
Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65644 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Ethyl Ester
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Bendamustine (B132500) impurity.<br></p>Formule :C18H26ClN3O3Couleur et forme :NeatMasse moléculaire :367.87(S)-(-)-Tolvaptan
CAS :Produit contrôlé<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formule :C26H25ClN2O3Couleur et forme :Off White SolidMasse moléculaire :448.94Ticagrelor Acetate
CAS :Produit contrôlé<p>Applications Ticagrelor Acetoxide is an acetoxy impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formule :C25H30F2N6O5SCouleur et forme :White To Off-WhiteMasse moléculaire :564.61-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid
CAS :Produit contrôlé<p>Stability Hygroscopic, Moisture Sensitive<br>Applications 1-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Formule :C24H22ClNO10Couleur et forme :NeatMasse moléculaire :519.895-Ethyl-5-phenyl-2-(1-phenylpropyl)dihydropyrimidine-4,6(1H,5H)-dione (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Impurity Primidone EP Impurity F<br>Applications An impurity arising in the synthesis of Primidone.<br>References Pippenger, C.E., et al.: J. Anal. Toxicol., 1, 118 (1977),<br></p>Formule :C21H24N2O2Couleur et forme :NeatMasse moléculaire :336.43Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS :Formule :C18H16ClFN4O2Couleur et forme :NeatMasse moléculaire :374.8N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS :Produit contrôlé<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formule :C18H18D3N3O3SCouleur et forme :NeatMasse moléculaire :362.46trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol
CAS :Produit contrôlé<p>Applications trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is an impurity of Ketoconazole (K186000).<br>References Ryu, J., et al. Bull. Korean Chem. Soc., 24, 460 (2003)<br></p>Formule :C14H14Cl2N2O3Couleur et forme :NeatMasse moléculaire :329.182,5-Bis(trifluoromethyl)aniline
CAS :Produit contrôlé<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Formule :C8H5F6NCouleur et forme :ColourlessMasse moléculaire :229.12N,N’-Desethylene Levofloxacin Hydrochloride
CAS :<p>Impurity Levofloxacin USP Related Compound E<br>Applications Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution. Levofloxacin USP Related Compound E.<br>References Yoshida, Y., et al.: Arzneim.-Forsch., 43, 601 (1993),<br></p>Formule :C16H18FN3O4·ClHCouleur et forme :Off White SolidMasse moléculaire :371.79Hydrolyzed Pomalidomide M10
CAS :Produit contrôlé<p>Applications Hydrolyzed Pomalidomide M10 is an impurity of pomalidomide (P688200), which is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.<br>References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)<br></p>Formule :C13H13N3O5Couleur et forme :NeatMasse moléculaire :291.26N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide
CAS :Produit contrôlé<p>Applications N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.<br>References Edupuganti, R., et al.: Bioorg. Med. Chem., 25, 2609 (2017); Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formule :C29H31N5O2Couleur et forme :NeatMasse moléculaire :481.59Dutasteride-13C6
CAS :Produit contrôlé<p>Applications Labelled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Formule :C2113C6H30F6N2O2Couleur et forme :NeatMasse moléculaire :534.49Prochlorperazine Sulfoxide
CAS :Produit contrôlé<p>Applications A metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Formule :C20H24ClN3OSCouleur et forme :NeatMasse moléculaire :389.94Ezetimibe-13C6
CAS :Produit contrôlé<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formule :C1813C6H21F2NO3Couleur et forme :NeatMasse moléculaire :415.383-Hydroxy-4-methoxybenzaldehyde
CAS :Produit contrôléFormule :C8H8O3Couleur et forme :NeatMasse moléculaire :152.154-Isobutylamino-3-aminoquinoline
CAS :Produit contrôlé<p>Applications 4-Isobutylamino-3-aminoquinoline is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formule :C13H17N3Couleur et forme :NeatMasse moléculaire :215.29N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide
CAS :Produit contrôlé<p>Applications Sitagliptin intermediate.<br>References Sarges, R, et al.: J. Med. Chem., 33, 2240 (1990),<br></p>Formule :C6H9F3N4OCouleur et forme :NeatMasse moléculaire :210.16Flumequine Ethyl Ester
CAS :Produit contrôlé<p>Applications Flumequine Ethyl Ester is an impurity of Flumequine (F445000), a quinolone antibacterial.<br>References Stilwell, G., et al.: Antimicrob. Agents Chemother., 7, 483 (1975), Rohlfing, S.R., et al.: J. Antimicrob. Chemother., 3, 615 (1977),<br></p>Formule :C16H16FNO3Couleur et forme :NeatMasse moléculaire :289.30Telmisartan tert-Butyl Ester
CAS :Produit contrôlé<p>Impurity Telmisartan EP Impurity C<br>Applications Telmisartan tert-Butyl Ester (Telmisartan EP Impurity C) is an impurity of Telmisartan (T017000). Telmisartan impurity C.<br>References Ruth, R., et al.: J. Med. Chem., 39, 625 (1996), Merlos, M., et al.: J. Drugs Future, 22, 1112 (1997), Battershill, A., et al.: J. Drugs, 66, 51 (2006),<br></p>Formule :C37H38N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :570.72N-Nitroso Niraparib
Produit contrôléFormule :C19H19N5O2Couleur et forme :NeatMasse moléculaire :349.393-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
CAS :<p>Applications Sitagliptin intermediate.<br>References Mohri, K., et al.: Chem. Pharm. Bull., 30, 3097 (1982), Sarges, R., et al.: J. Med. Chem., 33, 2240 (1990), Cameron, M., et al.: J. Pharm. Biomed. Anal., 28, 137 (2002),<br></p>Formule :C6H7F3N4·ClHCouleur et forme :WhiteMasse moléculaire :228.60(±)-Epinephrine-2,5,6,α,β,β-d6
CAS :Produit contrôlé<p>Applications (±)-Epinephrine-2,5,6,alpha,beta,beta-d6 (CAS# 1219803-77-6) is a useful isotopically labeled research compound.<br></p>Formule :C92H6H7NO3Couleur et forme :NeatMasse moléculaire :189.24N-Triphenylmethyl-5-[4'-methylbiphenyl-2-yl]tetrazole
CAS :Produit contrôlé<p>Applications An intermediate in the preparation of Candesartan. Also used in the synthesis of novel biphenyltetrazole derivatives.<br>References Chao, S. et al.: J. Chin. Chem. Soc., 52, 539 (235);<br></p>Formule :C33H26N4Couleur et forme :NeatMasse moléculaire :478.59(±)-Oxomemazine
CAS :Produit contrôléFormule :C18H22N2O2SCouleur et forme :NeatMasse moléculaire :330.44Oprozomib
CAS :Produit contrôlé<p>Applications Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.<br>References Zang, Y., et al.: Autophagy., 8, 1837 (2012); Zang, Y., et al.: Clin. Cancer. Res., 18, 5639 (2012); Mato, A.R., et al.: Oncologist., 17, 694 (2012); Zhou, H.J., et al.: J. Med. Chem., 52, 3028 (2009);<br></p>Formule :C25H32N4O7SCouleur et forme :NeatMasse moléculaire :532.61(S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester
CAS :Produit contrôlé<p>Impurity Ambrisentan Hydroxyester Impurity<br>Applications (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester is an impurity in the synthesis of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive. (Ambrisentan Hydroxyester Impurity)<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formule :C17H18O4Couleur et forme :NeatMasse moléculaire :286.32O-Desbromo-pyrimidinyl Macitentan
CAS :Produit contrôléFormule :C15H19BrN4O4SCouleur et forme :NeatMasse moléculaire :431.3Lonafarnib
CAS :Produit contrôlé<p>Applications Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells<br>References Liu, M. et al.: Cancer Res., 58, 4947 (1998); Basso, A. et al.: J. Biol. Chem., 280, 31101 (2005); Sun, S. et al.: J. Biol. Chem., 282, 18800 (2007);<br></p>Formule :C27H31Br2ClN4O2Couleur et forme :NeatMasse moléculaire :638.823-Amino-4-methylbenzoic Acid
CAS :Produit contrôlé<p>Applications 3-Amino-4-methylbenzoic acid is used as a starting material to synthesize cyclopropamitosene compounds, which have potential antitumour activity. 3-Amino-4-methylbenzoic acid also has some partial herbicidal activity.<br>References Jones, G. & Moody, C.: J. Chem. Soc., Perkin Trans., 1, 2455 (1989); Thomas, G.: J. Agr. Food Chem., 32, 747 (1984)<br></p>Formule :C8H9NO2Couleur et forme :Light BrownMasse moléculaire :151.162-Nitrodeamino Fingolimod
CAS :Produit contrôlé<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formule :C19H31NO4Couleur et forme :NeatMasse moléculaire :337.455-Sulfosalicylic Acid Dihydrate
CAS :Produit contrôlé<p>Applications 5-Sulfosalicylic Acid Dihydrate is for reducing and fixation of proteins in agarose and polyacrylamide gels.<br></p>Formule :C7H6O6S·2H2OCouleur et forme :WhiteMasse moléculaire :254.213-Methyl-8-quinolinesulfonyl Chloride
CAS :Produit contrôlé<p>Stability Moisture Sensitive - Store Under Inert Atmosphere<br>Applications 3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.<br></p>Formule :C10H8ClNO2SCouleur et forme :NeatMasse moléculaire :241.69(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol
CAS :Produit contrôlé<p>Applications (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a building block used in organic synthesis including bein an intermediate in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formule :C8H7ClF2OCouleur et forme :NeatMasse moléculaire :192.59Nilvadipine
CAS :Produit contrôlé<p>Applications Used as an antihypertensive and antianginal.<br>References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)<br></p>Formule :C19H19N3O6Couleur et forme :NeatMasse moléculaire :385.37Perphenazine-d8 Dihydrochloride Salt (1.0 mg/mL in Methanol)
CAS :Formule :C21H18D8ClN3OS·2HClCouleur et forme :ColourlessMasse moléculaire :484.935-Methoxy-1-[4-(difluoromethyl)phenyl]-1-pentanone Oxime
CAS :Produit contrôlé<p>Applications Defluoro Fluvoxamine intermediate.<br></p>Formule :C13H17F2NO2Couleur et forme :NeatMasse moléculaire :257.28N-Nitroso Amodiaquine
Produit contrôléFormule :C20H21ClN4O2Couleur et forme :NeatMasse moléculaire :384.859(S)-Propyl Pramipexole
CAS :Produit contrôlé<p>Applications (S)- Propyl Pramipexole is (S)-Pramipexole (P700750) analogue. (S)-Pramipexole (P700750) is a dopamine-D2-receptor agonist. Antiparkinsonian. Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.<br>References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987);Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992);Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997);<br></p>Formule :C13H23N3SCouleur et forme :NeatMasse moléculaire :253.41Risperidone 9-Ethylidenecarboxylate Hydrochloride
Produit contrôlé<p>Applications Risperidone 9-Ethylidenecarboxylate Hydrochloride, is the derivative of Risperidone (R525000), which is combined serotonin (5-HT2) and dopamine (D2) receptor antagonist, used for the treatment of schizophrenia, bipolar disorder and behavior problems in people with autism.<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Formule :C25H27FN4O4Couleur et forme :NeatMasse moléculaire :466.503646Nitrofurantoin Monohydrate
CAS :Produit contrôlé<p>Applications 1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate (CAS# 17140-81-7) is a useful research chemical compound.<br></p>Formule :C8H8N4O6Couleur et forme :YellowMasse moléculaire :256.184’-Bromomethylbiphenyl-2-carboxylic Acid, Methyl Ester
CAS :Produit contrôléFormule :C15H13BrO2Couleur et forme :NeatMasse moléculaire :305.17Levofloxacin Hydrochloride
CAS :Formule :C18H20FN3O4·(HCl)Couleur et forme :White To Light BeigeMasse moléculaire :361.37 + (36.46)N-Sulfamoylethyl Naratriptan Pyridinium Chloride
CAS :Produit contrôlé<p>Impurity Naratriptan Impurity F<br>Stability Hygroscopic<br>Applications 4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium Chloride is an impurity of Naratriptan (N378730).<br></p>Formule :C20H27ClN4O4S2Couleur et forme :NeatMasse moléculaire :487.04OPC 3930
CAS :Produit contrôlé<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>Formule :C19H23N5O2Couleur et forme :NeatMasse moléculaire :353.42Nitroso Norquetiapine-d8
Produit contrôléFormule :C17D8H8N4OSCouleur et forme :NeatMasse moléculaire :348.4492-N-Propyl Pramipexole
CAS :Produit contrôlé<p>Impurity Pramipexole EP Impurity B; Pramipexole BP Impurity B<br>Applications 2-N-Propyl Pramipexole (Pramipexole EP Impurity B; Pramipexole BP Impurity B) is a Pramipexole derivative.<br></p>Formule :C13H23N3SCouleur et forme :NeatMasse moléculaire :253.411-Ethyl-2-[(methylamino)methyl]pyrrolidine
CAS :<p>Applications 1-Ethyl-2-[(methylamino)methyl]pyrrolidine is an intermediate of the neuroleptic drug Amisulpride (A633250).<br>References Tahara, T., et al.: Chem. Pharmaceut. Bull., 38, 1609 (1990);<br></p>Formule :C8H18N2Couleur et forme :Colourless OilyMasse moléculaire :142.242N,O-Diacetyl Pseudoephedrine
CAS :Produit contrôlé<p>Applications N,O-Diacetyl Pseudoephedrine is the diacetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br></p>Formule :C14H19NO3Couleur et forme :NeatMasse moléculaire :249.314,6-Dichloro-2-(propylthio)pyrimidin-5-amine
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Ticagrelor (T437700) and reversible P2Y12 receptor antagonists.<br>References Zhang, H. et al.; Bioorg. Med. Chem. Lett. 22, 3598 (2012); Springthorpe, B. et al.; Bioorg. Med. Chem. Lett. 17, 6013 (2007)<br></p>Formule :C7H9Cl2N3SCouleur et forme :NeatMasse moléculaire :238.14L-threo-Methylphenidate Hydrochloride
CAS :Produit contrôlé<p>Applications Controlled substance. CNS stimulant. The less potent threo-enantiomer of Methylphenidate. The threo enantomers have shown that the pharmacological activity residues predominantly in the d-threo enantiomer.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Formule :C14H19NO2·ClHCouleur et forme :NeatMasse moléculaire :269.77(S)-(-)-Felodipine
CAS :Produit contrôlé<p>Applications A dihydropyridine calcium channel blocker. Enantiomer S of Felodipine.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formule :C18H19Cl2NO4Couleur et forme :White To Off-WhiteMasse moléculaire :384.25Rivaroxaban N-Hydrolyse N-5-Chlorothiophene-2-carbaldehyde
CAS :<p>Stability Hygroscopic<br>Applications Rivaroxaban N-Hydrolyse N-5-Chlorothiophene-2-carbaldehyde is an intermediate in synthesizing Rivaroxaban Pseudodimer (R538015), which is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ansell, J., et al.: Drugs, 64, 1 (2004); Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005); Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005)<br></p>Formule :C24H21Cl2N3O7S2Couleur et forme :NeatMasse moléculaire :598.48(6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine
CAS :<p>Stability Hygroscopic<br>Applications (6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine can be obtained from (-)-2-Amino-6-propionamido-tetrahydrobenzothiazole (A628150) and is the byproduct of process for the preparation of pramipexole and salts thereof by reductive amination of (diamino)tetrahydrobenzothiazole with propanal. It is also a Pramaxo Impurity C.<br>References Deo, K., et al.: Indian Pat. Appl. (2015), IN 2013MU02843 A<br></p>Formule :C20H32N6S2Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :420.6383Haloperidol Decanoate
CAS :Produit contrôlé<p>Applications Antidyskinetic; antipsychotic.<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Formule :C31H41ClFNO3Couleur et forme :NeatMasse moléculaire :530.11N-Desethyl Sunitinib-d4 Maleate
CAS :Produit contrôlé<p>Applications N-Desethyl Sunitinib-d4 Maleate, is the labeled analogue of N-Desethyl Sunitinib (D289650), a metabolite of Sunitinib (S820000).<br>References Sun, L., et al.: J. Med. Chem., 46, 1116 (2003), Mendel, D.B., et al.: Clin. Cancer Res., 9, 327 (2003), Sistla, A., et al.: Drug Dev. Ind. Pharm., 30, 19 (2004), Sakamoto, K.M., et al.: Curr. Opin. Invest. Drugs, 5. 1329 (2004),<br></p>Formule :C20H19D4FN4O2•C4H4O4Couleur et forme :NeatMasse moléculaire :347.45116074'-Desmethoxy Omeprazole
CAS :Produit contrôlé<p>Applications 4'-Desmethoxy Omeprazole is one of two impurities in the synthesis of Esomeprazole, an anti-ulcerative drug for treatment of acid-related diseases.<br>References Liu, X., et al.: Lat. Am. J. Pharm., 34, 1265-1268 (2015);<br></p>Formule :C16H17N3O2SCouleur et forme :NeatMasse moléculaire :315.39Leflunomide EP Impurity F
CAS :Produit contrôléFormule :C12H9F3N2O2Couleur et forme :WhiteMasse moléculaire :270.212-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride
CAS :Produit contrôlé<p>Impurity Irbesartan Lactam Impurity<br>Applications 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one is an intermediate of Irbesartan (Avapro) (I751000).<br>References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999),<br></p>Formule :C11H18N2O·ClHCouleur et forme :NeatMasse moléculaire :230.73De(2,3-dihydroxy) Nadolol Hydrochloride
CAS :Produit contrôlé<p>Applications De(2,3-dihydroxy) Nadolol Hydrochloride is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Formule :C17H27NO2·ClHCouleur et forme :NeatMasse moléculaire :313.86N-(S)-Glycidylphthalimide
CAS :Produit contrôlé<p>Applications N-(S)-Glycidylphthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500).<br>References Rajesh, T. et al.: Pharm. Chem., 3, 168 (2011);<br></p>Formule :C11H9NO3Couleur et forme :WhiteMasse moléculaire :203.192-Amino-3-benzyloxypyridine
CAS :Produit contrôlé<p>Applications 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.<br>References Jen, T., et al.: J. Med. Chem., 20, 1258 (1977), Chung, D., et al.: Antican. Res., 11, 1373 (1991),<br></p>Formule :C12H12N2OCouleur et forme :NeatMasse moléculaire :200.24Isoproturon-d3
CAS :Produit contrôlé<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>Formule :C122H3H15N2OCouleur et forme :White To Off-WhiteMasse moléculaire :209.302-(Dimethylamino)thioacetamide Hydrochloride
CAS :<p>Impurity Nizatidine EP Impurity H<br>Applications 2-(Dimethylamino)thioacetamide (Nizatidine EP Impurity H) is used in the preparation of thiazole derivatives. 2-(Dimethylamino)thioacetamide is an impurity of the histamine H2-receptor antagonist Nizatidine (N598500).<br>References Johnson, R.A. et al.: J. Org. Chem., 57, 2869 (1992):<br></p>Formule :C4H10N2S·ClHCouleur et forme :NeatMasse moléculaire :154.66Everolimus Isomer C (>60%, contains everolimus)
CAS :Produit contrôlé<p>Stability Unstable in solution, revert back to Everolimus<br>Applications Everolimus Isomer C is an isomer of Everolimus (E945400), a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002)<br></p>Formule :C53H83NO14Couleur et forme :NeatMasse moléculaire :958.22Repirinast-d4
CAS :Produit contrôléFormule :C20H17D4NO5Couleur et forme :NeatMasse moléculaire :359.415-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS :Produit contrôlé<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>Formule :C14H11F3O5Couleur et forme :NeatMasse moléculaire :316.23Furagin-13C3
Produit contrôlé<p>Applications Furagin-13C3 is the isotope labelled analogue of the antibacterial Furagin (F863000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Agace, W., et al.: J. Clin. Invest., 92, 780 (1993); Lawrenson, R., et al.: J. Antimicrob. Chemother., 48, 895 (2001); Dalhoff, A., et al.: Lancet Infect. Dis., 3, 359 (2003); Thumbikat, P., et al.: J. Immunol., 176, 3080 (2006);<br></p>Formule :C713C3H8N4O5Couleur et forme :NeatMasse moléculaire :267.176-Hydroxy-7-methoxy-4(1H)-quinazolinone
CAS :Produit contrôlé<p>Applications 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.<br>References Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009); Tasler, S., et al.: Bioorg. Med. Chem. Lett., 17, 6728 (2009);<br></p>Formule :C9H8N2O3Couleur et forme :BeigeMasse moléculaire :192.17N-Desmethyl N-Nitroso Olopatadine-d3
Produit contrôléFormule :C20D3H17N2O4Couleur et forme :NeatMasse moléculaire :355.402Afoxolaner
CAS :Produit contrôléFormule :C26H17ClF9N3O3Couleur et forme :NeatMasse moléculaire :625.871-Nitroso-4-phenylpiperazine
CAS :Produit contrôlé<p>Applications Metabolite of N-Phenylpiperazine (P336040) found in wastewater treatment facilities.<br>References Jung, C. et al., Appl. Environ. Microb., 74, 6147 (2008)<br></p>Formule :C10H13N3OCouleur et forme :NeatMasse moléculaire :191.23N-Nitroso-1-(2-methoxyphenyl)piperazine
CAS :Produit contrôlé<p>Applications N-Nitroso-1-(2-methoxyphenyl)piperazine is a reagent used in the preparation of 9-aminoacridine-based agents that impair bovine viral diarrhea virus replication.<br>References Loddo, R. et al.: Bio. & Med. Chem., 26(4), 855-868, (2018)<br></p>Formule :C11H15N3O2Couleur et forme :Off-White To Light BrownMasse moléculaire :221.26Everolimus Retroaldol Degradation Product
CAS :Produit contrôlé<p>Impurity Everolimus Impurity<br>Stability Light and temperature Sensitive<br>Applications Everolimus Retroaldol Degradation Product is an impurity of Everolimus (E945400). Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Everolimus Impurity D<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>Formule :C53H83NO14Couleur et forme :NeatMasse moléculaire :958.22Denitro Tolcapone
CAS :Produit contrôléFormule :C14H12O3Couleur et forme :NeatMasse moléculaire :228.24Methyl 3,4,5-Tris(benzyloxy)benzoate
CAS :Produit contrôlé<p>Applications Intermediate in the production of Gallic Acid derivatives.<br>References Dodo, K., et al.: Bioorg. Med. Chem., 16, 7975 (2008), Dodo, K., et al.: Chem. Pharm. Bull., 57, 190 (2009),<br></p>Formule :C29H26O5Couleur et forme :NeatMasse moléculaire :454.51(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine(Mixture of 2 Diastereomers)
CAS :Produit contrôlé<p>Applications An impurity arising in the synthesis of Efavirenz (E425000).<br>References Chen, C., et al.: Enantiomer, 4, 599 (1999), Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Formule :C21H17ClF3NO2Couleur et forme :NeatMasse moléculaire :407.814-Cyano Loratadine
CAS :Produit contrôlé<p>Applications Intermediate for the synthesis of 4-Hydroxymethyl Loratadine.<br>References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).<br></p>Formule :C23H22ClN3O2Couleur et forme :NeatMasse moléculaire :407.89Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br></p>Formule :C16H13Cl2N5O2SCouleur et forme :NeatMasse moléculaire :410.28(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl
CAS :Produit contrôlé<p>Applications Tadalafil (T004500) derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity.<br>References Beghyn, T. et al.: Bioorgan. Med. Chem. Lett. 17, 789(2007)<br></p>Formule :C20H18N2O4Couleur et forme :Off White SolidMasse moléculaire :350.37Ticagrelor Sulfone
CAS :Produit contrôlé<p>Applications Ticagrelor Sulfone is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formule :C23H28F2N6O6SCouleur et forme :NeatMasse moléculaire :554.57Afatinib Impurity AFT-8
CAS :Produit contrôlé<p>Applications Afatinib Impurity AFT-8 is an impurity of its parent compound Afatinib (A355300), which is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Formule :C24H27ClFN5O4Couleur et forme :NeatMasse moléculaire :503.9544-(2-Nitrophenyl)morpholin-3-one
CAS :Produit contrôlé<p>Applications 4-(2-Nitrophenyl)morpholin-3-one is an intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985). 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.<br>References Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004); Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005)<br></p>Formule :C10H10N2O4Couleur et forme :NeatMasse moléculaire :222.2Desthiazolylmethyloxycarbonyl Ritonavir
CAS :Produit contrôléFormule :C32H45N5O3SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :579.802-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
CAS :Produit contrôlé<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>Formule :C16H19FN4O3Couleur et forme :NeatMasse moléculaire :334.353,3'-Disulfanediylbis[(2S)-2-methylpropanoic] Acid
CAS :Produit contrôléFormule :C8H14O4S2Couleur et forme :NeatMasse moléculaire :238.324-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS :Produit contrôlé<p>Applications 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.<br>References Liao, H., et al.: Tetrahedron: Asymmetry, 28, 105, (2017)<br></p>Formule :C13H10ClN3O2SCouleur et forme :NeatMasse moléculaire :307.76Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers)Mps1-IN-1 dihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Lisinopril (L468985) impurity.<br>References Drummer, O., et al.: Arzneim.-Forsch. Drug Res., 38, 647 (1988), Simpson, K., et al.: Drugs, 59, 1149 (2000),<br></p>Formule :C21H29N3O4Couleur et forme :NeatMasse moléculaire :387.47(±)-2-Phenylpropanoic Acid
CAS :<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>Formule :C9H10O2Couleur et forme :Light Yellow LiquidMasse moléculaire :150.174-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS :Produit contrôléFormule :C13H15N3O4Couleur et forme :Off WhiteMasse moléculaire :277.28Olanzapine Dimer Impurity
Produit contrôlé<p>Applications An impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formule :C29H28N6S2Couleur et forme :NeatMasse moléculaire :524.703Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
CAS :Produit contrôlé<p>Applications Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is an impurity of loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formule :C22H21ClN2O2Couleur et forme :NeatMasse moléculaire :380.874-Amino-2-fluoro-N-methylbenzamide
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Formule :C8H9FN2OCouleur et forme :NeatMasse moléculaire :168.172-(2,4-Difluorophenyl)-1,2,3-propanetriol
CAS :<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>Formule :C9H10F2O3Couleur et forme :NeatMasse moléculaire :204.17Sitagliptin N-Sulfate Sodium Salt
CAS :Produit contrôlé<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Formule :C16H15F6NaN5O4SCouleur et forme :NeatMasse moléculaire :509.36Verapamil Ethyl Methanethiosulfonate, Bromide
CAS :Produit contrôlé<p>Applications An analog of Verapamil. P Glycoprotein drug binding domain verapamil methanethiosulfonate. Useful for mapping the pore region of L-type calcium channels and Kv1.3 potassium channels.<br>References Loo, T., et al.: J. Biol. Chem., 270, 843 (1995), Sharom, F., et al.: J. Membr. Biol., 160, 161 (1997), Kim, R., et al.: J. Clin. Invest., 101, 289 (1998), Lee, C., et al.: Biochemistry., 37, 3594 (1998),<br></p>Formule :C30H45N2O6S2·BrCouleur et forme :NeatMasse moléculaire :673.72
