Peptides et Protéines

Applications (1R,3S)-Camphoric Acid is used primarily as a reagent in syntheses of crystalline structures. It is used in the preparation of polymeric transition metal dipyridylamine D-camphorate complexes.
References Blake, K. et al.: Crys. Growth Des., 12, 5215 (2012);

Applications 5-Oxo-DL-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials.
References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);

Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Applications (S)-Lisinopril (L468985) impurity. Lisinopril Impurity G (Dimer Impurity)

Impurity Bortezomib USP Related Compound A
Applications (1R,2R)-Bortezomib is a diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)

Applications 5-9-Leuprolide is a metabolite of Leuprolide (L330590), a gonadotropin-releasing hormone (GnRH) analogue acting as an agonist at pituitary GnRH receptors.
References Handelsman, David J., et al.: J. of Steroid Biochem. and Mol. Bio., 141, 113-120 (2014);Okada, Hiroaki, et al.: Pharma. Res., 8(6), 787-91 (1991)

Stability Light Sensitive
Applications Protoporphyrin-9 is the precursor to heme sites and chlorophyll.

Applications L-Thioproline is used to create a monolayer on gold electrodes for the determination Copper(II). L-Thioproline has shown to be an effect inhibitor of proline absorption in Saccharomyces chevalieri.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cui, X., et. al.: Sci. China Chem., 53, 257 (2010); Magana-Schwenchke, N., Schwencke, J.: BBA-Biomembranes, 173, 313 (1969)

Impurity Bortezomib N-Pentyl Impurity
Applications Desisobutyl-n-butyl Bortezomib is an impurity of Bortezomib (B675700). Bortezomib impurity 5.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, G., et al.: J. Biol. Chem., 283, 34423 (2008);

Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.
References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);

Applications Used for the synthesis of Bortezomib from L-phenylalanine via dipeptidyl boronic acid ester intermediates.
References Zhu, Y., et al.: J. Med. Chem., 52, 4192 (2009),

Impurity Lisinopril EP Impurity D
Stability Hygroscopic
Applications Lisinopril (S,S,R)-Diketopiperazine (Lisinopril EP Impurity D) is an impurity of Lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor (1).
References 1. Goa, K. et al.: Drugs. 1996 Oct;52(4):564-88.

Impurity Levothyroxine beta-Hydroxy Impurity / Levothyroxine beta-Hydroxy T4 Impurity
Applications It has been prepared for testing as possible antithyroid. It showed some thyromimetic activity.
References Wawzone, S., et al.: J. Med. Chem., 6, 442 (1963),

Applications R,S,S-Isomer of Lisinopril (L468985).
References Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)

Applications (2R,4R)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

Impurity Teriparatide Impurity
Applications A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 30 N-terminal residues of hPTH.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974);

Applications Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014)

Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F
Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);

Applications A Cyclosporin A (C988900) analog, an immunosuppressant.
References Emmer, G., et al.: J. Med. Chem., 37, 1918 (1994), High, K., et al.: J. Biol. Chem., 269, 9105 (1994),

Applications Bivalirudin Trifluoroacetic Acid Salt is an anticoagulant drug that is a direct thrombin inhibitor. It is used for treatment of acute coronary syndromes, and is a safer alternative to heparin due to lower rates of bleeding as an adverse effect of anticoagulant in patients.
References Stone, G., et al.: N. Engl. J. Med, 355, 2203 (2006); Stone, G., et al.: N Engl J Med, 358, 2218 (2008);

Applications Labelled L-Methionine, an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.
References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),

Applications L-Carnitine-L-tartrate (cas# 36687-82-8) is a useful research chemical.

Applications Used in the treatment of cataracts and in the treatment of UV-induced immunosuppression. May act with with lipoic acid (L468725) to reverse age-related metabolic decline and also the indicies of oxidative stress.
References Babizhayev, M., et al.: J. Pharmacol. Toxicol., 1, 201 (2006), Min, J., et al.: J. Neurosci. Res., 86, 2984 (2008), Babizhayev, M., et al.: J. Drug Target., 17, 36 (2009); Hagen et. al, PNAS 99: 1870 (2002); Liu et. al, PNAS 99, 2356 (2002)

Applications Glecaprevir is an antiviral drug used in the treatment of patients with hepatitis C virus (HCV) genotype 1-6, of special interest for the treatment of patients with chronic kidney disease also suffering from HCV.
References Kwo, P., et. al.: J. Hepatol, 67, 263 (2017)Gane, E., et. al.: N. Engl. J. Med, 377, 1448 (2017)

Applications Labelled Bortezomib, which the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.d6-3%d7-10%d8-86%
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)

Stability Moisture Sensitive
Applications (2S,4S)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

Impurity Bortezomib USP Impurity B
Applications N-[(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide is a metabolite of Bortezomib (B675700), a proteasome inhibitor for the treatment of multiple myeloma and is known to also target the ubiquitin-proteasome pathway.
References Pekol, T., et al.: Drug. Meta. Disp., 33, 771 (2005); Hsieh, F.Y., et al.: J. Pharma. Biomed. Anal., 49, 115 (2009);

Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.
References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),