Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
Chez CymitQuimica, nous proposons des dérivés des purines et pyrimidines pour la recherche en biologie moléculaire, génomique et le développement de thérapies innovantes.
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3-(2-CHLOROPYRIMIDIN-4-YL)-1-(CYCLOPROPYLSULFONYL)-1H-INDOLE
Degré de pureté :95.0%Masse moléculaire :333.79000854492196-CHLORO-1-(4-METHOXYBENZYL)-3-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE
CAS :Degré de pureté :95.0%Masse moléculaire :280.7099914550781Zolmitriptan-d6 (Major)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formule :C16H15D6N3O2Couleur et forme :NeatMasse moléculaire :293.39Methotrexate γ-Methyl Ester
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity H<br>Applications Methotrexate γ-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C21H24N8O5Couleur et forme :NeatMasse moléculaire :468.47Regadenoson
CAS :Produit contrôlé<p>Applications Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).<br>References (1) Gao, Z., et al.: J Pharmacol Exp Ther. 298, 209 (2001) (2) Yuan, G., et al.: Expert Opin Drug Discov. 10, 63 (2015) (3) Jackson, S., et al.: J Neurooncol. 126, 433 (2016)<br></p>Formule :C15H18N8O5Couleur et forme :Off WhiteMasse moléculaire :390.356-Methylpurine
CAS :Produit contrôlé<p>Applications 6-Methylpurine (cas# 2004-03-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formule :C6H6N4Couleur et forme :NeatMasse moléculaire :134.14Methotrexate-d3 Hexaglutamate Trifluoroacetic Acid Salt
CAS :Produit contrôlé<p>Applications Methotrexate-d3 Hexaglutamate is the isotope labelled analog of Methotrexate Hexaglutamate (M260745); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C45H54D3N13O20•x(C2HF3O2)Couleur et forme :NeatMasse moléculaire :1103.0311402Sumatriptan-d6
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A serotonin 5HT1-receptor agonist. Antimigraine.<br>References Humphrey, P.P.A., et al.: Br. J. Pharmacol., 94, 1123 (1988),<br></p>Formule :C14H15D6N3O2SCouleur et forme :NeatMasse moléculaire :301.44LY-338979
CAS :<p>Applications LY 338979 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Formule :C20H21N5O7Couleur et forme :NeatMasse moléculaire :443.41Methopterine (>90%)
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity C; Methotrexate USP Related Compound C<br>Applications Methopterine (Methotrexate EP Impurity C) is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy. Methotrexate USP Related Compound C<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),<br></p>Formule :C20H21N7O6Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :455.42(S)-Tenofovir
CAS :Produit contrôlé<p>Applications (S)-Tenofovir is an S-enatiomeric derivative of Tenofovir (T018500). (S)-Tenofovir displays virucidal activity against herpes, visna virus and retrovirus. The S enantiomer of Tenofovir (T018500) is less effective against HIV than their (R)-enantiomeric counterparts.<br>References Balzarini, J. et al: Biochem. Biophys. Res. Comm., 219, 337 (1996); Balzarini, J. et al.: Antimicrob. Agents. Ch., 37, 332 (1993); Thormar, H. et al.: Antimicorb. Agents. Ch., 37, 2540 (1993)<br></p>Formule :C9H14N5O4PCouleur et forme :NeatMasse moléculaire :287.21Iopamidol
CAS :<p>Applications Nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982), Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982), Sovak, M., et al.: Radiology, 142, 115 (1982), Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988),<br></p>Formule :C17H22I3N3O8Couleur et forme :WhiteMasse moléculaire :777.096-Amino-2-methylpyrimidin-4-ol
CAS :Degré de pureté :95.0%Couleur et forme :LiquidMasse moléculaire :125.13099670410156Sulbutiamine
CAS :Produit contrôlé<p>Applications Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements.<br>References Micheau, J., et al.: Pharmacol. Biochem. Behav., 23, 195 (1985), Bettendorff, L., et al.: Biochem. Pharmacol., 40, 2557 (1990), van Reeth, O., et al.: Drugs Today, 35, 187 (1999),<br></p>Formule :C32H46N8O6S2Couleur et forme :Off WhiteMasse moléculaire :702.89β-Nicotinamide Mononucleotide
CAS :<p>Stability Very Hygroscopic<br>Applications A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.<br>References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);<br></p>Formule :C11H15N2O8PCouleur et forme :WhiteMasse moléculaire :334.22N-6-Benzyladenine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :225.2550048828125Nicotinic Acid-13C6
CAS :<p>Applications Nicotinic Acid-13C6 is labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Formule :C6H5NO2Couleur et forme :NeatMasse moléculaire :129.074-Hydroxy-3-nitrophenylacetic Acid
CAS :Produit contrôlé<p>Applications A metabolite of Nitrotyrosine (N597000), which is excreted in the urine.<br>References van der Vliet, A., et al.: J. Biol. Chem., 272, 7617 (1997), Tabrizi-Fard, M., et al.: Drug Metab. Dispos., 27, 429 (1999), Souza, J., et al.: Arch. Biochem. Biophys., 380, 360 (2000),<br></p>Formule :C8H7NO5Couleur et forme :NeatMasse moléculaire :197.144,6-Dihydroxypyrazolo[3,4-d]pyrimidine-13C,15N2
CAS :Produit contrôlé<p>Applications A labelled metabolite of Allopurinol.<br>References Marro, P., et al.: Brain Res., 650, 9 (1994), Abramov, A., et al.: J. Neurosci., 27, 1129 (2007), Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007),<br></p>Formule :CC4H415N2N2O2Couleur et forme :White To BeigeMasse moléculaire :155.09Caffeine-d3 (1-methyl-d3)
CAS :Produit contrôlé<p>Applications Caffeine-d3 (1-methyl-d3) (CAS# 26351-03-1) is a useful isotopically labeled research compound.<br></p>Formule :C8H7D3N4O2Couleur et forme :NeatMasse moléculaire :197.20L-Phenyl-d5-alanine-2,3,3-d3
CAS :Produit contrôlé<p>Applications L-Phenyl-d5-alanine-2,3,3-d3 is an isotope labelled compound of L-Phenylalanine (P319415). L-Phenylalanine (Aspartame EP Impurity C) is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame. Neuroprotective product.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>Formule :C9D8H3NO2Couleur et forme :NeatMasse moléculaire :173.24Ormetoprim
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>Formule :C14H18N4O2Couleur et forme :Off-WhiteMasse moléculaire :274.32N-(9-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
CAS :Degré de pureté :98%Masse moléculaire :373.3439941406254-(4-Methoxyphenyl)-2-(methylthio)pyrimidine
CAS :Degré de pureté :95.0%Masse moléculaire :232.3000030517578(R)-Methotrexate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications R-Methotrexate is an enantiomer of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C20H22N8O5Couleur et forme :Dark YellowMasse moléculaire :454.54Desisobutyl Febuxostat
CAS :Produit contrôléFormule :C12H8N2O3SCouleur et forme :Light Yellow SolidMasse moléculaire :260.276-[(E)-4-Hydroxy-3-methylbut-2-enylamino]-9-β-D-ribofuranosylpurine
CAS :Produit contrôlé<p>Applications A well-known, highly active stimulant of cell divisions in plant tissue cultures.<br>References D.S. Letham: Phytochemistry, 12, 2445 (1973)<br></p>Formule :C15H21N5O5Couleur et forme :NeatMasse moléculaire :351.363-Descyano-3-((hydroxyimino)methyl) Febuxostat
CAS :Produit contrôléFormule :C16H18N2O4SCouleur et forme :NeatMasse moléculaire :334.39Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS :Formule :C14H13NO4SCouleur et forme :NeatMasse moléculaire :291.32Methotrexate-d3 Triglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Methotrexate-d3 Triglutamate is the isotope labelled analog of Methotrexate Triglutamate (M260725); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C30H33D3N10O11(C2HF3O2)xCouleur et forme :NeatMasse moléculaire :715.69Isonicotinic Acid
CAS :<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>Formule :C6H5NO2Couleur et forme :Light BrownMasse moléculaire :123.11Tenofovir Disoproxil Fumarate
CAS :<p>Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C19H30N5O10P·C4H4O4Couleur et forme :White To Off-WhiteMasse moléculaire :635.51L-Aspartyl-L-phenylalanine Hydrochloride
CAS :Produit contrôlé<p>Applications L-Aspartyl-L-phenylalanine is an impurity of Thiamine (T344185). Thiamine Impurity B.<br>References Aluwihare, L., et al.: Science, 308, 1007 (2005), Koch, B., et al.: Anal. Chem., 79, 1758 (2007), Reemtsma, T., et al.: Environ. Sci. Technol., 42, 1430 (2008),<br></p>Formule :C13H16N2O5xHClCouleur et forme :NeatMasse moléculaire :280.28(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
CAS :Degré de pureté :97%Masse moléculaire :571.5609741210938Porphobilinogen
CAS :Produit contrôlé<p>Applications An intermediate in the biosynthesis of Heme, found in the urine of patients with acute porphyria.<br>References Westall, et al.: Nature, 170, 614 (1952), Cookson, R., et al.: Biochem, J., 57, 476 (1954), MacDonald, J., Can. J. Chem., 35, 715 (1957),<br></p>Formule :C10H14N2O4Couleur et forme :NeatMasse moléculaire :226.23Allopurinol
CAS :<p>Applications Allopurinol is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978); Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005); Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005);<br></p>Formule :C5H4N4OCouleur et forme :Off-WhiteMasse moléculaire :136.116-Methylmercaptopurine-d3
CAS :Produit contrôlé<p>Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.<br>References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),<br></p>Formule :C62H3H3N4SCouleur et forme :NeatMasse moléculaire :169.22Theophylline-13C2d6
CAS :Produit contrôlé<p>Applications Labelled Theophylline is a xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),<br></p>Formule :C513C2H2D6N4O2Couleur et forme :NeatMasse moléculaire :188.19Methotrexate-d3 Tetraglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Methotrexate-d3 Tetraglutamate is the isotope labelled analog of Methotrexate Tetraglutamate (M260730); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C35H40D3N11O14•(C2HF3O2)xCouleur et forme :NeatMasse moléculaire :844.87-Methyl Xanthine
CAS :Produit contrôlé<p>Applications Metabolite of Theophylline and Caffeine.<br>References Yu, Ch. et al.: J. Bacteriol. 191, 4624 (2009); Geraets, L. et al.: Biochem. Pharmacol. 72, 902 (2006).<br></p>Formule :C6H6N4O2Couleur et forme :NeatMasse moléculaire :166.14Paraxanthine-1-methyl-d3
CAS :Produit contrôlé<p>Applications An adenosine receptor ligand and a major metabolite of caffeine.<br>References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)<br></p>Formule :C72H3H5N4O2Couleur et forme :YellowMasse moléculaire :183.18N-Methylguanidine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications N-Methylguanidine is an alkylated guanidine which shows inhibitory action against trypsin catalysis. N-Methylguanidine inhibited metabolism of certain hepatic drugs that was mediated by cytochrome P 450 protein in human liver microsome and hepatocyte.<br>References Inagami, T. et al.: Biochemistry, 7, 4045 (1968); Hanada, K. et al.: Nephron, 103, 179 (2006);<br></p>Formule :C2H8ClN3Couleur et forme :NeatMasse moléculaire :109.56Tryptamine
CAS :<p>Applications Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.<br>References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1(2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)<br></p>Formule :C10H12N2Couleur et forme :YellowMasse moléculaire :160.22L-Phenylalanine-d7
CAS :Produit contrôlé<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>Formule :C9H4D7NO2Couleur et forme :NeatMasse moléculaire :172.23Pemetrexed Methyl Ester
CAS :Produit contrôlé<p>Applications Protected Pemetrexed.<br></p>Formule :C22H25N5O6Couleur et forme :NeatMasse moléculaire :455.4638Istradefylline
CAS :<p>Applications Istradefylline is a selective A(2A) antagonist used in the treatment of Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dungo, R. et al.: Drugs., 73, 875 (2013); Stoessel, A. et al.: J. Med. Chem., 56, 4580 (2013);<br></p>Formule :C20H24N4O4Couleur et forme :NeatMasse moléculaire :384.431,2,3,9-Tetrahydro-4H-carbazol-4-one
CAS :Produit contrôlé<p>Applications A carbazole derivative with antimycobacterial activity.<br>References Romeo, G., et al.: Bioorg. Med. Chem., 14, 5211 (2006),<br></p>Formule :C12H11NOCouleur et forme :BeigeMasse moléculaire :185.226-O-Methyl Guanosine
CAS :Produit contrôlé<p>Applications A guanine derivative that acts as modulators of GTPases and modulator-resistant enzymes; used in drug design and target validation.<br>References Goth-Goldstein, R., et al.: Cancer Res., 40, 2623 (1980), Nakabeppu, Y., et al.: J. Biol. Chem., 259, 13723 (1984), Modrich, P., et al.: Science, 266, 1959 (1994),<br></p>Formule :C11H15N5O5Couleur et forme :WhiteMasse moléculaire :297.27rac Tenofovir-d6
CAS :Produit contrôlé<p>Applications A deuterated acyclic phosphonate nucleotide analogue, reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C92H6H8N5O4PCouleur et forme :Off White SolidMasse moléculaire :293.25CAL-101
CAS :Produit contrôlé<p>Applications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.<br>References Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);<br></p>Formule :C22H18FN7OCouleur et forme :Light BrownMasse moléculaire :415.40
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