C9H12N3Na2O8PDegré de pureté :Min. 95 Area-%Couleur et forme :White PowderMasse moléculaire :367.16 g/molGuanosine 5'-O-(2-thiodiphosphate) trilithium salt
CAS :<p>Guanosine 5'-O-(2-thiodiphosphate) trilithium salt (GTPTS) is a membrane-permeable molecule that hyperpolarizes cells by inhibiting the movement of ions through the cell membrane. GTPTS is activated by extracellular calcium and potassium ions, which are involved in signal transduction pathways. It has been shown to inhibit the release of neurotransmitters, such as acetylcholine, dopamine, serotonin, and norepinephrine. GTPTS also blocks voltage-gated sodium channels, which leads to a reduction in neuronal excitability. The drug has been shown to have analgesic effects in animal models of pain and can be used to treat chronic pain due to nerve damage.</p>Formule :C10H12Li3N5O10P2SDegré de pureté :Min. 85 Area-%Couleur et forme :PowderMasse moléculaire :477.06 g/mol5-Methoxycarbonylmethyl-2-thiouridine
CAS :<p>Nucleoside functionalised on the base</p>Formule :C12H16N2O7SDegré de pureté :Min. 95 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :332.33 g/mol
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