Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65630 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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Dothiepin
CAS :<p>Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing</p>Formule :C19H21NSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.44MMP-145
CAS :<p>MMP-145 is used as a protease inhibitor.</p>Formule :C20H20N2O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.45ICI 204448
CAS :<p>ICI 204448 is a potent and peripherally selective κ-opioid agonist.</p>Formule :C23H26Cl2N2O4Couleur et forme :SolidMasse moléculaire :465.37Pirtobrutinib
CAS :<p>Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.</p>Formule :C22H21F4N5O3Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :479.43Saredutant
CAS :<p>Saredutant (SR 48968) is a selective neurokinin-2 (NK2) receptor antagonist that inhibits neurokinin A by blocking NK2 receptor, antidepressant and anxiolytic.</p>Formule :C31H35Cl2N3O2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :552.54MMP-7-IN-3
CAS :<p>MMP-7-IN-3 (compound 15) is a potent and selective MMP-7 inhibitor, inhibiting renal fibrosis in a unilateral ureteral obstruction mouse model.</p>Formule :C34H43ClF3N7O9SDegré de pureté :99.915%Couleur et forme :SolidMasse moléculaire :818.26Celiprolol hydrochloride
CAS :Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity.Formule :C20H33N3O4·HClCouleur et forme :White Crystalline SolidMasse moléculaire :415.96Ubrogepant
CAS :Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.Formule :C29H26F3N5O3Degré de pureté :99.452% - 99.78%Couleur et forme :SolidMasse moléculaire :549.54Apratastat
CAS :Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs)Formule :C17H22N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.5Fluvalinate
CAS :<p>Fluvalinate is a synthetic chemical compound and can be commonly used to control varroa mites in honey bee colonies.</p>Formule :C26H22ClF3N2O3Couleur et forme :SolidMasse moléculaire :502.91Etidocaine Hydrochloride
CAS :<p>Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel.</p>Formule :C17H29ClN2ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :312.88Cobimetinib racemate
CAS :<p>Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated</p>Formule :C21H21F3IN3O2Degré de pureté :98.00% - 99.71%Couleur et forme :SolidMasse moléculaire :531.31Frovatriptan
CAS :<p>Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.</p>Formule :C14H17N3OCouleur et forme :SolidMasse moléculaire :243.3Cipemastat
CAS :<p>Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).</p>Formule :C22H36N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.55Collagen proline hydroxylase inhibitor
CAS :<p>Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.</p>Formule :C18H18N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.36FGIN-1-27
CAS :<p>FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM).</p>Formule :C28H37FN2ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :436.6MMP3 inhibitor 1
CAS :MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).Formule :C23H31N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.57Quizalofop
CAS :Quizalofop (Xylafop) is a reagent of biochemical.Formule :C17H13ClN2O4Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :344.75LX7101
CAS :LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formule :C23H29N7O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.52Naxagolide free base
CAS :Naxagolide is a sustained release formulation. It is a dopamine agonist.Formule :C15H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :247.33Brasofensine
CAS :<p>Brasofensine, a benztoalkane MA reuptake inhibitor, shows promise for Parkinson's and Alzheimer's.</p>Formule :C16H20Cl2N2OCouleur et forme :SolidMasse moléculaire :327.25Levocabastine
CAS :<p>Levocarbastine: 2nd-gen H1 antagonist, treats allergic conjunctivitis, selective NTS2 neurotensin inhibitor.</p>Formule :C26H29FN2O2Couleur et forme :SolidMasse moléculaire :420.52XL-784
CAS :XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.Formule :C42H42Cl2F4MgN6O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1122.15MMP-7-IN-2
CAS :<p>MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.</p>Formule :C28H40ClF3N6O9SDegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :729.17Ro 31-9790
CAS :<p>Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP).</p>Formule :C15H29N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.41RU 58668
CAS :<p>Pure antiestrogen that downregulates estrogen receptor expression</p>Formule :C34H43F5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.76Yonkenafil
CAS :<p>Yonkenafil, a PDE5 inhibitor, may reduce stroke damage and aid in Alzheimer's treatment.</p>Formule :C24H33N5O4SCouleur et forme :SolidMasse moléculaire :487.61Bufuralol
CAS :<p>Bufuralol (Ro 3-4787) is a 尾-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.</p>Formule :C16H23NO2Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :261.36Zandelisib
CAS :<p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>Formule :C31H38F2N8ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :576.68Gepirone
CAS :<p>Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.</p>Formule :C19H29N5O2Degré de pureté :99.35% - 99.89%Couleur et forme :SolidMasse moléculaire :359.47Bufuralol (hydrochloride)
CAS :<p>Bufuralol hydrochloride is a potent, non-selective, orally active β-blocker with partial agonist effects and a CYP2D6 probe.</p>Formule :C16H24ClNO2Couleur et forme :SolidMasse moléculaire :297.82XL-784 free base
CAS :<p>XL-784 free base selectively inhibits MMPs with IC50: MMP-1 (1.9µM), MMP-2 (0.81nM), MMP-3 (120nM), MMP-8 (10.8nM), MMP-9 (18nM), MMP-13 (0.56nM).</p>Formule :C21H22ClF2N3O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.93LY52
CAS :LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.Formule :C22H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.45Dibenamine hydrochloride
CAS :<p>Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.</p>Formule :C16H19Cl2NDegré de pureté :96.43%Couleur et forme :Oily Liquid SolidMasse moléculaire :296.23Gisadenafil
CAS :<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Formule :C23H33N7O5SDegré de pureté :98.82% - 99.50%Couleur et forme :SolidMasse moléculaire :519.62KB-R7785
CAS :<p>KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.</p>Formule :C18H27N3O4Couleur et forme :SolidMasse moléculaire :349.42MMP-9 Inhibitor I
CAS :<p>MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).</p>Formule :C27H33N3O5SCouleur et forme :SolidMasse moléculaire :511.63Caroverine
CAS :Caroverine is a potential chemotherapeutical agent in HNSCC cell lines.Formule :C22H27N3O2Couleur et forme :SolidMasse moléculaire :365.47Inz-1
CAS :Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human.Formule :C16H14N2O2Degré de pureté :99.55% - 99.88%Couleur et forme :SolidMasse moléculaire :266.29Brilaroxazine
CAS :<p>Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.</p>Formule :C22H25Cl2N3O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :450.36MMP13-IN-3
CAS :MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Formule :C24H22N4O5Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :446.46Z-PDLDA-NHOH
CAS :<p>Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].</p>Formule :C22H32N4O6Couleur et forme :SolidMasse moléculaire :448.51ONO 4817
CAS :ONO-4817 suppresses MMPs, limiting plaque progression and aortic hyperplasia in hyperlipidemic rabbits.Formule :C22H28N2O6Couleur et forme :SolidMasse moléculaire :416.47Collagen proline hydroxylase inhibitor-1
CAS :<p>Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。</p>Formule :C24H21N5O4Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :443.457'-Methyl-2'-propyl-2,5'-bi-1H-benzimidazole
CAS :<p>7'-Methyl-2'-propyl-2,5'-bi-1H-benzimidazole (7'-MPB) is a benzimidazole derivative that is used as a medicine. It is made from recycled chemicals and has shown to have industrial applications as a catalyst for cyclization reactions. 7'-MPB is also used in the production of benzenesulfonic acid, which is an organic solvent. This chemical has been shown to be effective against high blood pressure, but has not been tested on humans yet. Telmisartan, which belongs to the angiotensin II receptor blocker class of drugs, can inhibit the synthesis of prostaglandins.</p>Formule :C18H18N4Degré de pureté :Min. 95%Masse moléculaire :290.36 g/molElobixibat
CAS :<p>Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.</p>Formule :C36H45N3O7S2Degré de pureté :97.43% - 98.03%Couleur et forme :SolidMasse moléculaire :695.89Aderamastat
CAS :<p>Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.</p>Formule :C21H18N2O4SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :394.44Sitagliptin impurity E
CAS :<p>Sitagliptin impurity E is an inhibitor of dipeptidyl peptidase-4 (DPP-IV) that is used as a hypoglycemic agent. Sitagliptin impurity E has been shown to increase the glucose-lowering effect in diabetic patients with type 2 diabetes mellitus. It is also effective in reducing postprandial glucose and insulin levels. Sitagliptin impurity E has been shown to increase the concentration of insulin in plasma for up to 24 hours after administration, which suggests that it may be useful for the treatment of metabolic disorders such as obesity and type 2 diabetes mellitus.</p>Formule :C16H15F6N5ODegré de pureté :Min. 95%Masse moléculaire :407.31 g/mol4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride
CAS :<p>4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride is a drug product. It is used as an analytical standard and in the development of drugs. The metabolite of 4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride, 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N-(4-nitrophenyl)benzamide, has been shown to inhibit the production of cytokines IL6 and TNFα by human monocytes, macrophages, and dendritic cells. Metabolism studies have shown that 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N</p>Formule :C13H20ClNO3Degré de pureté :Min. 95%Masse moléculaire :273.76 g/molMaralixibat Chloride
CAS :<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Formule :C40H56ClN3O4SDegré de pureté :99.19% - 99.65%Couleur et forme :SolidMasse moléculaire :710.41
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