Autres

Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.
References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)

Applications Tert-butyl Acetate is a common solvent used in the production of various industrial cleansers, thinners and adhesives and is also known as a VOC.Environmental contaminants; Food contaminants
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mackay, D., et al.: SAR. QSAR. Enviro. Res., 23, 205 (2012); Yang, Y.S., et al.: Toxicol. Res., 26, 293 (2010);

Applications Hexamethylcyclotrisiloxane is used in the preparation of Silicone coated Celgard-2400 for the adhesion of canine platelets and leucocytes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chawla, A.S.: Biomaterials, 2, 83 (1981)

Applications An intermediate in the production of Bimatoprost (B386800).

Applications Perfluorophenol is used in the synthesis of PGA-films as biodegradable polymers. It also participates in the synthesis of tripod macrocyclic Gd(III) chelates for cancer molecular MRI.
References Lee, K. et al.: Langmuir., 20, 2531 (2004); Zhou, Z. et al.: Biomater., 34, 7683 (2013);

Applications The main metabolite of Chlordiazepoxide (C327050).
References Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002);

Impurity Fulvestrant EP Impurity A
Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.
References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),

Applications Diazepam N-Oxide is a derivative of Diazepam (D416855), an anxiolytic.
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004)

Applications Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),

Stability Hygroscopic
Applications A metabolite of Memantine (M218000), used for the treatment of neurological disorders.
References Eiichi, K., et al.: Chem. Pharm. Bull., 33, 4680 (1985),

Stability Hygroscopic
Applications By-product in the preparation of a Lorazepam metabolite.

Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Stability Hygroscopic
Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)

Applications 5-9-Leuprolide is a metabolite of Leuprolide (L330590), a gonadotropin-releasing hormone (GnRH) analogue acting as an agonist at pituitary GnRH receptors.
References Handelsman, David J., et al.: J. of Steroid Biochem. and Mol. Bio., 141, 113-120 (2014);Okada, Hiroaki, et al.: Pharma. Res., 8(6), 787-91 (1991)

Applications It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Applications Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),

Applications 5,6-Dimethylbenzimidazole (cas# 582-60-5) is a useful research chemical.

Applications N-Nitrosoatenolol is an N-nitroso derivative of Atenolol (A790075), which is a cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II). N-Nitrosoatenolol can be used for its genotoxic effect in rat and human hepatocytes.
References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Robbiano, L., et.al., Cancer Res., 51, 2273-2279, (1991);

Applications A labelled β-adrenergic agonist, related to Clenbuterol and Mabuterol. A repartitioning agent.
References Engelhardt, G., et al.: Arzneim.-Forsch., 34, 1625 (1984),

Applications 15-Keto Bimatoprost is an impurity of Bimatoprost (B386800). Bimatoprost impurity III.
References Stjernschantz, J., et al.: Drugs Fut., 17, 691 (1992), Resul, B., et al.: J. Med. Chem., 36, 243 (1993),

Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.
References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)

Impurity Lorazepam USP Related Compound D
Stability Very Hygroscopic
Applications 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid (Lorazepam Related Compound D) is a metabolite of Lorazepam (L469850).
References Schillings, R.T., et al.: Drug Metab. Dispos., 3, 85 (1975),

Applications Tetramethylurea is an excellent solvent for organic substances, in particular aromatic compounds.
References Lüttringhaus, A., et al.: Angew. Chem. Int. Ed. Engl., 3, 260 (1964)

Applications Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),

Applications Rhodamine 6G is a fluorescent hydrophilic pH-sensitive dye that has been used on organosilicate nanoparticles as cell-preserving labels for photoacoustic signal generation. Dyes and metabolites, Environmental Testing
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References O’Malley, S.M., et. al.: Chem. Phys. Lett., 615, 30 (2014); Silina, Y.E., et. al.: Analyst, 140, 771 (2015); Ramirez-Perez, F.I., et. al.: J. Biomed. Nanotech., 10, 3337 (2014)

Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.
References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);

Applications An impurity in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.
References Barve, I. et al.: Tetra., 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995), Murata, S., et al.: J. Urol., 164, 578 (2000),

Stability Hygroscopic
Applications α-Epoxyabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

M04074 - 5-Bromo-6-chloro-3-indolyl beta-D-glucuronide cyclohexylammonium salt

Applications 3-Phenoxy-1,2-propanediol (cas# 538-43-2) is a useful research chemical.

Stability Light Sensitive, Very Hygroscopic
Applications An antioxidant for grape and apple juice.
References Kim, K., et al.: Agric. Biol. Chem., 38, 53 (1974), Vichi, S., et al.: Food Chem., 102, 1260 (2007),

Applications N-Desmethyl Zopiclone-d8 is a labelled metabolite of Zopiclone (Z700500), which is Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.
References Fernandez, C., et al.: Clin. Pharmacokinet., 29, 431 (1995), Nordgren, H., et al.: Ther. Drug Monit., 24, 410 (2002)

Applications Diazepam is an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a controlled substance (depressant).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);

Applications (15R)-Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost (B386820). (15R)-Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.
References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011); Resul, B., et al.: J. Med. Chem., 36, 243 (1993)

Applications 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.
References Francesco, C., et al.: Eur. J. Org. Chem., 27, 6011 (2015)

Applications A labelled metabolite of Diazepam; it had a much weaker anticonvulsant effect.
References Hara, T., et al.: J. Med. Chem., 21, 263 (1978),

Stability Hygroscopic
Applications Used as an antiparkinsonian and antispasmodic.
References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)