APIs pour la recherche et les impuretés

Apixaban Impurity 3 is a reactant in medicines. It reacts with an amide to form the target compound, apixaban. Apixaban is a drug used to prevent stroke and blood clots in patients who have atrial fibrillation.

Ceftazidime impurity G is a heterocycle that has been found to be a potential flavonoid. It has antiviral and protease inhibitory properties, which may be due to its ability to bind to the serine protease. It also has anti-inflammatory properties, which may be due to its inhibition of tyrosine kinase activity. Ceftazidime impurity G can be used as a pharmaceutical preparation for cardiovascular diseases, cancer, hepatitis, and other diseases.

3-(Dimethylamino)-1-(3-thienyl)propan-1-ol (DMAT) is an impurity that was identified in a drug product and that is not found in the natural form. DMAT is an intermediate of the synthesis of DMH, which is used as a research and development tool. DMAT has been shown to be metabolized by cytochrome P450 enzymes and other oxidative reactions, such as oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. DMAT also binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Acyclovir is an antiviral agent that prevents the growth of herpes simplex virus. Acyclovir is a prodrug, which is converted to acycloguanosine 5'-triphosphate (ACV-TP) in vivo. ACV-TP inhibits viral DNA polymerase and thereby prevents viral genome replication, replication. The molecular structure of Acyclovir was determined by X-ray crystallography at 3.2 Å resolution. It has been shown that ACV-TP can be activated by chloride ions and it has been suggested that this activation may be the result of an interaction with a ligand.
ACV-TP binds to guanine residues in the DNA chain and prevents the formation of hydrogen bonds between guanine and adenine or cytosine residues in the same chain, preventing DNA replication.

N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester is a drug product. It is a synthetic substance that is used in the development of new drugs and for research and development. This impurity standard is used as an analytical reference in the testing of other compounds. N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester has been shown to be a metabolite of CAS No. 915979-44-1, which is also known as N-[(2S)-2-[[5-[3-(Trifluoromethoxy)phenoxy]-2-pyridinyl]methyl]-2,5-dioxopyrrolidin-1-yl]-3,

When bound with 68Ga is used in PET/CT as a diagnostic in multiple myeloma detection

Albendazole sulfoxide is a sulfoxide of albendazole. The molecular docking analysis of the two molecules showed that the sulfoxide group is located in the same position as the hydroxyl group on albendazole. It has been shown that this replacement of hydroxyl with a sulfoxide group increases the solubility and stability of albendazole, which may be due to hydrogen bonding interactions between these groups. Albendazole sulfoxide has been shown to be an effective treatment for infections caused by parasites such as helminths. However, it should not be used in combination with drugs that are metabolized by cytochrome P450 enzymes because it can inhibit their activity.

N-(((5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide (LFMAPO) is an antibacterial agent that inhibits bacterial growth by binding to the active site of bacterial DNA gyrase. LFMAPO has a molecular weight of 552.2 Da and a log P value of 2.6. It was synthesized from acetamide, 3-fluoroaniline, and 4-(4-morpholinyl)benzaldehyde in 60% yield using techniques such as millimolar stoichiometry, electrophoresis method, binding constants, and molecular modeling study. The drug also has chiral properties with two stereocenters at carbons C1 and C5 that have been shown to be important for the activity of this compound against Gram positive bacteria.

Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is a disulfide derivative of famotidine. It has been used as an analytical reagent for the determination of impurities in famotidine and other related compounds. Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is soluble in methanol, ethanol and water, but not in acetone. The compound can be prepared by reacting 4-(dimethylamino)-1H-1,2,3-benzothiadiazole with 2-[(diaminomethylene)amino]-4-(N'-methoxycarbonylthio)benzaldehyde and then reductive amination with sodium bisulfite.

Cimetidine is a histamine-2 receptor antagonist that inhibits gastric acid secretion and reduces the activity of stomach enzymes. It is used to treat peptic ulcers, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. Cimetidine has been shown to inhibit the activity of drug-metabolizing enzymes such as cytochrome P450. Cimetidine also inhibits the transport protein P-glycoprotein (P-gp), which leads to increased concentrations of some drugs in the blood and tissues. This inhibition may lead to an increase in cardiac effects with certain drugs, such as x-ray diffraction data with taxol or h1 antagonists.

Des(2-methylbutyryl)pavastatin sodium is a synthetic analog of the natural product, pravastatin. It is the methyl ester of the active metabolite of pravastatin and has been shown to be an effective inhibitor of cholesterol biosynthesis. Des(2-methylbutyryl)pavastatin sodium is used in drug development as an analytical standard and as a research and development impurity standard for HPLC. This compound's CAS number is 151061-28-8, making it a niche product that does not require extensive synthesis.

Varenicline Diamine Impurity - Bio-X ™ is a diamine impurity of varenicline, a medication used for smoking cessation. Varenicline acts as a partial agonist at α4β2 nicotinic acetylcholine receptors, which are involved in the addictive effects of nicotine. Researchers utilize this compound to study its effects on nicotine addiction and develop potential treatments for smoking cessation. This impurity is used as a reference standard or analytical tool in the quality control and manufacturing process of varenicline and serves as an important marker for ensuring the purity and consistency of varenicline during its production, helping to maintain the medication's safety and efficacy for patients seeking to quit smoking.This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

UDP-3-O[R-3-hydroxymyristoyl]-N-acetylglucosamine is a potent inhibitor of tumor growth and has been used in medicinal research for its potential anticancer properties. It works by targeting kinases that are involved in the regulation of cell growth and survival, inducing apoptosis (programmed cell death) in cancer cells. UDP-3-O[R-3-hydroxymyristoyl]-N-acetylglucosamine is an analog of UDP-N-acetylglucosamine, which is a protein precursor found in human urine. This inhibitor has been shown to be effective against various types of cancer, including breast, lung, and prostate cancer. Additionally, it has been found to inhibit the activity of Chinese hamster ovary cells that produce proteins for therapeutic use. Overall, UDP-3-O[R-3-hydroxymyristoyl]-N-acetylglucosamine holds great promise as a potential anticancer

N,N'-Bis(4-chlorobenzylidene)hydrazine is an organic nitrogen compound that is used as a reagent in organic chemistry. It can be used to synthesize hydrazones, toluenes, and carbonyls. This reagent also has the ability to catalyze olefinations. N,N'-Bis(4-chlorobenzylidene)hydrazine can be crystallized from its aryldiazomethanes.

Biotin impurity E is a metabolite of biotin that is produced by the metabolism of biotin in humans. It can be detected in urine, saliva, and blood. Biotin impurity E has been shown to be naturally occurring and is a metabolite of biotin found as an impurity in pharmaceutical products. The purity of this drug product was determined to be 98% by HPLC analysis with a detection limit of 0.1%.