Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
Chez CymitQuimica, nous proposons des dérivés des purines et pyrimidines pour la recherche en biologie moléculaire, génomique et le développement de thérapies innovantes.
8897 produits trouvés pour "Dérivés des Purines et Pyrimidines"
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1-(4-tert-Butylphenyl)-2-pyrimidin-4-yl ethanol
CAS :Formule :C16H20N2ODegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :256.349trans-Zeatin
CAS :Produit contrôlé<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>Formule :C10H13N5OCouleur et forme :NeatMasse moléculaire :219.24Tert-butyl 4-(5-hydroxypyrimidin-2-yl)piperazine-1-carboxylate
CAS :Degré de pureté :98%Masse moléculaire :280.3280029296875[6-(3-Amino-piperidin-1-yl)-pyrimidin-4-yl]-cyclopropyl-amine hydrochloride
CAS :Degré de pureté :95.0%Masse moléculaire :269.7799987792969N-(1-phenylethyl)guanidine hydrochloride
CAS :Formule :C9H14ClN3Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :199.68Isonicotinic Acid
CAS :<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>Formule :C6H5NO2Couleur et forme :Light BrownMasse moléculaire :123.111-Methyl-4-[5-(2-methylsulfamoylethyl)-1H-indol-3-yl]pyridinium Chloride
Produit contrôlé<p>Impurity Naratriptan pyridinium Impurity<br>Stability Hygroscopic<br>Applications Naratriptan (N378730) impurity.<br></p>Formule :C17H20ClN3O2SCouleur et forme :NeatMasse moléculaire :365.881,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one
CAS :Produit contrôlé<p>Impurity Ondansetron EP Impurity D; Ondansetron USP Related Compound D<br>Applications 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one (Ondansetron EP Impurity D; Ondansetron USP Related Compound D) is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011); Zizkovsky, V. et al.: J. Pharm. Biomed. Anal., 44, 1048 (2007)<br></p>Formule :C14H13NOCouleur et forme :WhiteMasse moléculaire :211.263-[(4,6-Dimethylpyrimidin-2-yl)amino]benzoic acid
CAS :Formule :C13H13N3O2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :243.2664-(5-Bromo-1H-indol-3-yl)pyrimidin-2-amine
CAS :Degré de pureté :97%Masse moléculaire :289.1359863281252-[5-amino-3-(2-thienyl)-1H-pyrazol-1-yl]-5,6-dimethylpyrimidin-4(3H)-one
CAS :Degré de pureté :95.0%Masse moléculaire :287.33999633789066-(4-CHLOROPHENYL)-2-METHYLPYRIMIDIN-4-AMINE
CAS :Degré de pureté :95.0%Masse moléculaire :219.6699981689453Sumatriptan-d6
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A serotonin 5HT1-receptor agonist. Antimigraine.<br>References Humphrey, P.P.A., et al.: Br. J. Pharmacol., 94, 1123 (1988),<br></p>Formule :C14H15D6N3O2SCouleur et forme :NeatMasse moléculaire :301.44Tenofovir Disoproxil Fumarate
CAS :<p>Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C19H30N5O10P·C4H4O4Couleur et forme :White To Off-WhiteMasse moléculaire :635.514-(3-Aminophenyl)-2-methylpyrimidine
CAS :Formule :C11H11N3Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :185.23(E)-3-(2-chlorophenyl)-N-(4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)acrylamide
CAS :Degré de pureté :98%Masse moléculaire :414.8599853515625Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS :<p>Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C13H13NO3SCouleur et forme :NeatMasse moléculaire :263.31Oxo-Pemetrexed acid
CAS :Produit contrôléFormule :C15H14N4O4Couleur et forme :NeatMasse moléculaire :314.34-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
CAS :Degré de pureté :95%Masse moléculaire :211.22799682617188N'-Methyl-N,N-diphenylurea
CAS :<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>Formule :C14H14N2OCouleur et forme :NeatMasse moléculaire :226.27L-Aspartyl-L-phenylalanine Hydrochloride
CAS :Produit contrôlé<p>Applications L-Aspartyl-L-phenylalanine is an impurity of Thiamine (T344185). Thiamine Impurity B.<br>References Aluwihare, L., et al.: Science, 308, 1007 (2005), Koch, B., et al.: Anal. Chem., 79, 1758 (2007), Reemtsma, T., et al.: Environ. Sci. Technol., 42, 1430 (2008),<br></p>Formule :C13H16N2O5xHClCouleur et forme :NeatMasse moléculaire :280.28ETHYL 2-(2,6-DICHLORO-9H-PURIN-9-YL)ACETATE
CAS :Degré de pureté :90.0%Masse moléculaire :275.0899963378906(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride
CAS :Formule :C13H20ClN5O2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :313.794-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
CAS :Degré de pureté :99.0%Couleur et forme :SolidMasse moléculaire :482.82000732421875Ref: 10-F361865
1gÀ demander5gÀ demander10gÀ demander25gÀ demander10mgÀ demander50mgÀ demander100mgÀ demander250mgÀ demander500mgÀ demander4-(3,4-dimethylphenyl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :365.43301391601563-Nitropyridine
CAS :Produit contrôlé<p>Applications Used in the novel synthesis of biologically active nitro heterocyclic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pawar, N., et al.: Eur. J. Pharm. Sci., 21, 115 (2004), Badgujar, D., et al.: J. Sci. Ind. Res., 66, 250 (2007),<br></p>Formule :C5H4N2O2Couleur et forme :NeatMasse moléculaire :124.104-(3,4-dimethylphenyl)-6-(4-fluorophenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :293.34500122070314-[6-(2-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Degré de pureté :95.0%Masse moléculaire :278.315002441406252-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS :Produit contrôlé<p>Applications 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H.,e t al.: J. Pharm. Biomed. Anal., 56, 749 (2011);<br></p>Formule :C16H17NO5SCouleur et forme :White SolidMasse moléculaire :335.371-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
CAS :Degré de pureté :95.0%Masse moléculaire :396.45098876953125N-[bis(4-methoxyphenyl)methyl]-6-oxo-2-(pyridazin-3-yl)-1,6-dihydropyrimidine-5-carboxamide
CAS :Degré de pureté :95%Masse moléculaire :443.46301269531254-(5-methylthiophen-2-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :273.3699951171875Tenofovir Alafenamide Fumarate
CAS :Produit contrôlé<p>Applications Tenofovir Alafenamide Fumarate is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C21H29N6O5P·C4H4O4Couleur et forme :NeatMasse moléculaire :592.5381Tri-POC Tenofovir Dimer (>90%)
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Tri-POC Tenofovir Dimer is a dimer of Tenofovir Disoproxil (T018505), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. It is also used in the preparation of phosphocitrate for the treatment of rheumatoid and osteoarthritis in the elderly.<br>References Turhanen, P. et al.: J. Org. Chem., 72, 1468 (2007);<br></p>Formule :C34H52N10O17P2Degré de pureté :>90%Couleur et forme :White To Light BeigeMasse moléculaire :934.78Tenofovir Phosphate Diammonia Salt, >90%
CAS :Produit contrôlé<p>Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formule :C9H21N7O7P2Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :401.254,6-Diaminopyrimidin-2(1H)-one hydrochloride
CAS :Degré de pureté :97%Masse moléculaire :162.58000183105472,5-Ethyl Acetate Febuxostat
CAS :Produit contrôlé<p>Applications Febuxostat (F229000) is the parent compound for 2,5-Ethyl Acetate Febuxostat. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C20H25NO5SCouleur et forme :NeatMasse moléculaire :391.48Mono-POC Tenofovir
CAS :<p>Stability Hygroscopic<br>Applications An impurity of Tenofovir Disoproxil (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. It is used as an anti-HIV agent and an antiviral.<br>References Gan, L., et al.: Drug Metab. Dispos., 24, 344 (1996), Annaert, P., et al.: Pharm. Res., 14, 492 (1997), Naesens, L., et al.: Antimicrob. Agents Chemother., 42, 1568 (1998), Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formule :C14H22N5O7PCouleur et forme :White To Light BeigeMasse moléculaire :403.33N,N-DIBENZYL-2-CHLORO-9H-PURIN-6-AMINE
CAS :Degré de pureté :95.0%Masse moléculaire :349.82000732421875Chloromethyl Isopropyl Carbonate
CAS :Produit contrôlé<p>Stability Moisture sensitive<br>Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),<br></p>Formule :C5H9ClO3Couleur et forme :NeatMasse moléculaire :152.583,4-Dihydro Naratriptan Oxalate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 3,4-Dihydro Naratriptan Oxalate is the basic form of 3,4-Dihydro Naratriptan(D449205); it is an impurity of Naratriptan (N378730), It is a triptan drug and is used for the treatment of migraine headaches.<br>References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),<br></p>Formule :C17H23N3O2S·C2H2O4Couleur et forme :White To Light YellowMasse moléculaire :333.45 + 90.035-{[(4,6-dimethylpyrimidin-2-yl)thio]methyl}-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol
CAS :Degré de pureté :95.0%Masse moléculaire :347.067465668Memantine Glycine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications An impurity of the antiparkinsonian and antispasmodic agent Memantine (M218000).<br>References Rystov, L. et al.: J. Pharmac. Biomed. Anal., 56, 887 (2011);<br></p>Formule :C14H23NO2Couleur et forme :NeatMasse moléculaire :237.342-CHLORO-N-(4-CHLOROPHENYL)-9-METHYL-9H-PURIN-6-AMINE
CAS :Degré de pureté :95.0%Masse moléculaire :294.14001464843754-(3,3-Dipropyl-ureido)benzenesulfonyl chloride
CAS :Formule :C13H19ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :318.824,6-diphenyl-1,2-dihydropyrimidin-2-one
CAS :Degré de pureté :98%Masse moléculaire :248.285003662109385-BENZYLOXY-2-(5-CHLORO-PYRIDIN-3-YL)-4-METHOXY-PYRIMIDINE
CAS :Degré de pureté :95.0%Masse moléculaire :327.76998901367192-(5-amino-3-cyclopropyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
CAS :Degré de pureté :95.0%Masse moléculaire :245.28599548339844Nitroso-Caffeidine
CAS :Produit contrôléFormule :C7H11N5O2Couleur et forme :NeatMasse moléculaire :197.21-(4-Methoxyphenyl)-2-pyrimidin-4-ylethanone
CAS :Formule :C13H12N2O2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :228.251(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS :Produit contrôlé<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.21Tenofovir Disoproxil Isopropoxycarbonyl
CAS :<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Formule :C23H36N5O12PCouleur et forme :White SolidMasse moléculaire :605.535-CHLORO-N2-(4-FLUOROBENZYL)-N4-(5-ISOPROPOXY-1H-PYRAZOL-3-YL)PYRIMIDINE-2,4-DIAMINE
CAS :Degré de pureté :95.0%Masse moléculaire :376.82000732421875(S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :320.35998535156254-(6-Thiophen-2-yl-pyridin-3-yl)-pyrimidin-2-ylamine
Degré de pureté :95.0%Masse moléculaire :254.30999755859375ethyl 2-morpholin-4-yl-4-(trifluoromethyl)pyrimidine-5-carboxylate
Masse moléculaire :305.2569885253906N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester
CAS :Degré de pureté :97%Masse moléculaire :540.6680297851562Ref: 10-F863727
1g16,00€5g45,00€10g87,00€1kg2.694,00€25g196,00€50g287,00€100g507,00€250g994,00€500g1.580,00€250mgÀ demanderFebuxostat-d7
CAS :Produit contrôlé<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C16H9D7N2O3SCouleur et forme :NeatMasse moléculaire :323.42TERT-BUTYL 3-(2-CHLOROPYRIMIDIN-4-YL)-1H-PYRROLO[2,3-C]PYRIDINE-1-CARBOXYLATE
CAS :Degré de pureté :95.0%Masse moléculaire :330.76998901367191-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
CAS :Degré de pureté :95.0%Masse moléculaire :366.85000610351561,3-dioxo-2-pyrimidin-2-ylisoindoline-5-carboxylic acid
CAS :Degré de pureté :95.0%Masse moléculaire :269.216003417968754-Ethoxy-3-(3-methyl-ureido)-benzenesulfonylchloride
CAS :Formule :C10H13ClN2O4SCouleur et forme :SolidMasse moléculaire :292.73Iopamidol-D3
CAS :Produit contrôlé<p>Applications Labelled nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982), Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982), Sovak, M., et al.: Radiology, 142, 115 (1982), Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988),<br></p>Formule :C17H19D3I3N3O8Couleur et forme :Off-WhiteMasse moléculaire :780.10Ethyl-S-(+)-Clopidogrel Sulfate
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formule :C17H20ClNO6S2Couleur et forme :White To Off-WhiteMasse moléculaire :433.93Thyroxine
CAS :Produit contrôlé<p>Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.<br>References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);<br></p>Formule :C15H11I4NO4Couleur et forme :Off-WhiteMasse moléculaire :776.87N-Methylguanidine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications N-Methylguanidine is an alkylated guanidine which shows inhibitory action against trypsin catalysis. N-Methylguanidine inhibited metabolism of certain hepatic drugs that was mediated by cytochrome P 450 protein in human liver microsome and hepatocyte.<br>References Inagami, T. et al.: Biochemistry, 7, 4045 (1968); Hanada, K. et al.: Nephron, 103, 179 (2006);<br></p>Formule :C2H8ClN3Couleur et forme :NeatMasse moléculaire :109.564,5,6-Trifluoro-2-trifluoromethyl-pyrimidine
CAS :Formule :C5F6N2Couleur et forme :LiquidMasse moléculaire :202.0593-(Formylamino)-1H-pyrazole-4-carboxamide
CAS :Produit contrôlé<p>Impurity Allopurinol EP Impurity B / Allopurinol USP Related Compound B<br>Stability Hygroscopic<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity B) is an impurity of Allopurinol (A547300) with inhibitory effects on human hypoxanthine phosphoribosyltransferase.<br>References Krenitzky, T.A. et al.: J. Biol. Chem., 244, 1263 (1969);<br></p>Formule :C5H6N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :154.1271,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one (Ondansetron Impurity G)
CAS :Produit contrôlé<p>Applications 1,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one is an metabolite of Ondansetron (O655000), is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting.<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988), Faris, P..L., et al.: Lances, 355, 792 (2000), Ye, J.H., et al.: CNS Drug Reviews., 7, 199 (2001);<br></p>Formule :C17H17N3OCouleur et forme :White To Off-WhiteMasse moléculaire :279.34N-Nitroso Frovatriptan 1
Formule :C14H16N4O2Couleur et forme :Off-White To Light YellowMasse moléculaire :272.3Tert-Butyl (6-(hydroxymethyl)pyrimidin-4-yl)carbamate
CAS :Degré de pureté :95.0%Masse moléculaire :225.2480010986328N-1-Adamantyl-N'-(2-hydroxy-1,1-dimethylethyl)urea
CAS :Degré de pureté :95.0%Masse moléculaire :266.385009765625N-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :355.354003906252-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester
CAS :<p>Applications 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester, can be used for the synthesis of Febuxostat (F229000), an antipodagrics.<br>References Zheng, F., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 726 (2009);<br></p>Formule :C14H12N2O3SCouleur et forme :NeatMasse moléculaire :288.321,3-Dimethyladamantane
CAS :<p>Impurity Memantine Related Compound A (1,3-Dimethyladamantane)<br>Applications 1,3-Dimethyladamantane is a dimethylated adamantane derivative. Memantine impurity A. Memantine Related Compound A (1,3-Dimethyladamantane).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formule :C12H20Couleur et forme :NeatMasse moléculaire :164.296-Methylpurine
CAS :Degré de pureté :95.0%Couleur et forme :Solid, Light yellow solidMasse moléculaire :134.14199829101562N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :287.754-(3-Ethylureido)-2-methylbenzenesulfonyl chloride
CAS :Formule :C10H13ClN2O3SCouleur et forme :SolidMasse moléculaire :276.74N4-BENZYL-N2-(4-BROMOPHENYL)-5-FLUOROPYRIMIDINE-2,4-DIAMINE
Degré de pureté :95.0%Masse moléculaire :373.22900390625N-Demethyl Ondansetron
CAS :<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Formule :C17H17N3OCouleur et forme :White To BrownMasse moléculaire :279.34Tetrabenazine-d6
CAS :Produit contrôlé<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formule :C19H21D6NO3Couleur et forme :NeatMasse moléculaire :323.461-Methyl Xanthine-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Formule :C62H3H3N4O2Couleur et forme :NeatMasse moléculaire :169.165,6-Dihydro Uracil-13C,15N2
CAS :<p>Applications Isotope Labelled 5,6-Dihydro Uracil is a degradation product of DNA and was used in mass spectrometric studies of cellular DNA damage.<br>References Nelson, V.C., et al.: J. Label. Com. Radiopharma., 38, 713 (1996)<br></p>Formule :C313CH615N2O2Couleur et forme :Off-White To BeigeMasse moléculaire :117.08Methotrexate a-tert-Butyl Ester
CAS :Produit contrôlé<p>Applications Methotrexate α-tert-Butyl Ester is an intermediate to the synthesis of folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.<br>References Yoshii, T., et al.: J. Am. Chem. Soc., 136, 16635 (2014);<br></p>Formule :C24H30N8O5Couleur et forme :NeatMasse moléculaire :510.5464-(3-Bromo-4-oxobutyl)benzoic Acid Methyl Ester
CAS :Produit contrôlé<p>Applications 4-(3-Bromo-4-oxobutyl)benzoic Acid Methyl Ester is used as a reagent in the synthesis of furoxanoxyalkyl esters of pemetrexed as antifolates and nitric oxide donors for use as anticancer agents and their activities against four human cancer cell lines.<br>References Min, T., et al.: Med. Chem. Res., 18, 495 (2009); Barnett, C.J., et al.: Org. Process Res. Dev., 3, 184 (1999)<br></p>Formule :C12H13BrO3Couleur et forme :NeatMasse moléculaire :285.136-Aminopyrimidin-4-ol
CAS :Formule :C4H5N3ODegré de pureté :97.0%Couleur et forme :SolidMasse moléculaire :111.104D-Neopterin
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formule :C9H11N5O4Couleur et forme :NeatMasse moléculaire :253.21Methyl Acetoacetate
CAS :Produit contrôlé<p>Applications 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Ranu, B. et al.: J. Org. Chem. 65, 6270 (2000); Lu, J. et al.: Tetrahedron Lett., 41, 9075 (2000); Lu, J. et al.: Synlett., 1, 63 (2000);<br></p>Formule :C5H8O3Couleur et forme :NeatMasse moléculaire :116.12(2R,3R,4S,5R)-2-(6-((3-Hydroxybenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS :Degré de pureté :97.0%Masse moléculaire :373.36898803710942-Chloro Adenosine
CAS :<p>Applications A selective A1-adenosine receptor agonist. Induces apoptosis.<br>References Evans, et al.: Neurosci. Lett., 83, 287 (1987), Szondy, Z.: Biochem. J., 304, 877 (1994)<br></p>Formule :C10H12ClN5O4Couleur et forme :Off-WhiteMasse moléculaire :301.697-Hydroxy Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of Memantine (M218000), used for the treatment of neurological disorders.<br>References Eiichi, K., et al.: Chem. Pharm. Bull., 33, 4680 (1985),<br></p>Formule :C12H21NO·ClHCouleur et forme :NeatMasse moléculaire :231.76
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