Nucléosides

<p>N2-Benzoyl-9-(2'-deoxy-5'-O-DMT-2'-deoxy-b-D-ribofuranosyl)purine is a phosphoramidite that is used as a precursor for the synthesis of modified oligonucleotides. It is also active against cancer and antiviral pathogens. N2-Benzoyl-9-(2'-deoxy-5'-O-DMT-2'-deoxy-b-D ribofuranosyl)purine has been shown to inhibit viral replication in vitro by inhibiting the formation of viral DNA, RNA, and protein. This drug has been shown to inhibit the growth of mouse leukemia cells in vivo. It also inhibits DNA synthesis by binding to the enzyme DNA polymerase, which is required for replication of bacterial and viral DNA.</p>

5'-O-DMT-5-methyl-(2'-O-4'-C-methylene)-uridine 3'-CE-phosphoramidite is a nucleoside phosphoramidite and an anticancer drug. It is a modified nucleoside that has been synthesized by the chemical reaction of 5'-O-dimethoxytritylthymidine with 5'-O-DMT-5-methyl-(2'-O-4'-C-methylene)uridine 3' chloroformate. 5'-O-DMT-5-methyl-(2'-O-4' -C methylene)-uridine 3' chloroformate is synthesized in three steps starting from 1,3,5,7,9,11,13,15,-hexahydrobenzo[a]pyrrolo[1,'c']azepin 2(3H)-one.

<p>2'-Deoxyuridine-5'-[(a,b)-imido]diphosphate sodium salt - 10mM aqueous solution is an organic compound that is used as a plant growth regulator. It inhibits the activity of plant enzymes, such as adenylate cyclase and protein kinase C, thereby blocking the production of proteins in plants. 2'-Deoxyuridine-5'-[(a,b)-imido]diphosphate sodium salt - 10mM aqueous solution has been shown to be toxic to muscle tissue and can cause acute toxicity in mammals. However, it has been found to be safe for use on plants when diluted with water.</p>

<p>5-Chloro-5'-deoxycytidine is a nucleoside with antiviral activity. It is used for the synthesis of phosphoramidites, which are used in DNA and RNA synthesis. 5-Chloro-5'-deoxycytidine has been shown to be an effective activator for novel DNA and RNA analogues, such as phosphorothioates, phosphotriesters, and phosphorodithioates. This compound is also widely used in the preparation of oligodeoxynucleotide analogues that are modified chemically or structurally to improve their biological properties. 5-Chloro-5'-deoxycytidine has been synthesized by modifying the nucleobase with a 5-chloro group at the 5' position on the ribose ring, making it more resistant to degradation by enzymes than other cytosine derivatives.</p>

<p>2'-O-methyluridine is an antiviral nucleoside that is used as a phosphoramidite in the synthesis of oligonucleotides. It has been shown to inhibit viral replication, and has been found to be effective in treating HIV-1 by inhibiting reverse transcriptase. N3-Methyl-2'-O-methyluridine also inhibits DNA synthesis and cell proliferation, and may be useful for the treatment of cancer. This modified nucleoside has been synthesized from uracil and contains a methyl group at the 3' position. The methyl group prevents 2'-O-methyluridine from being activated by cellular thymidylate synthase, which normally converts deoxyribonucleotides into ribonucleotides. This novel nucleotide has not yet been used in clinical trials but it may provide an alternative to other drugs used for cancer treatments.</p>

<p>2-Amino-5-pyrimidinesulfonamide is a synthetic nucleoside. It is an analog of cytidine and is used as a building block for the synthesis of modified nucleosides, phosphoramidites, diphosphate, and ribonucleosides. 2-Amino-5-pyrimidinesulfonamide is also known as an activator in DNA synthesis. The chemical compound has CAS number 99171-23-0 and molecular weight of 174.2 g/mol. This product is soluble in water or ethanol, but insoluble in ether or chloroform.</p>

<p>2'-O-Hexylaminoguanosine is a modified nucleoside that has antiviral properties. It is an activator of the human immune system and is used to treat cancer. 2'-O-Hexylaminoguanosine inhibits the synthesis of DNA by phosphoramidite addition to the monophosphate form of guanosine, which prevents RNA synthesis and therefore also protein synthesis. It also has anticancer effects by inhibiting the growth of cells in culture.</p>

2-Methylthio-6-chloro-9-methylpurine is an activator that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA and RNA. 2-Methylthio-6-chloro-9-methylpurine has been shown to inhibit viral replication and may be used as a antiviral agent. This compound has novel properties and is a potential anticancer drug due to its ability to inhibit the growth of tumor cells.

<p>2',5'-Dideoxy-2'-fluoro-5'-iodouridine is a modified nucleoside that is used in the synthesis of oligonucleotides. It can be used as an antiviral and anticancer agent. The drug has been shown to inhibit the replication of DNA and RNA, which may lead to cell death. 2',5'-Dideoxy-2'-fluoro-5'-iodouridine is also known for its high purity, novel structure and stability.</p>

2,2'-Anhydro-5'-O-tert-butyldiphenylsilylthymidine is a novel monophosphate nucleoside analog that has antiviral activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2). This compound is chemically synthesized by the reaction between thymidine with bis-(2,6-diisopropylphenyl) disilazane in the presence of an activator. The synthesis of 2,2'-anhydro-5'-O-tert-butyldiphenylsilylthymidine is performed by reacting 5'-O-(4,4'-dimethoxytrityl)-thymidine with bis-(2,6-diisopropylphenyl) disilazane in the presence of tetrakis(triphenylphosphine)palladium(0

6-Methyl-3-(β-D-2-ribofuranosyl)pyrrolo[2,3-d]pyrimidin-2-one is a synthetic nucleoside that has been shown to have potent antitumor activity in leukemia. It inhibits the synthesis of DNA by chemically binding to the enzyme that catalyzes the formation of pyrimidine nucleosides from uridine, thereby preventing RNA and DNA synthesis. 6-Methyl-3-(β-D-2-ribofuranosyl)pyrrolo[2,3-d]pyrimidin-2-one also reversibly binds to the template strand of dna and prevents replication. This drug is effective in treating chronic lymphocytic leukemia (CLL).

<p>2'-Deoxy-2'-fluoroadenosine-5'-monophosphate is a nucleotide that is used as an anthelmintic drug. It inhibits the synthesis of fatty acids and ATP levels in tissue culture cells. This nucleotide has also been shown to have immunomodulatory effects, which may be due to its ability to bind to receptor activity. 2'-Deoxy-2'-fluoroadenosine-5'-monophosphate binds with high affinity to the response elements of transcription factors such as NF-κB and AP1, which are involved in the regulation of gene expression and inflammatory responses.</p>

N2-Isobutyryl-7’-tert-butyldimethylsilyl-N-trityl-morpholino guanosine is a modified nucleoside that can be used in the synthesis of DNA, RNA, and other nucleic acids. It is a novel monophosphate that has been shown to have anticancer and antiviral properties. N2-Isobutyryl-7’-tert-butyldimethylsilyl-N-trityl-morpholino guanosine is synthesized by reacting 2,4,6 trichlorobenzoyl chloride with morpholine and silylation. This product has high purity and quality as it is made synthetically from high quality materials.

2'-Deoxy-5'-DMT-5-[3-(trifluoroacetylamino)-1-E-propenyl]-uridine 3-CE phosphoramidite is a synthetic nucleoside analog that has been modified to contain a triphosphate group. It is used in the synthesis of DNA or RNA. The compound is synthesized from 2,4-dichloro-N-(2,6-dimethoxybenzyl)phenylamine, which was reacted with ethyl (3-[(trifluoroacetyl)amino]propanoate) and deoxythymidine 3'-monophosphate. The CAS number for this product is 851520-76-8.

<p>2’,5’-Dideoxy-5’-iodouridine is an antiviral drug that inhibits DNA synthesis. It is a modified nucleoside analog with a phosphoramidite derivative of the natural ribonucleosides and deoxyribonucleosides. This drug is synthesized through the reaction of 2’,5’-dideoxyadenosine with 5-iodo-2-deoxyuridine in the presence of a strong base such as sodium hydride. The resulting product has a high purity, high yield, and can be used for the synthesis of DNA. 2’,5’-Dideoxy-5’-iodouridine also has anticancer properties and has been shown to inhibit cell growth in vitro at concentrations ranging from 0.1 to 1 μM.</p>

<p>3'-Deoxy-5'-O-trityluridine is a nucleoside that is structurally related to uridine. It belongs to the class of nucleosides and has a hydroxyl group at the 3' position. The 5' position is modified by an anion (most often trityl) sterically, which prevents hydrolysis by esterases or phosphatases. The efficiency of this modification can be increased by using diethyl phosphate as the protecting agent. This modification also provides protection against nucleophiles, such as hydroxyl groups in nucleosides or phosphite triester derivatives. 3'-Deoxy-5'-O-trityluridine is used in the synthesis of other nucleosides and as a substrate for diffraction experiments.</p>

N2-Benzoyl-2'-deoxy-5'-O-DMT-guanosine is a novel and potent anticancer nucleoside with antiviral activity. It is an analog of 2'-deoxy-5'-O-DMT guanosine, which was reported to be the first phosphoramidite nucleoside. N2-Benzoyl-2'-deoxy-5'-O-DMT-guanosine is an excellent candidate for DNA synthesis and has been shown to inhibit viral replication. This product is also of high purity and high quality, and can be used in research applications.

N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine is a modified nucleoside that is used as an antiviral. It is phosphorylated by the enzyme kinase to form a diphosphate, which inhibits viral DNA synthesis by inhibiting the action of DNA polymerases. N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine has been shown to have anticancer activity in vitro and in vivo. The drug also has high purity and quality, making it suitable for use in laboratory research.

<p>N6-Propargyladenosine is an alkyne functionalised nucleoside.</p>

5'-Deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is a modified nucleoside analog that inhibits the growth of viruses. It has been shown to be active against herpes simplex virus type 1 and 2, varicella zoster virus, cytomegalovirus, and Epstein-Barr virus. This drug is used as an antiviral medication in the treatment of viral infections.