Bêta-bloquants
Sous-catégories appartenant à la catégorie "Bêta-bloquants"
1503 produits trouvés pour "Bêta-bloquants"
2-Hydroxy Atenolol
CAS :Formule :C14H22N2O4Couleur et forme :White To Off-White SolidMasse moléculaire :282.34(R)-Propranolol Glucuronide
Formule :C22H29NO8Couleur et forme :Off-White SolidMasse moléculaire :435.48Propranolol-d5 Glucuronide
CAS :Formule :C22H24NO8D5Couleur et forme :Yellow SolidMasse moléculaire :440.51N-Nitroso Timolol EP Impurity B (N-Nitroso Timolol USP Related Compound B)
Formule :C13H23N5O4SMasse moléculaire :345.42N-Nitroso Timolol EP Impurity E (N-Nitroso Timolol USP Related Compound E (Free Form))
Formule :C17H25N5O7SMasse moléculaire :443.484-Hydroxy Propranolol β-D-Glucuronide Methyl Ester (Mixture of Diastereomers)
Formule :C23H31NO9Masse moléculaire :465.501-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid
CAS :Formule :C25H24N4O5Couleur et forme :Light Orange ColourMasse moléculaire :460.48Hydroxy Dehydro Nifedipine Lactone
CAS :Produit contrôléFormule :C16H12N2O6Couleur et forme :NeatMasse moléculaire :328.28N-Nitrosooxprenolol
CAS :Produit contrôléFormule :C15H22N2O4Couleur et forme :Light YellowMasse moléculaire :294.3462-(2-Aminoethoxy)anisole
CAS :Produit contrôléApplications 2-(2-Aminoethoxy)anisole is used as an additive to vinylphosphonic acid esters and acrylonitrile forming compounds displaying hypotensive activity. An impurity from the process of Carvedilol (C184625)
References Reznik, V. et al.: Russ. Chem. Bull., 48, 979, (1999); Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),Formule :C9H13NO2Couleur et forme :NeatMasse moléculaire :167.2Nadolol
CAS :Produit contrôléApplications β-Adrenergic blocker. Antihypertensive; antianginal.
References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977), Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978), Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980),Formule :C17H27NO4Couleur et forme :NeatMasse moléculaire :309.4Edoxaban Tosylate Monohydrate
CAS :Applications Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.
References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)Formule :C31H38ClN7O7S2•xH2OCouleur et forme :White To Off-WhiteMasse moléculaire :720.262-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid
CAS :Produit contrôléApplications 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid is a potential metabolite of Chlorthalidone.
References Salado C., et al.: J. Chromatography. Biomed. App., 690, 195 (1997);Formule :C14H10ClNO5SCouleur et forme :NeatMasse moléculaire :339.75Atenolol-d7
CAS :Produit contrôléApplications Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),Formule :C14D7H15N2O3Couleur et forme :Off-WhiteMasse moléculaire :273.38Pravastatin Lactone
CAS :Produit contrôléStability Hygroscopic
Applications Pravastatin Lactone is a metabolite of Pravastatin (P702000).
References Boberg, M., et al.: Drug Metab. Dispos., 25, 321 (1997), Neuvonen, P., et al.: Clin. Pharmacol. Ther., 63, 332 (1998), Boyd, R., et al.: J. Clin. Pharmacol., 40, 91 (2000),Formule :C23H34O6Couleur et forme :NeatMasse moléculaire :406.51Ramipril-d5
CAS :Produit contrôléApplications A labelled antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite.
References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),Formule :C23H27D5N2O5Couleur et forme :WhiteMasse moléculaire :421.54Rosuvastatin Ethyl Ester
CAS :Applications Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol.
References Sterk, D.; et al.: Tetrahedron Lett., 57, 1338 (2016); Olsson, A. G.; et al.: Am. Heart J., 144, 1044 (2002).Formule :C24H32FN3O6SCouleur et forme :Off-White To Light BeigeMasse moléculaire :509.593-Isopropylamino-1,2-propanediol
CAS :Impurity Metoprolol EP Impurity N
Applications 3-Isopropylamino-1,2-propanediol (Metoprolol EP Impurity N) is a versatile organic building block, used in different chemical synthesis. It is used in the preparation of heterocyclic propanolamines, which are shown to have β-adrenergic antagonist activity.
References Dean, V. et al.: Drug Design and Discovery,10, 89 (1993);Formule :C6H15NO2Couleur et forme :ColourlessMasse moléculaire :133.19ent-Rosuvastatin Sodium Salt
CAS :Produit contrôléImpurity Rosuvastatin EP Impurity G
Stability Hygroscopic
Applications ent-Rosuvastatin is an enantiomer of Rosuvastatin (R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor (1). Antilipemic (2,3).
References 1. Watanabe, M. et al.: Bioorg. Med. Chem. 1997 Feb;5(2):437-44.2. Lee, E. et al.: Clin. Pharmacol. Ther. 2005 Oct;78(4):330-41.3. Ferdinand, C. et al.: Am. J. Cardiol. 2006 Jan 15;97(2):229-35.Formule :C22H27FN3NaO6SCouleur et forme :NeatMasse moléculaire :503.522'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid
CAS :Produit contrôléStability Hygroscopic
Applications 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is a transformation product of Valsartan (V095750); a nonpeptide angiotensin II AT1-receptor antagonist and antihypertensive. 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is also referred to as Valsartan acid.
References Noedler, K., et al.: Water Res., 47, 6650 (2013); Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)Formule :C14H10N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :266.254-Hydroxyphenylacetic Acid
CAS :Applications A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
References Shu, Y., et al.: Guangdong Huagong, 37, 108 (2010), Papadopoulos, G., et al.: J Am Oil Chem Soc, 68, 669 (1991),Formule :C8H8O3Couleur et forme :NeatMasse moléculaire :152.15Nor Verapamil Hydrochloride
CAS :Impurity Verapamil EP Impurity J HCl
Applications Nor Verapamil Hydrochloride (Verapamil EP Impurity J HCl) is a metabolite of Verapamil.
References Mutlib, A.E., et al.: The Journal of Pharm. & Exp. Therapeutics, 252, 2, 593 (1989)Formule :C26H37ClN2O4Couleur et forme :WhiteMasse moléculaire :477.04Nicergoline-d3
CAS :Produit contrôléApplications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)Formule :C24D3H23BrN3O3Couleur et forme :NeatMasse moléculaire :487.404Atorvastatin Lactam Sodium Salt Impurity
CAS :Impurity Atorvastatin Pyrrolidone Analog (USP)
Stability Light Sensitive
Applications A photodegradation product of Atorvastatin (a cyclic impurity of Atorvastatin). Atorvastatin Pyrrolidone Analog (USP).
References Roger, D., et al.: Clin. Exp. Dermatol., 19, 88 (1994), Cosa, G., et al.: Photochem. Photobiol., 80, 159 (2004), Kerwin, B., et al.: J. Pharm. Sci., 96, 1468 (2007),Formule :C33H34FN2O6·NaCouleur et forme :WhiteMasse moléculaire :596.621,3-Bis(9H-carbazol-4-yloxy)-2-propanol(Carvedilol Impurity)
CAS :Produit contrôléApplications A carvedilol Impurity.
Formule :C27H22N2O3Couleur et forme :NeatMasse moléculaire :422.484-Hydroxyphenylacetamide
CAS :Produit contrôléImpurity Atenolol EP Impurity A
Applications 4-(Hydroxyphenyl)acetamide (Atenolol EP Impurity A) is used as an intermediate for the synthesis of Atenolol (A790075) and various other organic compounds and pharmaceuticals. It is a process impurity for Atenolol (A790075)
References Inkum, R., et al.: Maejo Int. J. Sci. Tech., 6, 372 (2012); Pai, N.R., et al.: J. Chem. Pharma. Rsch., 4, 375 (2012); Moon, J.T., et al.: Bio-org. Medn. Chem., 20, 734 (2012);Formule :C8H9NO2Couleur et forme :NeatMasse moléculaire :151.16Ezetimibe Ketone
CAS :Produit contrôléImpurity Ezetimibe Ketone (USP)
Applications Phase-I metabolite of Ezetimibe (E975000).
References Shah, V., et al: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Watts, G., et al.: Clin. Sci.,103, 595 (2002), Ghosal, A., et al.: Drug Metab. Dispos., 32, 314 (2004), Sistla, R., et al.: J. Pharm. Biomed. Anal., 39, 517 (2005),Formule :C24H19F2NO3Couleur et forme :NeatMasse moléculaire :407.41Ezetimibe Tetrahydropyran Impurity
CAS :Impurity Ezetimibe Tetrahydropyran Impurity
Applications Ezetimibe (E975000) tetrahydropyran impurity.Formule :C24H21F2NO3Couleur et forme :NeatMasse moléculaire :409.43N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
CAS :Produit contrôléApplications A Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.
References Beck, et al.: J. Med. Chem., 33, 52 (1999),Formule :C16H20FN3O3SCouleur et forme :NeatMasse moléculaire :353.41Simvastatin Dimer Impurity
CAS :Formule :C50H76O10Couleur et forme :White To Light YellowMasse moléculaire :837.13N-Desmethyl Rosuvastatin Disodium Salt Monohydrate
CAS :Produit contrôléApplications Inhibits the enzyme HMG-CoA reductase in vitro.
References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),Formule :C21H24FN3Na2O6S•H2OCouleur et forme :NeatMasse moléculaire :511.481802Des(isopropylamino) Atenolol Diol
CAS :Formule :C11H15NO4Couleur et forme :WhiteMasse moléculaire :225.24alpha-Hydroxy Metoprolol (Mixture of Diastereomers)
CAS :Produit contrôléApplications A metabolite of Metoprolol.
References Lennard, M.S., et al.: Br. J. Clin. Pharmacol., 14, 713 (1982), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 36, 320 (1984),Formule :C15H25NO4Couleur et forme :Off-White To BeigeMasse moléculaire :283.36C-Desmethyl Metoprolol
CAS :Produit contrôléImpurity Metoprolol EP Impurity A
Applications C-Desmethyl Metoprolol (Metoprolol EP Impurity A) is a new byproduct detected in Metoprolol tartrate. Metoprolol impurity.
References Erickson, M., et al.: J. Pharma. Biomed. Analysis, 13, 567 (1995), Phinney, K., et al.: Chirality, 15, 287 (2003), Zheng, J., et al.: Anal. Chem., 78, 1535 (2006),Formule :C14H23NO3Couleur et forme :NeatMasse moléculaire :253.342-(3-(tert-Butylamino)-2-hydroxypropyl)-4-morpholino-1,2,5-thiadiazol-3(2H)-one (>90%)
CAS :Impurity Timolol EP Impurity H
Applications 2-(3-(tert-Butylamino)-2-hydroxypropyl)-4-morpholino-1,2,5-thiadiazol-3(2H)-one is a impurity of Timolol (T443710), an antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.
References Lacroix, P.M., et. al.: Chirality, 6, 484 (1994); Wasson, et al.: J. Med. Chem., 15, 651 (1972); Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972); Heel, R.C., et al.: Drugs, 17, 38 (1979); Rofman, B.A., et al.: Hypertension, 2, 643 (1980); Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987)Formule :C13H24N4O3SDegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :316.42(1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane
CAS :Produit contrôléApplications (-)-Nebivolol intermediate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageFormule :C18H20FNO2Couleur et forme :WhiteMasse moléculaire :301.36Benazepril Acyl-β-D-glucuronide
Produit contrôléStability Hygroscopic
Applications Used as an antihypertensive.This compound is very unstable in solution and will hydrolyze readily to give benazapril.Formule :C30H36N2O11Degré de pureté :>85%Couleur et forme :NeatMasse moléculaire :600.61Ibutilide Fumarate
CAS :Produit contrôléFormule :C20H36N2O3S·C4H4O4Couleur et forme :NeatMasse moléculaire :885.22(2R,3S)-rel-Nadolol-de(N-tert-butyl)methoxy
Impurity Nadolol EP Impurity B
Stability Hygroscopic
Applications (2R,3S)-rel-Nadolol-de(N-tert-butyl)methoxy is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.
References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)Formule :C14H20O5Couleur et forme :NeatMasse moléculaire :268.3cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester-d5
CAS :Produit contrôléApplications cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester-d5 is an isotopic analog of cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester. cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester is an ethyl analog of cis-7,10,13,16-Docosatetraenoic Acid (D494510). cis-7,10,13,16-Docosatetraenoic Acid has been identified as a protein kinase inhibitor, affecting serotonin levels in studies.
References Mirnikjoo, B. et al.: J. Biol. Chem., 276, 10888 (2001);Formule :C24D5H35O2Couleur et forme :NeatMasse moléculaire :365.604N-Des(4-Fluorophenyl)-N-(3-fluorophenyl) Ezetimibe
CAS :Formule :C24H21F2NO3Couleur et forme :Off White SolidMasse moléculaire :409.43Indocyanine Green >d6
CAS :Produit contrôléApplications It is the labeled analogue of Indocyanine Green (I697000), a tricarbocyanine type of dye with infrared absorbing properties that can be used as a diagnostic aid (blood volume determination, cardiac output, hepatic function).
References Papageorgiou, P., et al.: Br. J. Dermatol., 142, 973 (2000), Dreno, B., et al.: Dermatology, 203, 135 (2001), Gollnick, H., et al.: Drugs, 63, 1579 (2003), Seaton, E., et al.: Lancet, 362, 1347 (2003),Formule :C7H14N2OCouleur et forme :NeatMasse moléculaire :NA(3R,5R)-Rosuvastatin Sodium Salt
CAS :Impurity Rosuvastatin EP Impurity B
Stability Hygroscopic
Applications A diastereomer of Rosuvastatin (R700500) used for treatment, prevention and combination therapy of lipid-related disorders. Rosuvastatin EP Impurity BFormule :C22H27FN3NaO6SCouleur et forme :White To Light YellowMasse moléculaire :503.52Perindoprilat(Mixture of Diastereomers)
CAS :Produit contrôléApplications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)Formule :C17H28N2O5Couleur et forme :NeatMasse moléculaire :340.41Mevastatin Hydroxy Acid Sodium Salt
CAS :Produit contrôléStability Hygroscopic
Applications An active carboxylate of Mevastatin (M340500). It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood.
References Endo, A. et al.: Atheroscler. Supp., 5, 39 (2004); Hosobuchi, M. et al.: J. Ferm. Bioeng., 76, 470 (1993);Formule :C23H35O6·NaCouleur et forme :NeatMasse moléculaire :430.51(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid
CAS :Impurity Fluocinolone Acetonide EP Impurity B
Applications (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching.
References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),Formule :C23H28F2O6Couleur et forme :Off-WhiteMasse moléculaire :438.46Epinephrine Sulfonic Acid
CAS :Applications An Epinephrine (E588585) derivative formed in injection solutions and eye drops during sterilization and storage of L-Epinephrine Bitartrate.
References De Mol, N.J. et al.: Pharmac. Week., 117, 1 (1982); Liu, C. et al.: Yao. Fen. Zaz., 2, 200 (1982);Formule :C9H13NO5SCouleur et forme :NeatMasse moléculaire :247.27Norepinephrine Sulfonic Acid
CAS :Applications Norepinephrine Sulfonic Acid is a derivative of DL-Norepinephrine Hydrochloride (N674500), antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Piguet, P., et al.: J. Exp. Med., 173, 673 (1991), Hosoi, J., et al.: Nature, 363, 159 (1993), Elenkov, I., et al.: Pharmacol. Rev., 52, 595 (2000), Kaplan, D., et al.: Immunity, 23, 611 (2005),Formule :C8H11NO5SCouleur et forme :Red To GreyMasse moléculaire :233.24N-Benzyl Carvedilol
CAS :Produit contrôléImpurity Carvedilol EP Impurity C; Carvedilol Impurity C; Carvedilol USP C
Applications N-Benzyl Carvedilol (Carvedilol EP Impurity C) is an impurity of Carvedilol (C184625) and a degradation product in Carvedilol tablets.
References Karle, C., et al.: Cardiovasc. Res., 49, 361 (2001), Chen, J., et al.: Acta Cardiol. Sin., 19, 93 (2003), Xiang, T., et al.: Pharm. Res., 22, 1205 (2005),Formule :C31H32N2O4Couleur et forme :NeatMasse moléculaire :496.6Oxyfedrine
CAS :Produit contrôléStability Moisture Sensitive
Applications Oxyfedrine acts as a vasodilator affecting the coronary base flow.
References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);Formule :C19H23NO3Couleur et forme :NeatMasse moléculaire :313.39
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