Nucléosides

<p>5'-O-tert-Butyldimethylsilyl-2,2'-anhydrouridine is a modified nucleoside that has been used as an anticancer agent and antiviral and antifungal agent. It has been shown to inhibit the growth of tumor cells in animal models by inhibiting DNA synthesis and repair. 5'-O-tert-Butyldimethylsilyl-2,2'-anhydrouridine is also able to bind to RNA with high affinity, making it a potential candidate for use as an antiviral agent against HIV. This compound does not occur naturally in cells and can be synthesized from other nucleosides.</p>

<p>N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-tritylcytidine 3-CE phosphoramidite is an antiviral, anticancer, and activator molecule that is a monophosphate. It has been shown to be active against DNA viruses such as herpes simplex virus type 1, hepatitis B virus, and human immunodeficiency virus type 1. N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-tritylcytidine 3-CE phosphoramidite can also be used in the synthesis of deoxyribonucleosides or ribonucleosides. This molecule has novel and modified structures that make it useful in the synthesis of nucleoside analogues with improved pharmacokinetics.</p>

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine is a chemically modified nucleoside that contains a fluorinated sugar moiety and a thymine base, with a dimethoxytrityl (DMT) protecting group on the 5'-hydroxyl of the sugar.

N4-Benzoyl-2'-O-tert-butyldimethylsilylcytidine is a nucleoside that is modified by the attachment of an acetyl group at the 2' position. It is used as a component in the synthesis of oligonucleotides and can also be used in antiviral and anticancer applications. N4-Benzoyl-2'-O-tert-butyldimethylsilylcytidine is synthesized by reacting 4,5′-dihydroxybenzoic acid with 4-(dimethylamino)pyridine and diisopropylethylamine to form an intermediate, which reacts with cytosine to produce the desired product. This process requires high purity, which can be achieved through high quality production methods.

Flucytosine is an antifungal agent that inhibits the synthesis of DNA by preventing the conversion of deoxyuridine monophosphate to uracil monophosphate. It is used as an antiretroviral therapy in combination with other drugs, such as zidovudine and dideoxyinosine, to treat HIV infections. Flucytosine has been shown to have a strong antitumor response in a model system involving mice with sarcoma 180. This drug can cause serious side effects, including drug interactions and resistance mutations in microorganisms. These side effects are often observed in patients undergoing cancer chemotherapy or immunosuppressive therapy.

<p>3’-Deoxy-3’-fluoro-2-thiouridine is a nucleoside analog that has been modified to have antiviral and anticancer activity. It is an activator of the ribonucleotide reductase enzyme, which is involved in DNA synthesis. 3’-Deoxy-3’-fluoro-2-thiouridine has been used successfully as an antiviral agent against HIV and other viruses, and as an anticancer agent against leukemia. The monophosphate form of this drug has been shown to inhibit DNA replication in vitro.</p>

3'-Amino-5'-O-tert-butyldimethylsilyl-3'-deoxy-D3-thymidine is a synthetic nucleoside analogue that inhibits the synthesis of DNA. It is a monophosphate and diphosphate analog of thymidine, which are incorporated into DNA during replication. 3'-Amino-5'-O-tert-butyldimethylsilyl-3'-deoxy-D3-thymidine is an activator of RNA polymerase II and inhibits viral replication by inhibiting the function of reverse transcriptase. This drug has been shown to be effective against HIV in vitro and in vivo, as well as herpes simplex virus type 1. 3'-Amino-5'-O-tert-butyldimethylsilyl-3'-deoxy-D3-thymidine also has antitumor activity as it inhibits the growth of

2'-Deoxy-5'-O-DMT-N2-isobutyrylguanosine 3'-CE phosphoramidite is a nucleoside analogue that has been modified to contain an isobutyryl group. It is an activator of the polymerase enzyme, which helps to synthesize DNA. This product can be used in the synthesis of oligonucleotides for use as therapeutic or diagnostic agents. It has anticancer and antiviral activities, due to its ability to inhibit viral replication. This product also has high purity and quality.

<p>N2-DMF-guanosine is a novel antiviral agent that has been synthesized by modifying the nucleoside guanosine. It is an analog of guanosine in which the 2'-hydroxyl group has been replaced with a 2'-deoxy-2'-fluoro group, and it inhibits viral replication by inhibiting viral DNA polymerase. N2-DMF-guanosine is also used as a high quality deoxyribonucleoside monophosphate for the synthesis of ribonucleosides and nucleosides. This compound has a CAS number of 6074-37-4.</p>

<p>2',3',5'-Tri-O-acetyluridine is a uridine derivative with potential for use in organic synthesis such as the preparation of modified nucleosides, nucleotides, and RNA analogs.</p>

<p>5’-Azido-5’-deoxy-2’-O-methyl-5-methyluridine is a novel nucleoside with the ability to activate ribonucleosides and phosphoramidites. It is a modified nucleoside that has been shown to have anticancer and antiviral properties. 5’-Azido-5’-deoxy-2’-O-methyl-5-methyluridine also inhibits the synthesis of viral RNA and DNA, which may result in its antiinflammatory properties. 5’-Azido-5’deoxy -2′O methyl -5′ methyl uridine has a CAS number of 187733–73–9.</p>

5'-O-DMT-N2-phenoxyacetyl-2'-O-methylguanosine 3'-CE phosphoramidite is a nucleoside analog that inhibits DNA synthesis by forming a covalent bond with the beta-subunit of DNA polymerase. It is a modified nucleoside that has been synthesized from 2'-O-methylguanosine and N2,N2-dimethoxyacetyl. 5'-O-DMT-N2-phenoxyacetyl-2'-O methylguanosine 3'-CE phosphoramidite possesses the CAS No. 16053526.

3’-Deoxy-3’-alpha-C-methyl-N6,N6-dimethyladenosine is a nucleoside with anticancer activity. It is a novel nucleoside that has been shown to have antiviral and antitumor activities. Research has shown that 3’-Deoxy-3’-alpha-C-methyl-N6,N6-dimethyladenosine inhibits tumor growth in animals without toxicity to the normal cells of the body. This nucleoside also has an effect on DNA and RNA synthesis, which may be due to its ability to inhibit viral replication enzymes.

<p>3’,2-anhydro-2'-deoxyuridine is a nucleoside analog that has antiviral and anticancer activities. It is an activator of the ribonucleotide reductase enzyme, which catalyses the conversion of ribonucleotide diphosphates to deoxynucleotides. 3’,2-anhydro-2'-deoxyuridine also inhibits DNA synthesis by cytostatic mechanisms. This product is used as a building block in phosphoramidite synthesis and can be used for the preparation of novel nucleosides and phosphoramidites. This product was originally synthesized for use as an antiviral agent against herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (HCMV). It is also used as an anticancer agent in preclinical research.</p>

<p>3'-O-Allyladenosine is an antiviral agent that inhibits the replication of DNA and RNA viruses. It has been shown to have anticancer properties, and is a novel nucleoside analog with potential as an antitumor agent. 3'-O-Allyladenosine is a modified nucleoside analog that can be synthesized with high purity and quality. This compound has shown antiviral activity against influenza virus and herpes simplex virus type 1. In addition, 3'-O-Allyladenosine has been found to inhibit tumor growth in mice without any significant side effects.</p>

2'-Deoxy-5'-O-DMT-2'-fluoro-N2-isobutyrylguanosine is a synthetic nucleoside. It is an activator for DNA synthesis and has anticancer, antiviral and antifungal properties. This product can be used as a reagent in the synthesis of DNA or RNA. This compound also has high purity and high quality.

5'-O-p-Anisoyl-N4-benzoyl-2',3'-dideoxycytidine is a synthetic nucleoside that belongs to the class of deoxyribonucleosides. It is a modified nucleoside with an anisoyl group at the 5' position and a benzoyl group at the 2' position. This product can be used in the synthesis of DNA, RNA, and phosphoramidites. 5'-O-p-Anisoyl-N4-benzoyl-2',3'-dideoxycytidine has antiviral properties and has been shown to inhibit viral replication in vitro and in vivo. It also has anticancer activities as it inhibits cell proliferation and induces apoptosis, which may be due to its ability to inhibit DNA synthesis.

<p>5-Hydroxycytidine is a pyrimidine nucleoside that is found in DNA and RNA. It can be produced by the conversion of cytidine 5-monophosphate to cytidine 5'-diphosphate, which is then hydrolyzed to produce 5-hydroxycytidine. This conversion requires the enzyme cytidylate kinase. The structure of 5-hydroxycytidine differs from other pyrimidine nucleosides as its hydroxyl group does not have an acidic proton present. Biological functions that have been attributed to 5-hydroxydihydrocytidylic acid include its ability to inhibit translation and induce cell death in lung cells. This compound has also been shown to modify DNA duplexes and form bioconjugates with proteins or small molecules, such as fluorescein and digoxigenin. These modifications are used in analytical methods such as phase chromatography, nuclear magnetic resonance spectroscopy</p>

A potential role in apoptosis and cellular senescence.

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite is an antiviral nucleoside phosphoramidite that is used in the synthesis of DNA. It has been shown to have antiviral activity against HIV and herpes, as well as anticancer effects. It also has high purity, being a novel synthetic nucleoside with a CAS number. N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite is synthesized using novel methods. The synthesis process includes activation with diphosphate, DNA, and Novel nucleosides, which are high quality and modified.