Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
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4-(3,4-dimethylphenyl)-6-(3-methylphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :289.3819885253906trans (2,3)-Dihydro Tetrabenazine
CAS :Produit contrôlé<p>Applications A metabolite of Tetrabenazine in vivo. The trans izomer of Dihydrotetrabenazine is used for the treatment of hyperkinetic movement disorders.<br>References Kilbourn, M., et al.: Eur. J. Pharmacol., 278, 249 (1995), Perera, R., et al.: J. Med. Chem., 46, 2599 (2003), Mager, D., et al.: J. Pharm. Sci., 94, 2475 (2005), Zheng, G., et al.: Bioorg. Med. Chem., 16, 5018 (2006),<br></p>Formule :C19H29NO3Couleur et forme :NeatMasse moléculaire :319.443-[(4,6-Dimethylpyrimidin-2-yl)amino]benzoic acid
CAS :Formule :C13H13N3O2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :243.266Thyroxine
CAS :Produit contrôlé<p>Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.<br>References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);<br></p>Formule :C15H11I4NO4Couleur et forme :Off-WhiteMasse moléculaire :776.87Pemetrexed Sodium Methyl Ester
Produit contrôlé<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Formule :C21H22N5NaO6Couleur et forme :NeatMasse moléculaire :463.4195-Azido Oseltamivir
CAS :Produit contrôlé<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Kim, C., et al.: J. Med. Chem., 41, 2451 (1998), Carbain, B., et al.: Chem. Med. Chem., 4, 335 (2009),<br></p>Formule :C16H26N4O4Couleur et forme :NeatMasse moléculaire :338.401-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :375.4070129394531Thyroxine Ethyl Ester
CAS :Produit contrôlé<p>Applications An analog of Thyroxine (L425600) with stimulatory effects on human red blood cell membrane Ca2+-activated ATPase. It is a potential inactivator of iodothyronine deiodinase type II.<br>References Davis, F.B. et al.: J. Biol. Chem., 258, 12373 (1983); Safran, M. et al.: J. Biol. Chem., 268, 14224 (1993);<br></p>Formule :C17H15I4NO4Couleur et forme :NeatMasse moléculaire :804.92Ondansetron-d3
CAS :Produit contrôlé<p>Applications Ondansetron-d3 is a labeled specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formule :C18H16D3N3OCouleur et forme :NeatMasse moléculaire :296.38Ethyl-S-(+)-Clopidogrel Sulfate
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formule :C17H20ClNO6S2Couleur et forme :White To Off-WhiteMasse moléculaire :433.932-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE
CAS :Degré de pureté :95.0%Masse moléculaire :176.58000183105471-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine 1-oxide (Imatinib Impurity)
CAS :Degré de pureté :98%Masse moléculaire :509.614Nitroso-Caffeidine
CAS :Produit contrôléFormule :C7H11N5O2Couleur et forme :NeatMasse moléculaire :197.2N-Hydroxymethyl Sumatriptan
CAS :Produit contrôlé<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Formule :C15H23N3O3SCouleur et forme :NeatMasse moléculaire :325.434-Chloro Kynurenine-13C2,15N
CAS :Produit contrôlé<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Formule :C813C2H11ClN15NO3Couleur et forme :NeatMasse moléculaire :245.643-Nitro-L-tyrosine-d3
CAS :Produit contrôlé<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formule :C9D3H7N2O5Couleur et forme :NeatMasse moléculaire :229.24-(4,6-Dimethoxypyrimidin-2-yl)benzoic acid
CAS :Formule :C13H12N2O4Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :260.2493-Des[2-(Dimethylamino)ethyl] Zolmitriptan 3-Acetic Acid
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications The indole acetic acid metabolite of Zolmitriptan (Z639000) formed by human hepatocytes.<br>References Wild, M.J. et al.: Xenobiotica, 29, 847 (1999);<br></p>Formule :C14H14N2O4Couleur et forme :NeatMasse moléculaire :274.273-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one Hydrochloride
CAS :Produit contrôlé<p>Impurity Ondansetron EP Impurity A/ Ondansetron USP Related Compound A<br>Applications 3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron EP Impurity A) is an impurity of Ondansetron (O655000), an antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackinnon, J.W.M., et al.: Eur. J. Cancer Clin. Oncol., 25, 61 (1989);<br></p>Formule :C16H20N2O·ClHCouleur et forme :NeatMasse moléculaire :292.80(E)-3-(2-chlorophenyl)-N-(4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)acrylamide
CAS :Degré de pureté :98%Masse moléculaire :414.85998535156256-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-9H-purine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :277.260009765625trans-Zeatin
CAS :Produit contrôlé<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>Formule :C10H13N5OCouleur et forme :NeatMasse moléculaire :219.24(S)-Tenofovir Disoproxil Fumarate
CAS :Produit contrôlé<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formule :C19H30N5O10P·C4H4O4Couleur et forme :White SolidMasse moléculaire :635.52Acetaldehyde 2,4-Dinitrophenylhydrazone
CAS :<p>Stability Hygroscopic<br>Applications Acetaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic alldehyde found in mainstream cigarette smoke. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zwiener, C. et al.: Anal. Bioanal. Chem., 372, 615 (2002); Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Formule :C8H8N4O4Couleur et forme :YellowMasse moléculaire :224.17Phenylhydrazine
CAS :Produit contrôlé<p>Applications An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lattova, E. et al.: Meth. Mol. Biol., 534, 65 (2009); Anderson, L.B. et al.: J. Biol. Chem., 275, 4920 (2000);<br></p>Formule :C6H8N2Couleur et forme :Yellowish LiquidMasse moléculaire :108.14Methotrexate
CAS :<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C20H22N8O5Couleur et forme :Yellow To Dark YellowMasse moléculaire :454.444-(2H-1,3-benzodioxol-5-yl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :319.364013671875Methotrexate-Cadaverine-Biotin Conjugate
Produit contrôlé<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C35H48N12O6SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :764.94-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester, 100 mg
CAS :<p>Impurity Oseltamivir EP Impurity D<br>Applications 4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester (Oseltamivir EP Impurity D) is an impurity in the antiviral drug Oseltamivir (O700100).<br></p>Formule :C11N13NO4Couleur et forme :NeatMasse moléculaire :223.23Pirimiphos-methyl, 90%
CAS :Produit contrôlé<p>Applications Pirimiphos-methyl is a phosphorothioate used as an insecticide. Pirimiphos-methyl is commonly used for mosquito control as well as control of greenhouse crop pests and stored-product insects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deighton, J. et al.: Mosq. News, 34, 163 (1974); LaHue, D.W.: J. Econ. Entomol., 68, 236 (1975); Antonious, G.F. et al.: J. Entomol. Sci., 30, 191 (1995):<br></p>Formule :C11H20N3O3PSDegré de pureté :90%Couleur et forme :ColourlessMasse moléculaire :305.33Urea-15N2
CAS :Produit contrôlé<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Formule :CH415N2OCouleur et forme :Off White SolidMasse moléculaire :62.04Guanosine-13C,15N2 Hydrate
CAS :Formule :CC9H1315N2N3O5·H2OCouleur et forme :NeatMasse moléculaire :304.244-([1,1'-Biphenyl]-4-yl)-6-chloro-2-phenylpyrimidine
CAS :Degré de pureté :95.0%Masse moléculaire :342.82998657226561-Methylurea
CAS :Degré de pureté :97.00%Couleur et forme :Solid, CrystallineMasse moléculaire :74.083000183105472-Amino-5-ethynylpyrimidine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :119.126998901367195-Nitro Nicotinic Acid
CAS :Produit contrôlé<p>Applications An intermediate in the synthesis of nicotinamide with potential anticoccidial activity.<br>References Morisawa, Y. et al.: J. Med. Chem., 20, 129 (1977);<br></p>Formule :C6H4N2O4Couleur et forme :NeatMasse moléculaire :168.11Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C12H21N·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :215.76Tenofovir
CAS :<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formule :C9H14N5O4PCouleur et forme :White To Off-WhiteMasse moléculaire :287.214-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Degré de pureté :95.0%Masse moléculaire :278.31500244140625N-Desmethyl Zolmitriptan
CAS :<p>Impurity Zolmitriptan USP Related Compound A<br>Stability Hygroscopic<br>Applications A metabolite of Zolmitriptan (Z639000). Zolmitriptan USP Related Compound A.<br>References Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 453 (2005),<br></p>Formule :C15H19N3O2Couleur et forme :NeatMasse moléculaire :273.33(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS :Produit contrôlé<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.217-Methyl Memantine Hydrochloride
CAS :<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C13H23N·ClHCouleur et forme :White SolidMasse moléculaire :229.79N'-Formylkynurenine
CAS :<p>Stability Hygroscopic<br>Applications N'-Formylkynurenine is a photooxidation product of Tryptophan (T947200), and is also used as a photosensitizer of near-ultraviolet radiation by generating singlet oxygen and superoxide.<br>References Grossweiner, L.: Curr. Eye Res., 3, 137 (1984); Møller, I. & Kristensen, B.: Free Radical Bio. Med., 40, 430 (2006); Pileni, M., et al.: J. Phys. Chem., 80, 1804 (1976)<br></p>Formule :C11H12N2O4Couleur et forme :Off White To Dark BeigeMasse moléculaire :236.225-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
CAS :Degré de pureté :95.0%Masse moléculaire :360.39599609375Nicotinamide-d4 N-Oxide (d4 Major)
CAS :Produit contrôlé<p>Applications A labelled metabolite of Nicotinamide.<br>References Musfeld, C., et al.: J. Pharm. Biomed. Anal., 24, 391 (2001), Sakakibara, Y., et al.: Brain Res., 931, 68 (2002), Zielonka, J., et al.: Chem. Res. Toxicol., 19, 668 (2006), Wieczorkowska, M., et al.: Pharmacol. Rep., 59, 216 (2007),<br></p>Formule :C6H2D4N2O2Couleur et forme :NeatMasse moléculaire :142.156-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
CAS :Formule :C5H4N2O3SCouleur et forme :No data available.Masse moléculaire :172.164,6-bis(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :259.3500061035156
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