APIs pour la recherche et les impuretés

Applications Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Used for preparation of glycopyranoside phosphates for treatment of T lymphocyte mediated inflammatory diseases.
References Detheux, M., et al.: Eur. J. Biochem., 200(2), 553 (1991),

Applications Intermediate in the production of Deoxyfuconojirimycin
References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997),

Applications 1,5-Dichloro-2-methoxy-4-(4-nitrophenoxy)benzene, is used for the synthesis of three major ring-hydroxylated metabolites of Diclofop-methyl, acting as herbicide.
References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);

Applications A metabolite of Alpidem.
References Padovani, P., et al.: Eur. J. Drug Metab. Pharmacokinetics, 12, 295 (1987).

Applications N-Carbamoyl-DL-aspartic Acid (cas# 923-37-5) is a useful research chemical.

Applications 1-(6-Amino-9-β-D-ribofuranosyl-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid is used in the preparation of adenosine receptor nanoagonists.
References Gao, X., et al.: ACS Nano, 8, 3678 (2014)

Applications A metabolite of Perhexiline.
References Shah, R., et al.: Br. Med. J., 284, 295 (1982), Gould, B., et al.: Xenobiotica, 16, 491 (1986), Marquet, P., et al.: Ther. Drug Monit., 24, 255 (2002), Sallustio, B., et al.: Br. J. Clin. Pharmacol., 54, 107 (2002),

Applications A process impurity of Rabeprazole (R070500).

Applications α-Phenyloxiranepropanenitrile is used in the preparation of CC-1065 and its analogs.
References Bryson, T.A., et al.: Synlett, 9, 723 (1992),

Applications A useful building block for oligoribonucleotide synthesis.

Applications [(Dimethylamino)methylene]malononitrile (cas# 16849-88-0) is a compound useful in organic synthesis.

Applications 2,5-Dimethylterephthalic acid

Applications Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.
References Kjell, D.P., et al.: Org. Proc. Res. Development., 9, 738 (2005); Taylor, E. C., et al.: J. Org. Chem., 66, 3726 (2001);

Applications PYRENE-4,5-QUINONE (cas# 6217-22-7) is a useful research chemical.

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.
References Wakita, T., et al.: J. Pesticide. Sci., 29, 348 (2004);

Applications A labelled isotpe of Isopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (I485580). A short-acting intravenous anaesthetic agent used for dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),

Applications (6α,11β,16α,17α)-6-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxo-androsta-1,4-diene-17-carboxylic Acid is a fluorosteroid which was prepared and used in the study of hormone pharmacology and tested for androgenic, anabolic, antiandrogenic, gestagenic, estrogenic, antiestrogenic thymolytic, antiinflammatory, and mineralocorticoid activities.
References Gusarova, T. I., Khimiko-Farmatsevticheskii Zhurnal, 14, 39-42, (1980)

Applications 1,3-dimethylpyrrolidin-2-one (cas# 19597-07-0) is a useful research chemical.

Applications Isatin sulfonamide analog as Caspase-3 inhibitors.
References Thompson, C., et al.: Science, 267, 1456 (1995), Chu, W., et al.: J. Med. Chem., 48, 7637 (2005), Jana, S., et al.: Curr. Med. Chem., 14, 2369 (2007), Schoenberger, J., et al.: Curr. Med. Chem., 15, 187 (2008),

Applications 2-Hydroxy Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast & prostate.
References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

Applications 3,5-Dichlorobenzonitrile is an internal standard in the determination of dichlobenil and it’s metabolites in onions.
References Herrero, A., et al.: Chemom. Intell. Lab. Syst., 133, 92 (2014)

Applications 2,4,6-Trimethylbenzeneamine-d11 (cas# 1126138-13-3) is a compound useful in organic synthesis.

Applications 2-Hydroxy-estrone-6-N3-adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogenous initiators of various human cancers, such as breast & prostate.
References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

Applications Apalutamide-d3 is a labelled analog of Apalutamide (A726120) and has been explored for its pharmacological activities.
References Pang, X., et al.: Bioorg. Med. Chem. Lett., 27, 2803 (2017)

Applications 3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Stability Moisture Sensitive, Hygroscopic
Applications 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (cas# 137049-02-6) is a useful research chemical.

Applications Homoallylglycine is a glycine derivative that displays translational activity in Escherichia coli.
References Van H. et al.: J. Am. Chem. Soc., 122, 1282 (2000)

Applications Isocitronellene is part of an essential oil extract of Campanula glomerata L. subsp. hispida which may contain antimicrobial activity. Also may display anti-platelet activity when extracted from Allium atroviolaceum Boiss growing in Iran.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sinek, K. Asian J. Chem., 24, 1931 (2012); Lorigooini, Z. et al.: Int. J. Biosci., 5, 151 (2014);

Applications Used in glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo.
References Mahal, L., et al.: Science, 276, 1125 (1997), Apweiler, R., et al.: Biochim. Biophys. Acta, 1473, 4 (1999), Becker, D., et al.: Glycobiology, 13, 41R (2003),

Applications Intermediate for the preparation of Elacridar.

Applications N-Acetyl-D,L-homotryptophan Ethyl Ester (cas# 110504-55-7) is a compound useful in organic synthesis.

Applications Neopatulin is a mycotoxic substance which is produced by Penicillium and Aspergillus species. The molecule possesses useful antibiotic and antibacterial properties, but it is also an unwelcome contaminant in food and a general plant toxin.
References Ellis, J.R., et al.: Appl. Microbiol., 25, 562 (1973), Priest, J.W., et al.: Biochemistry, 28,  9192 (1989),

Applications Valsartan intermediate.
References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)

Applications N2-t-Boc-N6-(biotinamido-6-N-caproylamido)lysine (cas# 102910-26-9) is a compound useful in organic synthesis.

Applications Lumiflavin (L473900) derivative.

Applications 3-Methylpentyl Chloroformate is an isomer of 2-Methylpentyl Chloroformate (M324735) which is an intermediate used to prepare azidoformates in a high yield.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wu, P., et al.: J. Chinese Chem. Soc., 47, 271 (2000)

Applications (2S,3R)-3-Hydroxynorleucine is an analogue of DL-6-Hydroxy Norleucine (H948855) which is an intermediate for antiviral and antihypertensive drugs.
References Kaufman, S., et al.: J. Biol. Chem., 257, 14667 (1982), Hanson, R., et al.: Bioorg. Chem., 18, 116 (1990), Oshima, T., et al.: J. Bacteriol., 173, 3943 (1991), Oshima, T., et al.: Eur. J. Biochem., 222, 305 (1994), Robl, J., et al.: J. Med. Chem., 40, 1570 (1997)

Applications 2-[2-(2-Aminophenoxy)ethoxy]-4-methyl-benzenamine (cas# 96331-95-2) is a compound useful in organic synthesis.

Applications Protected trapping agent.

Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)

Applications 2-Bromo-1,4-dichlorobenzene is a reactant used in the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708.
References Plesescu, M., et. al.: J. Labelled Compd. Rad., 56, 464 (2013)

Applications N-[(1R)-1-(Phenylmethyl)-2-propen-1-yl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of N-protected α-amino epoxids, key intermediates for HIV protease inhibitors.
References Blacker, A.J., et al.: Org, Proc. Res, Develop., 15, 331 (2011)

Applications 3-Methyl-3-azetidinecarboxylic Acid is a useful reagent for the synthesis of PD-1/PD-L1 inhibitors for treatment of cancer.
References Aktoudianakis, E., et al.: PCT Int. Appl. (2020), WO 2020014643 A1

Applications A useful synthetic intermediate.
References Li, A., et al.: J. Med. Chem., 42, 706 (1999), Low, E., et al.: Bioorg. Med. Chem. Lett., 19, 196 (2009),

Stability Moisture Sensitive
Applications A synthetic intermediate

Applications Benazeprilat Ethyl tert-Butyl Diester is an analog of Benazepril (B119750).

Applications 6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.

Applications 6-Chloro-D,L-tryptophan (cas# 17808-21-8) is a compound useful in organic synthesis.

Stability Very Hygroscopic
Applications A useful ligand for incorporation of EDTA-metal complexes into proteins particularly for investigating orientation of DNA binding proteins.
References Ebright, Y.W., et al.: Biochemistry, 31, 10664 (1992), Flaus, A. and Owen-Hughes, T.: Mol. and Cell. Biology, 23, 21, 7677 (2003), Bruno, M., et al.: Methods Enzymol, 375, 211 (2004)

Applications 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)-ethyl]methyl-amino}-pentanenitrile (cas# 95748-23-5) is a compound useful in organic synthesis.

Applications 7-Ethyl-10-(4-[[benzylcarbamoyl]amino]-1-piperidino)carbonyloxycamptothecin (cas# 1217686-49-1) is a compound useful in organic synthesis.

Applications 2-hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid (cas# 101949-49-9) is a useful research chemical.

Applications An intermediate in the synthesis of various beta-lactam antibiotics.
References Jones, R., et al.: J. Clin. Microbiol.,15, 677 (1982), Matagne, A., et al.: Biochem. J., 330, 581 (1998), Zlokarnik, G., et al.: Science, 279, 84 (1998),

Applications 2,3-Dichloro-5-fluoropyridine is a reagent that is used in the synthesis of 3-Chloro-5-fluoro Clodinafop Propargyl (C368645), which is an impurity of Clodinafop Propargyl (C584515).
References Aliverdi, A., et al.: Weed Biol. Management, 9, 292 (2009), Hochberg, O., et al.: Weed Res., 49, 37 (2009), Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010),

Applications A diazirine photophore used in photoaffinity labelling for probing receptor-ligand interfaces and other biopolymer research.
References Hatanaka, Y. et al.: Heterocycles, 47, 625 (1998); Hashimoto, M. et al.: Anal. Biochem., 348, 154 (2006);

Applications Protected Lysine

Applications 2-Iodo Adenosine 2’,3’-Acetonide (cas# 141018-25-9) is a compound useful in organic synthesis.

Applications The N-oxide impurity of the selective serotonin reuptake inhibitor Dapoxetine (D185700).

Applications A sulfhydryl reactive homobifunctional reagent for polypeptide or small molecule conjugation.
References Moller, J., et al.: J. Biol. Chem., 268, 18659 (1993), Farrens, D., et al.: Science, 274, 768 (1996), Musatov, A., et al.: Biochemistry, 39, 12996 (2000), Fotiadis, D., et al.: Nature, 421, 127 (2003), Vogel, R., et al.: J. Mol. Biol., 338, 597 (2004),

Applications 2-Iodo-5’-ethylcarboxamido-2’,3’-O-isopropylidineadenosine (cas# 162936-24-5) is a compound useful in organic synthesis.

Applications 4-Bromo-1-naphthoic acid

Applications 6-Benzyloxy Warfarin (cas# 30992-68-8) is a compound useful in organic synthesis.
References Barker, W., et al.: J. Med. Chem., 14, 167 (1971),

Applications Protected Enalaprilat (E555375) a metabolite of Enalapril (E555245).

Stability Hygroscopic
Applications (R)-isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate is an impurity of Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Applications Bisphenol A (B519495) impurity with estrogenic activity.
References Terasaki, M. et al.; Environ. Sci Tech. 39, 3703 (2005); Poskrobko, J. Chromatoogr. A 883, 291 (2000)

Applications 5-Bromo-2,3-dihydroxybenzoic Acid (B684125) derivative. Used in the preparation of hydroxyalbuterol and bisubstrate inhibitors. Displays low inhibitory activity towards sn-glycerol-3-phosphate oxidase of Trypanosoma brucei brucei.
References Ellermann, M. et al.: Chem. Eur. J., 17, 6369 (2011); Yee, N. et a.: Bioorg. Med. Chem. Lett., 6, 2279 (1996); Grady, R. et al.: Mol. Biochem. Parasit., 21, 55 (1986)

Applications A potent selective adenosine receptor agonist.
References Gallo-Rodriquez, et al.: J. Med. Chem., 37, 636 (1994), Gao, Z., et al.: Biochem. Pharmacol., 65, 1675 (2003), Rodenko, B., et al.: Bioorg. Med. Chem., 14, 1618 (2006),

Applications An intermediate for the synthesis of Alpidem.

Applications (4R, 2S)-4-Hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-proline Methyl Ester (cas# 179990-59-1) is a compound useful in organic synthesis.