APIs pour la recherche et les impuretés

<p>Azithromycin N-ethyl is a drug development and analytical impurity standard. It is used as an analytical reference material for high-performance liquid chromatography (HPLC) and nuclear magnetic resonance spectroscopy (NMR). Azithromycin N-ethyl has been shown to be a metabolite of azithromycin, which is a niche antibiotic with broad activity against Gram-positive bacteria. This product can also be synthesized from erythromycins using methylation. CAS Number: 92594-45-1</p>

<p>Flumethasone Impurity 11 is a drug product that is used in the research and development of drugs. Flumethasone Impurity 11 is an analytical impurity that can be found in the natural API, Flumethasone. It has a molecular weight of 537.3 and its CAS number is 1069-81-4. Flumethasone Impurity 11 is synthesized from other synthetic chemicals and is used as an impurity standard for HPLC analysis. This product has been shown to be pharmacopoeia grade with a purity of 99%.</p>

<p>2-Deoxy-5-O-toluoyl-D-ribofuranose is an analytical standard for the determination of purity in drug products. It is also used as a reference compound for HPLC and as a metabolite to study metabolism. This impurity can be synthesized from D-ribose and 2(3,4,5)-O-benzylidenebutyraldehyde.</p>

<p>N-Formyl-L-leucine (1S)-1-[[(2R,3R)-3-hexyl-4-oxo-2-oxetanyl] methyl] dodecyl ester is an impurity in the drug product. It can be used as a custom synthesis or natural standard and has been shown to have metabolites that are toxic to human cells. This impurity can be synthesized for HPLC analysis and research purposes.</p>

<p>Pruvanserin hydrochloride is a synthetic compound that belongs to the group of drugs called selective serotonin reuptake inhibitors (SSRIs). It is used for research and development purposes. Pruvanserin hydrochloride has not been marketed as a drug product. This compound has shown to be an impurity in several commercial products and has been found to be present in two drugs, including fluoxetine HCl and sertraline HCl. Pruvanserin hydrochloride is metabolized by cytochrome P450 enzymes and glucuronidases. The half life of this drug is between 3-5 hours following oral administration, with higher doses leading to higher plasma concentrations.</p>

<p>Please enquire for more information about PBT Impurity 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Solifenacin Impurity D is a synthetic impurity of solifenacin. Solifenacin is an anti-cholinergic drug used to treat overactive bladder and urinary incontinence. The purity of this product is 99%. It is soluble in methanol, ethanol, chloroform, and acetone. Solifenacin Impurity D can be used as a reference material for analytical purposes or as an impurity standard in the development of new drugs.</p>

<p>Ethyl 2-methoxy-5-sulfamoylbenzoate is a research and development impurity standard. It is a white to off-white crystalline solid that is soluble in water. The product has been synthesized for use as a drug product, synthetic, and in the synthesis of other compounds. It has also been used as a metabolite in metabolism studies and an analytical standard for HPLC.</p>

<p>4-(Phthalazin-1-yloxy)aniline is an analog of cyclin-dependent kinase (CDK) inhibitors that has shown promising anticancer activity. It inhibits the activity of CDKs, which are enzymes involved in regulating cell division and proliferation. This compound has been tested on Chinese hamster ovary cells and has demonstrated potent antiproliferative activity against various cancer cell lines. 4-(Phthalazin-1-yloxy)aniline induces apoptosis in tumor cells, leading to their death. This compound may be a potential candidate for the development of novel anticancer drugs that target CDKs and promote tumor cell death. Additionally, this compound can be detected in urine samples, making it a useful biomarker for cancer diagnosis and monitoring.</p>

<p>Dihydrexidine hydrochloride is a phosphate ion transport inhibitor that binds to the acetylcholine transporter, and inhibits the uptake of acetylcholine in the brain. It is used as an opioid analgesic, as well as to treat depression, cognitive disorders, and Parkinson's disease. Dihydrexidine hydrochloride binds to the catechol-O-methyltransferase (COMT) enzyme and prevents it from breaking down dopamine. This leads to increased levels of dopamine in the synapse and enhanced transmission of nerve impulses between neurons. Dihydrexidine hydrochloride also has been shown to bind to antigen molecules on cells, which may be important for its antiviral properties.</p>

<p>7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one is an analytical reference standard for HPLC. It is a white to light yellow crystalline powder that is soluble in water and ethanol. This compound has been synthesized from 4-(2,3-dichlorophenyl)piperazine and 3,4-dihydroquinoline 2(1H)-one. This molecule has been identified as an impurity in the drug product, Cefdinir (7-(2-(3,4-Dihydroxyphenoxy)propoxy)-3,4-dihydroquinolin-2(1H)-one). The purity of this chemical has been shown to be greater than 99.5% by high performance liquid chromatography (HPLC).</p>

<p>Please enquire for more information about N-Desformyl N-acetyl (S,S,R,S)-orlistat (orlistat impurity) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Toremifene-N-oxide is a drug that has been shown to have genotoxic effects in human liver cells in an incubated system. Toremifene-N-oxide is the active form of toremifene, which is a selective estrogen receptor modulator (SERM). Toremifene-N-oxide is metabolized by peroxidases and can react with reactive oxygen species (ROS) to produce DNA damage. It also binds to DNA at the site of supercoiled DNA, leading to changes in the molecule's structure. Toremifene-N-oxide has been shown to have an optimum pH of 7.4 and ionization mass of 367. This drug binds to lactoperoxidase found in human liver cells and produces reactive molecules that cause oxidative DNA damage.</p>

<p>Hexadecanedioic acid mono-L-carnitine ester chloride is an analog of a naturally occurring compound that has been found to have medicinal properties. This compound has shown potential as an anticancer agent due to its ability to inhibit cancer cell replication and induce apoptosis. It has been studied extensively in human tumor cells, where it has been shown to inhibit kinase activity and protein synthesis. This inhibitor may also have potential as a urinary biomarker for cancer diagnosis. Additionally, this compound has been tested in Chinese hamster ovary cells, where it showed potent inhibitory effects on the growth of these cells. Overall, Hexadecanedioic acid mono-L-carnitine ester chloride is a promising candidate for further research into its potential therapeutic uses in cancer treatment.</p>

<p>Please enquire for more information about (rac)-Bl-918 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pidotimod Diketopiperazine is a test substance that is a phosphoric acid salt of pidotimod with a diketopiperazine group. Pidotimod Diketopiperazine has an elution time of approximately 3 minutes, on the Agilent HPLC column. It is soluble in water and has a pH of around 1.5-2.5. Pidotimod Diketopiperazine is used to solubilize phosphoric acid and can be used as an eluant for phosphoric acid in HPLC analysis.</p>

<p>9-[[(2,2,2-Trifluoroethyl)amino]carbonyl]-9H-fluorene-9-butanoic acid is a research and development impurity standard. It is used as a reference material for HPLC analysis of metabolites in drug product and drug development. This compound has been synthesized using synthetic methods. It is also used as a pharmacopoeia impurity standard for the synthesis of drug products, as well as an analytical reference material for determining the purity of drugs. The CAS number for 9-[(2,2,2-trifluoroethyl)amino]carbonyl]-9H-fluorene-9-butanoic acid is 182439-11-8.</p>

<p>Avanafil impurity 26 is a metabolite of avanafil that has been synthesized for use as an impurity standard. It is a white to off-white crystalline powder and has a purity of 99% or greater. Avanafil impurity 26 is insoluble in water and soluble in methanol, ethanol, and acetone.</p>

<p>7α,24(S)-Dihydroxycholesterol (7α,24(S)-DHCH) is a fatty acid that is produced by the liver and is an intermediate in cholesterol biosynthesis. 7α,24(S)-DHCH has been detected in plasma samples of patients with cerebrotendinous xanthomatosis (CTX). It has also been found to be elevated in tuberculosis patients with carotid involvement. The levels of 7α,24(S)-DHCH were found to be higher than those of other oxysterols in CTX patients. In order to identify the origin of this molecule, a LC-MS/MS method was developed for the detection and quantification of 7α,24(S)-DHCH. This method uses chemical ionization for mass spectrometric analysis and can detect 7α,24(S)-DHCH at concentrations as low as 1 ng/mL. Histological analyses were conducted on human tissue samples</p>

<p>Lenvatinib impurity 2 is a drug product that is used as an HPLC standard. It is a natural metabolite of lenvatinib, which is developed for the treatment of various types of cancers. The compound has been shown to inhibit the growth of human tumor cells and induce apoptosis in cell lines.<br>Lenvatinib impurity 2 is a synthetic compound that can be custom synthesized to meet specific requirements and needs. It has been found to have pharmacological effects similar to those of lenvatinib, but with less toxicity.<br>Lenvatinib impurity 2 can be used as an analytical or API impurity for the development, research and analysis of lenvatinib-based drugs. This compound has also been found to be useful in metabolism studies when testing for potential adverse reactions due to its similarity with lenvatinib.</p>

<p>Lisinopril is a drug product that is used to treat high blood pressure, heart failure and other conditions. It belongs to the class of angiotensin-converting enzyme inhibitors and has been shown to inhibit the activity of angiotensin I converting enzyme (ACE) in the body, which leads to increased levels of bradykinin, an important peptide in inflammation. Lisinopril is a metabolite of cilazapril and lisinoprilat, both of which are prodrugs. Lisinopril has been shown to be effective in reducing blood pressure and improving survival rates in patients with heart failure.</p>

<p>Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid is a reagent that is used in analytical procedures for the determination of phosphate and potassium. Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid can be used to determine the concentrations of phosphate and potassium in human plasma, serum, or other biological fluids. It reacts with phosphates to form an insoluble salt which can be detected by fluorimetry. Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid can also be used as an analytical standard in high performance liquid chromatography (HPLC) to measure the concentration of phosphate.</p>

<p>Imidapril tert-butyl ester is a drug product that is custom synthesized. It has a purity of &gt;98% and analytical data available. Imidapril has been shown to be metabolized in vivo through hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. There is also an impurity standard for this compound. Imidapril tert-butyl ester is used in pharmacological research and development to identify the metabolites of this compound.</p>

<p>Impurity A is an impurity of the drug product, dexamethasone. The impurity is a natural metabolite of dexamethasone that is found in the urine of patients taking this medication. Impurity A is chemically identified using HPLC and its purity verified using GC-MS and LC-MS. This impurity can be used as a reference standard for analytical purposes and as an impurity standard for pharmacopoeia testing.</p>

<p>Decladinose roxithromycin is a novel drug that can be used for the diagnosis and treatment of disorders related to the mutation. Decladinose roxithromycin has been shown to be effective in the detection and treatment of mutants, such as those related to cystic fibrosis.</p>

<p>Balsalazide Isopropyl ester is a synthetic compound that is used as an active pharmaceutical ingredient in the treatment of irritable bowel syndrome. Balsalazide Isopropyl ester is metabolized to balsalazide and its metabolites are excreted in the urine. It has been evaluated for use in drug development and research, but it is not approved by the FDA for human use.</p>

<p>Fusidic acid EP Impurity C is an impurity found in Fusidic acid EP. It is a natural product with CAS No. 598-10-3 and molecular weight of 225.24 g/mol. It is a synthetic product with CAS No. 477-81-8 and molecular weight of 219.25 g/mol. This impurity has been shown to be pharmacologically active and may account for the observed activity of the drug product in some cases, but not all cases. This impurity can be synthesized from commercially available starting materials or by custom synthesis as required by customers' specifications.</p>

<p>6-Hydroxy melatonin is a metabolite of the hormone melatonin. It is used as a research and development impurity standard for drug product, as well as a custom synthesis. 6-Hydroxy melatonin is synthesized from the amino acid tryptophan, which is converted to serotonin in the pineal gland by the enzyme tryptophan hydroxylase. This conversion occurs through two steps: tryptophan hydroxylase converts tryptophan to 5-hydroxytryptamine (serotonin), and then 5-hydroxytryptamine to 6-hydroxytryptamine (6-OHMT). 6-OHMT can be methylated to form 6-methoxyindoleacetic acid (6-MITA) or oxidized to form melatonin.</p>

<p>Rjr 2429 dihydrochloride is a tumor promoter that has been shown to induce tumor growth in tissues and in cell culture. It inhibits the proliferation of tumor cells by binding to retinol-binding protein, thereby preventing the uptake of vitamin A. Rjr 2429 dihydrochloride also induces the production of flavanones, which are known to be inhibitors of proliferative processes. This compound has been studied for its ability to prevent retinopathy and has been shown to inhibit light-induced photoreceptor degeneration in rats.</p>

<p>3,3'-Bisdemethylpinoresinol is a phenylpropanoid that has been shown to have antioxidant properties. It inhibits melanogenesis, tyrosinase activity, and lipoprotein oxidation. 3,3'-Bisdemethylpinoresinol has also been shown to prevent the oxidation of low-density lipoprotein (LDL) cholesterol, which is thought to be the cause of atherosclerosis and cardiovascular disease. This compound may be useful in preventing the development of cancerous tumors due to its ability to inhibit radical scavenging activities by various oxidative species and its antioxidative activity.</p>

<p>1-Cyclopropyl-7-8-difluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester is a research and development impurity standard. It is a custom synthesis and is sold as drug product for use in drug development. 1CPDE is a synthetic compound that has been shown to have pharmacological activity. This compound has not been approved by the FDA or other regulatory agency as of yet. The CAS number for this compound is 1329836-33-0, and it can be found on the National Institute of Standards and Technology (NIST) website under the Chemical Abstract Service (CAS) registry number. 1CPDE has been shown to be an intermediate metabolite in metabolism studies and also has analytical applications such as HPLC standards.</p>

<p>p-Iodoclonidine hydrochloride is a cholinergic agent that binds to both acetylcholine and dopamine receptors. It is also an antagonist of the 2-adrenergic receptor and α2-adrenergic receptor. p-Iodoclonidine hydrochloride has been shown to inhibit phosphatase activity and cellular membrane hyperpolarization in vitro, leading to respiratory control in vivo. This compound also has an excitatory effect on the central nervous system, which may be due to its ability to stimulate β-adrenergic receptors in the rostral ventrolateral medulla.</p>

<p>1,4-Dihydro-1-(5-methoxy-1H-benzimidazol-2-yl)-3,5-dimethyl-4-oxo-2-pyridinecarboxylic acid ammonium salt is a drug product that is custom synthesized to meet the requirements of our customers. It has high purity and analytical properties. Metabolism studies are performed to determine how the drug is broken down in the body and how it may affect other drugs or chemicals. The natural form of this chemical is found in plants and animals. Drug development studies are conducted to find out if this chemical can be used to treat a disease or condition. Pharmacopoeia standards are established for this compound and impurity standards are developed for quality control purposes. CAS No. 2227107-89-1</p>

<p>Metamizole EP impurity E is a synthetic research and development impurity standard for the drug product. Metamizole EP Impurity E is used in the synthesis of drugs as an API impurity, or as a metabolite of drugs. The chemical purity is typically greater than 98%. Metamizole EP Impurity E can be used as an analytical standard for HPLC and GC analysis. This product is also used in metabolism studies to identify the metabolites of a drug.</p>

<p>1,1-Bis-(methylthio)-2-nitroethene is a versatile molecule that can be used as an imine. It is synthesized by reacting trifluoromethanesulfonic acid with the amine in the presence of a base. The imine product has been shown to bind to amines and is therefore a potential drug candidate for prostate cancer cells. 1,1-Bis-(methylthio)-2-nitroethene reacts with triflic acid to produce an intramolecular hydrogen bond, leading to its efficient synthesis. The resulting compound then undergoes reactions that are characterized by nmr spectra and profiles. This functional group is inhibitory against prostate cancer cell lines at high concentrations, although it has no effect on other cell lines.</p>

<p>Please enquire for more information about Rivaroxaban impurity 79 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ketoconazole Impurity A is a synthetic impurity of Ketoconazole, which is used as an anti-fungal agent. Ketoconazole Impurity A can be found in ketoconazole formulations and also in ketoconazole synthesized by the body. Ketoconazole Impurity A is a metabolite of Ketoconazole and has been shown to have cytotoxic effects on human cells in vitro. Ketoconazole Impurity A has been shown to inhibit RNA synthesis and protein synthesis, leading to cell death. The cytotoxic effects of this drug are due to its ability to bind DNA and inhibit DNA synthesis. It also inhibits the activity of beta-lactamase, an enzyme that breaks down penicillin antibiotics.</p>

<p>3-[2-[4-(1,2-Benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one is an analog of the antibacterial drug cefuroxime. It has been shown to be a potent inhibitor of bacterial DNA gyrase and topoisomerase IV. This compound has been shown to have a greater degree of activity against Gram Positive bacteria than Gram Negative bacteria in vitro. 3-[2-[4-(1,2-Benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-- 2 -methyl-- 4H-- pyrido[1,2-- a]pyrimidin-- 4 -one is not active against acid</p>

<p>Please enquire for more information about Benserazide EP Impurity B hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cladribine Impurity D is a polymerase chain reaction (PCR) diagnostic agent that is used to identify the presence of Cladribine in the blood. Cladribine Impurity D binds to an RNA polymerase enzyme, which prevents it from synthesizing DNA and RNA, resulting in a lack of cell proliferation. This drug has been shown to be effective in treating bowel disease and solid tumours. It also has a number of side effects including interactions with other medications, such as natural compounds and autoimmune diseases, as well as bronchiolitis obliterans and lymphoma. Cladribine Impurity D also interacts with the IL-2 receptor on cells, which may cause allergic reactions. The MDA-MB-231 breast cancer cells are resistant to this drug due to their expression of the protein MCL-1.</p>

<p>2-Cyclohexyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine is a synthetic research and development impurity standard. This compound is used as an analytical reference in pharmacopoeia to determine the purity of synthesized drugs. 2-Cyclohexyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine is also a metabolite of other compounds and can be used for metabolism studies.</p>

<p>Nilotinib N-oxide is a bosutinib metabolite that is categorized as a profile 1B inhibitor. It has a chemical structure similar to imatinib and dasatinib. The metabolite of nilotinib N-oxide, which is an active form, focuses on the inhibition of chronic myeloid leukemia (CML) cells by targeting the oncoprotein BCR-ABL. Nilotinib N-oxide has been shown to have cardiac toxicity, which may be due to its ability to inhibit the synthesis of uridine and reduce thrombocytopenia. It also has the potential for toxicities such as pancreatitis and hepatotoxicity.</p>

<p>Oxybutynin EP Impurity E is a research and development impurity standard that is used in the synthesis of Oxybutynin. It can be synthesized by reacting 2-chloro-4-nitroaniline with potassium tert-butoxide, followed by acetylation with acetic anhydride. The purity and structure of this compound have been verified by gas chromatography, mass spectrometry, and melting point analysis. This impurity standard has a CAS number of 1215677-72-7.<br>Oxybutynin EP Impurity E is used as a drug product for the treatment of overactive bladder, urinary incontinence, and painful bladder syndrome/interstitial cystitis. It also helps to reduce pain due to spinal cord injury or multiple sclerosis. <br>The pharmacopoeia name for this compound is 4-(2-Chloroethyl)-1H-imidazoleacetic acid. It has been found to be</p>

<p>(Z)-2-(2-Oxopyrrolidin-1-yl)but-2-enoic acid is an impurity that is found in the drug product, Metabolite, which is a pharmacopoeia. The CAS number for this compound is 358629-39-7. This compound can be found in the natural and synthetic forms.</p>

<p>Metabolite of mupirocin</p>

<p>Sofosbuvir impurity 6 is an impurity in the drug Sofosbuvir. It is a metabolite that is a by-product of the synthesis process of Sofosbuvir, which is used to treat chronic hepatitis C infection. The purity of this compound has been tested with HPLC and found to be 99.99% pure. This compound can also be synthesized from natural or synthetic sources.</p>

<p>Alfuzosin is a drug used to treat the signs and symptoms of benign prostatic hyperplasia (BPH). The active form of alfuzosin, 1-alfuzosin, is a competitive antagonist at the α1-adrenoceptor. Alfuzosin minimizes the effects of BPH by reducing prostate size and increasing urine flow rate. It is also an impurity in N2-methyl alfuzosin hydrochloride (1:x), which has similar therapeutic uses as alfuzosin.</p>

<p>N-Ethoxycarbonyl norfloxacin is a custom synthesis for research and development. It is an impurity standard used to determine the purity of drug product. This compound is synthesized using the chemistry of synthetic organic compounds, and it has a high purity. N-Ethoxycarbonyl norfloxacin can be used as a pharmacopoeia reference material or as a metabolite in metabolism studies.</p>

<p>5-Methyl-L-norleucine orlistat analogue is an anticancer compound that acts as a kinase inhibitor. It has been shown to inhibit the growth of tumors and cancer cells by inducing apoptosis, or programmed cell death. This analog has been tested in Chinese hamster ovary cells and found to be effective against calcitonin receptor and human oxytocin receptor proteins. Additionally, 5-Methyl-L-norleucine orlistat analogue has been identified as a promising urine-based biomarker for early detection of cancer. Its potential as a therapeutic agent makes it a valuable addition to cancer research and treatment.</p>

<p>4-Oxo diazepam is an impurity that is found in the production of 4-oxodiazepam, a drug product. It has been used in analytical applications as a natural impurity and as an impurity standard. It has also been used in pharmacopoeia to develop high purity standards for HPLC.</p>

<p>4,4'-Bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,1'-biphenyl is a drug product that has been custom synthesized to meet the needs of specific research and development. The CAS number for this compound is 1007882-27-0. It has a purity of ≥99%. This compound is metabolized in vivo to its natural metabolite, 4,4'-bis(2-(pyrrolidin-2-yl)imidazol-5-yl)-1,1'-biphenyl sulfoxide. Metabolism studies have been conducted on rats.</p>

<p>Liriope muscari saponin C is a saponin from the roots of Liriope muscari. The stereoisomers of this compound have been shown to be effective in reversing leukemia cells in mice. Moreover, it has been shown to have anticancer properties in a clinical study that was conducted on human subjects. This compound also has antibacterial properties, which are due to its ability to form conjugates with bacterial cell wall proteins and organic solvents. Furthermore, Liriope muscari saponin C has an anti-inflammatory effect that is mediated by inhibition of prostaglandin synthesis.</p>

<p>Lamivudine acid is a synthetic orotate prodrug that is converted to the active form, lamivudine. It inhibits the synthesis of viral DNA by inhibiting the reverse transcriptase enzyme and has been used as a treatment for HIV infection. Lamivudine acid is soluble in organic solvents such as acetone and cyclohexane. The crystal structure of this compound has been determined using X-ray crystallography and exhibits a zwitterion structure with a hydrogen bond between the carboxylate group and the amide nitrogen atom of the molecule.</p>

<p>10-Hydroxy nortriptyline maleate is a drug product that is manufactured in high purity. This compound is an HPLC standard and is used in the development of drugs. 10-Hydroxy nortriptyline maleate can be natural or synthetic, which will depend on the application. The impurity standard for this compound is 10-hydroxynortriptyline. This compound has been shown to have anti-inflammatory properties and may be useful for neuropathic pain relief.</p>

<p>Apixaban impurity 11 is an analytical standard used in research and development, drug development, and the production of API. It has a purity of 99.5% by HPLC and is a metabolite of apixaban. Apixaban impurity 11 has the CAS number 2204368-51-2 and is a Metabolite and Impurity standard for pharmacopoeia with a purity of 99.5% by HPLC. This product can be custom synthesized or natural with a purity of 99.5% by HPLC.</p>

<p>4-Hydroxy atorvastatin lactone-d5 is a stable isotope that is used to characterize the 3-hydroxy-3-methylglutaryl-coa reductase (HMGCR) inhibition constant of atorvastatin. It is used for calibration and quantification in the analysis of atorvastatin in human liver supernatants and interactions with cytochrome P450 enzymes. The high degree of hydrophilicity of 4-hydroxy atorvastatin lactone-d5 makes it suitable for hydrophilic interaction chromatography (HILIC) separation.</p>

<p>(Z) -2- [4- (1, 2- Diphenylethenyl) phenoxy] - N, N- diethyl- ethanamine hydrochloride is a drug product that is an analytical impurity. It is used as a metabolite standard in drug development and metabolism studies. The CAS number for this compound is 97800-41-4.</p>

<p>Belinostat glucuronide is an analytical standard that is used in HPLC. This compound is a metabolite of Belinostat, which is a drug used to treat lymphoma and other cancers. Belinostat glucuronide has been shown to be active against leukemia cells and can inhibit the growth of cancer cells by inhibiting protein synthesis. It also inhibits the activity of topoisomerase I, II, and III.</p>

<p>Adefovir dipivoxil dimer is a synthetic and natural product that is used as an analytical standard for HPLC, as well as in the development of new drug products. It is also used to identify impurities in API. Adefovir dipivoxil dimer has CAS number 323201-05-4 and can be found on the FDA Orange Book.</p>

<p>CAS No. is a drug product that has been custom synthesized for research and development purposes. It is a white crystalline powder with a melting point of 256-258°C. Metabolism studies have shown that olsalazine sodium impurity E is metabolized to sulfapyridine, which is an active metabolite of olsalazine sodium. Impurity standard A has been synthesized as an analytical standard for HPLC analysis. This impurity standard exhibits the same retention time as olsalazine sodium in the HPLC system and can be used for the quantitative determination of this impurity in olsalazine sodium samples.</p>

<p>Fumarranol is a potent inhibitor of kinases that play a crucial role in cancer cell growth and proliferation. It has been shown to inhibit the growth of tumor cells by inducing apoptosis, or programmed cell death. Fumarranol is effective against various types of cancer, including leukemia, and has been tested on human cell lines. This compound works by blocking the activity of kinases that are essential for the progression of the cell cycle, preventing cancer cells from dividing and multiplying. Fumarranol has also been found in urine samples and may have potential as a biomarker for cancer detection. With its ability to target specific proteins involved in cancer development, fumarranol shows promise as a potential treatment option for various types of cancer.</p>

<p>Fingolimod is a drug product that belongs to the class of synthetic drugs. It is an impurity standard for fingolimod phosphate d4 and its metabolites. Fingolimod phosphate d4 is a metabolite of fingolimod and has been shown to inhibit the synthesis of phosphatidylinositol 3-kinase (PI3K) in vitro, which may be due to its ability to inhibit protein synthesis. The pharmacopoeia for fingolimod phosphate d4 is CAS No. 1794828-93-5.</p>

<p>Apitoxin is a natural toxin found in the venom of honeybees. Studies have shown that it has potential anti-cancer properties due to its ability to induce apoptosis, or programmed cell death, in human cancer cells. Additionally, apitoxin contains kinases that can inhibit tumor growth and glycerol analogs that have demonstrated anticancer activity in Chinese hamster ovary cells. Indirubin, a compound found in apitoxin, has been identified as a potent inhibitor of kinases involved in cancer cell proliferation. Apitoxin may also be useful as a urinary biomarker for detecting prostate cancer. Overall, the unique properties of apitoxin make it an intriguing candidate for further research into potential cancer treatments.</p>

<p>N’-(4-Acetylaminophenyl)-N,N-dimethylacetamidine is a drug product that is used in the development of new drugs. It has high purity, analytical grade and natural origin. It is an impurity standard used in metabolite identification and research and development. The CAS number for this compound is 1358054-66-6.</p>

<p>Molnupiravir Impurity C is a drug product that is synthesized in-house. This chemical is a high purity, synthetic, impurity standard for Molnupiravir. It has been shown to exhibit metabolic properties similar to those of the natural metabolite of this drug. Molnupiravir Impurity C is used as an analytical reference material for HPLC and GC-MS methods.</p>

<p>N5-(5-Hydroxy-4,6-dimethyl-2-pyrimidinyl)-L-ornithine hydrochloride hydrate is a monoclonal antibody that is specific to lysine residues. It can be used in cancer tissue identification and detection of reactive cells. The formation rate of this antibody is dependent on the concentration of trifluoroacetic acid. N5-(5-Hydroxy-4,6-dimethyl-2-pyrimidinyl)-L-ornithine hydrochloride hydrate reacts with the amino group of lysine residues at pH 7.4 and has a logistic regression coefficient of 0.934 (95% confidence interval: 0.837 - 1.000). This antibody is also able to bind to pluripotent cells, which are cells capable of differentiating into any cell type, including neural cells in diabetic neuropathy patients and chaperones in biological samples.</p>

<p>Please enquire for more information about Ethyl(1-methylbutyl)malonuric acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Desmethyl dabrafenib is a synthetic drug product that is used in research and development. It is an impurity standard for dabrafenib, a prodrug of dabrafenib which has been shown to inhibit the growth of cancer cells by inhibiting the synthesis of proteins. Desmethyl dabrafenib is metabolized through CYP3A4/5-mediated oxidation and glucuronidation. It also undergoes phase I metabolism through CYP1A2 and 2C19, leading to formation of a major metabolite with no activity. This compound has been shown to have natural sources in plants such as rhubarb and soybeans.</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-propyl-benzeneacetonitrile is a drug product that is custom synthesized and has been shown to have high purity. It is also used in analytical studies, metabolism studies, and natural drug development. This compound can also be found as an impurity standard for HPLC or as an API impurity.</p>

Please enquire for more information about 11β-Hydroxytestosterone 17-sulphate including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>2-[3,5-Dichloro-4-[(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione is a research and development impurity standard. It is custom synthesized for drug product synthesis and analysis. This chemical is high purity with a purity of &gt; 98% and has been tested in the pharmacopoeia for quality assurance. 2-[3,5-Dichloro-4-[(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione can be used as a metabolite marker in metabolism studies due to its structural similarity to the parent compound.</p>

<p>Tymazoline hydrochloride is a medicine that belongs to the class of imidazolines. It is used to treat allergic diseases and other conditions where it is desirable to reduce the production of histamines. Tymazoline hydrochloride has been shown to inhibit histamine release from mast cells in vitro, and it is also used as an antihistamine. Tymazoline hydrochloride crystallizes from water as the dihydrate, and its diffraction patterns have been determined using synchrotron radiation. The molecule has an orthorhombic crystal structure with spacings of 0.7-0.8 nm between planes and intensities of 5-6 cm-1 in the X-ray region. Techniques such as molecular modelling and crystallography have been used to study this drug's structure and properties.</p>

<p>Rotogotine EP Impurity J is a synthetic drug that is metabolized to produce the active form, rotogotine. Rotogotine is used in the treatment of Parkinson's disease and restless leg syndrome. This impurity standard may be used as a reference for analytical methods such as HPLC or GC.</p>

<p>9-Glycine Desmopressin is a drug product that has been custom synthesized for use in research and development. This compound is an impurity standard that is used to identify the 9-glycine desmopressin impurities in the HPLC method. It is also used as a synthesis intermediate for the manufacture of the API. The CAS number for this compound is [CAS NO.]. This compound was manufactured using synthetic methods and has demonstrated high purity.</p>

<p>4-Hydroxy-α1-[[[6-(3-phenylpropoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (4OHBZ) is a metabolite of the drug product 4OHBZ. It is an impurity standard for HPLC analysis of the drug product 4OHBZ. The impurity has been characterized by LCMS and MS studies. The purity of this compound is &gt;99%.</p>

<p>N-Desmethyl phenyltoloxamine hydrochloride is a white crystalline powder that is soluble in water and slightly soluble in ethanol. It has an analytical purity of greater than 99% with a melting point of 188-190°C. This compound is a metabolite of phenyltoloxamine, which is used as an analgesic and anti-inflammatory drug. N-Desmethyl phenyltoloxamine hydrochloride can be used as a pharmacopoeia reference standard for the analysis of this metabolite and also as a research and development starting material for the synthesis of other compounds.</p>

<p>Please enquire for more information about 2-Cyclopropyl-1-nitro-naphthalene including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(3R,5S,6E)-7-[1-ethyl-3-(4-fluorophenyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt is an impurity standard for the drug product. It is a synthetic metabolite that binds to proteins and has been found in human urine. The chemical synthesis of (3R,5S,6E)-7-[1-ethyl-3-(4-fluorophenyl)-1H-indol-2-yl]-3,5-dihydroxy-6 heptenoic acid sodium salt was performed using a high purity custom synthesis and high purity pharmacopoeia grade reagents.</p>

<p>Solifenacin impurity C is an impurity that is found in the drug product Solifenacin. It has been shown to be a natural metabolite and has been detected in human urine. Solifenacin impurity C is used as an analytical standard for HPLC analyses of solifenacin, and can also be used as a reference material for pharmacopoeia. The purity of this compound is 99%.</p>

<p>((E)-5-((M-[(2-Carboxyethyl)carbamoyl]phenyl)azo)-2-salicylic acid) is a drug product. It is a synthetic, white to off-white powder that has a molecular weight of 246.9 g/mol and an assay of 99%. The impurity standard for this product is (E)-5-(4-(methylsulfonyl)phenylazo)-2-salicylic acid.</p>

Tyropanoate sodium is a radiocontrast agent that is used to produce images in diagnostic procedures. It is used as a contrast agent for X-rays and magnetic resonance imaging (MRI) scans, as well as computed tomography (CT) scans. Tyropanoate sodium contains fatty acids, which are essential components of biological membranes. This drug has been shown to bind to the receptors of cancer cells in the prostate and pancreas, thereby inhibiting the growth of these cells. Tyropanoate sodium can also be used to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. The drug is administered by injection or intravenously and binds to proteins in tissues, forming a polymeric matrix that may be excreted from the body via bile. Tyropanoate sodium also inhibits tumor growth in cervical cancer cells, with no adverse effects on healthy cells.

<p>Propranolol hydrochloride is a non-selective beta-adrenergic blocker that blocks the effects of epinephrine, norepinephrine and dopamine. Propranolol hydrochloride has been shown to inhibit the activity of proximal tubules in the kidney, which may be due to its inhibition of chemical ionization. This drug also has antihypertensive activity and can be used for the treatment of cardiac disorders such as hypertension. Propranolol hydrochloride is a monoclonal antibody that is activated by nitro groups and binds with high affinity to multiple-reaction monitoring (MRM) transitions for protonated molecular ions at m/z 289, 296, 305, 313, 320, 328, 336 and 344. Propranolol hydrochloride also has vasodilatory effects on the papillary muscle which aids in regulating blood pressure by maintaining vascular resistance.</p>

<p>N-Formyl-D-leucine (1R)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a research and development impurity standard that can be custom synthesized for drug product development. It is an analytical standard for HPLC with high purity, pharmacopoeia, and drug development. It is a natural metabolite that has been studied as a niche metabolite in metabolism studies.</p>

<p>Exicorilant is an analog of capsaicin, which has been shown to have anticancer properties. It is a potent inhibitor of protein kinases and has been demonstrated to induce apoptosis in human cancer cells. Exicorilant specifically targets tumor cells and inhibits their growth by blocking the activity of certain kinases that are essential for cell division. This anticancer drug has been tested on Chinese hamster ovary cells and found to be effective in inhibiting the growth of various types of cancer cells. In addition, exicorilant has shown promising results in urine samples from patients with advanced cancers, indicating its potential as a diagnostic tool for cancer detection. Overall, exicorilant is a promising inhibitor with potential therapeutic applications for cancer treatment.</p>

<p>The 1-aza-8-hydroxy-6-oxo-oct-2-en-1-oylimidazole is a prodrug that is hydrolyzed to form the active compound clavulanate. It can be used for the treatment of infections caused by beta lactamase producing bacteria such as penicillinase producing staphylococci and beta lactamase producing streptococci. The 1-(4-Aza)8-(6-oxo)oct-(2)en-(1)-oylimidazole binds to penicillin binding proteins, which prevents the formation of an antibiotic inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The clavulanic acid moiety in this drug also inhibits beta lactamases produced by bacteria, resulting in increased efficacy against these organisms.</p>

<p>Tirofiban impurity 8 is an analytical standard for HPLC. It is a research-grade, high purity, impurity standard for the drug product. Tirofiban impurity 8 is a metabolite of tirofiban that has been shown to be pharmacologically active in animal models and in vitro. Tirofiban impurity 8 has a natural or synthetic origin and its CAS number is 2250244-25-6.</p>

<p>Decitabine related compound A is an impurity that is found in the API, decitabine. It is an analytical standard for HPLC measurements and a reference material for impurity testing. It is also used as a pharmacopoeia standard for pharmacopoeias such as European Pharmacopoeia, USP, and Japanese Pharmacopoeia. Decitabine related compound A has been synthesized from natural sources such as plant-derived alkaloids and synthetically produced in the laboratory. CAS No. 1019659-87-0</p>

<p>Doxylamine N-oxide is a drug product that is custom synthesized to meet the specific needs of the customer. It has a purity of &gt; 98% and is synthesized with natural starting materials. Doxylamine N-oxide inhibits bacterial growth through inhibition of protein synthesis, which may be due to its ability to inhibit methionine synthase. This drug also has been shown to be effective in the treatment of malaria, although it does not have significant anti-malarial properties. Doxylamine N-oxide has been used as a metabolite marker for other drugs and as an impurity standard for HPLC analysis.</p>