Nucléosides
3573 produits trouvés pour "Nucléosides"
Tenofovir disoproxil
CAS :Anti-viral; reverse transcriptase inhibitor
Formule :C19H30N5O10PDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :519.44 g/molZidovudine
CAS :Inhibitor of reverse transcriptaseFormule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :267.24 g/molAbacavir sulfate
CAS :Anti-viral; reverse transcriptase inhibitor
Formule :C14H18N6OH2SO4Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :670.75 g/molAbacavir
CAS :Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase (RT) inhibitor with anti-retroviral activity against HIV. Good oral bioavailability, high aqueous solubility and good cerebrospinal fluid penetrance. Synergistic with other nucleoside RT inhibitors such as AZT.Formule :C14H18N6ODegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :286.33 g/molTenofovir
CAS :Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.Formule :C9H14N5O4PDegré de pureté :Min. 95%Couleur et forme :White Clear LiquidMasse moléculaire :287.21 g/molStavudine
CAS :Anti-viral; reverse transcriptase inhibitorFormule :C10H12N2O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :224.22 g/molCytarabine
CAS :Anti-viral; anti-neoplasticFormule :C9H13N3O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :243.22 g/molOleoyl coenzyme A potassium salt
CAS :Ribonuclesides are a class of modified nucleosides that have been shown to be effective against cancer cells. Oleoyl CoA potassium salt is a Ribonucleoside that inhibits the growth of cancer cells by inhibiting DNA synthesis and RNA synthesis. The Ribonucleosides inhibit the formation of DNA by preventing the conversion of ribose-5-phosphate to deoxyribose-5-phosphate, which is required for DNA synthesis. Oleoyl CoA potassium salt also binds to the enzyme ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides, thereby inhibiting DNA synthesis. This drug has been studied in preclinical animal trials.Formule :C39H67N7O17P3S·xKDegré de pureté :Min. 95%Masse moléculaire :1,070.07 g/molTenofovir disoproxil fumarate
CAS :Anti-viral; reverse transcriptase inhibitor
Formule :C23H34N5O14PDegré de pureté :Min. 97.5 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :635.52 g/mol(2’OMe-5’P-A)pG
CAS :A nucleoside product for research purposes
Formule :C39H73N13O14P2Masse moléculaire :1,010.02 g/mol2'-Deoxyuridine-5'-diphosphate triethylammonium, 10 mM aqueous solution
CAS :a deoxynucleotide diphosphate
Formule :C9H14N2O11P2•C6H15NMasse moléculaire :489.35 g/mol3N’-Boc-α-(aminoacetyl)propyl-N-2’,3’,5’-tri-O-acetyluridine
Based functionalised uridineFormule :C25H35N3O13Masse moléculaire :585.56 g/molAminoallyl-UTP trisodium
Please enquire for more information about Aminoallyl-UTP trisodium including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormule :C12H20N3O15P3•Na3Degré de pureté :Min. 95%Masse moléculaire :608.22 g/mol5'-O-DMT-uridine
CAS :5'-O-DMT-uridine is an oligodeoxynucleotide that has been conjugated to tetracycline. It is a bioconjugate that can be used for photooxidation of DNA, as well as for the prevention of bacterial efflux. The 5'-O-DMT group can be removed from the uridine by light irradiation or by bioconjugate chemistry, which results in the release of tetracycline and subsequent binding to bacterial ribosomes. This prevents protein synthesis and cell division. The linker can be any cyclic or dehydrating compound.Formule :C30H30N2O8Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :546.58 g/mol7-Methylguanosine-5’-diphosphate disodium
CAS :Inhibition of decapping.Formule :C11H17N5O11P2•Na2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :503.21 g/mol2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine
CAS :2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine (2F-6ENPE) is a novel antiviral agent that inhibits the synthesis of RNA in the body. It is a monophosphate nucleotide analog and a prodrug that is converted to its active form, 2F-6ENP by ribonucleoside kinases. This drug has been shown to inhibit the growth of cancer cells in vitro and in vivo. 2F-6ENPE has also been shown to be effective against methicillin resistant staphylococcus aureus (MRSA).Formule :C18H18FN5O7Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :435.36 g/molClevudine
CAS :Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.
Formule :C10H13FN2O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :260.22 g/mol4-Amino-2,6-dihydroxy-5-nitrosopyrimidine
CAS :4-Amino-2,6-dihydroxy-5-nitrosopyrimidine is a molecule that has been shown to be an effective inhibitor of the enzyme tyrosinase in the oxidation of tyrosine to DOPA, which is a precursor of melanin. It is believed that vibrational and structural changes during these reactions are responsible for the inhibitory effects. 4-Amino-2,6-dihydroxy-5-nitrosopyrimidine has also been shown to have anti cancer effects on glioma cells. This molecule binds to copper ions, forming a chelate ring that can stabilize reactive intermediates and terminate free radicals. The chlorine atom on this molecule may be responsible for its cytotoxic effects by reacting with nucleophilic sites on proteins. The functional groups on this molecule react with acid catalysts, such as protonation or dehydration reactions.Formule :C4H4N4O3Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :156.1 g/mol2'-O-tert-Butyldimethylsilyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite
CAS :2'-O-tert-Butyldimethylsilyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a novel, high quality, high purity, and deoxyribonucleoside. It is a phosphoramidite that is used in the synthesis of oligodeoxyribonucleotides and has antiviral, anticancer, and anti-inflammatory activities. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite inhibits the replication of DNA by inhibiting the synthesis of RNA from DNA. This deoxynucleoside also activates nucleases to degrade proteins that are involved in cancer cell proliferation.Formule :C45H61N4O9PSiDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :861.05 g/molPolycytidylic acid
CAS :Polycytidylic acid is a single stranded RNA analog which is combined with Polyinosinic acid to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'Degré de pureté :Min. 95%
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