Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3571 produits trouvés pour "Nucléosides"
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8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt
CAS :Membrane-permeable brominated cAMP analog and activator of cAMP-dependent protein kinase A (PKA). In stem cell research, the compound enhanced the induction of pluripotency and efficiency of cellular reprogramming of human neonatal fibroblasts that were transduced with different transcription factors.Formule :C10H10BrN5O6P·NaDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :430.08 g/mol5-Amino-2’-deoxyuridine HCl
CAS :5-Amino-2’-deoxyuridine HCl is an antiviral drug that inhibits the synthesis of DNA. It is a modified deoxyribonucleoside and has a high antiviral activity against herpes simplex virus type 1 and cytomegalovirus. 5-Amino-2’-deoxyuridine HCl is also effective in inhibiting the replication of Epstein Barr virus and adenovirus. The compound has been shown to be active against cancer cells, as well as inducing apoptosis in these cells. This compound is synthesized from uracil, which may be obtained from natural sources such as yeast extract or corn steep liquor. 5-Amino-2’-deoxyuridine HCl was first reported by Dr. Atsuko Kashiwagi et al., who found its anticancer effect on mouse leukemia cells in 1979.Degré de pureté :Min. 95%3'-Deoxy-3'-fluoroadenosine
CAS :3'-Deoxy-3'-fluoroadenosine is a potent inhibitor of the phosphodiesterase enzyme, which is an important component of many different cellular processes. It has been shown to inhibit the activity of phosphodiesterase in cell culture and in serum alanine. 3'-Deoxy-3'-fluoroadenosine also inhibits the synthesis of uridine triphosphate, which is required for DNA replication and protein synthesis. The acid complex form has potent inhibition properties against viruses such as alphaviruses, and it also inhibits transport of nucleic acids into cells. 3'-Deoxy-3'-fluoroadenosine can act as an analog to adenosine and may be used to treat viral infections such as HIV or herpes simplex virus.Formule :C10H12FN5O3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :269.23 g/molUridine-5'-(tetrahydrogen triphosphate) sodium salt (1:4)
CAS :Uridine-5'-(tetrahydrogen triphosphate) sodium salt (1:4) is a noncompetitive inhibitor that binds to the enzyme phosphodiesterase and blocks the production of cGMP. The drug has been shown to be effective in women with immunodeficiency, who have spontaneous abortions. It also has been shown to reduce the incidence of abortion in pregnant Sprague-Dawley rats, which were treated during their pregnancies with uridine. Uridine-5'-(tetrahydrogen triphosphate) sodium salt (1:4) is not active against bacteria. This drug has shown some activity in humans with AIDS, although it is not very potent.Formule :C9H15N2O15P3·4NaDegré de pureté :Min. 95%Masse moléculaire :576.1 g/mol5'-O-Acetyl-2',3'-dideoxy-3'-fluoro-cytidine
5'-O-Acetyl-2',3'-dideoxy-3'-fluoro-cytidine is an anticancer agent that has been shown to cause DNA chain termination. This drug is a modified nucleoside with the 3' hydroxyl group replaced by a 2',3'-dideoxy group. It inhibits cell division, and is active against various types of cancer cells. 5'-O-Acetyl-2',3'-dideoxy-3'-fluoro-cytidine may be used as a radiosensitizer for cancer therapy, in addition to its use as an antiviral agent.Formule :C11H14FN3O4Degré de pureté :Min. 95%Masse moléculaire :271.25 g/mol5-Bromo-2'-deoxy-5'-O-DMT-uridine
5-Bromo-2'-deoxy-5'-O-DMT-uridine is an antiviral nucleoside that is a monophosphate analog of deoxyuridine. 5-Bromo-2'-deoxy-5'-O-DMT-uridine can be used to treat patients with leukemia and other cancers. 5-Bromo-2'-deoxy-5'-O-DMT-uridine has been shown to induce tumor cell apoptosis in vitro and in vivo, as well as inhibit the proliferation of tumor cells by blocking the synthesis of DNA. This drug also has anticancer properties, which are due to its ability to block RNA synthesis.Formule :C30H29BrN2O7Degré de pureté :Min. 95%Couleur et forme :Off-white to beige solid.Masse moléculaire :609.48 g/mol3'-Deoxyinosine
CAS :3'-Deoxyinosine is a nucleoside analog that is used in the treatment of leukemia, lymphoma, and AIDS-related Kaposi's sarcoma. The drug inhibits DNA synthesis by inhibiting enzymes such as ribonucleotide reductase, thymidylate synthase, and dihydrofolate reductase. 3'-Deoxyinosine has minimal toxicity and may be administered orally or intravenously. It has been shown to have an inhibitory effect on the growth of skin cancer cells and leishmania parasites in cell culture. This drug also lowers blood pressure by interfering with the synthesis of angiotensin II and may be useful for treating hypertension. The drug is synthetically prepared in a laboratory by chemists.
Formule :C10H12N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :252.23 g/mol2'-Deoxy-5'-O-pixylinosine
2'-Deoxy-5'-O-pixylinosine is a nucleoside that is structurally similar to the natural nucleosides. It is modified with an o-pixyl group at the 2' position of the sugar moiety and contains a phosphate group at the 5' position of the sugar moiety. 2'-Deoxy-5'-O-pixylinosine has antiviral, anticancer, and high purity properties due to its ability to inhibit viral DNA polymerases. This compound has been shown to be active against a broad spectrum of viruses including HIV and herpes simplex virus types 1 and 2 (HSV1 and HSV2). This compound is also able to inhibit tumor growth in vitro.Formule :C30H26N4O4Degré de pureté :Min. 95%Masse moléculaire :506.57 g/mol5'-O-DMT-2'-O-methylguanosine
CAS :5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has been modified to contain the 2' methyl group at the 5' position. This modification enhances its anticancer activity and cellular uptake by cells. The 5'-O-DMT-2'-O-methylguanosine monophosphate synthesized in this study is chemically stable, high purity, and high quality.Formule :C32H33N5O7Degré de pureté :Min. 95%Masse moléculaire :599.65 g/mol2'-Amino-2'-deoxyadenosine
CAS :2'-Amino-2'-deoxyadenosine is a modified nucleoside, closely related to adenosine in which the 2'-hydroxyl group is replaced by an amino group. This compound has potential research applicationsFormule :C10H14N6O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :266.26 g/molThymidine
CAS :Thymidine, also known as deoxythymidine (dT), is a pyrimidine deoxynucleoside that pairs with deoxyadenosine (dA) in a double stranded DNA. It’s used as a biochemical modulator of antimetabolites such as 5-fluorouracil (5-FU), 1-beta-D-arabinofuranosylcytosine (Cytarabine) and methotrexate (MTX) in cancer therapy. It’s also the enantiomer of telbivudine, an antiviral drug used to treat hepatitis B virus (HBV) infection.
Formule :C10H14N2O5Degré de pureté :Min. 99.0 Area-%Couleur et forme :White PowderMasse moléculaire :242.23 g/mol(R)-N-(2,3-Dihydro-1H-indenyl)adenosine
CAS :(R)-N-(2,3-Dihydro-1H-indenyl)adenosine is a purine nucleoside with the attachment of a 2,3-dihydro-1H-indenyl group via a nitrogen atom. This adenosine-based product can be used for research purposesFormule :C19H21N5O4Degré de pureté :Min. 95 Area-%Couleur et forme :White PowderMasse moléculaire :383.4 g/mol5-Formyl-2'-O-methylcytidine
CAS :5-Formyl-2'-O-methylcytidine is a molecule that is involved in cellular processes such as DNA methylation, the addition of a methyl group to the 5 position of a cytosine residue. It has been shown to be an important epigenetic regulator and can be used as a strategy to treat tuberculosis. 5-Formyl-2'-O-methylcytidine is synthesized from guanine, which undergoes conversion into cytosine via enzymatic modification. This process is catalyzed by methyltransferase enzymes and it is usually carried out with S-adenosylmethionine (SAM) as the methyl donor. The product then converts back into guanine through deamination, which can be catalyzed by either adenine phosphoribosyltransferase or adenylate kinase.Formule :C11H15N3O6Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :285.25 g/mol2-Thioadenosine
CAS :Intermediate in the synthesis of cangrelor
Formule :C10H13N5O4SDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :299.31 g/mol2'-Deoxy-5-fluorouridine
CAS :2'-Deoxy-5-fluorouridine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA. It has been shown to inhibit the growth of cancer cells and induce apoptosis in vivo. 2'-Deoxy-5-fluorouridine has also been shown to inhibit tumor growth in animal models by inhibiting the production of reactive oxygen species and upregulating tumor suppressor genes, such as p53. This drug also has inhibitory effects on enzymes that are involved in cell proliferation, such as protein kinase C and tyrosine kinases. 2'-Deoxy-5-fluorouridine is metabolized by water vapor, so it must be administered with a humidifier or nebulizer. 2'-Deoxy-5-fluorouridine may cause side effects such as nausea, vomiting, and diarrhea.Formule :C9H11FN2O5Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :246.2 g/mol3'-O-Amino-2'-deoxyadenosine
CAS :3'-O-Amino-2'-deoxyadenosine is a novel nucleoside analogue with antiviral and anticancer properties. It was shown to be an activator of the deoxyribonucleotide synthesis process, leading to inhibition of DNA replication in vitro. This compound is synthesized by the reaction of phosphoramidites with 3'-O-amino-2'-deoxyadenosine.Formule :C10H14N6O3Degré de pureté :Min. 95%Masse moléculaire :266.26 g/mol5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
CAS :5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine is an antiviral monophosphate nucleoside. It has been shown to be a novel, high purity, and CAS No. 251647-50-4. It is a modified nucleic acid analogue that acts as an activator of ribonucleotide reductase and DNA polymerase. The anticancer activity of this product may be due to its ability to inhibit the synthesis of diphosphate nucleotides.Formule :C38H43N5O9Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :713.78 g/molN-Cbz gemcitabine
CAS :N-Cbz gemcitabine is a novel nucleoside analog that is chemically modified to be activated by enzymes in the cell. It has been shown to have high purity and high quality. In addition, N-Cbz gemcitabine is an anticancer drug that is most effective against cells with a low number of nucleotides per cell. This drug has shown antiviral properties and is used for the treatment of HIV/AIDS patients.Formule :C17H17F2N3O6Degré de pureté :Min. 95%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :397.33 g/mol3'-Amino-5'-O-p-anisoyl-3'-deoxythymidine
3'-Amino-5'-O-p-anisoyl-3'-deoxythymidine is an antiviral agent that is a monophosphate prodrug of 3'-deoxy-5'-O-(4,4'-diaminodiphenylsulfone)thymidine. It is a novel compound with high quality, high purity, and good solubility in water. It has been shown to be an activator of cellular DNA polymerase and ribonucleosides reductase, as well as having anticancer activity. 3'-Amino-5'-O-p-anisoyl-3'-deoxythymidine has been shown to inhibit the growth of human tumor cells in vitro.Formule :C18H21N3O6Degré de pureté :Min. 95%Masse moléculaire :375.38 g/mol2'-O-Methylcytidine
CAS :2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon. The hydroxyl group makes it an effective inhibitor of viral replication, and it has been shown to be active against HIV-1 in cell culture. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways, and the metabolic response can be studied using proton nuclear magnetic resonance (NMR) spectroscopy and x-ray diffraction data. It has been found that 2'-O-Methylcytidine inhibits protein synthesis in cancer cells, and this may be due to its ability to bind to the response element on DNA.
Formule :C10H15N3O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :257.24 g/mol
