Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3569 produits trouvés pour "Nucléosides"
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Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution
Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is a modified nucleoside with antiviral activity. It is a phosphoramidite that can be used for the synthesis of DNA, RNA and other nucleic acids. Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is an active ingredient in many research laboratories.Formule :C22H35N6O15P3SDegré de pureté :Min. 95%Masse moléculaire :748.53 g/mol1,N6-Ethenoadenosine-5'-diphosphate, Sodium salt
CAS :Emission max - 415nmMolar extinction coefficient ε [L·mol⁻¹·cm⁻¹] - 6000Fluorescent analogue of 5'-ADP, NA10698Formule :C12H15N5O10P2Degré de pureté :Min. 95%Masse moléculaire :451.22 g/mol8-Amino-2'-deoxy-N6,N8-di-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite
CAS :8-Amino-2'-deoxy-N6,N8-di-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite is a novel nucleoside analog with antiviral and anticancer properties. It is synthesized by reacting 8-aminoimidazo[2,1-b]thiazole 1,3(2H)-dione (AITD) with N6,N8-diisopropyl dATP to form the aminothiazole phosphate intermediate. This intermediate is then reacted with 5'-O-(4,4'-dimethoxytrityl)-2',3',5' triphosphate (DMTrP) to produce the desired product. The synthesis of 8AAODMTAP has been shown to be more efficient than other synthesized nucleosides due to its high purity and lack of impurities.Formule :C46H59N10O6PDegré de pureté :Min. 95%Masse moléculaire :879 g/mol2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate)
CAS :2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) (2,3'-ddGTP) is a nucleoside that is synthesized using phosphoramidite chemistry. It has antiviral and anticancer activity, as well as the ability to activate cellular transcription. 2,3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) can be used in the synthesis of modified nucleosides or in the synthesis of novel nucleosides. The compound was found to inhibit DNA replication by binding to the enzyme ribonucleotide reductase. 2,3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) can also be used for DNA sequencing and as a cytotoxic agent in cancer chemotherapy.Formule :C10H16N5O11P3SDegré de pureté :Min. 95%Masse moléculaire :507.25 g/mol5,6-Diaminouracil
CAS :5,6-Diaminouracil is a nitrogen-containing heterocyclic compound that inhibits bacterial enzymes. 5,6-Diaminouracil is used as a pharmaceutical preparation for the treatment of cancer, and has been shown to be effective against various cancers, including colon cancer and breast cancer. 5,6-Diaminouracil can inhibit the growth of cells by binding to DNA and inhibiting DNA synthesis. This drug also has potent antitumor activity. 5,6-Diaminouracil has been used in analytical chemistry as an analytical method for determining the purity of products such as pharmaceuticals or dyes. The potency of this drug was determined electrochemically using cyclic voltammetry and it was found to have a constant inhibitory effect on tumor cell growth at low concentrations.Formule :C4H7ClN4O2Degré de pureté :Min. 95%Masse moléculaire :178.58 g/mol8-Bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine
CAS :8-Bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine is a phosphoramidite that is used in the preparation of antiviral nucleosides and monophosphate. It has been shown to have anticancer activity. 8-Bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine is synthesized by reacting an acid halide with a 2'-deoxyribonucleotide. This reaction produces a 2'-bromo adenosine derivative, which is then reacted with dimethylamine to produce the desired product. The synthesis of 8-bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine can be performed on a large scale using an automated process.Formule :C13H17BrN6O3Degré de pureté :Min. 95%Masse moléculaire :385.22 g/mol1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole
CAS :1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole is a nitrofuranose analog that is used in the synthesis of nucleic acids. It has been shown to be effective as a template for DNA sequencing and as a probe for magnetic resonance spectroscopy. 1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole inhibits the polymerase chain reaction by binding to the primer and causing misincorporation at mismatched sites, leading to reduced amplification of the target sequence. This compound also has antiviral properties and can prevent the replication of HIV and other viruses by destabilizing their dna duplexes.Formule :C9H12N2O5Degré de pureté :Min. 95%Masse moléculaire :228.2 g/molN-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate
CAS :N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate is a synthetase that is involved in the biosynthesis of purines and pyrimidines. It catalyzes the ATP-dependent formation of N-succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate from succinyl CoA and aspartic acid. This enzyme has been studied in wild type strains of bacteria, such as Escherichia coli, but not in humans or other organisms. N-Succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate has been shown to be an inhibitor of antimicrobial agents such as penicillin G, erythromycin, and tetracycline. The mechanism for this inhibition is unclear, but it may involve hydrogen bonding interactions or structural changes that prevent bindingFormule :C13H19N4O12PDegré de pureté :Min. 95 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :454.28 g/molO6-Phenyl-2'-deoxyinosine
CAS :O6-Phenyl-2'-deoxyinosine is a high purity, modified nucleoside that is a novel anticancer agent. It is used as a phosphoramidite in the synthesis of DNA and RNA. It has been shown to have cytotoxic effects against tumor cells and enhances the efficacy of chemotherapy. O6-Phenyl-2'-deoxyinosine has also been shown to be an activator of transcription factors, including NF-κB, AP-1, and STAT3.Formule :C16H16N4O4Degré de pureté :Min. 95%Masse moléculaire :328.32 g/mol2'-Deoxy-5-(trifluoromethyl)cytidine
CAS :2'-Deoxy-5-(trifluoromethyl)cytidine is a synthetic nucleoside analogue that inhibits the cytidine deaminase enzyme. It is used in the treatment of some types of leukemia and other cancers. The compound, which has a trifluoromethyl group on the 2' position, binds to the active site of cytidine deaminase and prevents it from functioning. This leads to an accumulation of thymidylate, which is required for DNA synthesis. The tumor tissue also contains high concentrations of this drug and its metabolites, making it more effective against cancer cells than normal cells. 2'-Deoxy-5-(trifluoromethyl)cytidine has been shown to inhibit anabolism in tumor tissue in the presence of high concentrations of phosphorylases, which are enzymes that catalyze reactions that break down carbohydrates and proteins into smaller molecules such as glucose or amino acids.Formule :C10H12F3N3O4Degré de pureté :Min. 95%Masse moléculaire :295.22 g/molN6-Benzoyl-2',3'-dideoxyadenosine
CAS :N6-Benzoyl-2',3'-dideoxyadenosine is a nucleoside analog that inhibits the growth of Mycobacterium tuberculosis by preventing DNA replication. It is also a potent inhibitor of DNA synthesis, and binds to the beta-subunit of bacterial RNA polymerase, leading to inhibition of transcription. N6-Benzoyl-2',3'-dideoxyadenosine has shown in vitro activity against Mycobacterium tuberculosis and other bacteria that have been found to be resistant to conventional antibiotics.Formule :C17H17N5O3Degré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :339.36 g/mol2'-Deoxy-5-fluoroadenosine
2'-Deoxy-5-fluoroadenosine is a nucleoside that is used in the synthesis of DNA and RNA. It has antiviral activity and can be used as an anticancer agent. This nucleoside is synthesized by reacting 2'-deoxyadenosine with 5-fluorouracil in a high-quality, high purity environment under stringent conditions. 2'-Deoxy-5-fluoroadenosine has also been shown to have antiretroviral activity against HIV and hepatitis B virus.
Degré de pureté :Min. 95%Chemical phosphorylating reagent (cpr)
CAS :Chemical phosphorylating reagent (CPR) is a powerful tool for the study of kinases, which are enzymes that regulate cellular processes such as cell division and apoptosis. CPR has been shown to be effective in inhibiting the activity of certain kinases that are involved in tumor growth and progression. It has also been used as an anticancer agent, inducing apoptosis in cancer cells. CPR is an analog of toxaphene and labetalol, two compounds with known kinase inhibitor activity. This reagent has been tested on human urine samples and Chinese hamster ovary cells, demonstrating its potential as a valuable research tool for studying kinase signaling pathways and developing new cancer therapies.Formule :C5H10O5Degré de pureté :Min. 95%Masse moléculaire :150.13 g/mol5'-o-(Dimethoxytrityl)-5-methyl-2'-o-methyluridine
CAS :5'-O-(Dimethoxytrityl)-5-methyl-2'-O-methyluridine is a DNA building block that is used as a monophosphate and can be converted to diphosphate or modified with various protecting groups. This compound has been shown to have antiviral and anticancer properties, as well as being a novel nucleoside analog. 5'-O-(Dimethoxytrityl)-5-methyl-2'-O-methyluridine has the CAS number of 115173-73-4.Formule :C32H34N2O8Degré de pureté :Min. 95%Masse moléculaire :574.6 g/mol2',3'-Didehydro-2',3'-dideoxyuridine
CAS :2',3'-Didehydro-2',3'-dideoxyuridine (DDDU) is a nucleoside analog that inhibits the formation of HIV. It is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication in cell culture, and has been shown to inhibit the production of HIV-1 virions in vitro. 2',3'-Didehydro-2',3'-dideoxyuridine has been shown to bind to the enzyme glycosyltransferase, which is required for HIV-1 replication. DDU also binds to human CD4+ T cells, deflecting them from the HIV-infected target cell. This compound may be useful as an antiviral agent against HIV-1 infection by inhibiting viral replication and infectivity.
Formule :C9H10N2O4Degré de pureté :Min. 95%Masse moléculaire :210.19 g/molAdenosine 5'-(tetrahydrogen triphosphate)
CAS :Adenosine is a nucleoside consisting of adenine and ribose. It is used in biochemical analysis to quantify the cytosolic Ca2+ concentration, which is an important cellular signal that regulates many cellular processes. Adenosine stimulates the uptake of Ca2+ by binding to the monophosphate-activated protein (AMPAR), which results in the opening of voltage-gated calcium channels. These channels allow Ca2+ to enter the cell, increasing its intracellular concentration. Adenosine also has been shown to stimulate muscle contraction through increased release of Ca2+. This drug also possesses inhibitory effects on synaptic transmission and may have anti-inflammatory properties due to its ability to inhibit proteolytic enzymes in muscle cells.Formule :C10H14MgN5O13P3Degré de pureté :Min. 95%Masse moléculaire :529.47 g/molGuanosine-5'-carboxylic acid
CAS :Guanosine-5'-carboxylic acid (GCA) is a nucleotide that interacts with mammalian cells. It reacts in a vessel to form the antigen, which can then be detected using an antibody. The conformational properties of this molecule are important for its function, and it has been shown to be effective against cancer cells in vivo. GCA has also been shown to interact with toll-like receptor 2 and induce an antibody response.Formule :C10H11N5O6Degré de pureté :Min. 95%Masse moléculaire :297.22 g/molN2-DMF-9-(2'-deoxy-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite
CAS :N2-DMF-9-(2'-deoxy-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite is a novel, modified nucleoside analog with antiviral and anticancer properties. It is synthesized by the reaction of 2′,5′-O-(4,4′-dimethoxytrityl)-9-(2′deoxy-5′-O-DMT b D ribofuranosyl)purine 3′ with a phosphoramidite reagent in DMF at elevated temperature. The compound has been shown to inhibit viral replication in vitro and in vivo. In addition to its antiviral activity, N2DMFP3'-CE also inhibits tumor cell growth.Formule :C43H53N8O6PDegré de pureté :Min. 95%Couleur et forme :Off white solid.Masse moléculaire :808.93 g/mol2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate
2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate is a synthetic nucleotide that has antiviral properties. It activates the transcription of genes by preventing the synthesis of viral DNA and RNA. 2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate is also an anticancer agent, as it prevents cell proliferation by inhibiting the synthesis of DNA, RNA, and protein. This drug can be used for treatment of HIV infection or cancer. 2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate is a novel nucleotide with high purity.
Degré de pureté :Min. 95%3'-Deoxy-3'-fluorocytidine
CAS :3'-Deoxy-3'-fluorocytidine is an activating agent that has been shown to inhibit coxsackie virus and other single-stranded RNA viruses. It is a nucleoside analogue that binds to the enzyme ribofuranoside, preventing the formation of the active site. 3'-Deoxy-3'-fluorocytidine has also been shown to inhibit the biochemical reactions involving S-adenosylhomocysteine hydrolase, which catalyzes the conversion of S-adenosylhomocysteine into adenosine, a precursor for DNA synthesis. Mechanistic studies have indicated that 3'-deoxy-3'-fluorocytidine inhibits enzymatic activity through stereochemical interactions with S-adenosylhomocysteine hydrolase.
Formule :C9H12FN3O4Degré de pureté :Min. 95%Masse moléculaire :245.21 g/mol
