Étalons de l'industrie alimentaire

<p>Applications A benzylisoquinoline alkaloid.<br>References Bognar, R., et al.: Biochem. Physiol. Alkaloide, Int. Symp., 4, 307 (1972); Kerekes, P., et al.: J. Prakt. Chem., 313, 923 (1971)<br></p>

<p>Applications 5-Ethyl-6-hydroxyhexanoic Acid is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).<br>References Kaulen, J., et al.: Tetrahedron., 38, 3299 (1982);<br></p>

<p>Applications Palmitoleic Acid is a polyunsaturated fatty acid which contributes to reduced protein oxidation in mammals.<br>References Mendez, L. et al.: Free Rad. Biol. Med., 55, 8 (2013);<br></p>

<p>Applications 1,2-Dichloropropane is a byproduct in the production of epichlorohydrin (E582310), an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stratula, C., et al.: Revista. De. Chimie., 56, 677 (2005); Kaiser, E.W., et al.: J. Phy. Chem., 100, 9788 (1996);<br></p>

<p>Applications Pivalic Acid is a metabolite of oral cephem (β-lactam) antibiotics such as S-1108, containing pivaloyl moieties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mizojiri, K. et al.: Antimicrob. Agents, Chemother. 39, 1445 (1995);<br></p>

<p>Applications L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture.<br>References Kurata, S., et al.: J. Biol. Chem., 266, 9997 (1991); Svetec, N., et al.: J. Exp. Biol., 208, 891 (2004); Furue, M., et al.:Proc. Natl. Acad. Sci. USA, 105, 13409 (2008)<br></p>

<p>Applications Ethyl Benzoylformate is a general chemical reagent used in the preparation of diaminoethanediyl bismethylpyridinium salts for designing recyclable organocatalysts.<br>References Lisnyak, V. et al.: J. Org. Chem., 80, 8570 (2015);<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester-d4 is the isotope labelled analog of Phthalic Acid Bis(3,7-dimethyloctyl) Ester (P384535); a diester derivative of Phthalic Acid (P384480) which can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications Tetracosanoic Acid is a chemical component of a dried mushroom powder exhibiting antioxidant properties. It is a long chain fatty acid present in peanut oil.<br>References Carneiro, A. et al: Food Chem., 138, 2168 (2013); Beare-Rogers, J. et al. Pure Appl. Chem., 74, 685 (2001);<br></p>

<p>Applications Isotope labelled Di-n-heptyl Phthalate is a Phthalate derivative and an organic extract contaminant found in drinking water, which was shown to activate Nrf-2-Mediated Antioxidant response in human cell line.<br>References Wang, S., et al.: Environ. Sci. Technol., 47, 4768 (2013);<br></p>

<p>Applications Isotope labelled Diundecyl Phthalate is a phthalate diester and has been investigated for its toxicology in male rats for risk assessment.<br>References Kwack, S.J., et al.: J. Toxicol. Environ. Health., 72, 1446 (2009); Serafimova, R., et al.: Chem. Res. Toxiciol., 20, 662 (2007);<br></p>

<p>Applications 2β-Hydroxy-androst-4-ene-3,17-dione is the microbial oxidation product of Androstenedione (A637550), which is a Testosterone precursor and metabolite with androgenic activity.<br>References Bednarski, P., Nelson, S.: J. Med. Chem., 32, 203 (1989); Holland, H., et al.: Can. J. Chem., 67, 268 (1989); Valdes, E., et al.: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol., 107A, 261 (1994); Walker, V.R., et al.: Anal. Biopchem., 234, 194 (1996); King, D.S., et al.: J. Am. Med. Assoc., 281, 2020 (1999);<br></p>

<p>Applications A component of garlic which revealed antiplatelet, antithrombotic activity and reduced LDL oxidation thus indicating their possible use for cardiovascular disease.<br>References Steinberg, D., et al.: J. Biol. Chem., 272, 20963 (1997), Lawson, L., et al.: J. Agric. Food Chem., 53, 6254 (2005), Gonen, A., et al.: Pathobiology, 72, 325 (2005),<br></p>

<p>Applications Benzil is used in organic synthesis as a building block and in polymer chemistry as a photoinitiator. It has also been found to be an inhibitor of mammalian carboxylesterases.<br>References Encinas, M., et al.: J. Polym. Sci. A1., 22, 2469 (1984); Wadkins, R., et al.: J. Med. Chem., 48, 2906 (2005); Hicks, L., et al.: Bioorgan. Med. Chem., 15, 3801 (2007);<br></p>

<p>Applications Diethyl DL-Malate is used as a reagent in the synthesis of dicarboxylic nitroxyalkylamides and nitroxyalkylimides as anti-ischemic agents.<br>References Fedorov, B.S., et al.: Russ. Chem. B+., 63, 1119 (2014)<br></p>

<p>Applications 2,2,2-Trifluoroethanol is used in the synthesis of competitive inhibitors for phospholipase A2. Used in the preparation of a key Efavirenz (E425000) intermediate, a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jain, M. et al.: Biochem., 30, 10256 (1991); Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995), Tan, L. et al.: Angew. Chem. Int. Ed., 38, 711 (1999);<br></p>

<p>Applications Monooctyl Phthalate β-D-Glucuronide is a glucuronide conjugate of Monooctyl Phthalate (M566650) which is a Phthalate metabolite.<br>References Jones, P., et al.: PCT Int. Appl. (2007), WO 2007138351 A2 20071206<br></p>

<p>Applications 2,2-Dimethoxy-2-phenylacetophenone (cas# 24650-42-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Tetrahydrofuran-2,2,5,5-d4 (CAS# 20665-63-8) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).<br>References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)<br></p>

<p>Applications Phenyl Acetate is a metabolite of Phenylbutyrate (PB), useful in the treatment of neuroblastoma and lung cancer. An odorant found in strawberries, passion fruit and black tea.<br>References Ubeda, C. et al.; J. Agr. Food Chem. 60, 6095 (2012); Burzynski, S.R. &amp; Nagy-Kubove, E.; J. Cancer Ther. 2, 518 (2011); Brat, P. et al.; J. Agr. Food Chem., 48, 6210 (2000); Mick, W. &amp; Schreier, P.; J. Agr. Food Chem., 32, 924 (1984)<br></p>

<p>Applications 4-Methylindan is a shoyu flavouring that is used in soy sauce.<br>References Nunomura, N., et al.: Agri. Biol. Chem., 48, 1753 (1984);<br></p>

<p>Applications n-Hexyl-d13-amine (CAS# 352438-81-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Phenyl-d5-ethan-1,1,2,2-d4-ol (CAS# 42950-74-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl eicosapentaenoate is the methyl ester derivative of Eicosapentaenoic acid (E477800). Methyl eicosapentaenoate is a highly unsaturated compound that is extracted from algae, and has some practical application in protecting stored grains against rice weevils.<br>References Aresta, M., et al.: Environ. Chem. Lett., 3, 136 (2005); Khani, M., et al.: J. Med. Plants. Res., 5, 259 (2011)<br></p>

<p>Applications 4-Methoxybenzoic-d7 Acid (CAS# 1219803-08-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Xylene-d4 (ring-d4) (CAS# 62367-40-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications NPG Glycol is used in the synthesis of tetraphenylporphyrins. Also used in the synthesis of Bryostatin 2, a protein kinase modulator.<br>References Lindsey, J. et al.: J. Org. Chem., 52, 827 (1987); Evans, D. et al.: J. Am. Chem. Soc., 121, 7540 (1999);<br></p>

<p>Applications Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).<br>References Shohat, B., et al.: Cancer Chemother. Rep., 51, 271 (1967), Shohat, B., et al.: Int. J. Cancer., 8, 487 (1971); Chem. and Eng. News p. 6, Aug. 8, 2016<br></p>

<p>Applications Dibutyl Carbonate is a potential fuel substitute due to the observed decrease in CO2 emissions. Also used in CO2 catalytic activation.<br>References Hellier, P. et al.: Energy Fuel, 27, 5222 (2013); Shang, J. et al.: Green Che,., 14, 2899 (2012);<br></p>

<p>Applications 1,3,5-Trioxane is used in organic chemical processes such as aldol condensation of amides and syntheses of chloromethyl esters or other plastics.<br>References Foo, S. et al.: Tetrahedron Lett., 53, 5445 (2012); Mudryk, B. et al.: Tetrahedron Lett., 43, 6317 (2002);<br></p>

<p>Applications 5-Bromo-7-ethyl-2-formyl-benzofuran (cas# 137206-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethylene Glycol Dicaprate-d4 is a deuterated version of Ethylene Glycol Dicaprate (E917474), a plasticizer for chloroethylene polymers.<br>References Van V. G. J., et al.: Kunststoffe, 57, 561 (1967); Van V. G. J., et al.: Plastica, 19, 175 (1966)<br></p>

<p>Applications (+/-)-Exo-6-hydroxytropinone is a useful reagent for the preparation of racemic scopolamine (tropane alkaloid).<br>References Nocquet, P. A., et al.: Eur. J. Org. Chem., 2016, 1156 (2016)<br></p>

<p>Applications trans-p-Methoxycinnamaldehyde is used in the food industry as a flavor and fragrance agent. It also acts as a nematicidal agent in certain organisms.<br>References Kawashima, Y. et al.: Foods. Food. Ingred. J. Jpn., 169, 29 (1996); Kong, J.O. et al.: J. Nematol., 39, 31 (2007);<br></p>

<p>Applications A labelled glucuronide conjugate of the phthalate ester metabolite Monomethyl Phthalate (M566540).<br>References Thompson, R.M. et al.: Drug Metab. Disp., 1, 489 (1973);<br></p>

<p>Applications 4'-Methyl-d3-acetophenone (CAS# 114379-92-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>

<p>Applications A metabolite of Nefazodone (N389100), a novel antidepressant.<br>References Myol, R., et al.: Clin. Pharmacol. Ther., 37, 210 (1985), Haria, M., et al.: Drugs Aging, 4, 331 (1994), Kalgutkar, A., et al.: Drug Metab. Dispos., 33 243 (2005),<br></p>

<p>Applications Steviol is an aglycone of the natural sweetener Stevioside (90%, S686730) and is found to be highly mutagenic compared to Stevioside.<br>References Toskulkac, C., et al.: Drug Chem. Toxicol., 20, 31 (1997); Pezzuto, J.M., et al.: P. Natl. Acad. Sci. USA, 82, 2478 (1985); Matsui, M., et al.: Mutagenesis, 11, 573 (1996); Koyama, E., et al.: Food Chem. Toxicol., 41, 875 (2003)<br></p>

<p>Applications (2-Decyl)benzene is a linear alkylbenzene used to synthesize aryl olefins.<br>References Faghihian, H., et al.: App. Surface. Sci., 264, 492 (2013);<br></p>

<p>Applications Lactitol is listed as an excipient in some prescription drugs, such as Adderall. Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods. It is also used medically as a laxative.<br>References Bolhuis, G., et al.: Drug Dev. Ind. Pharm., 35, 671 (2009); Toda, Y.: New Food Ind., 33, 21 (1991); Egger, B., et al.: Eur. J. Clin. Pharmacol., 37, 205 (1989)<br></p>

<p>Applications 1-Octanoyl-2-decanoyl-3-chloropropanediol belongs to a group of 3-Chloropropanediol fatty acid esters, which are contaminants found in edible oils and other food sources.<br>References Z. Zelinková, et al.: Food Addi. &amp; Conta., 23:12, 1290-1298 (2006)<br></p>

<p>Applications Bromoform is a brominated organic solvent, sedative and flame retardant, in the past. Now it is mainly used as a laboratory reagent, for example as an extraction solvent.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haag, W., et al.: Environ. Sci. Technol., 26, 1005 (1992); Giesen, D., et al.: Theoretical Chem. Accounts, 98, 85 (1997); Shvakumar, D., et al.: J. Chem. Theory Compt., 5, 919 (2009)<br></p>

<p>Applications 2-Hydroxy-1,4-naphthoquinone-5,6,7,8-d4 is the isotope labelled analog of 2-Hydroxy-1,4-naphthoquinone (Lawsone) (H949535); the active ingredient of Lawsonia inermis (henna) leaves extract. Lawsone has potential antimicrobial activity and can be used for the detection of latent fingermarks on paper surfaces.<br>References Tekin, V., et al.: J. Radioanal. Nucl. Ch., (2014); Rahmoun, N.M., et al.: Am. J. Med. Biol. Res., 1, 16 (2013); Jelly, R., et al.: Chem. Commun., 30, 3513 (2008)<br></p>

<p>Applications Di-n-nonyl Phthalate-3,4,5,6-d4 (CAS# 1202865-43-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications A flavor compound from orange essence oil.<br>References Shaw, P., et al.: J. Agric. Food Chem., 27, 246 (1979), Swaine, R., et al.: Perf. Flav., 13, 2 (1988), Weyerstahl, P., et al.: Flav. Fragr. J., 14, 225 (1999),<br></p>

<p>Applications 2-Methoxynaphthalene-1,3,4,5,6,7,8-d7 (CAS# 1219795-25-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Ethyl-alpha,alpha-d2-pyrazine-3,5,6-d3 (CAS# 1276197-45-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Propiophenone-d10 (CAS# 288400-96-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Pyrrolidinone-3,3,4,4,5,5-d6 is D6 labelled 2-Pyrrolidinone which is widely used organic polar solvent for various applications. 2-Pyrrolidinone is also an intermediate in the manufacture of polymers.<br>References Rashid, M.D., et al.: J. Nanosci. Nanotech., 12, 840 (2012); Yeao, S.M., et al.: Advc. Sci. Tech., 64, 33 (2010);<br></p>

<p>Applications 1,3-Bis(2-chloroethyl-d4)-1-nitrosourea is a useful isotopically labeled compound of Carmustine (C183875)<br></p>

<p>Applications Methyl Nonanoate can be used to synthesize vanillyl nonanoate, a capsinoid. Capsinoids are found in chili peppers and exhibit anti‑obesity, anti‑hypertension, anti‑diabetes and anti‑inflammatory properties. Environmental contaminants; food contaminants.<br>References Kobata, K., et al.: Biosci Biotechnol Biochem. 66, 319 (2002); Snitker, S., et al.: Am J Clin Nutr. 89, 45 (2009); Hong, Q., et al.: Mol Med Rep. 11, 1669 (2015)<br></p>

<p>Applications Dimethyl-1,1,1-d3 Sulfide (CAS# 12/9/4752) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Dodecyl Alcohol-OD (CAS# 14848-65-8) is a useful isotopically labeled research compound. It can be used for neutron spin-echo spectroscopy.<br>References Yamaguchi, T., et.al., J. Phy. Chem. B., 123, 239-246, (2019);<br></p>

<p>Applications A substituted piperidine as pesticide.<br>References Nishizawa, R., et al.: Bioorg. Med. Chem. Lett., 20, 763 (2010), Liras, S., et al.: Bioorg. Med. Chem. Lett., 20, 503 (2010),<br></p>

<p>Applications L-4-Hydroxyphenyl-d4-alanine-2-d1 (CAS# 1226919-57-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications A nitrosoamine compound that shows carcinogenic effect.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004),<br></p>

<p>Applications 2,2-Dimethyloctanoic Acid is used in biological studies as benzyl dimethyloctanoate metabolite of sewage bacteria.<br>References Millier, A., et al.: Bull. Environ. Contam. Toxicol., 28, 113 (1982);<br></p>

<p>Stability Hygroscopic<br>Applications α-Cyclodextrin is a 6 member dextrin ring used as an encapsulation agent for bioactive compounds and pharmaceuticals.<br>References Pinho, E. et al.: Carb. Polym., 101, 121 (2014);<br></p>

<p>Applications 3-Buten-2-ol is a useful compound in organic synthesis.<br>References Kumar, Gangam S., et al.: J. of Org. Chem., 83(7), 3941-3951 (2018); Han, Sang H., et al.: Asian J. of Org. Chem., 6(12), 1823-1829 (2017);Vasil'ev, A. A., et al.: Russ. Chem. Bul., 66(4), 661-665 (2017)<br></p>

<p>Applications Ethyl Octadecanoate-d35 (CAS# 1219795-49-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(2-ethoxyethyl) Phthalate-3,4,5,6-d4 (CAS# 1398066-12-0) is a useful isotopically labeled research compound.<br></p>