APIs pour la recherche et les impuretés
Les principes actifs pharmaceutiques (API) sont les substances présentes dans les médicaments qui sont responsables de leurs effets thérapeutiques. Dans cette section, vous trouverez une grande variété d'API destinés à un usage de recherche. Ces composés sont essentiels pour le développement, les tests et la validation de nouvelles formulations pharmaceutiques. Chez CymitQuimica, nous proposons des API de haute qualité pour soutenir la recherche dans la découverte et le développement de médicaments.
Sous-catégories appartenant à la catégorie "APIs pour la recherche et les impuretés"
- Acides Aminés et Dérivés(12.440 produits)
- Anthraquinones et Dérivés(407 produits)
- Dérivés du Benzimidazole et de l’Imidazole(10.465 produits)
- Dérivés des Benzodiazépines(335 produits)
- Glucides et Glycoconjugués(5.388 produits)
- Esters et Dérivés(42.306 produits)
- Acides Gras et Dérivés Lipidiques(32.487 produits)
- Flavonoïdes et Polyphénols(17.101 produits)
- Radicaux Libres et Agents Oxydants/Réducteurs(214 produits)
- Cétones et Dérivés(2.692 produits)
- Antibiotiques Naturels et Semi-Synthétiques(6.410 produits)
- Nitriles et Dérivés Cyano(3.070 produits)
- Nitrosamines et Dérivés(55 produits)
- Nucléosides et Nucléotides(3.492 produits)
- Phosphates et Phosphonates Organiques(1.205 produits)
- Sulfonates et Sulfates Organiques(10.451 produits)
- Composés Organométalliques(4.425 produits)
- Autres(6.340 produits)
- Peptides et Protéines(3.163 produits)
- Polymères et Dérivés(100 produits)
- Dérivés des Purines et Pyrimidines(8.975 produits)
- Dérivés de Quinazoline et de Quinoléine(66.222 produits)
- Quinones et Dérivés(24.379 produits)
- Sels et Dérivés d’API(92.956 produits)
- Stéroïdes et Dérivés(4.987 produits)
- Sulfamides et Dérivés(2.607 produits)
- Terpénoïdes et Dérivés(3.860 produits)
- Thiazolidinediones et Thiopyranes(2.755 produits)
- Composés β-Adrénergiques(231 produits)
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66881 produits trouvés pour "APIs pour la recherche et les impuretés"
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(R)-5-Hydroxymethyl tolterodine
CAS :(R)-5-Hydroxymethyl tolterodine is a prodrug that is metabolized by cytochrome P450 3A4 (CYP3A4) in the liver to its active form, tolterodine. This drug can be used as an alternative for gabapentin in the treatment of detrusor muscle overactivity associated with neurogenic bladder dysfunction. The pharmacokinetic properties of (R)-5-hydroxymethyl tolterodine are similar to those of gabapentin, including the elimination half-life and volume of distribution. However, unlike gabapentin, which has been shown to increase the glomerular filtration rate (GFR) and renal blood flow, there is no evidence that this drug has any effect on GFR or renal blood flow. There is also no evidence that (R)-5-hydroxymethyl tolterodine causes any symptoms that may be attributed toFormule :C22H31NO2Degré de pureté :Min. 98 Area-%Couleur et forme :Off-White PowderMasse moléculaire :341.49 g/mol5,6-Dichloro-1,4-dihydro-2-quinazolinamine
CAS :5,6-Dichloro-1,4-dihydro-2-quinazolinamine (5,6-DCQ) is a small molecule that has been used in vitro to study postnatal development. 5,6-DCQ binds to magnesium and forms a cation complex. This binding inhibits the activity of various enzymes such as phosphodiesterase and acetylcholinesterase. 5,6-DCQ also blocks the proliferation of cancer cells in vitro by inhibiting colony-stimulating factor and other proteins required for cell division. 5,6-DCQ has been shown to be safe in clinical trials and may be an effective treatment for cancer.Formule :C8H7Cl2N3Degré de pureté :Min. 95%Masse moléculaire :216.07 g/mol2-Carboxybenzoyl amlodipine
CAS :2-Carboxybenzoyl amlodipine is a metabolite of the antihypertensive drug amlodipine. It is a white crystalline solid that is soluble in water. 2-Carboxybenzoyl amlodipine can be used as an impurity standard for HPLC analyses, and as an analytical standard for the determination of amlodipine in human plasma.
Formule :C28H29ClN2O8Degré de pureté :Min. 95%Couleur et forme :White to off-white solid.Masse moléculaire :556.99 g/molEmpagliflozin R-furanose
CAS :Empagliflozin R-furanose is a drug product that belongs to the class of drugs for treatment of type II diabetes. It is a synthetic derivative of Empagliflozin, which is a natural compound found in plants. Empagliflozin R-furanose has been shown to inhibit the activity of dipeptidyl peptidase 4 (DPP-4) and reduce postprandial glucose levels in healthy subjects. This drug product has also been shown to be safe and effective in lowering blood sugar and hemoglobin A1c levels in patients with type II diabetes mellitus or impaired glucose tolerance.Formule :C23H27ClO7Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :450.91 g/molPantoprazole sodium hydrate - Mixture of impurities D and F
CAS :Pantoprazole sodium hydrate is a custom synthesis that is used as a drug product. The CAS number for this compound is 624742-53-6. This compound has the following impurities: D and F. Pantoprazole sodium hydrate has been shown to be metabolized in vitro by human liver microsomes to its metabolites, including the following: (1) pantoprazol acid, (2) 4-hydroxypantoprazol acid, (3) 4-hydroxyisoxazole acid, and (4) 5-(4-hydroxyphenyl)-2H-1,2-benzoxazin-3(4H)-one. The metabolite 4-hydroxypantoprazol acid has been found to be pharmacologically active in animal models of gastric ulceration and healing.Formule :C17H17F2N3O4SDegré de pureté :Min. 95%Couleur et forme :Off-white to yellow powder.Masse moléculaire :397.4 g/mol5-Benzamidolevulinic acid
CAS :5-Benzamidolevulinic acid is an ethylamine derivative that inhibits the enzyme carbonic anhydrase. It is used as a synthetic intermediate in the production of other drugs, such as dopamine and remoxipride. 5-Benzamidolevulinic acid can be found as a metabolite in the urine of humans exposed to this chemical. The major urinary metabolites are 5-benzamidolevulinate, 5-benzamidoethanol, and 2,5-dihydroxybenzoic acid.Formule :C12H13NO4Degré de pureté :Min. 95%Masse moléculaire :235.24 g/molN,N-Dimethyl-2-ene-3-(4-methylbenzoyl)-propionamide
CAS :Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is an impurity that is found in N,N-dimethyl-3-(4-methylbenzoyl)-propionamide. It is a white solid and has a melting point of 132°C. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is not soluble in water or ethanol. This compound is used as a high purity, API impurity, HPLC standard, niche, pharmacopoeia, Custom synthesis, Drug development, analytical and Synthetic drug product. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide can be metabolized by the liver to 2-[(2E)-1H-[1]benzopyran--5(6H)-ylidene]-N,N'-dimethylethane--3(2H)-carboxFormule :C13H15NO2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :217.26 g/molL-138,037
CAS :Please enquire for more information about L-138,037 including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormule :C28H34N4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :426.6 g/molLisinopril EP Impurity E
CAS :Lisinopril EP Impurity E is an impurity of lisinopril, which is a prescription drug used to treat high blood pressure. This impurity was found in a preparative high performance liquid chromatography (HPLC) and mass spectroscopy analysis of the drug. The molecular weight of Lisinopril EP Impurity E was determined to be 317.2 amu, which corresponds to the molecular formula C7H13NO2. The FT-IR spectrum showed that this impurity has an ammonium group at 1859 cm-1 and butanoic acid at 1647 cm-1.Formule :C21H31N3O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :405.49 g/molOlmesartan medoxomil
CAS :Olmesartan is a drug that belongs to the class of angiotensin II receptor antagonists. It is used for the treatment of high blood pressure, heart failure, and kidney disease. The therapeutic effect of olmesartan can be increased by concomitant use with other drugs if it is being used as a combination therapy. This drug interacts with many other drugs, including diuretics and ACE inhibitors. Drugs that are known to interact with olmesartan include furosemide, hydrochlorothiazide, amiloride, spironolactone, triamterene, chlorothiazide and quinethazone. Blood sampling is often required during therapy in order to monitor the efficacy of this drug.
Formule :C29H30N6O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :558.59 g/mol2-Phenylbutyric acid
CAS :2-Phenylbutyric acid is a product of the oxidation of phenylacetic acid by flavus. 2-Phenylbutyric acid is an inhibitor of contactor reactions that use α1-acid glycoprotein as a chromatographic support. It has been shown to inhibit the reaction mechanism of extractants (e.g., butamirate citrate) with enantiomeric compounds (e.g., creatine). It also inhibits subclinical mastitis in cows and fatty acid synthesis, leading to decreased cholesterol synthesis in humans.
Formule :C10H12O2Degré de pureté :Min. 95%Masse moléculaire :164.2 g/molN-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methylsulphinyl]ethyl]guanidine
CAS :N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methylsulphinyl]ethyl]guanidine is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. It has been shown to be safe and effective in clinical studies with a number of populations. The drug binds to the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. This action prevents the breakdown of acetylcholine, leading to increased levels of this chemical in the brain and improved function. NCAEMG has also been found to increase uptake of drugs by proximal tubules in humans, which may be due to its ability to inhibit cimetidine metabolism.Formule :C10H16N6OSDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :268.34 g/mol2-(4-Butylphenyl)propionic acid, racemic
CAS :2-(4-Butylphenyl)propionic acid (p-butylhydratropic acid) is a known impurity of ibuprofen (Ibuprofen impurity B) which derives from an impurity present in the isobutylbenzene starting material and 2-(4-butylphenyl)propionic acid. p-Butylhydratropic acid is therefore used as a reference analytical standard.Formule :C13H18O2Degré de pureté :Min. 95%Couleur et forme :Colorless PowderMasse moléculaire :206.28 g/molCetirizine impurity B dihydrochloride
CAS :Cetirizine impurity B dihydrochloride is a minor impurity of cetirizine, which is a non-sedating antihistamine. The purity of the compound was determined by high performance liquid chromatography (HPLC) and its bioequivalence to cetirizine was assessed in a population pharmacokinetic study. Cetirizine impurity B dihydrochloride has been shown to have a similar pharmacokinetic profile to cetirizine and can be used as an alternative for the treatment of allergic rhinitis.Formule :C19H21ClN2O2•(HCl)2Degré de pureté :Min. 90 Area-%Couleur et forme :PowderMasse moléculaire :417.76 g/molPravastatin lactone
CAS :Pravastatin lactone is a prodrug of pravastatin that is hydrolyzed in vivo to its active form. It is used for the treatment of bowel disease and has been shown to have concentration-time curves that are linear and dose-dependent. Pravastatin lactone has an acidic pH, which may be due to the presence of carboxyl groups on the molecule. This drug also inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is an enzyme that catalyzes the conversion of HMG CoA to mevalonate in order to produce cholesterol. Pravastatin lactone also suppresses the production of fatty acids by inhibiting their synthesis at the level of acetyl-coenzyme A (acetyl-CoA). The drug has not shown any evidence of toxicity when administered to rats at doses up to 10 mg/kg body weight per day
Formule :C23H34O6Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :406.51 g/mol[2-(3-Pyridinyl)ethylidene]bisphosphonic acid
CAS :2-(3-Pyridinyl)ethylidene]bisphosphonic acid (3PPE) is a prenyl analog that inhibits the enzyme farnesyl pyrophosphate synthase, which is involved in the biosynthesis of prenyl groups. 3PPE has been shown to inhibit cellular proliferation and induce cell death in cultured cells. This drug also inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.Formule :C7H11NO6P2Degré de pureté :Min. 95%Masse moléculaire :267.11 g/molN-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride
CAS :N-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride is a metabolite that is produced by the metabolism of naphthalene. It is an impurity in the naphthalene standard, which is used as an API to assess the purity of other substances. N-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride has been shown to be a substrate for CYP2D6. This metabolite is also found in pharmaceuticals and other drugs.Formule :C22H22F3N•HClDegré de pureté :Min. 95%Masse moléculaire :393.87 g/mol3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide
CAS :3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is an impurity in the synthesis of a drug. It is not active and has no known therapeutic value. 3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is used as a reference standard for HPLC and has been shown to be metabolized by cytochrome P450 enzymes.Formule :C11H11NO5SDegré de pureté :Min. 95%Couleur et forme :White to off-white solid.Masse moléculaire :269.27 g/mol(1,2-Dimethylpropyl)benzene
CAS :1,2-Dimethylpropylbenzene is an alkenylbenzene that is used as a precursor to other chemicals. It can be synthesized by the dehydrogenation of 1,2-dimethylethylbenzene with a nickel catalyst or by the formylation of benzene with formaldehyde and potassium hydroxide. The cyclohexenyl group in 1,2-dimethylpropylbenzene can be converted to an alkene group by alkylation with acetylene. The linear regression analysis showed that the toolkit of 1,2-dimethylpropylbenzene isomerization reactions are useful for the synthesis of many different compounds and provide a better understanding of their reactivity.Formule :C11H16Degré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :148.24 g/molFlumethasone Impurity 12
Flumethasone impurity 12 is a high purity, HPLC standard that is used for research and development. This impurity is an analytical standard that is also used in the drug development process as a pharmacopoeia to measure the purity of an API. Flumethasone impurity 12 can be purchased in various quantities and purities and can be custom synthesized to meet your needs. It has CAS number 511-24-2 and a molecular weight of 306.45 g/mol.Degré de pureté :Min. 95%
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