Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
Chez CymitQuimica, nous proposons des dérivés des purines et pyrimidines pour la recherche en biologie moléculaire, génomique et le développement de thérapies innovantes.
8901 produits trouvés pour "Dérivés des Purines et Pyrimidines"
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5-Nitro Nicotinic Acid
CAS :Produit contrôlé<p>Applications An intermediate in the synthesis of nicotinamide with potential anticoccidial activity.<br>References Morisawa, Y. et al.: J. Med. Chem., 20, 129 (1977);<br></p>Formule :C6H4N2O4Couleur et forme :NeatMasse moléculaire :168.114-Hydroxy-3,5-diiodobenzyl Alcohol
CAS :Produit contrôlé<p>Applications Intermediate in the production of Thyroxine<br></p>Formule :C7H6I2O2Couleur et forme :NeatMasse moléculaire :375.931-(5-Bromopyrimidin-2-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS :Degré de pureté :95.0%Masse moléculaire :291.1080017089844Fenclorim
CAS :Produit contrôlé<p>Applications Herbicide safener.<br>References Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005), Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007), Brazier-Hicks, M., et al.: J. Biol. Chem., 283, 21102 (2008), Vinggaard, A., et al.: Chem. Res. Toxicol., 21, 813 (2008),<br></p>Formule :C10H6Cl2N2Couleur et forme :BeigeMasse moléculaire :225.07N10-Methyl Pteroic Acid
CAS :<p>Impurity Methotrexate EP Impurity D<br>Applications N10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.<br>References Cramer, S., et al.: Cancer Res. 1984, 44, 1843 (1984), Hendel, J., et al.: Eur. J. Clin. Pharmacol., 26, 103 (1984),<br></p>Formule :C15H14N6O3Couleur et forme :Orange To Dark RedMasse moléculaire :326.31Theophylline-d6
CAS :Produit contrôlé<p>Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),<br></p>Formule :C72H6H2N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :186.206-Methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one
CAS :Degré de pureté :95.0%Masse moléculaire :187.20199584960938Lifitegrast
CAS :Produit contrôlé<p>Applications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer.<br>References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);<br></p>Formule :C29H24Cl2N2O7SCouleur et forme :White To Off-WhiteMasse moléculaire :615.481Pemetrexed-13C5 Disodium Heptahydrate
CAS :Produit contrôlé<p>Applications Pemetrexed-13C5 Disodium Salt, is the labeled analogue of Pemetrexed Disodium (P219500), used as Antineoplastic agent.<br>References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),<br></p>Formule :C1513C5H19N5Na2O6•7(H2O)Couleur et forme :Off-WhiteMasse moléculaire :476.34718021,3-Dimethyluric Acid
CAS :Produit contrôlé<p>Applications 1,3-Dimethyluric Acid, is a metabolite of Caffeine (C080100), that is shown to have some of Its similar effects.<br>References Kalow, W., et al.: Clin. Pharmacol. Ther., 53, 503 (1993), Sharma, S., et al.: Cancer Res., 54, 5848 (1994), Sugawara, M., et al.: J. Biol. Chem., 275, 16473 (2000), Takeda, M., et al.: J. Pharmacol. Exp. Ther., 302, 666 (2002),<br></p>Formule :C7H8N4O3Couleur et forme :NeatMasse moléculaire :196.165-(1-Biphenyl-4-yl-1H-tetrazol-5-yl)-4-methyl-pyrimidin-2-ylamine
CAS :Couleur et forme :SolidMasse moléculaire :329.36700439453125Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C12H21N·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :215.764-(6-BROMOIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE
CAS :Degré de pureté :95.0%Masse moléculaire :290.12399291992192,3-Diamino-6-(trifluoromethyl)-4(3H)-pyrimidinone
CAS :Formule :C5H5F3N4ODegré de pureté :99.0%Couleur et forme :SolidMasse moléculaire :194.1174-(3-fluorophenyl)-6-(furan-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :255.25199890136722-Oxo Clopidogrel Hydrochloride(Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>Formule :C16H17Cl2NO3SCouleur et forme :NeatMasse moléculaire :374.281-(1,3-Dioxolan-2-ylmethyl)-N-methyl-4-(methylamino)-1H-imidazole-5-carboxamide
CAS :Produit contrôléFormule :C10H16N4O3Couleur et forme :NeatMasse moléculaire :240.264-(3-Bromo-4-oxobutyl)benzoic Acid Methyl Ester
CAS :Produit contrôlé<p>Applications 4-(3-Bromo-4-oxobutyl)benzoic Acid Methyl Ester is used as a reagent in the synthesis of furoxanoxyalkyl esters of pemetrexed as antifolates and nitric oxide donors for use as anticancer agents and their activities against four human cancer cell lines.<br>References Min, T., et al.: Med. Chem. Res., 18, 495 (2009); Barnett, C.J., et al.: Org. Process Res. Dev., 3, 184 (1999)<br></p>Formule :C12H13BrO3Couleur et forme :NeatMasse moléculaire :285.13Caffeine-13C3
CAS :<p>Applications Caffeine-13C3 is a labelled analogue of Caffeine (C080100), a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants. In humans, caffeine acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. Caffeine is a cardiac and respiratory stimulant; diuretic. Caffeine is toxic at sufficiently high doses.A study at Johns Hopkins University indicates that caffeine can improve pattern separation memory.<br>References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988); Chem. and Eng. News p.34, Jan. 20, (2014)<br></p>Formule :C3C5H10N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :197.173-Iodo-L-tyrosine
CAS :Produit contrôléFormule :C9H10INO3Couleur et forme :NeatMasse moléculaire :307.09Uric Acid
CAS :<p>Applications Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006);<br></p>Formule :C5H4N4O3Couleur et forme :NeatMasse moléculaire :168.11Aminopterin
CAS :<p>Impurity Methotrexate EP Impurity B<br>Applications Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),<br></p>Formule :C19H20N8O5Couleur et forme :YellowMasse moléculaire :440.41Tenofovir
CAS :<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formule :C9H14N5O4PCouleur et forme :White To Off-WhiteMasse moléculaire :287.21Telbivudine-d3
CAS :Produit contrôlé<p>Applications Labelled nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.<br>References Standring, D.N., et al.: Antiviral. Chem. Chemother., 12, 119 (2001), Hernandez-Santiago, B., et al.: Antimicrob. Agents Chemother., 46, 1728 (2002), Lai, C.-L., et al.: Hepatology, 40, 719 (2004), Han, S.-H.B., et al.: Expert Opin. Invest. Drugs, 14, 511 (2005),<br></p>Formule :C10H11D3N2O5Couleur et forme :NeatMasse moléculaire :245.25Xanthine-13C15N2
CAS :Produit contrôlé<p>Applications Isotope labelled analog of Xanthine (X499950), a substance that can be found in animal organs, yeast, patatoes, coffee beans, tea. Xanthine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives that exhibits adenoside receptor antagonist properties.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>Formule :C413CH4N215N2O2Couleur et forme :Light Yellow To Light BeigeMasse moléculaire :155.09N-Demethyl Ondansetron
CAS :<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Formule :C17H17N3OCouleur et forme :White To BrownMasse moléculaire :279.341-Bromo-3-methyladamantane
CAS :Produit contrôléFormule :C11H17BrCouleur et forme :NeatMasse moléculaire :229.169-Propenyladenine
CAS :<p>Impurity Tenofovir Disoproxil USP Related Compound B<br>Applications 9-Propenyladenine (Tenofovir Disoproxil USP Related Compound B) is an N-substituted purine and an impurity of Tenofovir (T018500). Tenofovir Disoproxil Related Compound B ((E)-9-(Prop-1-enyl)-9H-purin-6-amine).<br>References Montgomery, J.A. et al.: J. Org. Chem., 30, 3235 (1965);<br></p>Formule :C8H9N5Couleur et forme :White To Light YellowMasse moléculaire :175.19Febuxostat 2-Butyl Isomer
CAS :Produit contrôlé<p>Applications Febuxostat 2-butyl Isomer is an impurity of Febuxostat (F229000) which is a xanthine oxidase/xanthine dehydrogenase inhibitor.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C16H16N2O3SCouleur et forme :NeatMasse moléculaire :316.371-(4-Methoxyphenyl)-2-pyrimidin-4-ylethanone
CAS :Formule :C13H12N2O2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :228.251Nicotinic Acid-13C6
CAS :<p>Applications Nicotinic Acid-13C6 is labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Formule :C6H5NO2Couleur et forme :NeatMasse moléculaire :129.072-pyrimidineacetic acid ethyl ester
CAS :Formule :C8H10N2O2Degré de pureté :97%Couleur et forme :LiquidMasse moléculaire :166.18Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
CAS :<p>Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C18H20N2O3SCouleur et forme :NeatMasse moléculaire :344.43D-Neopterin
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formule :C9H11N5O4Couleur et forme :NeatMasse moléculaire :253.21LY 368962
CAS :Produit contrôlé<p>Applications LY 368962 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Formule :C19H21N5O7Couleur et forme :NeatMasse moléculaire :431.402,2,2-Trichloro-acetic Acid
CAS :<p>Applications 2,2,2-Trichloro-acetic Acid is an acetic acid analogue used for the precipitation of macromolecules including proteins, DNA and RNA as well as for cosmetic treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wiley D. et al.: Clin. Infect. Dis., 35m S210 (2002);<br></p>Formule :C2HCl3O2Couleur et forme :Colourless To Off-WhiteMasse moléculaire :163.391-Methyl-4-[5-(2-methylsulfamoylethyl)-1H-indol-3-yl]pyridinium Chloride
Produit contrôlé<p>Impurity Naratriptan pyridinium Impurity<br>Stability Hygroscopic<br>Applications Naratriptan (N378730) impurity.<br></p>Formule :C17H20ClN3O2SCouleur et forme :NeatMasse moléculaire :365.883-Descyano Febuxostat
CAS :Produit contrôlé<p>Applications 3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Kadivar, M.H., et. al.: J. Pharmaceut. Biomed. Anal., 56, 749 (2011); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C15H17NO3SCouleur et forme :NeatMasse moléculaire :291.37Iopamidol-D3
CAS :Produit contrôlé<p>Applications Labelled nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982), Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982), Sovak, M., et al.: Radiology, 142, 115 (1982), Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988),<br></p>Formule :C17H19D3I3N3O8Couleur et forme :Off-WhiteMasse moléculaire :780.101-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
CAS :Degré de pureté :98.0%Masse moléculaire :339.190002441406253-(Formylamino)-1H-pyrazole-4-carboxamide
CAS :Produit contrôlé<p>Impurity Allopurinol EP Impurity B / Allopurinol USP Related Compound B<br>Stability Hygroscopic<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity B) is an impurity of Allopurinol (A547300) with inhibitory effects on human hypoxanthine phosphoribosyltransferase.<br>References Krenitzky, T.A. et al.: J. Biol. Chem., 244, 1263 (1969);<br></p>Formule :C5H6N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :154.1274-Chloro-5,6-dimethyl-2-(trifluoromethyl)-pyrimidine
CAS :Formule :C7H6ClF3N2Degré de pureté :97.0%Couleur et forme :LiquidMasse moléculaire :210.58Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS :Produit contrôléFormule :C17H18N2O3SCouleur et forme :NeatMasse moléculaire :330.45-[(1S)-1-(2-Chlorophenyl)-2-methoxy-2-oxoethyl]-6,7-dihydro-Thieno[3,2-c]pyridinium Bromide
CAS :Produit contrôléFormule :C16H15BrClNO2SCouleur et forme :NeatMasse moléculaire :400.724-Hydroxy-3-nitrophenylacetic Acid
CAS :Produit contrôlé<p>Applications A metabolite of Nitrotyrosine (N597000), which is excreted in the urine.<br>References van der Vliet, A., et al.: J. Biol. Chem., 272, 7617 (1997), Tabrizi-Fard, M., et al.: Drug Metab. Dispos., 27, 429 (1999), Souza, J., et al.: Arch. Biochem. Biophys., 380, 360 (2000),<br></p>Formule :C8H7NO5Couleur et forme :NeatMasse moléculaire :197.14
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