Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
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3-Chlorodiphenylamine
CAS :Produit contrôlé<p>Applications 3-Chlorodiphenylamine (cas# 101-17-7) is a compound useful in organic synthesis.<br></p>Formule :C12H10ClNCouleur et forme :NeatMasse moléculaire :203.675-Acetylamino-6-formylamino-3-methyluracil
CAS :Produit contrôlé<p>Applications Metabolite of Caffeine (C080100).<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983),<br></p>Formule :C8H10N4O4Couleur et forme :Light Yellow SolidMasse moléculaire :226.197-Hydroxy Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of Memantine (M218000), used for the treatment of neurological disorders.<br>References Eiichi, K., et al.: Chem. Pharm. Bull., 33, 4680 (1985),<br></p>Formule :C12H21NO·ClHCouleur et forme :NeatMasse moléculaire :231.76Acetal
CAS :<p>Stability Volatile<br>Applications Acetal is a flavouring component of Baiju and Rum. It is also a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Franitza, Laura, et al.: J. of Agric. and Food Chem., 64(47), 9041-9053 (2016);<br></p>Formule :C6H14O2Couleur et forme :ColourlessMasse moléculaire :118.177-Hydroxy DAMPA
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of DAMPA.<br>References Bleyer, W., et al.: Cancer, 41, 36 ( 1978), Abelson, H., et al.: J. Clin. Oncol., 1, 208 (1983), Fabre, G., et al.: Biochem. Pharmacol., 35, 1325 (1986), Widemann, B., et al.: Clin. Chem., 45, 223 (1999),<br></p>Formule :C15H15N7O3Couleur et forme :YellowMasse moléculaire :341.324-Dimethylaminobutyraldehyde Diethyl Acetal
CAS :Produit contrôlé<p>Impurity Zolmitriptan USP Related Compound H<br>Applications 4-Dimethylaminobutyraldehyde Diethyl Acetal (Zolmitriptan USP Related Compound H) is used in the preparation of N,N-Dimethyltryptamines, 5-HT1D receptor agonists, for medicinal treatments such as antimigraine drugs.<br>References Chen, C. et al.: J. Org. Chem., 59, 3738 (1994);<br></p>Formule :C11H23NO2Couleur et forme :NeatMasse moléculaire :189.3N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester
CAS :Produit contrôlé<p>Applications N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester prorug of PMPA, phenyl monophosphoramidate, and is a Tenofovir (T018500) derivative, an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007), Lee, W. et al.: Antimicrob. Agents Chemother., 49, 1898 (2005);<br></p>Formule :C15H25N6O5PDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :400.37N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-methylbenzamide
CAS :Masse moléculaire :396.4700012207031MTIC-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Temozolomide, an antineoplastic.<br></p>Formule :C5H5D3N6OCouleur et forme :Off White SolidMasse moléculaire :171.18Methotrexate Triglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Applications Methotrexate Triglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C30H36N10O11xC2HF3O2Couleur et forme :NeatMasse moléculaire :712.67Ioxitalamic Acid-d4
CAS :Produit contrôlé<p>Applications A substituted 2,4,6-triiodobenzoic acid, an excellent contrast media for ventriculography, radiculography, lumbar myelography and x-rays of the cardiovascular system.<br>References Frocrain, L., et al.: Radiology, 170, 531 (1989), van Waes, P.F., et al.: Eur. J. Radiology, 9,179 (1989)<br></p>Formule :C12H7D4I3N2O5Couleur et forme :White To Light BrownMasse moléculaire :647.966-Mercaptopurine-13C2,15N (major)
CAS :Produit contrôlé<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Formule :C313C2H4N315NSCouleur et forme :NeatMasse moléculaire :155.16Memantine Lactose Adduct
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A lactose adduct of Memantine (M218000). Intermediate in the synthesis of reducing carbohydrate Adamantane amines for use in treating Gram positive or Gram negative bacteria infections.<br>References Kustimur, et al.: Chinese Med. J., 116, 633 (2003),<br></p>Formule :C24H41NO10Couleur et forme :NeatMasse moléculaire :503.582-Amino-6-mercaptopurine-9-D-riboside Hydrate
CAS :<p>Stability Hygroscopic<br>Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.<br></p>Formule :C10H13N5O4S·x(H2O)Couleur et forme :Light Yellow PowderMasse moléculaire :299.31N-Desacetyl 5-Azido Oseltamivir
CAS :Produit contrôlé<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),<br></p>Formule :C14H24N4O3Couleur et forme :NeatMasse moléculaire :296.373-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS :<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formule :C7H9N3O3Couleur et forme :WhiteMasse moléculaire :183.16Tenofovir
CAS :<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formule :C9H14N5O4PCouleur et forme :White To Off-WhiteMasse moléculaire :287.21Methotrexate-Cadaverine-Biotin Conjugate
Produit contrôlé<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C35H48N12O6SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :764.9Urea-15N2
CAS :Produit contrôlé<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Formule :CH415N2OCouleur et forme :Off White SolidMasse moléculaire :62.04Methotrexate
CAS :<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C20H22N8O5Couleur et forme :Yellow To Dark YellowMasse moléculaire :454.443-Nitro-L-tyrosine-d3
CAS :Produit contrôlé<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formule :C9D3H7N2O5Couleur et forme :NeatMasse moléculaire :229.2Nitroso-Caffeidine
CAS :Produit contrôléFormule :C7H11N5O2Couleur et forme :NeatMasse moléculaire :197.2Tenofovir Disoproxil Isopropoxycarbonyl
CAS :<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Formule :C23H36N5O12PCouleur et forme :White SolidMasse moléculaire :605.53(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS :Produit contrôlé<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.21Memantine Glycine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications An impurity of the antiparkinsonian and antispasmodic agent Memantine (M218000).<br>References Rystov, L. et al.: J. Pharmac. Biomed. Anal., 56, 887 (2011);<br></p>Formule :C14H23NO2Couleur et forme :NeatMasse moléculaire :237.341,3,7-Trimethyluric Acid-d3
CAS :Produit contrôlé<p>Stability Store in freezer<br>Applications A caffeine metabolite.<br>References Regal, K.A., et al.: J. of Chromatography B, 708, 75 (1998)<br></p>Formule :C82H3H7N4O3Couleur et forme :NeatMasse moléculaire :213.217-Methyl Memantine Hydrochloride
CAS :<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C13H23N·ClHCouleur et forme :White SolidMasse moléculaire :229.79Tenofovir Phosphate Diammonia Salt, >90%
CAS :Produit contrôlé<p>Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formule :C9H21N7O7P2Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :401.25Tri-POC Tenofovir Dimer (>90%)
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Tri-POC Tenofovir Dimer is a dimer of Tenofovir Disoproxil (T018505), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. It is also used in the preparation of phosphocitrate for the treatment of rheumatoid and osteoarthritis in the elderly.<br>References Turhanen, P. et al.: J. Org. Chem., 72, 1468 (2007);<br></p>Formule :C34H52N10O17P2Degré de pureté :>90%Couleur et forme :White To Light BeigeMasse moléculaire :934.78N'-Formylkynurenine
CAS :<p>Stability Hygroscopic<br>Applications N'-Formylkynurenine is a photooxidation product of Tryptophan (T947200), and is also used as a photosensitizer of near-ultraviolet radiation by generating singlet oxygen and superoxide.<br>References Grossweiner, L.: Curr. Eye Res., 3, 137 (1984); Møller, I. & Kristensen, B.: Free Radical Bio. Med., 40, 430 (2006); Pileni, M., et al.: J. Phys. Chem., 80, 1804 (1976)<br></p>Formule :C11H12N2O4Couleur et forme :Off White To Dark BeigeMasse moléculaire :236.22Tenofovir Isopropyl Ethyl Diester
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Tenofovir Disopropyl Ethyl Diester is an impurity of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C18H28N5O10PCouleur et forme :NeatMasse moléculaire :505.42(R)-9-[2-(Diethylphosphonomethoxy)propyl] Adenine
CAS :Produit contrôlé<p>Applications A acyclic phosphonate nucleotide.<br></p>Formule :C13H22N5O4PCouleur et forme :White SolidMasse moléculaire :343.32Urea-urethane Compound (~85%)
CAS :Produit contrôlé<p>Applications Urea-urethane Compound is a reaction product of 4,4'-sulfonylbis[benzenamine] and 2,4-TDI.<br></p>Formule :C42H36N6O8SDegré de pureté :~80%Couleur et forme :NeatMasse moléculaire :784.84Tri-o-tolyl-Phosphine Oxide
CAS :Produit contrôlé<p>Impurity Eletriptan Impurity 14<br>Applications Tri-o-tolyl-Phosphine Oxide (Eletriptan Impurity 14) is an impurity of Eletriptan, a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines.<br>References Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998); Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999); Goadsby, P.J., et al.: Neurology, 54, 156 (2000)<br></p>Formule :C21H21OPCouleur et forme :NeatMasse moléculaire :320.365Lifitegrast
CAS :Produit contrôlé<p>Applications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer.<br>References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);<br></p>Formule :C29H24Cl2N2O7SCouleur et forme :White To Off-WhiteMasse moléculaire :615.481Pemetrexed-13C5 Disodium Heptahydrate
CAS :Produit contrôlé<p>Applications Pemetrexed-13C5 Disodium Salt, is the labeled analogue of Pemetrexed Disodium (P219500), used as Antineoplastic agent.<br>References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),<br></p>Formule :C1513C5H19N5Na2O6•7(H2O)Couleur et forme :Off-WhiteMasse moléculaire :476.3471802D-Neopterin
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formule :C9H11N5O4Couleur et forme :NeatMasse moléculaire :253.21Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS :Produit contrôléFormule :C17H18N2O3SCouleur et forme :NeatMasse moléculaire :330.4DAMPA-d3
CAS :Produit contrôlé<p>Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formule :C152H3H12N7O2Couleur et forme :Dark OrangeMasse moléculaire :328.341-Methyl Xanthine-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Formule :C62H3H3N4O2Couleur et forme :NeatMasse moléculaire :169.16O-Desisobutyl-O-n-propyl Febuxostat
CAS :Formule :C15H14N2O3SCouleur et forme :NeatMasse moléculaire :302.35Tetrabenazine-d6
CAS :Produit contrôlé<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formule :C19H21D6NO3Couleur et forme :NeatMasse moléculaire :323.462-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)
CAS :Produit contrôlé<p>Impurity Sumatriptan EP Impurity A<br>Stability Light Sensitive<br>Applications 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.<br>References Skwierawska, A.. et al.: Poish. J. Chem., 77, 329 (2003);<br></p>Formule :C27H37N5O2SCouleur et forme :Off White SolidMasse moléculaire :495.68Methotrexate-d3 Diglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C25H26D3N9O8•x(C2HF3O2)•xH2SO4Couleur et forme :NeatMasse moléculaire :586.58114029815-Diazoimidazole-4-carboxamide
CAS :Produit contrôlé<p>Impurity Temozolomide USP Related Compound A<br>Applications Temozolomide USP Related Compound A<br></p>Formule :C4H3N5OCouleur et forme :NeatMasse moléculaire :137.103,4-Dihydro Naratriptan Oxalate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 3,4-Dihydro Naratriptan Oxalate is the basic form of 3,4-Dihydro Naratriptan(D449205); it is an impurity of Naratriptan (N378730), It is a triptan drug and is used for the treatment of migraine headaches.<br>References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),<br></p>Formule :C17H23N3O2S·C2H2O4Couleur et forme :White To Light YellowMasse moléculaire :333.45 + 90.036,6'-Binicotinic Acid
CAS :Produit contrôlé<p>Applications A Nicotinic acid (N429250) derivative for treatment of hypercholesterolemia and hyperlipidemia and cardiovascular disease.<br>References Hales, N.J., et al.: J. Med. Chem., 36, 3853 (1993),<br></p>Formule :C12H8N2O4Couleur et forme :NeatMasse moléculaire :244.20
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