Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65615 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
CAS :Produit contrôlé<p>Impurity Risperidone EP Impurity L<br>Applications 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Formule :C11H15ClN2OCouleur et forme :NeatMasse moléculaire :226.70Dipyridamole-d20 (Major)
CAS :Produit contrôlé<p>Applications Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.A representative lot was: 36% d20; 25% d19; 13%d18; 24% d17; 1% d16.<br>References Buchalter, M.B., et al.: Postgrad. Med. J., 66, 531 (1990), Sundaram, M., et al.: J. Biol. Chem., 273, 21519 (1998), Denis, D., et al.: Eur. J. Pharmacol., 367, 343 (1999),<br></p>Formule :C24H20D20N8O4Couleur et forme :NeatMasse moléculaire :524.75Desmethyl Doxylamine Oxalate
CAS :Produit contrôlé<p>Impurity Carbinoxamine Related Compound C<br>Applications Desmethyl Doxylamine Oxalate is an impurity of Doxylamine (D562000), an H1 Histamine receptor antagonist used as a antihistaminic and sedative agent.<br>References Pande, S.S., et al.: Int. J. Pharmtech. Res., 3, 209 (2011); Tiford, C.H., et al.: J. Am. Chem. Soc., 70, 4001 (1948);<br></p>Formule :C16H20N2O·C2H2O4Couleur et forme :NeatMasse moléculaire :346.37N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib
CAS :Produit contrôlé<p>Impurity Celecoxib EP Impurity B<br>Applications N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib (Celecoxib EP Impurity B) is an isomeric impurity of Celecoxib (C251000) with selective inhibitory activity against human cyclooxygenase-2. USP Celecoxib Related Compound B<br>References Talley, J.J. et al.: Actual. Chim. Therap., 25, 123 (1999); Rao, R. et al.: Anal. Sci., 22, 1257 (2006);<br></p>Formule :C17H14F3N3O2SCouleur et forme :NeatMasse moléculaire :381.375-(1,3-Dioxolan-2-yl)-2-(3-methylbenzoyl)thiophene
CAS :Degré de pureté :97.0%Masse moléculaire :274.3299865722656Ranitidine Hydrochloride
CAS :<p>Stability Hygroscopic<br>Applications A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.<br>References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979), Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980), Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986),<br></p>Formule :C13H22N4O3S·ClHCouleur et forme :NeatMasse moléculaire :350.86Vildagliptin Cyclo Imidamide
CAS :<p>Applications Vildagliptin Cyclo Imidamide Hydrochloride is an impurity of vildagliptin (V305000). Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. ASide from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formule :C17H25N3O2Couleur et forme :NeatMasse moléculaire :303.404-chloro-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :275.75(2E)-1-(1H-1,2,3-Benzotriazol-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one
CAS :Masse moléculaire :255.3000030517578Ondansetron Hydrochloride Dihydrate
CAS :Formule :C18H19N3O·ClH·2H2OCouleur et forme :Off-WhiteMasse moléculaire :365.85Temocapril Hydrochloride
CAS :Produit contrôlé<p>Applications Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.<br>References Qizumi, K., et al.: Jpn. J. Pharmacol., 48, 349 (1988), Arita, M., et al.: Clin. Exp. Pharmacol. Physiol., 21, 195 (1994), Tokunaga, S., et al.: Drug Invest., 7, 161 (1994)<br></p>Formule :C23H28N2O5S2·ClHCouleur et forme :NeatMasse moléculaire :513.074-Methoxy Moxonidine
CAS :Produit contrôléFormule :C10H15N5O2Couleur et forme :GreyMasse moléculaire :237.26Ondansetron
CAS :Produit contrôlé<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formule :C18H19N3OCouleur et forme :White To Light BeigeMasse moléculaire :293.36Ramelteon Metabolite M-II (mixture of R and S at the hydroxy position)
CAS :Produit contrôlé<p>Applications The major metabolite of Ramelteon in serum (M-II).<br>References Karim, A., et al.: J. Clin. Pharmacol., 44, 1210 (2004), Prescott, E., et al.: Drug Metab. Rev., 36, 203 (2004), Kato, K., et al.: Neuropharmacology, 48, 301 (2005), Karim, A., et al.: J. Clin. Pharmacol., 46, 140 (2006),<br></p>Formule :C16H21NO3Couleur et forme :NeatMasse moléculaire :275.34FOY 251
CAS :<p>Applications A metabolite of Camostat. It is a pollen protease inhibitor for prevention and control of allergy.<br>References Senochuki, K., et al.: J. Med. Chem., 38, 2521 (1995)<br></p>Formule :C16H15N3O4·CH4O3SCouleur et forme :White SolidMasse moléculaire :409.41Aprepitant
CAS :Produit contrôlé<p>Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).<br>References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)<br></p>Formule :C23H21F7N4O3Couleur et forme :Off-WhiteMasse moléculaire :534.434-(Chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
CAS :Degré de pureté :95+%Masse moléculaire :429.9100036621094N-Phenyl-N-(1H-pyrazol-1-ylmethyl)aniline
CAS :Degré de pureté :97.0%Masse moléculaire :249.317001342773446-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one
CAS :Produit contrôlé<p>Applications 6-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one is derived from 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-6-triamine (F595655), which is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension;Also, it is an impurity of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.<br>References Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002); Straub, A., et al.: Bioorg. Med. Chem., 10, 3075 (2002);Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Formule :C18H13FN8OCouleur et forme :NeatMasse moléculaire :376.347Nocodazole
CAS :<p>M05733 - Nocodazole</p>Formule :C14H11N3O3SDegré de pureté :98%Couleur et forme :Solid, Beige powderMasse moléculaire :301.32000732421875Dehydronitroso Nifedipine
CAS :Produit contrôlé<p>Impurity Nifedipine EP Impurity B<br>Applications A photodegradation product of Nifedipine (N457000). Shown to relax contractions of the rat aortic strip induced by norepinephrine and other agonists.<br>References Hayase, N. et at.: J. Pharmac. Exp. Ther., 275, 813 (1995); De Vries, H. et al.: Photochem. Photobio., 62, 959 (1995);<br></p>Formule :C17H16N2O5Couleur et forme :NeatMasse moléculaire :328.324-(2-Keto-1-benzimidazolinyl)piperidine-d5 (Major)
CAS :Produit contrôlé<p>Applications Labelled 4-(2-Keto-1-benzimidazolinyl)piperidine is an impurity of labelled Pimozide. Pimozide impurity A.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andersson, L., et al.: J. Lipid Res., 36, 1392 (1995), Andersson, M., et al.: J. Biol. Chem., 2005, 280, 27578 (2005),<br></p>Formule :C12H10D5N3OCouleur et forme :NeatMasse moléculaire :222.32-Amino-3,4-dimethylpyridine
CAS :Formule :C7H10N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :122.171Carvedilol N’-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine
CAS :Produit contrôlé<p>Impurity Carvedilol Impurity A; Carvedilol USP A<br>Applications An impurity from the process of Carvedilol (C184625). Carvedilol impurity A. Carvedilol USP A.<br></p>Formule :C36H43N3O7Couleur et forme :NeatMasse moléculaire :629.744-Morpholinophenylglyoxal hydrate
CAS :Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :237.25500488281254-(4-Morpholinyl)-1,2,5-thiadiazol-3(2H)-one 1-Oxide
CAS :Produit contrôlé<p>Impurity Timolol EP Impurity G; Timolol BP Impurity G<br>Stability Moisture Sensitive<br>Applications 4-(4-Morpholinyl)-1,2,5-thiadiazol-3(2H)-one 1-Oxide (Timolol EP Impurity G; Timolol BP Impurity G) is an impurity of Timolol (T4437005), an antihypertensive, an adrenergic blocking agent (1); antiarrhythmic (class II); antianginal; antiglaucoma (2) and antihypertensive (3) agent.<br>References 1. Wasson, B. et al.: J. Med. Chem. 1972 Jun;15(6):651-5.2. Heel, R. et al.: Drugs. 1979 Jan;17(1):38-55.3. Rofman, et al.: Hypertension. 1980 Sep-Oct;2(5):643-8.<br></p>Formule :C6H9N3O3SCouleur et forme :WhiteMasse moléculaire :203.223-(3,4-dimethylphenyl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
CAS :Degré de pureté :98%Masse moléculaire :282.3599853515625N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS :Produit contrôléFormule :C16H13Cl2N5OSCouleur et forme :NeatMasse moléculaire :394.28DL-Norepinephrine-d6 Hydrochloride, 85%
CAS :Produit contrôlé<p>Applications Antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Piguet, P., et al.: J. Exp. Med., 173, 673 (1991), Hosoi, J., et al.: Nature, 363, 159 (1993), Elenkov, I., et al.: Pharmacol. Rev., 52, 595 (2000), Kaplan, D., et al.: Immunity, 23, 611 (2005),<br></p>Formule :C82H6H5NO3·ClHDegré de pureté :85%Couleur et forme :NeatMasse moléculaire :211.68Perazine Dihydrochloride
CAS :<p>Applications Antipsychotic.<br>References Hromatka, et al.: Monatsh. Chem., 88, 56 (1957), Franke, U., et al.: J. Pharm. Sci., 88, 89 (1999), Hashem, H., et al.: Pharmazie, 60, 186 (2005),<br></p>Formule :C20H25N3S·2ClHCouleur et forme :NeatMasse moléculaire :412.423-Phenyl-4-thioxo-3,4-dihydrophthalazine-1-carboxylic acid
CAS :Degré de pureté :98%Masse moléculaire :282.320007324218754-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :328.3753-Hydroxy Nevirapine
CAS :Produit contrôlé<p>Applications A metabolite of Nevirapine (N391275).<br>References Rettie, A., et al.: J. Biol. Chem., 263, 13733 (1988), Lamson, M., et al.: Biopharm. Drug Dispos., 20, 285 (1999), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Lu, W., et al.: Drug Metab. Dispos., 36, 1624 (2008),<br></p>Formule :C15H14N4O2Couleur et forme :NeatMasse moléculaire :282.302,6-Dichloro-N-methyl-3-nitropyridin-4-amine
CAS :Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :222.0299988rac 8-Hydroxy Efavirenz
CAS :Produit contrôléFormule :C14H9ClF3NO3Couleur et forme :NeatMasse moléculaire :331.67N-Nitroso Clonidine
CAS :Produit contrôléFormule :C9H8Cl2N4OCouleur et forme :NeatMasse moléculaire :259.09Retigabine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A new experimental anticonvulsant drug. Anxiolytic.<br>References Dailey, J.W.; et al.: Neuroscience Lett., 195, 77 (1995), Korsgaard, M.P.G., et al.: J. Pharmacol. Exp. Ther., 314, 1, 282 (2005),<br></p>Formule :C16H18FN3O2Couleur et forme :NeatMasse moléculaire :303.33Tazarotene
CAS :<p>Applications An acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Antiacne; antipsoriatic. Used in treatment of photodamaged skin.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>Formule :C21H21NO2SCouleur et forme :Light YellowMasse moléculaire :351.468-chloro-2-(3-methylphenyl)quinoline-4-carboxylic acid
CAS :Degré de pureté :95.0%Masse moléculaire :297.739990234375Nitisinone
CAS :<p>Applications Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.<br>References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),<br></p>Formule :C14H10F3NO5Couleur et forme :NeatMasse moléculaire :329.23rac Phenylephrine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Phenylephrine is a selective α1-adrenergic receptor agonist used as a decongestant. Phenylephrine lowers intraocular pressure and is used as an agent to dilate the pupil.<br>References Lorenzetti, O.J. et al.: Exp. Eye Res., 12, 80 (1971); Ando, J. et al.: Nip. Yakur. Zas., 61, 471 (1965);<br></p>Formule :C9H14ClNO2Couleur et forme :NeatMasse moléculaire :203.674-(methylthio)-N-(pyridin-3-ylmethyl)benzo[d]thiazol-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :287.39999389648442-(2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDIN-6-YL)PROPAN-2-OL
CAS :Degré de pureté :95.0%Masse moléculaire :313.799987792968756-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
CAS :Degré de pureté :98.0%Masse moléculaire :475.8500061035156Ref: 10-F549703
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander250mgÀ demander4-(5-methylthiophen-2-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :273.3699951171875
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