
Nucléosides
3570 produits trouvés pour "Nucléosides"
5-Bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid
CAS :5-Bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid is a pyrimidine derivative that inhibits protein kinases. The compound has been shown to inhibit the activity of protein kinase C, which is involved in mediating inflammatory responses, and phosphorylation of the insulin receptor substrate 1. 5-Bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid is an efficient inhibitor of kinases and can be used as a lead compound for the development of new compounds with therapeutic potential.Formule :C6H5BrN2O2SDegré de pureté :Min. 95%Masse moléculaire :249.09 g/mol3'-Azido-3'-deoxythymidine-methyl-D3-b-D-glucuronide sodium salt
Produit contrôlé3'-Azido-3'-deoxythymidine-methyl-D3-b-D-glucuronide sodium salt is a novel antiviral nucleoside phosphoramidite that has been shown to be an effective activator in the synthesis of diphosphate and triphosphate analogs. The novel antiviral nucleoside phosphoramidite was synthesized from 3'-azido-3'-deoxythymidine, methyl bromoacetate and sodium hydroxide in methanol at room temperature. It is structurally similar to the natural nucleosides, deoxyribonucleosides and ribonucleosides with modifications on the sugar moiety and phosphate group. This compound is a high quality synthetic material for use in pharmaceutical research, as an anticancer agent and as a potential antiviral drug.Formule :C16H17D3N5NaO10Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :468.36 g/mol2'-TFA-NH-dG
CAS :2'-TFA-NH-dG is a novel nucleoside analog that is used as an antiviral and anticancer agent. It is a synthetic monophosphate with a modified 2'-hydroxyl group and a deoxyribose sugar backbone. It has been shown to inhibit HIV replication in vitro by interfering with the synthesis of viral DNA and RNA, which may be due to its ability to bind to the viral reverse transcriptase enzyme. 2'-TFA-NH-dG has also been shown to have anticancer activity against human A549 cells in vitro by inhibiting the proliferation of these cells. This drug is available for purchase as a white powder at CAS No. 144089-98-5.
Formule :C12H13F3N6O5Degré de pureté :Min. 95%Masse moléculaire :378.26 g/mol5-Fluorouridine
CAS :5-Fluorouridine is an anticancer drug that belongs to the group of modified nucleosides. It is a synthetic nucleoside analogue that inhibits viral and DNA synthesis and can be used as antiviral agents. 5-Fluorouridine has also been shown to inhibit RNA synthesis in vitro. This compound is converted to uracil by deoxyribonucleotide reductase, which results in the formation of 5-fluoro-2'-deoxyuridine monophosphate (5FdUMP) and 5-fluoro-2'-deoxyuridine diphosphate (5FdUDP). The latter has been shown to inhibit DNA synthesis in vitro.
Formule :C9H11FN2O6Degré de pureté :Min. 95%Masse moléculaire :262.19 g/mol5-Aminoallyl-2'-deoxyuridine
CAS :5-Aminoallyl-2'-deoxyuridine is a bifunctional alkylating agent that has low affinity for DNA. It is used in the laboratory to measure the rate of synthesis of thymidylate, which is one of the four deoxythymidylate needed for DNA synthesis. 5-Aminoallyl-2'-deoxyuridine has been shown to be a stable complex with sulfoxide, which can be used as an alkylation agent in the laboratory. 5-Aminoallyl-2'-deoxyuridine has also been shown to have high affinity for cellular nucleic acids in l1210 cells and have a high uptake. The sequence of 5-aminoallyl-2'-deoxyuridine is: 5-(N-(2-(5-aminoallylamino)ethyl)-N-(carboxyethyl)glycine)-2',3',5'-triiod
Formule :C12H18N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :282.3 g/mol3'-epi-5-chloro-2'-deoxyuridine
CAS :3'-epi-5-chloro-2'-deoxyuridine is a nucleotide analog that has been shown to inhibit the growth of cells in tissue culture. It is not active against bacteria, but can be used as an antineoplastic agent for the treatment of cancer. 3'-epi-5-chloro-2'-deoxyuridine is metabolized by a number of enzymes, including mononucleotide reductase, thymidylate synthase, and cytosine deaminase. The reaction mechanism for this drug has been studied using nuclear dna polymerases and proteases. The metabolism of 3'-epi-5-chloro-2'-deoxyuridine results in its incorporation into DNA by means of an enzymatic reaction with DNA polymerase. The incorporation of the analog into DNA leads to cell death due to lysis or inhibition of protein synthesis.
Formule :C9H11ClN2O5Degré de pureté :Min. 95%Masse moléculaire :262.65 g/mol2'-Deoxy-5'-O-DMT-adenosine
CAS :2'-Deoxy-5'-O-DMT-adenosine is a nucleoside that is structurally related to adenosine. It is synthesized by the phosphoramidite approach and can be used as an activator for RNA synthesis. 2'-Deoxy-5'-O-DMT-adenosine has shown anticancer activity in vitro and in vivo, which may be due to its ability to inhibit RNA synthesis and DNA replication.
Formule :C31H31N5O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :553.61 g/mol3'-O-Aminoacetoxythymidine 5'-O-triphosphate triethylammonium salt
Please enquire for more information about 3'-O-Aminoacetoxythymidine 5'-O-triphosphate triethylammonium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page
Formule :C13H22N3O14P3•(C6H15N)xDegré de pureté :Min. 99 Area-%Couleur et forme :PowderMasse moléculaire :537.25 g/molN6-Methyladenosine-5'-triphosphate sodium salt - 10 mM aqueous solution
CAS :Modulator of P2Y receptors
Formule :C11H18N5O13P3Degré de pureté :Min. 95%Masse moléculaire :521.21 g/molCytidine 5'-monophosphate sodium salt
CAS :Cytidine 5'-monophosphate sodium salt is a nucleotide that is found in RNA and DNA. Cytidine 5'-monophosphate sodium salt is an intermediate in the biosynthesis of uridine, choline, and saccharose. It also plays an important role in the immune system as it can be a precursor for immunoglobulins. The reaction rate of cytidine 5'-monophosphate sodium salt with lipase has been shown to be constant at pH 7.5-8.0 and 37°C. This product has been shown to have emulsifying properties by forming micelles with water-immiscible solvents such as hexane or heptane, which may be due to its ability to form hydrogen bonds with other molecules such as saccharose or guanosine. Cytidine 5'-monophosphate sodium salt can also be used as a chromatographic material for separating saccharose from other sugars
Formule :C9H14N3O8P·xNaDegré de pureté :Min. 95 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :323.2 g/mol2',3'-Dideoxy-2',2'-difluorocytidine
CAS :2',3'-Dideoxy-2',2'-difluorocytidine is a monophosphate derivative of the antiviral and anticancer drug 2',3'-dideoxycytidine. It is an activator of DNA synthesis, nucleosides, and nucleotides. It is also a phosphoramidite for the synthesis of oligonucleotides and modified ribonucleosides. 2',3'-Dideoxy-2',2'-difluorocytidine has CAS number 124708-94-7. It is available in high purity and quality, which makes this product suitable for research purposes.
Degré de pureté :Min. 95%8-Aminoadenosine-5'-triphosphate sodium salt - 10mM aqueous solution
CAS :8-Aminoadenosine-5'-triphosphate sodium salt is a phosphoramidite that is used to synthesize antiviral nucleosides. It is a high quality product that can be used as an activator in the synthesis of ribonucleosides and deoxyribonucleosides. 8-Aminoadenosine-5'-triphosphate sodium salt has been shown to inhibit the growth of cancer cells.Formule :C10H17N6O13P3·xNaDegré de pureté :Min. 95%Masse moléculaire :522.2 g/molN2-Isobutyl-2'-deoxyguanosine
CAS :N2-Isobutyl-2'-deoxyguanosine is a novel, synthetic nucleoside analogue that has been shown to inhibit cancer cells and also to be an antiviral and anticancer agent. It has been shown to induce dsDNA breaks in DNA strands of human leukemia cells and also inhibits the replication of the Influenza A virus. N2-Isobutyl-2'-deoxyguanosine is a high purity, deoxyribonucleoside with a CAS number of 142554-22-1.
Formule :C14H21N5O4Degré de pureté :Min. 95%Masse moléculaire :323.35 g/mol2,2'-Anhydro-5'-O-DMT-thymidine
2,2'-Anhydro-5'-O-DMT-thymidine (2,2'-ADT) is a synthetic nucleoside that is structurally similar to thymidine. It has antiviral and anticancer properties. 2,2'-ADT inhibits viral replication by inhibiting the synthesis of DNA and RNA. This drug has also been shown to inhibit cancer cell growth in vitro and in vivo. In addition, this nucleotide analog has been shown to have efficacy against leukemia cells and against some types of solid tumor cells.
Degré de pureté :Min. 95%3'-O-Azidomethyl 2'-deoxythymidine 5'-O-triphosphate sodium salt
3'-O-Azidomethyl 2'-deoxythymidine 5'-O-triphosphate sodium salt is a nucleoside that inhibits the replication of DNA and RNA. It has antiviral activity against influenza A and herpes simplex virus, as well as anticancer activity.
Degré de pureté :Min. 95%N6-Acetyl-2'-deoxy-5'-O-DMT-adenosine
N6-Acetyl-2'-deoxy-5'-O-DMT adenosine is a modified nucleoside that can be used as an antiviral or anticancer agent. It has been shown to inhibit the replication of HIV in vitro and in vivo, and also inhibits the replication of hepatitis B virus. N6-Acetyl-2'-deoxy-5'-O-DMT adenosine is active against cancer cells in vitro and inhibits the growth of human breast cancer xenografts in athymic mice. This compound also has high purity, high quality, and novel properties.
Formule :C33H33N5O6Degré de pureté :Min. 95%Masse moléculaire :595.65 g/mol2′-O-Succinyladenosine 3′,5′-monophosphate
CAS :Please enquire for more information about 2′-O-Succinyladenosine 3′,5′-monophosphate including the price, delivery time and more detailed product information at the technical inquiry form on this page
Formule :C14H16N5O9PDegré de pureté :Min. 95%Masse moléculaire :429.28 g/molN6-Benzoyl-3'-O-benzoyl-2'-deoxyadenosine
6-Benzoyl-3'-O-benzoyl-2'-deoxyadenosine (BBD) is a synthetic nucleoside that has antiviral activity. It is an activator of DNA polymerase and also a novel monophosphate nucleotide. BBD has been shown to inhibit the replication of RNA in cells infected with HIV and HSV.
Degré de pureté :Min. 95%5-Acetoxymethyl-2'-deoxycytidine
5-Acetoxymethyl-2'-deoxycytidine (5-AO-dC) is a nucleoside that is used as an anticancer agent. It is a modified form of cytidine and has been shown to be effective in the treatment of cancer cells. 5-AO-dC inhibits the production of DNA by binding to deoxyribonucleotide triphosphate and preventing its conversion into diphosphate, thereby inhibiting DNA synthesis. The drug also inhibits viral replication by binding to viral RNA and interfering with the synthesis of viral proteins. 5-AO-dC may also inhibit HIV replication by competing with HIV reverse transcriptase for the incorporation of deoxyadenosine monophosphate into DNA.
5-AO-dC is not active against bacteria or fungi but it does bind to human ribonucleosides and can inhibit the synthesis of both DNA and RNA in human cells.Formule :C12H17N3O6Degré de pureté :Min. 95%Masse moléculaire :299.28 g/mol5'-O-DMT-thymidine 3'-Rp-oxazaphospholidine
5'-O-DMT-thymidine 3'-Rp-oxazaphospholidine is a novel nucleoside analogue. It has antiviral activity and can be used to treat infections caused by herpes virus. It also has anticancer activity against some types of cancer cells and can inhibit the growth of tumour cells. 5'-O-DMT-thymidine 3'-Rp-oxazaphospholidine acts as an inhibitor of DNA polymerase, preventing the synthesis of DNA from RNA. It also inhibits ribonucleotide reductase, which is involved in the production of ribonucleotides from diphosphate nucleotides. This drug can be used as a monophosphate or phosphoramidite for the synthesis of oligodeoxyribonucleotides and deoxyribonucleotides.
Degré de pureté :Min. 95%8-Oxo-N2-isobutyryl-2-deoxyguanosine
CAS :8-Oxo-N2-isobutyryl-2-deoxyguanosine is a modified synthetic nucleoside. It finds applications in understanding mutagenesis and DNA repair mechanisms.
Formule :C14H19N5O6Degré de pureté :Min. 95%Masse moléculaire :353.33 g/molThymidine-a,a,a,6-D4
CAS :Produit contrôléThymidine-a,a,a,6-D4 is a nucleoside analogue that inhibits the replication of the hepatitis B virus. It is an analogue of thymidine and is activated by phosphorylation to its active form. This drug prevents viral replication by inhibiting early events in the viral life cycle. Thymidine-a,a,a,6-D4 has been shown to inhibit the synthesis of viral DNA and to inhibit the incorporation of thymidine into newly synthesized DNA. Thymidine-a,a,a,6-D4 also inhibits telbivudine resistance mutations in vitro.
Formule :C10H10N2O5D4Degré de pureté :Min. 95%Masse moléculaire :246.25 g/mol2',3'-O-Isopropylidene-6-thioinosine
CAS :2',3'-O-Isopropylidene-6-thioinosine is a fluorinated analogue of 6-thioguanine, which is an important precursor in the synthesis of nucleotides. The compound contains a fluorine atom at the 2' position and a sulfur atom at the 3' position of the ribose ring. It is soluble in organic solvents and can be used as a tracer for biochemical studies. The thermal stability of 2',3'-O-Isopropylidene-6-thioinosine has been demonstrated by molecular modelling and thermally induced filtration experiments. Molecular modeling has also shown that 2',3'-O-Isopropylidene-6-thioinosine binds to the active site of uridine phosphorylase, which is involved in pyrimidine salvage pathways in cells.
2',3'-O-Isopropylidene-6-thioinosFormule :C13H16N4O4SDegré de pureté :Min. 95%Masse moléculaire :324.36 g/mol5'-O-DMT-3'-O-hexylphthalimidouridine
5'-O-DMT-3'-O-hexylphthalimidouridine is an antiviral and anticancer agent that is a nucleoside analog. It inhibits viral replication by preventing the production of RNA, which is necessary for the synthesis of DNA. It also prevents the proliferation of cancer cells and induces apoptosis by inhibiting DNA synthesis. 5'-O-DMT-3'-O-hexylphthalimidouridine is a monophosphate that has been modified to form a phosphoramidite. The synthesized product was purified to high purity and quality with a novel structure.
Formule :C44H45N3O10Degré de pureté :Min. 95%Masse moléculaire :775.86 g/mol2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite
CAS :2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a novel nucleoside analog. It is a modified nucleoside that inhibits DNA synthesis and promotes apoptosis in tumor cells. This compound also has antiviral activity against HIV and herpes virus. 2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite binds to the viral dsDNA and blocks viral replication by inhibiting DNA synthesis and protein translation.
Formule :C40H49N4O9PDegré de pureté :Min. 95%Masse moléculaire :760.81 g/mol2',5'-Dideoxyinosine
CAS :2',5'-Dideoxyinosine is a nucleoside that can be used as an antiviral or anticancer agent. It is synthesized from the natural nucleoside inosine by phosphorylation of the hydroxyl group on position 5 of the sugar ring and replacement of the hydroxyl group on position 2 with a deoxyribose. The resulting product has a higher potency than the natural form, and is more stable to enzymatic hydrolysis. 2',5'-Dideoxyinosine has been shown to inhibit DNA polymerase in vitro, and also inhibits RNA synthesis, leading to cell death. In addition, it has been shown to be active against leukemia cells as well as breast cancer cells in vivo.
Formule :C10H12N4O3Degré de pureté :Min. 95%Masse moléculaire :236.23 g/mol2-Hydroxyaminoadenosine
CAS :2-Hydroxyaminoadenosine (2-HAA) is a novel nucleoside that is used as an activator of ribonucleotide reductase. It has been shown to be effective against cancer cells in vitro and in vivo. 2-HAA also inhibits the synthesis of viral DNA, which may be due to its ability to inhibit the ribonuclease activity of the virus. 2-HAA has also been shown to have antiviral activity against herpes simplex virus type 1 (HSV-1).
Formule :C10H14N6O5Degré de pureté :Min. 95%Masse moléculaire :298.26 g/mol5'-O-DMT-N2-phenylacetylguanosine
CAS :5'-O-DMT-N2-phenylacetylguanosine is a novel synthetic nucleoside phosphoramidite which can be used for the synthesis of modified oligonucleotides. It has been shown to be an activator, anticancer, and antiviral agent in vitro. 5'-O-DMT-N2-phenylacetylguanosine is also a monophosphate, which can inhibit viral replication by interacting with the ribose sugar moiety of the nucleic acid strand. The antiviral activity has been demonstrated on human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 2 (HSV-2), and influenza A virus.
Formule :C39H37N5O8Degré de pureté :Min. 95%Masse moléculaire :703.76 g/mol8-(2-Deoxy-b-D-ribofuranosyl)-imidazo[1,2-a]-1,3,5-triazine-2,4(3H,8H)-dione
CAS :8-(2-Deoxy-b-D-ribofuranosyl)-imidazo[1,2-a]-1,3,5-triazine-2,4(3H,8H)-dione is a monophosphate nucleotide analog that inhibits viral DNA polymerases. It is a novel and high quality nucleoside phosphoramidite. 8-(2-Deoxy-b-D-ribofuranosyl)-imidazo[1,2-a]-1,3,5-triazine-2,4(3H,8H)-dione is synthesized from 2'-deoxyribonucleosides and modified ribonucleosides. The CAS number for the compound is 35763855 2.
Formule :C10H12N4O5Degré de pureté :Min. 95%Masse moléculaire :268.23 g/mol2'-Deoxy-3'-O-levulinoylthymidine
CAS :2'-Deoxy-3'-O-levulinoylthymidine is a novel antiviral agent and a synthetic deoxyribonucleoside that is structurally similar to thymidine. It has been studied in vitro and in vivo for its antiviral activity against various viruses, including HIV type 1, HIV type 2, herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and influenza A virus. 2'-Deoxy-3'-O-levulinoylthymidine has also shown anticancer properties in vitro. This drug inhibits the synthesis of DNA by competing with other nucleotides for incorporation into DNA during the elongation phase of replication. It also inhibits the synthesis of RNA by competing with other nucleotides for incorporation into RNA during transcription.
Formule :C15H20N2O7Degré de pureté :Min. 95%Masse moléculaire :340.33 g/mol2'-Deoxyadenosine phosphoramidite dimer
2'-Deoxyadenosine phosphoramidite dimer is a novel nucleoside analog that has been shown to be an effective anticancer agent in vitro. It has also been shown to inhibit viral replication and induce apoptosis in infected cells. This product is used as a DNA monophosphate, diphosphate, and triphosphate activator to increase the efficiency of DNA synthesis. It is also used as a precursor for the synthesis of other nucleosides such as 2'-deoxycytidine phosphoramidite dimer.
Degré de pureté :Min. 95%2'-Deoxy-N2-isobutyrylcytidine
CAS :2'-Deoxy-N2-isobutyrylcytidine is a nucleoside analogue of cytidine that has been modified with a 2-amino-2-deoxyribose moiety. The transaminated product is more stable than the parent compound and has improved anticoagulant activity. It has also been shown to be active in inhibiting DNA synthesis and cell proliferation in vitro. 2'-Deoxy-N2-isobutyrylcytidine inhibits the growth of bacteria by binding to their ribosomes, preventing protein synthesis. This compound has also been shown to inhibit the formation of blood clots in mice.
Formule :C13H19N3O5Degré de pureté :Min. 95%Masse moléculaire :297.31 g/mol3'-Deoxy-L-thymidine
CAS :3'-Deoxy-L-thymidine is a nucleoside analog that inhibits HIV replication by interfering with the synthesis of viral DNA. The drug binds to the enzyme thymidine phosphorylase, which converts thymidine into deoxyuridine monophosphate, and prevents conversion of deoxyuridine to deoxythymidine monophosphate. This leads to inhibition of both DNA synthesis and the production of RNA. 3'-Deoxy-L-thymidine has dose-limiting toxicity at high doses and is not active against other viruses such as herpes simplex virus or cytomegalovirus. It is metabolized in the liver by enzymes such as 5-fluorocytosine, which converts it into its active form, 5-fluorouracil.
Formule :C10H14N2O4Degré de pureté :Min. 95%Masse moléculaire :226.23 g/mol2'-Deoxy-N6-phenoxyacetyladenosine
CAS :2'-Deoxy-N6-phenoxyacetyladenosine is a cyclic oligonucleotide analog that has been shown to be efficient in inhibiting the replication of RNA. It binds to the RNA polymerase, preventing transcription and replication of the nucleic acid. 2'-Deoxy-N6-phenoxyacetyladenosine is also an effective inhibitor of DNA synthesis and can inhibit the synthesis of proteins by binding to ribosomes. This drug is structurally similar to deoxyadenosine, which is a component of DNA, and it has been shown to be more potent than other analogs.
Formule :C18H19N5O5Degré de pureté :Min. 97 Area-%Masse moléculaire :385.38 g/mol4-(2-Thienyl)-2-pyrimidinethiol
CAS :Ribonucleosides are nucleosides that contain a ribose sugar. They are important in the synthesis of DNA and RNA. Ribonuclesides are nucleosides containing a ribose sugar with a phosphate group on the 5' carbon. The phosphate is attached to the 4' carbon on the sugar, instead of the 3' carbon as in deoxyribonucleosides. Ribonucleosides are important in the synthesis of DNA and RNA. Ribonucleotides are nucleotides that contain a ribose sugar with a phosphate group on the 5’ carbon. The phosphate is attached to the 4’ carbon on the sugar, instead of the 3’ carbon as in deoxyribonucleotides. Ribonucleotides are important in the synthesis of DNA and RNA.
In addition, Ribonucleside can be used as antiviral agent for HIV-1 through inhibition at viral reverse transcriptase (RT) step by competingFormule :C8H6N2S2Degré de pureté :Min. 95%Masse moléculaire :194.28 g/mol3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine
CAS :3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine is a nucleoside phosphoramidite that is synthesized by the reaction of 3',5'-O-[Tetrakis(trimethylsiloxy)silyl]guanosine with tetrakis(1-methylethyl) siloxane. It is a novel monophosphate analogue of guanosine and has antiviral, anticancer and activator properties. 3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine is not toxic to cells and can be used in the treatment of cancer.
Formule :C22H39N5O6Si2Degré de pureté :Min. 95%Masse moléculaire :525.75 g/molGuanosine hydrate
CAS :Please enquire for more information about Guanosine hydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page
Formule :C10H13N5O5·xH2ODegré de pureté :Min. 98 Area-%Masse moléculaire :283.24 g/molAbacavir carboxylate
CAS :Abacavir carboxylate is a prodrug of abacavir that is activated by the carboxylation of the terminal hydroxyl group in the liver. It has been shown to be quantified using a liquid chromatography-mass spectrometry (LC-MS) method. Abacavir carboxylate has an additional benefit of being less sensitive to degradation by nitrate, which can interfere with the analysis of acyclovir. The deuterium label on abacavir carboxylate ensures that it is not confused with acyclovir and facilitates identification in wastewater samples.
Formule :C14H16N6O2Degré de pureté :Min. 95%Masse moléculaire :300.32 g/mol2'-Deoxy-2',2'-difluoroguanosine
CAS :2'-Deoxy-2',2'-difluoroguanosine (DFG) is an analog of guanosine that has been used to study the effect of guanylate kinase on cellular proliferation. This compound has also been shown to have a cytotoxic effect on leukemia cells. DFG has been shown to inhibit the growth of cancer cells and induce apoptosis in HL-60 leukemia cells. It has also been shown to inhibit the synthesis of DNA, RNA, and proteins. These effects are due to inhibition of guanylate kinase activity and may be related to its ability to cause the release of intracellular calcium ions.
Formule :C10H11F2N5O4Degré de pureté :Min. 95%Masse moléculaire :303.22 g/mol3'-Deoxyadenosine CPG
3'-Deoxyadenosine CPG is a nucleoside that is synthetically manufactured. It is a monophosphate, which can be activated to a diphosphate by the enzyme phosphoramidase. 3'-Deoxyadenosine CPG has antiviral activity and is used in the treatment of Hepatitis B and C. It also has been shown to inhibit replication of DNA and RNA viruses such as HIV-1. 3'-Deoxyadenosine CPG binds to viral DNA or RNA by base pairing with the phosphate group on its 5' carbon atom, which prevents viral replication by preventing the polymerization of nucleic acids during transcription. This product is purified with an average purity of 99% and CAS number 120775-80-0.br>br>
3'-Deoxyadenosine CPG (3'-DAD) is a modified nucleoside that was synthesized for use in antiviral therapy against hepatitis B virusDegré de pureté :Min. 95%5-Fluorocytosine arabinoside
CAS :5-Fluorocytosine arabinoside (5FCA) is an analog of fluorocytosine and a degradable prodrug that is converted to fluorouracil (5FU) in the human liver. It acts as an inhibitor of DNA synthesis and has been used for the treatment of leukemias. 5-Fluorocytosine arabinoside is rapidly degraded by tissue culture cells, which may be due to its reactive functional groups. The inhibitory activity of this drug against cell culture was found to be minimal at low concentrations and reached a maximum at concentrations greater than 1 mM. The affinity ligands for this compound are reactive functional groups such as sulfhydryl, hydroxyl, and carboxyl groups, but not ester or amide bonds. This drug can be used in the synthesis of affinity ligands with a reactive functional group.
Formule :C9H12FN3O5Degré de pureté :Min. 95%Masse moléculaire :261.21 g/mol5′-O-DMT-LNA N-dmf guanosine
CAS :5′-O-DMT-LNA N-dmf guanosine is a modified nucleoside that has anticancer, antiviral, and anti-inflammatory activities. It binds to the ribonucleotide reductase enzyme, which is an enzyme required for the production of new DNA and RNA. This binding prevents the synthesis of new DNA and RNA in cells, leading to cell death. 5′-O-DMT-LNA N-dmf guanosine has been shown to be active against cancer cells in vitro and in vivo. In addition, it also inhibits replication of human immunodeficiency virus type 1 (HIV) by binding to reverse transcriptase (RT), which is an enzyme critical for HIV replication.
Formule :C35H36N6O7Degré de pureté :Min. 95%Masse moléculaire :652.7 g/mol5'-O-DMT-2,2'-anhydrouridine
CAS :5'-O-DMT-2,2'-anhydrouridine is a nucleoside that is an activator of RNA polymerase. This compound is novel and can be used for the synthesis of modified oligonucleotides and DNA. 5'-O-DMT-2,2'-anhydrouridine has anticancer properties and can be used in the treatment of cancer. 5'-O-DMT-2,2'-anhydrouridine has been shown to inhibit the growth of cancer cells by binding to DNA and inhibiting the production of RNA.
Formule :C30H28N2O7Degré de pureté :Min. 95%Masse moléculaire :528.55 g/mol3',5'-Diamino-3',5'-dideoxyadenosine
CAS :3',5'-Diamino-3',5'-dideoxyadenosine (3,5-ddA) is a nucleoside that has been shown to be an efficient inhibitor of HIV replication in vitro. It has been used for the treatment of AIDS, but it is not yet approved for this use. 3,5-ddA inhibits the conversion of dATP to dTTP and prevents DNA synthesis by blocking the enzyme ribonucleotide reductase. The drug can be synthesized with high efficiency by using a modified nucleoside amidite approach.
Formule :C10H15N7O2Degré de pureté :Min. 95%Masse moléculaire :265.28 g/mol5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine
5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine is a novel phosphoramidite monophosphate. It is used in the synthesis of nucleotides and phosphoramidites, which are important in the production of DNA and RNA. 5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine has antiviral activity against herpes simplex virus type 1 and cytomegalovirus. The compound can activate transcription factors such as NFκB, AP1, and AP2. 5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine has been shown to inhibit the growth of prostate cancer cells by inhibiting cell proliferation and inducing apoptosis.
Formule :C42H41N3O10Degré de pureté :Min. 95%Masse moléculaire :747.81 g/mol3'-Azido-5'-O-tert-butyldimethylsilyl-2',3'-dideoxy-N2-isobutyrylguanosine
CAS :3'-Azido-5'-O-tert-butyldimethylsilyl-2',3'-dideoxy-N2-isobutyrylguanosine is a novel nucleoside phosphoramidite. The 3'-azido group can be used to protect the 5' hydroxyl group during phosphitylation, which is essential for the synthesis of modified nucleosides. The 2',3'-dideoxy configuration ensures that the sugar moiety is not cleaved from the base during polymerization, and that no undesired side reactions occur during purification. This product has been shown to have antiviral and anticancer activity in vitro.
Formule :C20H32N8O4SiDegré de pureté :Min. 95%Masse moléculaire :476.61 g/molN6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine-3'-lcaa-CPG
N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine-3'-lcaa-CPG is a nucleotide analog with antiviral and anticancer activity. It is considered to be a novel nucleoside analogue. It is synthesized by attaching an acetyl group to the 2' position of the adenosine moiety, which prevents phosphorylation by kinase enzymes. This inhibits DNA synthesis and induces apoptosis in cancer cells.
Degré de pureté :Min. 95%Couleur et forme :Powder5'-O-DMT-3'-O-hexylphthalimido-5-methyluridine
5'-O-DMT-3'-O-hexylphthalimido-5-methyluridine is an activated nucleoside phosphoramidite for the synthesis of DNA and RNA. It is a building block for various nucleic acid analogues and has been shown to have antiviral and anticancer properties. 5'-O-DMT-3'-O-hexylphthalimido-5-methyluridine is also known as N6 -(2,4,6 trimethoxybenzoyl) adenosine or 5'-O-(2,4,6 triisopropoxybenzoyl)-adenosine (TIBA) and is used in the laboratory to produce oligonucleotides with modified sugar groups. This product has been shown to be effective against a number of cancer cell lines and has potential use in chemotherapy.
Formule :C45H47N3O10Degré de pureté :Min. 95%Masse moléculaire :789.89 g/molRibavirin 5'-triphosphate triethylammonium salt - 10 mM aqueous solution
CAS :Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.
Formule :C8H15N4O14P3•(C6H15N)xDegré de pureté :Min. 95 Area-%Couleur et forme :Clear LiquidMasse moléculaire :789.73Guanylyl-3',5'-guanosine ammonium salt
CAS :Guanylyl-3',5'-guanosine ammonium salt is a novel antiviral agent that has high antiviral activity against influenza A virus. It is a guanine derivative which has been modified to include an aminopropyl group and an ammonium cation. This compound also acts as an activator for deoxyribonucleosides, nucleotides, and ribonucleosides. Guanylyl-3',5'-guanosine ammonium salt may be used in the manufacture of DNA, RNA, and phosphoramidites. This compound also has anticancer effects by inhibiting the proliferation of tumor cells and inducing apoptosis.
Formule :C20H25N10O12P·H3NDegré de pureté :Min. 95%Masse moléculaire :645.48 g/molN2-Benzoylguanosine
CAS :N2-Benzoylguanosine is a nucleotide derivative that is formed by the acetylation of guanosine. It has been shown to act as a buffer in alkaline solutions and isomerizes to its n-oxide form when heated. N2-Benzoylguanosine reacts with peroxides such as hydrogen peroxide, glyoxal, and organic peroxides, forming hydroperoxide intermediates that can be converted into other products. The acidic hydrolysis of N2-benzoylguanosine yields the corresponding 6-benzoyladenosines. It has been shown to enhance the activity of uridine in inhibiting bacterial growth, while also acting as an inhibitor of viral RNA synthesis. This compound also reacts with nitrous acid to form an n6-benzoyladenosine derivative that inhibits the formation of RNA chains during transcription.
Formule :C17H17N5O6Degré de pureté :Min. 95%Couleur et forme :White to beige solid.Masse moléculaire :387.35 g/molDMTr-TNA-C(Bz)-amidite
CAS :Please enquire for more information about DMTr-TNA-C(Bz)-amidite including the price, delivery time and more detailed product information at the technical inquiry form on this page
Formule :C45H50N5O8PMasse moléculaire :819.9 g/mol5-Methyl-L-uridine
CAS :5-Methyl-L-uridine is an antiviral drug which belongs to a class of compounds called nucleoside analogues. It is used in the treatment of chronic hepatitis B and C, as well as for prevention of hepatitis A and B. 5-Methyl-L-uridine inhibits the virus by turning off the production of viral DNA and RNA, through interactions with the virus's polymerase chain reaction process. This drug also prevents protein synthesis in cells infected with viruses such as HIV, herpes simplex virus type 1, and influenza A virus. 5-Methyl-L-uridine is a prodrug that is converted to its active form, uridine monophosphate, by enzymes in the liver. The cytotoxic effects of 5-methyluridine on cancer cells have been shown to be due to inhibition of cellular DNA synthesis and repair pathways.
Formule :C10H14N2O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :258.23 g/molRef: 3D-NM06240
Produit arrêtéN6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine 5'-CE phosphoramidite
CAS :A 5'-3’ “reverse” (or “inverse”) amidites
Formule :C47H52N7O7PDegré de pureté :Min. 95%Masse moléculaire :857.93 g/mol5'-O-Tosylthymidine
CAS :5'-O-Tosylthymidine is a bifunctional reagent that is used in the synthesis of DNA. It is a nucleophilic, inorganic compound that reacts with the electrophilic acrylonitrile group on 5'-hydroxythymidine to form a stable thiophosphate linkage. The reaction takes place stepwise and is catalyzed by an enzyme called DNA polymerase. This product has been used as an antimetabolite in medicine, mainly for treating leukemia.
Formule :C17H20N2O7SDegré de pureté :Min. 95%Masse moléculaire :396.42 g/mol2'-Deoxy-a-adenosine
CAS :2'-Deoxy-a-adenosine is a nucleoside that contains an adenine base. It has been studied for its biological properties, including its reaction with solution and its use as an antimicrobial agent. 2'-Deoxy-a-adenosine has been shown to inhibit the growth of bowel disease in mice by binding to the adenosine A3 receptor on the surface of cells. This nucleoside also binds to nuclear DNA and may be used as a pharmacological agent, but more research is needed to determine whether it would be effective against cancer cells. 2'-Deoxy-a-adenosine may also be useful as a potential drug target for the treatment of cancer due to its ability to bind with dna duplexes, which are found in all cancer cells.
Formule :C10H13N5O3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :251.25 g/mol5’-O-DMT-2’-O,4’-C-methylene-5-methyluridine
CAS :5’-O-DMT-2’-O,4’-C-methylene-5-methyluridine is a nucleoside that is used as an antiviral and anticancer agent. It is a novel compound that has not been previously described in the literature. 5’-O-DMT-2’-O,4’-C methylene 5 methyluridine has been shown to inhibit the replication of the herpes virus in vitro (in cell culture) and in vivo (in animals). This compound also inhibits the proliferation of cancer cells by inhibiting DNA synthesis. It may be used as an anticancer agent or an antiviral agent.
Degré de pureté :Min. 95%2',3'-O-Isopropylideneinosine
CAS :2',3'-O-Isopropylideneinosineis a nucleoside for use in research applications
Formule :C13H16N4O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :308.3 g/molRef: 3D-NI03500
Produit arrêtéAdenosine 5'-monophosphate sodium
CAS :Adenosine 5'-monophosphate sodium is a nucleotide that is involved in the energy metabolism of cells. It has been shown to inhibit oxidative injury and to activate signal pathways in response to external stimuli, such as glucose deprivation. Adenosine 5'-monophosphate sodium can be synthesized from ATP by the enzyme adenosine kinase.
Formule :C10H13N5O7P·NaDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :369.2 g/mol2'-Deoxy-4'-ethynyl-2-fluoroadenosine
CAS :2'-Deoxy-4'-ethynyl-2-fluoroadenosine (EFdA) is an analog of adenosine. EFdA is a potent inhibitor of HIV replication, and has been shown to be effective against other viruses such as influenza virus, herpes simplex virus, and vesicular stomatitis virus. EFdA was the first nucleoside analog to show antiviral activity in tissue culture against these viruses. This drug also inhibits the synthesis of mitochondrial rRNA and reduces the formation of mitochondrial DNA in human cells by inhibiting mitochondrial DNA polymerase γ. EFdA also prevents the binding of monoclonal antibodies to human B lymphocytes, which may be due to its steric interactions with plasma RNA. This drug is metabolized by cytochrome P450 2C8 and 2C9 into a variety of metabolites that are excreted in urine as glucuronides or sulfates. EFdA has a long
Formule :C12H12FN5O3Degré de pureté :Min. 95%Masse moléculaire :293.25 g/mol3′-Guanylic acid disodium
CAS :3′-Guanylic acid disodium is a nucleoside analog that inhibits viral replication and tumor growth. It is an antiviral agent that is active against herpes simplex virus type 1 and type 2, as well as cytomegalovirus. 3′-Guanylic acid disodium is also an anticancer agent that has shown promising results in animal models of glioma, lymphoma, lung cancer, and breast cancer. The molecule inhibits the synthesis of DNA by competitively inhibiting the action of ribonucleotide reductase. 3′-Guanylic acid disodium also inhibits protein synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. This drug has been shown to have a high purity and quality with no detectable impurities or contaminants.
Formule :C10H14N5O8P•Na2Degré de pureté :Min. 95%Masse moléculaire :409.2 g/mol2',3',5'-Tri-O-acetylinosine
CAS :2′,3′,5′-Tri-O-acetylinosine is a protected form of the nucleoside inosine, with potential for use in the preparation of modified nucleotides and nucleoside analogs.
Formule :C16H18N4O8Degré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :394.34 g/molSpacer-c3 cep
CAS :Spacer-C3 Cep is a novel modified nucleoside phosphoramidite. It has been chemically modified with a spacer arm and 3-Cep (1,2-diaminoethane). Spacer-C3 Cep is an activator for DNA polymerases, which are enzymes that synthesize DNA from deoxyribonucleosides. The modified nucleoside phosphoramidite has antiviral and anticancer activities. It can be used in the synthesis of oligodeoxyribonucleotides for gene therapy or as a monophosphate for the preparation of DNA probes. Spacer-C3 Cep can also be used to synthesize ribonucleotide analogs that inhibit viral replication by inhibiting RNA synthesis.
Formule :C33H43N2O5PDegré de pureté :Min. 95%Masse moléculaire :578.7 g/mol5′-O-DMT-LNA N-Bz adenosine
CAS :5′-O-DMT-LNA N-Bz adenosine is a novel nucleoside that has been modified with an aminooxy group. The compound is synthesized by the phosphoramidite method and it is designed for use in antiviral and anticancer research. 5′-O-DMT-LNA N-Bz adenosine can be used as a substrate for DNA polymerases and other enzymes to produce nucleic acid strands. This product is CAS No. 206055-74-5, monophosphate, Phosphoramidites, Synthetic, Deoxyribonucleosides, Anticancer, Ribonuclesides, High purity.
Formule :C39H35N5O7Degré de pureté :Min. 95%Masse moléculaire :685.73 g/mol2'-O-Methyluridine-5'-monophosphate triethylammonium
CAS :2'-O-Methyluridine-5'-monophosphate triethylammonium salt is a modified nucleoside analogue that is an antiviral agent. It inhibits viral replication by acting as an inhibitor of RNA synthesis and DNA polymerase, which are necessary for the virus to replicate. This compound also has anticancer activity and can be used as a chemotherapeutic agent. 2'-O-Methyluridine-5'-monophosphate triethylammonium salt is synthesized from uracil, phosphoramidite, and triethylamine. It has high purity and high quality with a CAS number of 67624-43-5.
Formule :C10H15N2O9P•(C6H15N)2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :439.21 g/mol2-Chloroadenosine 5'-monophosphate triethylamine salt
CAS :2-Chloroadenosine 5'-monophosphate triethylamine salt is a phosphoramidite that has anticancer and antiviral activities. It is synthesized by reacting 2-chloroadenosine with triethylamine. This product has a novel chemical structure and it can be used as an activator for the synthesis of modified DNA, RNA, and other nucleosides. It is also used in the manufacture of deoxyribonucleosides, ribonucleosides, and other nucleotides.
Formule :C10H13ClN5O7P·C12H30N2Degré de pureté :Min. 95%Masse moléculaire :584.05 g/mol2'-O-(2-Methoxyethyl)guanosine 5'-monophosphate
CAS :10umol is approx 5mg.2'-O-(2-Methoxyethyl)guanosine 5'-monophosphate is a novel nucleoside phosphorylated on the 5' position
Degré de pureté :Min. 95%dNaM
CAS :dNaM is a metabolite of DNA that has been shown to be a potential biomarker for metabolic disorders and autoimmune diseases. dNaM levels are elevated in the blood of pregnant women, which may serve as a marker for preeclampsia. Elevated levels have also been observed in patients with type 2 diabetes, obesity, and cancer. Methylation plays an important role in dNaM metabolism. The enzyme DNA methyltransferase (DNMT) catalyzes the transfer of methyl groups from S-adenosyl methionine to cytosine residues on the DNA molecule. DNMT activity is increased by high body mass index (BMI), low vitamin B12 levels, and HIV infection. This enzyme is also inhibited by valproic acid and deprenyl, which may affect dNaM methylation status.
Formule :C16H18O4Degré de pureté :Min. 95%Masse moléculaire :274.31 g/molRef: 3D-SUB89319
Produit arrêté2',3'-Dideoxy-3',5-difluorocytidine
CAS :2',3'-Dideoxy-3',5-difluorocytidine (ddF) is a nucleotide analogue that inhibits the viral polymerase. It binds to the enzyme and prevents it from synthesizing DNA, which is needed for viral replication. ddF has been shown to be effective against different types of cancer cells, including breast and prostate cancers. This drug also has antiviral properties and is used as an antiviral agent in AIDS therapy. ddF may also be used as a precursor in the synthesis of other nucleosides or nucleotides.
Degré de pureté :Min. 95%Archaeosine
CAS :Archaeosine is a low energy chemical compound that inhibits the enzyme transcriptase polymerase chain reaction (PCR), which is an enzyme that catalyzes the synthesis of DNA from RNA. Archaeosine has significant interactions with human proteins, such as leukocyte antigen, and can be used to study protein-protein interactions and enzyme kinetics. The asymmetric synthesis of archaeosine has been studied in rat liver microsomes, which is a type of cell found in the tissues of the liver. Archaeosine also prevents bacterial enzymes from synthesizing DNA.
Formule :C12H16N6O5Degré de pureté :Min. 95%Masse moléculaire :324.29 g/mol
