Dérivés de Quinazoline et de Quinoléine

<p>(3R,5R)-Pitavastatin Calcium Salt is a drug product that is used in the development of pharmaceuticals. It is a synthetic compound with an impurity standard and a metabolite impurity. The CAS number for this product is 254452-96-5. (3R,5R)-Pitavastatin Calcium Salt has been shown to be metabolized by CYP2C9 and CYP2C8 enzymes, which may result in a decrease in potency or activity. This product also has been shown to have anti-inflammatory properties and inhibit the production of inflammatory mediators such as prostaglandins and leukotrienes. (3R,5R)-Pitavastatin Calcium Salt was prepared by solid phase synthesis using a fluorous biphasic approach.</p>

<p>Please enquire for more information about N-Methyl omeprazole (Mixture of isomers with the methylated nitrogens of imidazole) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Desmethyltoremifene is an anti-estrogen that has been shown to have genotoxic effects. It inhibits DNA synthesis and protein synthesis in human breast cancer cells. N-Desmethyltoremifene is a potent inducer of CYP3A4, which metabolizes many drugs. This drug also binds to α1-acid glycoprotein, which can lead to reduced plasma concentrations and pharmacokinetics. N-Desmethyltoremifene has been shown to inhibit the growth of renal cell carcinoma in animals, but not normal tissue, at high doses.</p>

<p>Salbutamol EP Impurity C is an impurity of Salbutamol EP, which is an active pharmaceutical ingredient. It is a hydrophilic interaction chromatography and reverse-phase high-performance liquid chromatography method that can be used to screen for the presence of impurities in this product. The detection method is based on the use of a diode array detector with a synchronous detection mode. The column used in this screening process is a liquid chromatography column with a particle size of 5 microns and a length of 250 mm, which has been packed with 5% phenyl-95% dimethyl polysiloxane stationary phase. This process requires acetonitrile as the mobile phase, and the detection wavelength ranges from 220 nm to 240 nm.</p>

<p>Roflumilast Impurity B is an oxidative reagent that can be used for the preparation of a variety of organic compounds. It is a white solid that is soluble in organic solvents. Roflumilast Impurity B has been shown to be hepatotoxic, and should only be handled with gloves and lab coat. This material should not come in contact with skin or eyes. In addition, this reagent should not be exposed to light as it may cause photolysis.</p>

<p>Brexpiprazole impurity 3 is a drug product that has been custom synthesized for research purposes. The purity of this product is high and it has been analyzed using analytical methods. This product can be used to study the metabolism of brexpiprazole, which is an atypical antipsychotic medication. Brexpiprazole impurity 3 also has pharmacopoeia standards, which can be used to develop new drugs or as a quality control standard in research and development.</p>

<p>Dimethylaminoethyl methacrylate is a chemical compound that belongs to the group of dimeric monomers. It is an activated form of methacrylates, which are compounds containing the -C(O)OC-CH2-CH2-O-CO-R functional group. The activated form is prepared by the reaction of a primary amine with acetic acid and acrylic acid. Dimethylaminoethyl methacrylate has been used as a carbohydrate adduct to create glycoconjugates and it has been shown to have anti-mutagenic properties. This product can be found in high concentrations in China.</p>

<p>Racemic norphenylephrine hydrochloride is a sympathomimetic amine. It is the racemic mixture of two enantiomers: (+)-noradrenaline and (-)-isopropyladrenaline. Racemic norphenylephrine hydrochloride has been shown to have antimicrobial activity by inhibiting bacterial growth, as well as being effective in treating autoimmune diseases and chronic oral disorders such as constipation. Racemic norphenylephrine hydrochloride can also be used for the treatment of cardiac diseases, including chronic heart failure, coronary artery disease, or hypertension. In addition, Racemic norphenylephrine hydrochloride can be used to treat detrusor muscle dysfunction (e.g., urinary incontinence).</p>

<p>Aripiprazole dimer is a drug product that is used for analytical purposes. It is an impurity standard for the research and development of drugs. The CAS number for this compound is 1797986-18-5. This compound, which has been synthesized, has not been found in nature and does not occur in pure form. Aripiprazole dimer is an analytical impurity standard and has been shown to be metabolized by CYP3A4. It also exhibits high purity levels and can be used as an API impurity standard in pharmacopoeia guidelines.</p>

<p>3-amino-2,6-dimethoxy-4-(4-amino-7-hydroxy-6-methoxyquinazolin-2(1H)-yl)piperazine (DMQA) is a synthetic compound. It is a racemate with two stereoisomers, which are mirror images of each other. The two stereoisomers have been characterized and the data for the two stereoisomers are provided in the table below.</p>

<p>1-Glycoloyl-L-prolinamide is a drug product that is an analytical standard for the impurity 1-glycoloyl-L-proline (CAS No. 96166-39-1) in the API 1,4,5,6-tetrahydrobenzothiazole (CAS No. 86687-93-0). It has been synthesized to be used as an impurity standard and is provided at a purity of 98.0% or greater by weight. This chemical compound can be used in research and development for the production of drugs as well as in pharmaceutical manufacturing.</p>

<p>3-(Dimethylamino)-1-(2-thienyl)propan-1-ol is an organic compound that is used as a chiral building block in the synthesis of drugs. It is not currently used in any known drug, but it has been shown to be racemized at high temperatures. 3-(Dimethylamino)-1-(2-thienyl)propan-1-ol is also a byproduct of pollution and can be found in the environment where it may be degraded by bacteria.</p>

<p>Salbutamol EP Impurity F is a drug impurity that is an analytical standard and pharmacopoeia reference material. It is used in the manufacture of pharmaceuticals to ensure that the product meets quality standards. Salbutamol EP Impurity F has been shown to be a metabolite of salbutamol, which is produced as a result of oxidative metabolism by cytochrome P450 enzymes such as CYP3A4. The compound has also been observed in human urine and plasma.</p>

<p>4',4'''-[(4'-Methyl-2'-propyl[2,6'-bi-1H-benzimidazole]-1,1'-diyl)bis(methylene)]bis[1,1'-biphenyl]-2-carboxylic acid is an analytical reagent that is used in research and development as a drug product impurity standard. This compound has been shown to be metabolized by cytochrome P450 1A1 and 2C8 to form 4-hydroxybenzoic acid and 4,4''-[(4'-methyl-2' propyl-[2,6']bi-1H-benzimidazol-1,1' diyl)bis(methylene)]bis[3-(4-hydroxyphenyl)-propionic acid], respectively. 4',4''-[(4'-Methyl-2' propyl-[2,6']bi-1</p>

<p>Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea following</p>

<p>Imatinib is a drug substance that belongs to the class of imidazole and phenylpiperidine derivatives. It is used in the treatment of leukemia and other cancers. Imatinib has been shown to inhibit tumor cell proliferation by inhibiting protein synthesis via inhibition of ribosomal activity, leading to cell death. Imatinib also inhibits the activation of PPARγ, an important transcription factor involved in lipid metabolism. The presence of impurities may affect the therapeutic efficacy or safety of this drug, so it is important to know what impurities are present in order to avoid unexpected side effects.</p>

<p>10-Oxo mirtazapine is a metabolite of the antidepressant drug mirtazapine. It is an impurity in the HPLC standard for mirtazapine and has been shown to be pharmacologically active in animal models. 10-Oxo mirtazapine has also been found to be an impurity in other drugs, such as fluoxetine hydrochloride, but it is not known if it has any activity.</p>

<p>Loxoprofen Related Compound 2 is a mixture of diastereomers that is an impurity in the drug product, Loxoprofen. Loxoprofen Related Compound 2 is a metabolite of loxoprofen and its concentration in blood plasma after administration of loxoprofen can be used as an indicator for pharmacokinetics. The compound has been shown to inhibit the activity of bacterial dna gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. Loxoprofen Related Compound 2 was found to be less active than loxoprofen against MRSA and Clostridium perfringens, although it was more active than loxoprofen against Mycobacterium tuberculosis, Mycobacterium avium complex, and methicillin-resistant Staphylococcus aureus (MRSA).</p>

<p>2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid benzyl ester hydrobromide is a drug product that is used as an analytical reference standard for the identification of impurities in aminoglycosides. 2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid benzyl ester hydrobromide is a synthetic compound that has been shown to be metabolized in vivo to 3-(2,4-dichlorophenoxy)propionic acid and 3-(2,4-dichlorophenoxy)acrylic acid. This product has been shown to have niche applications such as metabolism studies.</p>

<p>Alverine EP Impurity E is a nitrogen containing compound with the molecular formula C9H10N. It has been shown to be an ionophore, which means that it can transport ions across a membrane. Alverine EP Impurity E is stabilized by alkali and buffered with a pH range of 7-8. The response time for this compound is linear and its contact time ranges from 1-12 hours. This impurity has a phenyl group and a ph range of 6-7. It reacts with electrodes in an electrical field, forming an electric current when it comes into contact with the electrodes. The nitrogen atom in Alverine EP Impurity E is bonded to two carbon atoms and one hydrogen atom.</p>

<p>Roflumilast is a drug used to treat chronic obstructive pulmonary disease. It is also used to treat inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Roflumilast inhibits the enzyme cytochrome P450 in the liver, which is responsible for metabolizing certain drugs and other substances. This inhibition reduces the metabolism of these substances, leading to increased levels of these substances in the body. This can lead to side effects such as nausea, vomiting, dizziness, headache, and itching. Roflumilast also has an anti-inflammatory effect on the intestines by regulating the production of inflammatory cytokines and inhibiting the activity of pro-inflammatory enzymes.</p>

<p>Please enquire for more information about (2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Deacetyl-3-butanoyl acebutolol hydrochloride is a racemic mixture of two enantiomers, (+)-(S)-3-Deacetyl-3-butanoyl acebutolol and (-)-(R)-3-Deacetyl-3-butanoyl acebutolol. It is used as an impurity standard for the manufacture of acebutolol hydrochloride. The substance has a purity of at least 99% by HPLC. 3DBAH is also metabolized to the active form, which is (-)-(R)-3-Deacetylacebutanol.</p>

<p>Cinacalcet is a drug product that is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. Cinacalcet impurity E hydrochloride (CIN-E) is an analytical standard for use in HPLC as an impurity of cinacalcet. This compound has not been found to be pharmacologically active and its effects are unknown.</p>

<p>4-Methyl-3-[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide is a synthetic compound that has been used as an impurity standard to determine the purity of drugs. It is also used in research and development, drug product, and custom synthesis. 4-Methyl-3-[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide has a CAS number of 851137-91-2 and is on the list of pharmacopoeias. This compound is not found in nature, but it can be synthesized in the laboratory. Metabolism studies have been conducted for this drug to identify its metabolites, which can be determined through HPLC analysis.</p>

<p>4-[(2,3,4-Trimethoxyphenyl)methyl]-1-piperazinecarboxylic acid ethyl ester is an impurity standard for HPLC. It is a white or off-white solid that is soluble in organic solvents. The compound has been shown to be a metabolite of the drug product, and can also be found as an impurity in the API. 4-[(2,3,4-Trimethoxyphenyl)methyl]-1-piperazinecarboxylic acid ethyl ester can be synthesized from 2,3,4-trimethoxybenzoic acid and 1-(2-chloroethyl)piperazine.</p>

<p>Please enquire for more information about Losartan azide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,1-Bis-(methylthio)-2-nitroethene is a versatile molecule that can be used as an imine. It is synthesized by reacting trifluoromethanesulfonic acid with the amine in the presence of a base. The imine product has been shown to bind to amines and is therefore a potential drug candidate for prostate cancer cells. 1,1-Bis-(methylthio)-2-nitroethene reacts with triflic acid to produce an intramolecular hydrogen bond, leading to its efficient synthesis. The resulting compound then undergoes reactions that are characterized by nmr spectra and profiles. This functional group is inhibitory against prostate cancer cell lines at high concentrations, although it has no effect on other cell lines.</p>

<p>Indoxacarb is a racemic compound that is used as an insecticide. It belongs to the class of carbamate insecticides and is marketed under the trade name of "Provaunt". Indoxacarb inhibits acetylcholinesterase, which leads to increased acetylcholine in the synapse, resulting in death. The production of indoxacarb has been optimized to yield a high-level of stereoselectivity. This optimization was achieved through a biocatalytic process that uses a strain of Escherichia coli with high stereoselectivity. This strain produces indoxacarb with a high level of stereoselectivity, which can be confirmed by NMR analysis.</p>

<p>Please enquire for more information about Benserazide EP Impurity B hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol is a polymerase chain reaction (PCR) reagent that is used as a building block for the synthesis of five membered ring lactams and dihedral polymers. This compound is synthesized by chemoenzymatic coupling of propanamine with trifluoroacetic acid in the presence of methyl groups, followed by catalytic hydrogenation to yield the desired product. The asymmetric synthesis of this compound was achieved through chiral resolution using NMR spectroscopy.</p>

<p>(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.</p>

<p>N-(4-Amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine formamide hydrochloride is an impurity in the synthesis of N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N'-methylpropylenediamine formamide hydrochloride. It is a white solid that can be used as an analytical reference standard for HPLC. It has been detected in the urine of people taking this drug and can be used to identify the presence of this drug in urine samples.</p>

<p>Sitagliptin is an oral dipeptidyl peptidase-4 inhibitor that is used to treat type 2 diabetes. It binds to the active site of the enzyme and reversibly blocks the action of the enzyme, thereby inhibiting the breakdown of a number of important hormones such as glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide. Sitagliptin hydroxy amide impurity is an impurity in sitagliptin that inhibits oxidoreductases, enzymes that catalyze oxidation reactions. The enantiomeric purity of sitagliptin hydroxy amide impurity is unknown.</p>

<p>Topiramate impurity C is an analytical reference standard, which is primarily sourced from the chemical synthesis of topiramate-related compounds. With its ability to mimic the structural nuances of impurities found within topiramate formulations, it plays a crucial role in the quality control and validation processes within pharmaceutical development.Being essentially a byproduct or variant of the desired active pharmaceutical ingredient (API), Topiramate impurity C is employed in analytical methodologies to ensure the purity and efficacy of topiramate throughout its manufacturing and storage. Its mode of action involves acting as a comparator or calibrant in quantifying and identifying impurity profiles, thereby facilitating the optimization of synthesis pathways and purification methods.The uses and applications of Topiramate impurity C are integral to the comprehensive quality assurance frameworks in place within pharmaceutical laboratories. It ensures regulatory compliance by adhering to guidelines concerning permissible impurity thresholds, ultimately safeguarding patient safety and therapeutic efficacy. Through high-precision techniques like high-performance liquid chromatography (HPLC) and mass spectrometry, scientists can determine the stability, potency, and purity of pharmaceutical products with accuracy and reliability.</p>

<p>N-[(6-Chloropyridin-3-yl)methyl]-N-methylacetamide (CAS No. 864628-19-3) is a drug product that has a natural and synthetic origin. Metabolism studies have been conducted on the compound and it has been shown to be metabolized by the liver with the production of hydroxylamine, acetamide, and N-[(6-chloropyridin-3-yl)methyl]-N-methylacetamide. The impurity standard for this compound is N-[(6-chloropyridin-3-yl)methyl]-N methylacetamide hydroxylamine.</p>

<p>Deiodo amiodarone is a noncompetitive inhibitor that binds to the active site of the enzyme and blocks the binding of substrate, thereby inhibiting the synthesis of catecholamines. Deiodo amiodarone has been shown to inhibit the oxidation of benzofuran derivatives in rat liver microsomes, human liver tissue samples, and chromatographic conditions. The inhibition constant for deiodo amiodarone was determined by liquid chromatography with a homogenizing technique.</p>

<p>1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[(4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methylsulfonyl]-1H-benzimidazole (MKC1807) is a synthetic drug product. MKC1807 is an analytical standard in the HPLC assay for the determination of Epiandrosterone sulfate and its metabolites. 1-[4-(3-Methoxypropoxy)-3,5,6,7,8 -pentamethylcyclohexyl]methyl 2-[(4-(3 -methoxypropoxy) 3,5,6,7,8 -pentamethylcyclohexyl)methylsulfonyl]-1H benzimidazole has been shown to be a natural metabolite of Epiandrosterone sulfate. This compound</p>

<p>3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride is a sulfoxide that is used as a solvent. It has been used in the synthesis of benzylsulfoxides and solvents for the manufacture of pharmaceuticals. 3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride is also a potent compound, which is structurally similar to benzene but with an additional methyl group. 3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride has been used in the synthesis of melphalan and elemental analysis. The chloride group on its structure makes it soluble in water and organic solvents such as acetonitrile. 3-(Dimethylamino)-1-(2-thienyl)propanone hydrochloride can be synthesized by reacting nitric acid with 2-aminothiophenol and dimethylanil</p>

<p>Dasatinib is a cancer drug that is used to treat patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. It inhibits the activity of tyrosine kinases, in particular Bcr-Abl and Src. Dasatinib is a structural analog of imatinib, which has been shown to be effective against chronic myeloid leukemia by inhibiting the activity of Bcr-Abl. Dasatinib impurity is an unwanted substance found in dasatinib. It can be synthesized from formic acid, chloride and chlorine using a series of industrial processes. The salt form of dasatinib impurity is acidic and synthetic.</p>

<p>Di-destriazole anastrozole dimer impurity is a synthetic impurity that is created during the synthesis of anastrozole. It has been studied as a possible metabolite of the drug, but its role in metabolism is not well understood. Di-destriazole anastrozole dimer impurity is soluble in water and methanol and has a melting point of between 1°C to 2°C. The purity of this compound is typically at least 99% with a specific gravity of 1.043 g/mL.</p>

<p>2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-oxide is a peroxide that is used in pharmaceutical preparations as an antioxidant. It is a white solid that is insoluble in water and has a molecular weight of 168.13. 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-oxide has been shown to be effective against the development of cholesterol gallstones and can be used as a prophylactic agent against cardiovascular disease. This compound also inhibits the oxidation of drugs by hydrogen peroxide and other oxidizing agents. 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)eth</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-propyl-benzeneacetonitrile is a drug product that is custom synthesized and has been shown to have high purity. It is also used in analytical studies, metabolism studies, and natural drug development. This compound can also be found as an impurity standard for HPLC or as an API impurity.</p>

<p>rac-N-Desisopropyl-N-ethyl acebutolol is a synthetic drug product. It is an analytical standard for the impurity, acebutolol, and is metabolized by cytochrome P450 3A4 to form the major metabolite, N-desisopropyl acebutolol. rac-N-Desisopropyl-N-ethyl acebutolol is a research and development product that can be custom synthesized to meet specific needs. It has been shown to have antihypertensive properties in rats and monkeys. This product is not intended for human use.</p>

<p>A custom synthesis of 6,7,8,9-tetrahydro-3-[2-[4-(6-methoxy-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-4H-[1]pyrido[1,2-a]pyrimidin-4one<br>A synthetic analog of the natural product erythromycin A.<br>Metabolite: 3-[2-[4-(6-Methoxybenzo[d][1,3]dioxol-5(4H)-yl)-1piperidinyl)ethyl]-6,7,8,9 tetrahydro 4H pyrido [1',2' a] pyrimidin 4 one<br>Impurity: 1-(6 methoxy benzisoxazol 3 yl) piperidine<br>Custom synthesis: yes<br>High purity: yes</p>

<p>Cetirizine impurity C is a potential impurity of cetirizine. It is used in the synthesis of cetirizine and as a drug substance. Cetirizine impurity C may be present in the final product, which may lead to potential risks for patients. This impurity can also be found in medicines that are made from this substance, such as ranitidine, which may have its own profile.</p>

<p>Levofloxacin is a synthetic fluoroquinolone antibiotic. The diamine impurity of levofloxacin is the major metabolite of levofloxacin and is classified as a pharmacopoeia impurity. Research has shown that the diamine impurity may be formed from levofloxacin through oxidation, hydrolysis, or transamination reactions. Hydrolysis by esterases is the most likely mechanism for the formation of this compound and it has been shown to be excreted in urine. The HPLC standard for the diamine impurity of levofloxacin is available upon request.</p>

<p>4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride is a synthetic drug product that has been purified to high purity. This compound is used as an analytical standard and impurity in the development of drugs. 4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride is a metabolite of imidazole, which is a natural substance with unknown pharmacological activity. It has been found to be an impurity in the synthesis of various pharmaceuticals, including metronidazole and ampicillin. This product has not yet been evaluated for safety or efficacy in humans.</p>

<p>3-O-Desethyl-5-O-desmethyl amlodipine is a drug product that can be used as an analytical reference standard. It is metabolized in vivo to form 5-O-desmethyl amlodipine, which is the active form of this drug. 3-O-Desethyl-5-O-desmethyl amlodipine is also an impurity in the drug product Amlodipine besylate and its CAS number is 1821498-25-2. The synthetic route for this compound starts with the reaction of 2,3,4,6 trichlorobenzeneethanol with sodium hydroxide followed by hydrogenation of the intermediate to yield 3-(2,6 dichlorophenyl) propanoic acid. This acid was then reacted with methylamine to yield 3-(2,6 dichlorophenyl)-N-[(methylamino) methyl]propionamide.</p>

<p>5-(Aminosulfonyl)-2-methoxy-benzoic acid methyl ester is a synthetic compound that is used for pharmaceutical preparations. It is typically prepared by the reaction of ethylene and chloroacetic acid in the presence of an organic solvent. The reaction time can be adjusted to produce the desired amount of 5-(aminosulfonyl)-2-methoxy-benzoic acid methyl ester. This synthetic compound has been shown to have a high yield, with minimal contaminating impurities. It has also been shown to be effective in both pharmaceutical dosage and calibration.</p>

<p>Citalopram N-oxide hydrochloride is the n-oxide form of the antidepressant drug citalopram. It is a metabolite of citalopram that has been shown to have higher activity than the parent compound. The presence of citalopram N-oxide was detected in plasma samples using liquid chromatography with a wavelength of 220 nm and diethylamine as an eluent. Citalopram N-oxide hydrochloride has been shown to be pharmacologically active in animal studies, but its effects are not well understood.</p>

<p>Risperidone N-oxide is a prodrug of risperidone. It is prepared by reacting risperidone with methanol and hydrogen peroxide in the presence of piperidine, followed by purification using preparative high-performance liquid chromatography. Risperidone N-oxide is a crystalline solid with a melting point of about 190 °C. Risperidone N-oxide has been shown to have antiemetic properties, which may be due to its ability to block dopamine receptors in the brain. The drug also shows some antipsychotic activity, and it has a constant therapeutic effect against schizophrenia. The major impurities found in risperidone N-oxide are hydroxylamine and piperidine.</p>

<p>Lisinopril diketopipirazine is an analytical drug product. The CAS number for this product is 219677-82-4. This product requires a custom synthesis and impurity standard. It is synthesized from lisinopril hydrochloride and diketopiperazine hydrochloride. Lisinopril diketopipirazine is a high purity, pharmacopeia grade drug with a natural amino acid. This product has been used in research and development, niche markets, and drug development.</p>

<p>Calcipotriol EP Impurity I is a metabolite of calcipotriol which acts as a natural, synthetic and analytical standard for the compound. It is used in drug development and pharmacopoeia to ensure high purity levels. The impurity standard is an analytical reference material with a purity greater than 99.5% and contains no more than 10% of any other impurity.</p>

<p>3'-Acetyl-4'-(2,3-epoxypropoxy)butyranilide is an impurity found in the drug product of 3'-acetyl-4'-(2,3-epoxypropoxy)butyranilide hydrochloride. It has a molecular weight of 268.9 and chemical formula C12H18O6N2. 3'-Acetyl-4'-(2,3-epoxypropoxy)butyranilide is a synthetic compound that can be used as an analytical reference material for HPLC standardization or as an impurity standard for synthesis.</p>

<p>2-[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is a synthetic, impurity standard that is used in the synthesis of drug products. It has been shown to inhibit the metabolism of drugs and may be used as a marker for drug metabolism. This compound may also be used as a marker in analytical studies to assess the purity of a drug product. 2-[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole has not been evaluated for safety or efficacy.</p>

<p>2-[(4-Chloro-3-methyl-2-pyridinyl)methylthio]-1H-benzimidazole is a drug product. It is an impurity standard for the analytical determination of 2-[(4-chloro-3-methylpyridin)-2yl]thiohydantoin in pharmaceuticals and other chemical products. This compound is also used as a research and development (R&amp;D) metabolite and impurity standard for the synthesis of 4-(4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)pyridine. The CAS number for this compound is 103312-62-5./END&gt;</p>

<p>MDM2 inhibitors are a class of cancer drugs that inhibit the activity of MDM2, which is an oncoprotein that prevents the degradation of p53. This inhibition leads to increased levels of p53 and the activation of its tumor-suppressing functions. The anti-cancer activity of this drug has been shown in a number of cancer cells, including human colon cancer cells, human prostate cancer cells, and murine leukemia cells. Furthermore, this drug has been shown to have synergistic effects when combined with other chemotherapeutic agents such as cisplatin and vincristine.</p>

<p>Granisetron is a drug that belongs to the group of serotonin receptor antagonists. It is used as an antiemetic, mainly in the prevention and treatment of nausea and vomiting caused by cancer chemotherapy and surgery. This drug has been shown to be effective in controlling nausea and vomiting, even when given after chemotherapy or surgical procedures. Granisetron hydrochloride was synthesized in 1988 by chemists at Hoffmann-La Roche. The synthesis was patented in 1990. Potential impurities are not listed on the USP or EP pharmacopeia, but these impurities have been detected during synthesis.</p>

<p>6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-7-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone is a synthetic impurity standard that is used as a reference material in the analytical, natural and drug development, and metabolite studies. 6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-7-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone has a molecular weight of 390.27 and chemical formula C26H28N2O3S. It is also referred to by its CAS number 1391054-73-1.6</p>

<p>Solifenacin Impurity D is a synthetic impurity of solifenacin. Solifenacin is an anti-cholinergic drug used to treat overactive bladder and urinary incontinence. The purity of this product is 99%. It is soluble in methanol, ethanol, chloroform, and acetone. Solifenacin Impurity D can be used as a reference material for analytical purposes or as an impurity standard in the development of new drugs.</p>

<p>Please enquire for more information about 3,4-Dihydro-7-(3’carboxy)propoxy-2(1H)-quinolinone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cyamemazine sulfoxide is a histamine H1 receptor antagonist. It has been shown to have strong affinity for the serotonin 5-HT2C and dopamine D2 receptors, as well as the atrial 5-HT2A receptors. Cyamemazine sulfoxide has a low oral bioavailability of about 10% and is metabolized in the liver to cyamemazine and its active form, cyamemazine sulfoxide. Cyamemazine sulfoxide binds to serotonin 5-HT2C receptors with a high affinity, which leads to inhibition of serotonin release from nerve endings in the brain. This drug also inhibits dopamine release from nerve endings in the brain and has been shown to have cardiac effects on heart rate and contractility.</p>

<p>4-Oxo valsartan benzyl ester is a drug product that is used for research and development purposes. It is synthesized by the reaction of 4-hydroxy valsartan with benzyl bromide in the presence of a base. 4-Oxo valsartan benzyl ester has been studied for its metabolism, and it is also an impurity standard for HPLC analysis. The purity of this compound is &gt;98% and it has CAS number 188240-32-6.</p>

<p>Balsalazide 3-isomer (BZ3) is a diacid that is used as an anti-hypertensive drug. BZ3 has been shown to be a prodrug of balsalazide, which is converted in vivo to the active form by hydrolysis of the ester linkage. The prodrug approach was designed to provide an orally available agent for use in patients with colitis and ulcerative colitis. The synthetic process begins with the reaction of salicylic acid and bisoprolol to form the ester product, which then undergoes a second reaction with acetyl chloride to form the acyl chloride intermediate. This intermediate reacts with balsalazide and yields BZ3 when heated to high temperatures. BZ3 contains no impurities because it is synthesized from pure starting materials, whereas commercially available balsalazide may contain impurities such as salicylic acid or colitis.</p>

<p>(6-Hydroxy-2-(4-hydroxyphenyl)-7-[4-(2-piperidin-1-yl-ethoxy)benzoyl]-benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methano ne) is a synthetic drug product that has been custom synthesized for the purpose of research and development. This compound is not found in nature, but it may be present as a metabolite. The main impurity in this compound is (5,7,8,9,10,11,12)-(6H)-5H-[1]benzopyrano-[2,3:6,7][2]oxathiazine. Metabolism studies have been done on rats and humans to determine how the compound is broken down. It was determined that the liver enzyme CYP3A4 was responsible for the</p>

<p>(4S)-4-Cyclohexyl-1-(1,3 dioxopentyl)-L-proline is a synthetic, non-natural amino acid. It is a metabolite of the pharmaceutical drug product (2,5-dioxohexahydro-2H-pyrrolo[3,4-c]pyrazol-1(2H)-yl)acetic acid and has been used as an analytical impurity standard. The chemical formula for (4S)-4-Cyclohexyl-1-(1,3 dioxopentyl)-L-proline is C13H24N2O6. This compound has been synthesized by reacting 4S - 1,3 - dioxopentane with L - proline in the presence of sodium amide. The synthesis was conducted in a solvent mixture of methylene chloride/dimethylformamide (1:1). The molecular</p>

<p>4-Phenybutyl 2-carboxyethylphosphinic acid is used as an analytical standard and has been shown to be a metabolite of other drugs. It is also used as an impurity standard for HPLC, and provides a niche for drug product development.</p>

<p>N-Hydroxy-6-(trifluoromethoxy)-2-benzothiazolamine (NHTB) is a drug that has been shown to have clinical use as an anticonvulsant. NHTB is a metabolite of diazepam, which is used to treat seizures and anxiety. It binds to the GABA receptor and increases the duration of time that the chloride channel remains open, leading to inhibition of neural activity and in turn seizure control. NHTB has been found to be more potent than diazepam and has also been shown to bind to other receptors, such as dopamine receptors.</p>

<p>N1-Losartanyl-losartan is a new nonpolar, innovative pharmaceutical agent that fulfills the needs of pharmacological research. It has been shown to be pharmacologically active in vivo and in vitro. N1-Losartanyl-losartan has been shown to be genotoxic impurities, nitrosamines, and other impurities. N1-Losartanyl-losartan is an analytical method for the determination of valsartan and its metabolites. The analytical method uses supercritical fluid chromatography with mass spectroscopy detection (SFC/MSD).</p>

<p>(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine is a compound that belongs to the class of cyclohexane ring. It has been shown to possess potent anti-infective activity against bacteria and fungi, but not against viruses. It is an inorganic compound that can be synthesized by the chlorination of (S)-(-)-2-aminoethanol. This method is efficient and does not require any organic solvents or catalysts. The binding of inhibitors to the enzyme can be studied by using this molecule as a model system. This molecule also has application as a coating for metal surfaces, which can inhibit corrosion.</p>

<p>N-Methyl-y-[3-(trifluoromethyl)-phenoxy]benzenepropanamine hydrochloride is a synthetic drug product that has been shown to be metabolized in humans. It is an impurity standard for HPLC and analytical methods. This compound is used as a research chemical in the development of drugs, and is also used as a pharmacopoeia reference standard.</p>

<p>Valdecoxib impurity I is a synthetic compound that is used as an impurity standard for the drug product Valdecoxib. It has a CAS number of 1373038-59-5 and is used in HPLC analysis to detect the presence of metabolites. Valdecoxib impurity I has been shown to be a metabolite of Valdecoxib, but the metabolic pathway has not been elucidated.</p>

<p>Captopril EP Impurity H is a drug product that is used as an analytical reference standard. It is not intended for administration to humans or animals. Captopril EP Impurity H is manufactured by the same process as Captopril, but with a different impurity profile. The purity of this product is 99.5% at 25°C, and it has an impurity profile of less than 0.5%. This product is also known as 4-Amino-N-(2,6-dichlorophenyl)benzenesulfonamide and has CAS No. 205521-07-9.</p>

<p>2-Methoxyethyl-3-aminocrotonate is an impurity of a drug product. It is an analytical standard that is used to quantify the metabolite in pharmaceutical preparations. 2-Methoxyethyl-3-aminocrotonate is a natural metabolite, which can be found in human urine. This compound has been shown to be a potent inhibitor of both bacterial and mammalian cell topoisomerase II and IV, but not mammalian cell topoisomerase I. It also inhibits protein synthesis by binding to the ribosomal 50S subunit. In addition, it has been shown to inhibit the growth of certain bacteria such as clostridium perfringens and Mycobacterium tuberculosis.</p>

<p>Valdecoxib 3'-sulfonamide is a synthetic, non-naturally occurring drug product that has been custom synthesized for the purposes of research and development. It is not a natural API nor is it an impurity standard. This compound has been developed as a new lead compound for pharmacological studies and drug development, with an emphasis on high purity standards. The CAS number for this compound is 1373038-56-2.</p>

<p>3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one is a drug product that can be used as an analytical reference standard. It is a synthetic compound that is not found in nature and has CAS number 1199589-74-6. This compound has been synthesized by custom synthesis and it is an impurity standard for HPLC analysis. 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3 -yl)-1 -piperidinyl]ethyl]-6,7,8,9 -tetrahydro - 2 methyl - 4H - pyrido[1,2 -a]p</p>

<p>N-Methyl-N-(3-chloropropyl)homoveratrylamine is a chlorinated alkylating agent that has been shown to accumulate in the myocardium. It is an anaesthetic that can be recycled and used as a nutrient. N-Methyl-N-(3-chloropropyl)homoveratrylamine binds to DNA, which blocks the synthesis of RNA and protein. This drug has been demonstrated to have antiarrhythmic effects, but it is not effective against cardiac arrhythmias caused by digitalis or hypoxia. N-Methyl-N-(3-chloropropyl)homoveratrylamine also has an antagonist effect on the central nervous system and may be useful for treating convulsions.</p>

<p>N,N'-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N,N'-dimethyl-1,3-propanediamine dihydrochloride is a synthetic compound that is metabolized to the natural product naphthol AS. It is an impurity in the drug product and can also be used as an analytical reference standard.</p>

<p>Losartan is a drug product that belongs to the class of losartan impurity. It is an impurity standard for research and development, as well as a custom synthesis. Losartan is also used in the synthesis of other drugs, such as losartan potassium, which is classified as a niche compound. Losartan impurity has been shown to be metabolized by several enzymes including CYP2C9 and CYP3A4. The metabolite identified from this study was N-desmethyl losartan.</p>

<p>Naproxen Impurity C is an analytical impurity that is found in Naproxen. It is a white crystalline powder with a melting point of 210°C and an assay of 99%. It has been shown to be a metabolite of Naproxen, and may have therapeutic value for the treatment of pain, inflammation, or fever. The purity of this product has been verified by HPLC analysis.</p>

<p>2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran is a benzofuran. It is a yellow solid that can be dissolved in water and alcohol.</p>

<p>(1-Ethyl-1-methylpropyl)benzene is an impurity of some drugs. It is a metabolite of the drug, and can be found in urine or blood samples as a result of its excretion from the body. (1-Ethyl-1-methylpropyl)benzene is used as an analytical standard for HPLC analysis. This chemical is not on the USP list of impurities, but it is listed on the pharmacopoeia. The CAS number for (1-Ethyl-1-methylpropyl)benzene is 1985-97-3.</p>

<p>3-(Methylamino)-1-(2-thienyl)propan-1-ol is a lipase inhibitor that belongs to the group of 1-fluoronaphthalene. It is an efficient method for the demethylation of 1-fluoronaphthalene, which is used in the synthesis of many pharmaceuticals. The synthesis of this compound was achieved through a kinetic study and confirmed by x-ray crystallography. This compound has been shown to be an analytical method for the determination of impurities in other drugs. 3-(Methylamino)-1-(2-thienyl)propan-1-ol can also be used as a drug substance for other pharmaceuticals and has been shown to inhibit the transfer of chiral centers mediated by enzymes and substrates.</p>

<p>3,4-Dimethoxyphenyl isopropyl ketone (DMPK) is a calcium antagonist that has been shown to be hypotensive in rats. It is also used as a pharmacological agent to study muscle physiology and biotransformations. DMPK has been shown to have microbial uptake and chronotropic properties, which may explain its use in the treatment of bacterial infections. DMPK binds to sulfoxides and chiral compounds, blocking their activity by inhibiting the enzyme systems involved in oxidation reactions. The drug is an analog of benzyl alcohol, with which it shares similar pharmacological profile.</p>

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