Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
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8901 produits trouvés pour "Dérivés des Purines et Pyrimidines"
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Memantine Glycine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications An impurity of the antiparkinsonian and antispasmodic agent Memantine (M218000).<br>References Rystov, L. et al.: J. Pharmac. Biomed. Anal., 56, 887 (2011);<br></p>Formule :C14H23NO2Couleur et forme :NeatMasse moléculaire :237.349-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one
CAS :Degré de pureté :97%Masse moléculaire :270.2200012207031Methyl 2-(trifluoromethyl)pyrimidine-4-carboxylate
CAS :Degré de pureté :95.0%Masse moléculaire :206.12399291992188(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS :Produit contrôlé<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.211,3,7-Trimethyluric Acid-d3
CAS :Produit contrôlé<p>Stability Store in freezer<br>Applications A caffeine metabolite.<br>References Regal, K.A., et al.: J. of Chromatography B, 708, 75 (1998)<br></p>Formule :C82H3H7N4O3Couleur et forme :NeatMasse moléculaire :213.21Tenofovir Isopropyl Ethyl Diester
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Tenofovir Disopropyl Ethyl Diester is an impurity of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C18H28N5O10PCouleur et forme :NeatMasse moléculaire :505.42Tenofovir Disoproxil Isopropoxycarbonyl
CAS :<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Formule :C23H36N5O12PCouleur et forme :White SolidMasse moléculaire :605.53TERT-BUTYL 2-(6-AMINO-9H-PURIN-9-YL)ACETATE
CAS :Degré de pureté :95.0%Masse moléculaire :249.2740020751953Pemetrexed Sodium Methyl Ester
Produit contrôlé<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Formule :C21H22N5NaO6Couleur et forme :NeatMasse moléculaire :463.419MTIC
CAS :<p>Applications A metabolite of Temozolomide, an antineoplastic.<br></p>Formule :C5H8N6OCouleur et forme :Off-WhiteMasse moléculaire :168.16Ethyl-S-(+)-Clopidogrel Sulfate
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formule :C17H20ClNO6S2Couleur et forme :White To Off-WhiteMasse moléculaire :433.934-(3,4-dimethylphenyl)-6-(4-fluorophenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :293.34500122070314-(3,4-dimethylphenyl)-6-(3-methoxyphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :305.3810119628906Nitroso-Caffeidine
CAS :Produit contrôléFormule :C7H11N5O2Couleur et forme :NeatMasse moléculaire :197.24,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
CAS :Degré de pureté :98.0%Masse moléculaire :349.17001342773443-[(benzylcarbamoyl)amino]propanoic acid
CAS :Degré de pureté :97%Masse moléculaire :222.24400329589844N-Hydroxymethyl Sumatriptan
CAS :Produit contrôlé<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Formule :C15H23N3O3SCouleur et forme :NeatMasse moléculaire :325.434-Chloro Kynurenine-13C2,15N
CAS :Produit contrôlé<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Formule :C813C2H11ClN15NO3Couleur et forme :NeatMasse moléculaire :245.643-Nitro-L-tyrosine-d3
CAS :Produit contrôlé<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formule :C9D3H7N2O5Couleur et forme :NeatMasse moléculaire :229.2L-Phenylalanine-13C6
CAS :Produit contrôlé<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>Formule :C313C6H11NO2Couleur et forme :White To Off-WhiteMasse moléculaire :171.15Methotrexate
CAS :<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C20H22N8O5Couleur et forme :Yellow To Dark YellowMasse moléculaire :454.44Guanosine-13C,15N2 Hydrate
CAS :Formule :CC9H1315N2N3O5·H2OCouleur et forme :NeatMasse moléculaire :304.24DAMPA-d3
CAS :Produit contrôlé<p>Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formule :C152H3H12N7O2Couleur et forme :Dark OrangeMasse moléculaire :328.341-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
CAS :Degré de pureté :95.0%Masse moléculaire :396.450988769531254-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Degré de pureté :95.0%Masse moléculaire :278.315002441406252-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS :Degré de pureté :98.0%Couleur et forme :SolidMasse moléculaire :349.31698608398445-Nitro Nicotinic Acid
CAS :Produit contrôlé<p>Applications An intermediate in the synthesis of nicotinamide with potential anticoccidial activity.<br>References Morisawa, Y. et al.: J. Med. Chem., 20, 129 (1977);<br></p>Formule :C6H4N2O4Couleur et forme :NeatMasse moléculaire :168.11Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C12H21N·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :215.76Tenofovir
CAS :<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formule :C9H14N5O4PCouleur et forme :White To Off-WhiteMasse moléculaire :287.21Methotrexate-Cadaverine-Biotin Conjugate
Produit contrôlé<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C35H48N12O6SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :764.94-(5-methylthiophen-2-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :273.36999511718754-(Tert-butyl)-N-(4-(N-(2,6-dimethylpyrimidin-4-yl)sulfamoyl)phenyl)benzamide
CAS :Degré de pureté :98%Masse moléculaire :438.54998779296875N-Desacetyl 5-Azido Oseltamivir
CAS :Produit contrôlé<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),<br></p>Formule :C14H24N4O3Couleur et forme :NeatMasse moléculaire :296.373-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS :<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formule :C7H9N3O3Couleur et forme :WhiteMasse moléculaire :183.166-Methyl Nicotinic Acid
CAS :Produit contrôlé<p>Applications A degradation product of Nicotinic acid (N429250). An impurity of Nicotinic acid.<br>References Ensign, J., et al.: Biol. Chem., 239, 2285 (1964), Houghton, C., et al.: Biochem. J., 130, 879 (1972),<br></p>Formule :C7H7NO2Couleur et forme :NeatMasse moléculaire :137.146-Mercaptopurine Monohydrate
CAS :Produit contrôlé<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004),<br></p>Formule :C5H4N4S·H2OCouleur et forme :YellowMasse moléculaire :170.192-Amino-6-mercaptopurine-9-D-riboside Hydrate
CAS :<p>Stability Hygroscopic<br>Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.<br></p>Formule :C10H13N5O4S·x(H2O)Couleur et forme :Light Yellow PowderMasse moléculaire :299.31Memantine Lactose Adduct
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A lactose adduct of Memantine (M218000). Intermediate in the synthesis of reducing carbohydrate Adamantane amines for use in treating Gram positive or Gram negative bacteria infections.<br>References Kustimur, et al.: Chinese Med. J., 116, 633 (2003),<br></p>Formule :C24H41NO10Couleur et forme :NeatMasse moléculaire :503.58N-Desmethyl Zolmitriptan
CAS :<p>Impurity Zolmitriptan USP Related Compound A<br>Stability Hygroscopic<br>Applications A metabolite of Zolmitriptan (Z639000). Zolmitriptan USP Related Compound A.<br>References Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 453 (2005),<br></p>Formule :C15H19N3O2Couleur et forme :NeatMasse moléculaire :273.334-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester, 100 mg
CAS :<p>Impurity Oseltamivir EP Impurity D<br>Applications 4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester (Oseltamivir EP Impurity D) is an impurity in the antiviral drug Oseltamivir (O700100).<br></p>Formule :C11N13NO4Couleur et forme :NeatMasse moléculaire :223.235,6-dimethyl-2-(pyridin-2-yl)-1,4-dihydropyrimidin-4-one
CAS :Degré de pureté :95%Masse moléculaire :201.22900396-METHYL-N1-(3-METHYL-1-(6-(METHYLAMINO)PYRIMIDIN-4-YL)-1H-PYRAZOL-5-YL)BENZENE-1,3-DIAMINE
CAS :Degré de pureté :95.0%Masse moléculaire :309.377014160156256-Mercaptopurine-13C2,15N (major)
CAS :Produit contrôlé<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Formule :C313C2H4N315NSCouleur et forme :NeatMasse moléculaire :155.16Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
CAS :<p>Applications Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.<br>References Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005);<br></p>Formule :C18H21NO4SCouleur et forme :NeatMasse moléculaire :347.43Nicotinamide-d4 N-Oxide (d4 Major)
CAS :Produit contrôlé<p>Applications A labelled metabolite of Nicotinamide.<br>References Musfeld, C., et al.: J. Pharm. Biomed. Anal., 24, 391 (2001), Sakakibara, Y., et al.: Brain Res., 931, 68 (2002), Zielonka, J., et al.: Chem. Res. Toxicol., 19, 668 (2006), Wieczorkowska, M., et al.: Pharmacol. Rep., 59, 216 (2007),<br></p>Formule :C6H2D4N2O2Couleur et forme :NeatMasse moléculaire :142.15Ethyl 2-(2-(methylamino)pyrimidin-4-yl)-1H-indole-5-carboxylate
CAS :Degré de pureté :95.0%Couleur et forme :Liquid, No data available.Masse moléculaire :296.3299865722656
![9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF620788.webp&w=3840&q=75)
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