Terpénoïdes et Dérivés

Applications O-Desmethyl Midostaurin-13C6 is the labelled analogue of O-Desmethyl Midostaurin (D291400), a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Applications (3R,4R,4aS,7R,8S,8aR)-Hexahydro-3-hydroxy-4,7-dimethyl-8-(3-oxobutyl)-1,2-benzodioxin-8a(3H)-carboxaldehyde is an impurity of Artesunate (A777800).
References Baker, J.K., et al.: Pharmaceut. Res., 10, 662 (1993),

Applications An impurity of Docetaxel (D494420).
References Zamir, L., et al.: Tetrahedron Lett., 33, 5173 (1992), Gueritte-Voegelein, F., et al.: J. Med. Chem., 34, 992 (1993), Volk, K., et al.: J. Chromatogr., 696, 99 (1997),

Applications (2’S, 3’R)-Cabazitaxel is a stereoisomer of Cabazitaxel (C046500), a novel tubulin binding taxane, that acts as a second-line treatment for those with castration-resistant prostate cancer.
References Paller, C. & Antonarakis, E.: Drug Des. Devel. Ther., 5, 117 (2011); Pal, S., et al.: Clin. Interv. Aging, 5, 395 (2010)

Applications 13-epi-10-Deacetyl Baccatin III is a new analog of 10-Deacetylbaccatin III (D198250).
References Gabetta, B., et al.: J. Natural Products, 58, 1508 (1995),

Stability Light Sensitive, Temperature Sensitive
Applications An oxo analogue of 9-cis,13-cis-Retinoic Acid (R245015): a major plasma metabolite of 9-cis Retinoic Acid (R245000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Light and Temperature Sensitive
Applications A metabolite of Retinoic acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hoyos, B., et al.: J. Exp. Med.,192, 835 ( 2000), Braungart, E., et al.: J. Invest. Dermatol.,116, 778 (2001), Fray, M., et al.: J. Med. Chem., 46, 3514 (2003), Ha, M., et al.: Exp. Dermatol., et al.: 13, 543 (2004),

Applications (+)-Fenchone is a terpenoid with broad spectrum activity against infective agents. It is a constituent of the essential oil component of fennel fruit. Fenchone is widely used as a flavouring agent in food industries, and also for perfumery in cosmetics industries.
References Mafud, A. C., et al.: Chem. Biol. Interact., 244, 129 (2016); Kan, Y., et al.: Ankara Universitesi Eczacilik Fakultesi Dergisi, 35, 95 (2006); Kpoviessi, S., et al.; J. Ethnopharmacol., 151, 652 (2014)

Stability Light Sensitive, Temperature Sensitive
Applications A synthetic retinoid which is the major metabolite of etretinate (E938000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Liu, X., et al.: Cancer Chemother. Pharmacol., 63, 167 (2008),

Applications Artemisic Acid is a derivative of Artemisinin (A777500), an antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial.
References Klayman, D.L., et al.: Science, 228, 1049 (1985), Price, R.N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000), Meshnick, S.R., et al.: Int. J., Parasitol., 32, 1655 (2002),

Applications DL-Camphene, is a minor constituent of many essential oils such as turpentine, cypress oil, camphor oil, citronella oil (C525020), neroli, ginger oil, and valerian. It can also be used in fragrances and as a food additive for flavoring.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Perino-Issartier, S., et al.: J. Chromatography A, 1305 (2013); Zhang, L., et al.; Shizhen Guoyi Guoyao, 23, 3061 (2012);

Impurity Docetaxel Impurity 20
Stability Hygroscopic
Applications 17-epi-10-Oxo-10-deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives. Docetaxel Impurity 20.
References Hu, S., et al.: Biocatal. Biotransform., 14, 241 (1997), Sun, D., et al.: Bioorg. Med. Chem., 9, 1985 (2001),

Stability Hygroscopic
Applications Ginsenoside C-K is reported to exhibit anti-wrinkle effects. Also, it potentiates tumor necrosis factor (TNF)-related apotosis-inducing ligand (TRAIL)-induced apotosis in HCT116 colon cancer.
References Han, S., et al.: J. Cell. Biochem., (2017); Chen, L., et al.: Cell Death Diff., 7, 2334 (2016)

Impurity Paclitaxel - In House Impurity
Applications Protected Baccatin III. Paclitaxel - In House Impurity.

Applications Tetramethrin is a synthetic pyrethroid pesticide used in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Anderson, J.F., et al.: J. Economic. Entomol., 105, 1789 (2012); Xu, S.M., et al.: Food. Chem., 135, 161 (2012);

Stability Light Sensitive
Applications A dehydrogenated metabolite of Capsaicin (C175680).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Glinsukon, T., et al.: Toxicon, 18, 215 (1980), Obach, R., et al.: Drug Metab. Dispos., 29, 1599 (2001), Reilly, C., et al.: Toxicol. Sci., 73, 170 (2003),

Stability Light Sensitive
Applications A cannabinoid anticancer quinone, HU-331, is more potent and less cardiotoxic than Doxorubicin and thus it has a high potential for development as a new anticancer drug.
References Dana, B., et al.: J. Clin. Oncol., 11, 644 (1993), Feleszko, W., et al.: Clin. Cancer Res., 6, 2044 (2000), Kogan, N., et al.: J. Med. Chem., 47, 3800 (2004),