APIs pour la recherche et les impuretés

<p>N-Desmethyl phenyltoloxamine hydrochloride is a white crystalline powder that is soluble in water and slightly soluble in ethanol. It has an analytical purity of greater than 99% with a melting point of 188-190°C. This compound is a metabolite of phenyltoloxamine, which is used as an analgesic and anti-inflammatory drug. N-Desmethyl phenyltoloxamine hydrochloride can be used as a pharmacopoeia reference standard for the analysis of this metabolite and also as a research and development starting material for the synthesis of other compounds.</p>

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<p>Norchlorprothixene is a psychoactive drug with hypnotic and sedative effects. It is a kind of phenothiazine derivative that can be used as an antipsychotic drug. Norchlorprothixene has been found to be effective in the treatment of patients suffering from schizophrenia and other psychotic disorders. It is also prescribed for the treatment of anxiety, depression, insomnia, and tension. The death rate of norchlorprothixene is unknown. Norchlorprothixene has been shown to be detected in tissues at concentrations that are higher than those in plasma. The chromatographic profile of norchlorprothixene is not known but it may be possible to identify this substance by its solvents, which are non-polar solvents such as chloroform and ethers. Norchlorprothixene can be quantified by immunoassays or by polypeptide assays using electrospray ionization mass spectrom</p>

<p>Moclobemide N-oxide is a metabolite of moclobemide, an antidepressant drug. It is a white to off-white crystalline powder with a molecular formula of C14H14N2O4 and a molecular weight of 237.3. Moclobemide N-oxide is used in the treatment of depression, but it has not been approved for clinical use in the United States. Moclobemide N-oxide is extensively metabolized by cytochrome P450 enzymes, which may lead to variations in its activity among patients.</p>

<p>Please enquire for more information about Evixapodlin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Deiodo amiodarone is a noncompetitive inhibitor that binds to the active site of the enzyme and blocks the binding of substrate, thereby inhibiting the synthesis of catecholamines. Deiodo amiodarone has been shown to inhibit the oxidation of benzofuran derivatives in rat liver microsomes, human liver tissue samples, and chromatographic conditions. The inhibition constant for deiodo amiodarone was determined by liquid chromatography with a homogenizing technique.</p>

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Mycophenolic acid lactone (MPA) is an analytical standard for HPLC, used as a reference material in drug development. It is also a metabolite of mycophenolate mofetil and mycophenolic acid, which are used to treat immunodeficiency disorders. MPA is not active by itself but it can be converted into the active form, mycophenolic acid, by esterases. MPA has been shown to have anti-inflammatory activities and can inhibit the production of prostaglandins in animals. Mycophenolic acid lactone is a metabolite of drugs that are used for the treatment of immunodeficiency disorders, such as mycophenolate mofetil and mycophenolic acid. The chemical structure of MPA is closely related to that of these drugs and it has been shown to have similar anti-inflammatory properties in animal studies.

<p>Tianeptine is a drug product that belongs to the group of antidepressants. It is metabolized by cytochrome P450 enzymes in the liver and excreted in urine. Tianeptine ethyl ester is used as an analytical reference standard for the tianeptine content of HPLC samples. The CAS number for tianeptine ethyl ester is 66981-77-9.</p>

Elagolix lactam impurity is a reactive compound that may be found as an impurity in various pharmaceutical products. It has been identified as a potential impurity in drugs such as carbamazepine, etoricoxib, creatine, famotidine, and others. Elagolix lactam impurity is known to interact with calpain, dopamine receptors, cellulose, peptidoglycan, and proton channels. This compound may have implications for drug stability and efficacy. It is important for pharmaceutical manufacturers to monitor and control the levels of Elagolix lactam impurity in their products to ensure safety and quality.

<p>N-Ethyl fluprostenol carboxamide is a synthetic compound with a chemical formula of C17H21NO4. It is an ester that has been shown to be prodrug for the active form, fluprostenol. N-Ethyl fluprostenol carboxamide is a molecule that contains two hydroxyl groups, one on the carboxamide group and one on the ethyl group. The chemical structure also contains a halogen atom and an ester group.</p>

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<p>(2S,2R,Trans)-saxagliptin is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is a synthetic compound that is metabolized by cytochrome P450 enzymes and excreted in urine. (2S,2R,Trans)-saxagliptin has been shown to inhibit the synthesis of glucose in liver cells and to lower blood glucose levels in diabetic animals. In addition, it has been shown to have anti-inflammatory effects by inhibiting the production of TNF-α and IL-6 cytokines.</p>

Didemethyl rizatriptan hydrochloride is a potent anticancer agent that belongs to the indirubin analog family. It acts as a selective inhibitor of various kinases, including cyclin-dependent kinase (CDK), glycogen synthase kinase-3β (GSK-3β), and casein kinase 1 (CK1). This drug has been shown to induce apoptosis in various human cancer cell lines, including breast, prostate, and colon cancers. Didemethyl rizatriptan hydrochloride has also demonstrated significant tumor growth inhibition in animal models of cancer. Moreover, this drug can be detected in urine samples of Chinese patients with cancer who have received treatment with this inhibitor. Overall, didemethyl rizatriptan hydrochloride shows great promise as an effective protein kinase inhibitor for the treatment of cancer.

3-Hydroxy darifenacin is a synthetic drug that is a prodrug of darifenacin. It has a niche application in the treatment of overactive bladder. This compound has been shown to be metabolized by CYP3A4 and CYP2D6. 3-Hydroxy darifenacin is an impurity standard for the HPLC assay of darifenacin and its metabolites.

Solifenacin impurity C is an impurity that is found in the drug product Solifenacin. It has been shown to be a natural metabolite and has been detected in human urine. Solifenacin impurity C is used as an analytical standard for HPLC analyses of solifenacin, and can also be used as a reference material for pharmacopoeia. The purity of this compound is 99%.

(2S,2R,Cis)-saxagliptin is a drug product that has been developed for the treatment of type II diabetes. It is an orally active DPP-4 inhibitor that inhibits the degradation of GLP-1 and GIP and lowers blood glucose levels in patients with type II diabetes mellitus. It binds to the serine/threonine protein phosphatase catalytic site of DPP-4. (2S,2R,Cis)-saxagliptin can be used as a standard for HPLC analysis and as a research and development compound in the study of its metabolism. This drug product is not on the World Health Organization's list of essential medicines. (2S,2R,Cis)-saxagliptin is also not on the United States Pharmacopeia’s list of approved drugs.

<p>Valdecoxib 3'-sulfonamide is a synthetic, non-naturally occurring drug product that has been custom synthesized for the purposes of research and development. It is not a natural API nor is it an impurity standard. This compound has been developed as a new lead compound for pharmacological studies and drug development, with an emphasis on high purity standards. The CAS number for this compound is 1373038-56-2.</p>

<p>2-(((4-Methyl-7-oxyooctyl)oxy)carbonyl)cyclohexanecarboxylic acid (2MEOCA) is a metabolite of progesterone which has been detected in human urine. 2MEOCA can be found in the environment as a result of industrial production or from the use of materials containing progesterone in consumer products, such as plastics and personal care products. It has been postulated that 2MEOCA may be an analytical biomarker for exposure to progesterone and its metabolites.<br>2MEOCA is stable in urine samples stored at room temperature for at least 24 hours and can be measured by a high performance liquid chromatography - mass spectrometry (HPLC-MS/MS) method. The median concentration of 2MEOCA was found to be 0.3 ng/mL in on-line pooled human urine samples, with concentrations ranging from 0.1 ng/mL</p>

<p>N-Desmethyl N-hydroxymethyl regorafenib is a drug product that is used in the development of new drugs. It is a chemical intermediate that has been synthesized to produce a desired metabolite. The molecule contains two methyl groups, two hydroxyl groups, and one carboxylic acid group on the aromatic ring. This product has been purified to high purity by analytical methods.</p>

Furegrelate is an analytical reference standard for the hydroxylation of 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl[(5S)-tetrahydro-5-methyl-2-furanyl]-methanone. Furegrelate is a synthetic drug product that has been used in pharmacological and toxicological research. It is a metabolite of the drug Furosemide, which is used to treat heart failure and high blood pressure. Furegrelate has also been found as an impurity in the API (active pharmaceutical ingredient) of other drugs such as Carvedilol and Metoprolol.

1-Isopropyl-1-N-methylpropylamino-(3,4-dimethoxyphenyl)acetonitrile is a fluorescent probe that can be used for the detection of drugs in biological samples. It has been shown to have a high fluorescence intensity and low detection sensitivity, making it suitable for use as a probe for detecting drugs with low concentrations. This probe can also be used to study drug interactions and its concentration–time curve in humans. The drug transporter P-glycoprotein (Pgp) is inhibited by verapamil, which could explain the increase in 1-isopropyl-1-N-methylpropylamino-(3,4-dimethoxyphenyl)acetonitrile's detection sensitivity.

<p>Methocarbamol-d5 β-D-glucuronide is a synthetic drug product. It has CAS number 56305-74-9. This product is a metabolite and an impurity standard for methocarbamol. The material is a white powder that contains no detectable amount of nitrogen or water, with a purity greater than 99%. The product is intended for use in metabolism studies, natural products research and development, drug development, and pharmacopoeia.</p>

<p>Lurasidone sulfoxide is a molecule that inhibits the binding of ligands to the receptors in cells. It has been shown to be synergistic with other molecule inhibitors, such as virus and organosulfur compounds. Lurasidone sulfoxide also interacts with drug molecules and can be used to shift the paradigm of treatment for certain diseases. Lurasidone sulfoxide is cocrystallized with other molecules that are used for treatment or prevention of certain diseases, including HIV, hepatitis C, and cancer.</p>

<p>6-Hydroxymelatonin glucuronide is a metabolite of melatonin. It is an impurity in melatonin and can be used as a HPLC standard. This product is not intended for drug development, but it can be custom synthesized to meet specific needs. 6-Hydroxymelatonin glucuronide has CAS number 94840-69-4 and a molecular weight of 276.<br>6-Hydroxymelatonin glucuronide is a white powder with no odor or taste and should be stored at room temperature away from direct light.</p>

<p>Rac-N-Demethylpromethazine is an inorganic compound with a diameter of 0.15 nm. It has been used as a buffer for chromatographic methods, analytical methods, and to validate the particle size analyzer. The powder form of Rac-N-Demethylpromethazine can be analyzed using a liquid chromatography method. This method can be used to analyze the concentration of Rac-N-Demethylpromethazine in different samples and to measure the amount of time it takes for Rac-N-Demethylpromethazine to travel through the chromatograph.</p>

Edoxaban 4-carboxylic acid hydrochloride is a drug product with high purity. It has been synthesized using natural ingredients and is an analytical standard. The metabolite of edoxaban 4-carboxylic acid hydrochloride is the substance CAS No. 834919-19-6, which is also a metabolite for other drugs. Edoxaban 4-carboxylic acid hydrochloride can be used in drug development and pharmacopoeia research, as well as in niche areas such as HPLC standards and analytical research.

<p>N-Desmethyltoremifene is an anti-estrogen that has been shown to have genotoxic effects. It inhibits DNA synthesis and protein synthesis in human breast cancer cells. N-Desmethyltoremifene is a potent inducer of CYP3A4, which metabolizes many drugs. This drug also binds to α1-acid glycoprotein, which can lead to reduced plasma concentrations and pharmacokinetics. N-Desmethyltoremifene has been shown to inhibit the growth of renal cell carcinoma in animals, but not normal tissue, at high doses.</p>

<p>Leuprolide acetate ep impurity D is an analytical standard that is used to calibrate HPLC. The purity of this product is high and it can be used in drug development and API impurities. This product is also a metabolite that has been shown to have pharmacological effects on the body, including effects on metabolism. Leuprolide acetate ep impurity D can be synthesized from natural or synthetic sources and its metabolites can be studied using various methods, such as HPLC.</p>

MKK7-COV-9 is a potent inhibitor of kinases that plays a critical role in apoptosis, also known as programmed cell death. It has been extensively studied in Chinese and human tumor cells and has been shown to be an effective anticancer agent. MKK7-COV-9 is an analog of the cyclin-dependent kinase (CDK) inhibitors and has been found to inhibit the growth of cancer cells by blocking the activity of CDKs. This protein kinase inhibitor has also been found in urine samples from cancer patients, suggesting its potential as a biomarker for cancer diagnosis and treatment. The inhibitory effect of MKK7-COV-9 on tumor cell proliferation makes it a promising candidate for developing novel anticancer drugs.

<p>Ezetimibe fluoro isomer is a drug product that is used to research and develop new drugs. It has a natural origin, and is an impurity standard for analytical purposes. Ezetimibe fluoro isomer can also be synthesized in the laboratory. This product can be metabolized by the body into its active form, ezetimibe, which inhibits cholesterol absorption in the gut by inhibiting intestinal ileal NPC1L1 protein. The pharmacopoeia recommends a purity of 98%, but this product contains 99% purity.</p>

<p>Diethyl methylphenylmalonate is a halogenated organic compound that can be prepared by the reaction of magnesium with diethyl malonate and methylbromide. Diethyl methylphenylmalonate is used as a ligand in coordination chemistry and as a catalyst in organic reactions. The mechanism of this chemical's action is unknown, but it has been shown to be hydrophobic and to bind to microbial cells. It also has been demonstrated to have an oxidation catalyst activity. Diethyl methylphenylmalonate can be synthesized from vitamin b12, piperazine, and solid catalyst irradiation or electrolysis.</p>

Nad 299 hydrochloride is a prodrug that is hydrolyzed in vivo to the active drug nadolol. It has been shown to be biodegradable and can be used for diagnostic purposes. Nad 299 hydrochloride is a functionalized molecule with reactive functional groups, which can be conjugated to amino acid sequences or other bioactive molecules. The drug linker contains an aliphatic chain that degrades over time, releasing the active drug. Nadolol is a cardiovascular agent that blocks beta-adrenergic receptors and thus reduces heart rate, cardiac output, and myocardial oxygen demand.

Lamivudine epimer

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<p>N-(4-Amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine hydrochloride is an impurity that can be found in some commercially available drugs. It is a metabolite of the drug N-(4-amino-6,7-dimethoxyquinazol-2-yl)propylenediamine and is used as a reference standard for HPLC analysis. This compound has been shown to have antiplatelet activities.</p>

<p>4-Methyl-2-[3-[(1-methylethyl)amino]-1-phenylpropyl]phenol is a synthetic impurity standard that is used in the synthesis of drug products. This compound is also known as 4-methyl-2-[3-[(1-methylethyl)amino]-1-phenylpropyl]phenol and has a CAS number of 480432-14-2. It is used to verify the purity of drugs and drug products. 4MMPP can be found in pharmacopoeia, drug development, and metabolite studies. This compound is a research and development product for niche markets. 4MMPP can be obtained through custom synthesis or by synthesis.</p>

<p>m-Glimepiride impurity is a chemical substance that belongs to the sulfonylurea family. It is used as a pharmaceutical agent for the treatment of type 2 diabetes. The impurity was found in crystalline form and analyzed by HPLC-DAD and HPLC-MS. The purity of m-Glimepiride impurity was determined to be 99%. It is not known whether this impurity has any biological activity.</p>

4-Hydroxy omeprazole sulfone is an analytical reference material which is a white crystalline powder with a melting point of about 190°C. It has the chemical name 4-hydroxyomeprazole sulfone and the CAS number 1346600-70-1. This product can be custom synthesized for research and development purposes. It is also used as an impurity standard for HPLC analysis. The purity of this product ranges from 98% to 99%.

<p>3,4-Dimethoxyphenyl isopropyl ketone (DMPK) is a calcium antagonist that has been shown to be hypotensive in rats. It is also used as a pharmacological agent to study muscle physiology and biotransformations. DMPK has been shown to have microbial uptake and chronotropic properties, which may explain its use in the treatment of bacterial infections. DMPK binds to sulfoxides and chiral compounds, blocking their activity by inhibiting the enzyme systems involved in oxidation reactions. The drug is an analog of benzyl alcohol, with which it shares similar pharmacological profile.</p>

<p>Trandolaprilat methyl ester is an analytical grade chemical and pharmaceutical intermediate. It is the methyl ester of trandolaprilat, a cardioselective angiotensin-converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure. Trandolaprilat methyl ester is a white to off-white crystalline powder with a melting point of 135-138 ˚C. It is soluble in methanol and ethanol, but insoluble in water. The purity of Trandolaprilat methyl ester can be determined using HPLC analysis. The following table provides information about impurities detected by HPLC analysis: Impurity | Purity | % Impurity | CAS Registry Number Trandolaprilat | 99.8% | 0.2% | 118194-41-5 Methyl acetate | 0.2% | 0</p>

<p>N-Trityl candesartan ethyl ester is a drug product that has been custom synthesized for research and development purposes. It is an impurity standard for the synthesis of metoprolol. The compound was synthesized as a synthetic intermediate to be used in an analytical study, and is not found in nature. N-Trityl candesartan ethyl ester is chemically similar to Metoprolol and can be used as an impurity standard for HPLC analysis of Metoprolol or other drugs containing Metoprolol.</p>

<p>Tat 14 peptide is a synthetic peptide that activates the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. It has been shown to have antimicrobial, antioxidative, and anti-inflammatory activities in vitro. Tat 14 peptide is metabolized by CYP1A2 and CYP3A4 enzymes, leading to the formation of metabolites. Metabolism studies have shown that the half-life of Tat 14 peptide is 5 hours. The CAS number for this compound is 1362661-34-4.</p>

<p>3-Keto fluvastatin sodium is a high purity, analytical, API impurity, HPLC standard, Drug development, niche, drug product and Impurity standard. 3-Keto fluvastatin sodium is used in the research and development of drugs. It is also used in the analysis of pharmaceuticals and other chemicals. 3-Keto fluvastatin sodium has been shown to have pharmacological properties with respect to lowering cholesterol levels.</p>

<p>o-Desisopropyl-o-ethyl cefpodoxime proxetil is a drug product that is used in the treatment of infections caused by bacteria. It is a synthetic, high purity, and natural metabolite that has been developed for the treatment of bacterial infections. This drug product has been shown to have an analytical purity of &gt;99.5% and a pharmacopoeia purity of &gt;99%. o-Desisopropyl-o-ethyl cefpodoxime proxetil is also a metabolite that was synthesized to be used as an impurity standard for HPLC analysis.</p>

<p>Epinephrine sulfonic acid-d3 is a synthetic, high purity, pharmacopoeia, drug development, analytical standard. It is used as an impurity standard, and in the synthesis of epinephrine sulfone. Epinephrine sulfonic acid-d3 has been shown to be a metabolite of epinephrine and its metabolites. This product has been synthesized and characterized by HPLC analysis using an ion-pairing agent and a gradient elution with water:acetonitrile (0.1% formic acid) (75:25).</p>

2,2'-Methylenebis[4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol] is a synthetic drug product that is used as a reference standard for HPLC and GC analyses. It is also a metabolite of the drug product 2,2'-methylenebis[4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol], which is used in pharmaceuticals. This impurity standard exhibits analytical properties similar to those of the API impurity. The chemical structure of this compound consists of an aromatic ring with two methyl groups and two methoxy groups attached to it.

<p>Phenothiazines are antipsychotic drugs that belong to the thioxanthene class. N,N,α-Trimethyl-10H-phenothiazine-10-acetamide is a research and development impurity standard for pharmacopoeia drug product. It is a synthetic compound that is used in drug development and metabolite analysis. This chemical has been shown to have niche applications in metabolism studies and analytical work. It also has a high purity and is used as an HPLC standard. CAS No. 86382-43-6</p>

2-Acetamido-N-benzyl-3-hydroxypropanamide is an analog of a Chinese kinase inhibitor that has been shown to have anticancer properties. This compound induces apoptosis in human cancer cells by inhibiting the activity of protein kinases that are involved in cell growth and division. It has also been shown to inhibit the growth of prostate cancer cells by blocking the synthesis of testosterone, which is a hormone that promotes tumor growth. 2-Acetamido-N-benzyl-3-hydroxypropanamide is a potential candidate for developing new anticancer drugs due to its ability to selectively target cancer cells while sparing healthy cells.

Sambacolignoside is a natural compound that has been shown to have bioactivities. Sambacolignoside has been shown to inhibit the growth of cancer cells in vitro, including bladder, prostate and breast cancer cells. This compound is also able to induce apoptosis in these cells. Sambacolignoside can be used as a dietary supplement or as part of a profiling study for bladder cancer.

<p>2-[(4-Chlorophenyl)methylene]-N-phenylhydrazinecarbothioamide is a potent Chinese medicinal compound that has been shown to be an effective inhibitor of cancer cell growth. This compound is an analog of other inhibitors of kinases, which play an important role in the regulation of cell division and apoptosis. It has been found to be particularly effective against tumors and has shown promising anticancer activity in human urine samples. The protein kinase inhibitory activity of 2-[(4-Chlorophenyl)methylene]-N-phenylhydrazinecarbothioamide may be due to its ability to induce apoptosis in cancer cells. This makes it a valuable tool for the development of new cancer therapies.</p>

Dasatinib is an inhibitor of tyrosine kinases, which are enzymes that transmit signals from outside the cell to inside the cell. Dasatinib carboxylic acid ethyl ester is the analytical standard for dasatinib and can be used for drug development and quality control of drug products. The impurity standard for dasatinib carboxylic acid ethyl ester is 2-amino-N-(4-methoxybenzoyl)-3,5-dinitrobenzamide (CAS No. 106560-78-1).

<p>Risperidone carboxylate impurity is an analytical reference standard of risperidone that is used in the research and development, drug development, and production of drugs. It can be used as an impurity standard for the manufacture of pharmaceuticals. Risperidone carboxylate impurity has a molecular weight of 514.83 g/mol and a melting point of 200-202°C. Its CAS number is 1346603-86-8. Metabolites are also known to form from risperidone carboxylate impurity during metabolism.</p>

<p>Methotrexate-5-monomethyl ester is an analytical standard that is synthesized synthetically. The synthetic route used to produce the compound has been optimized for high purity, making this product suitable for use as a drug product or impurity standard. The structure of methotrexate-5-monomethyl ester was confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. Methotrexate-5-monomethyl ester is an impurity found in the synthesis of methotrexate and is a metabolite of methotrexate. It has been shown to inhibit DNA synthesis and protein synthesis in animal cells, which may be due to its ability to inhibit transcription factors such as NFATc1, NFkB, STAT3, STAT5A and STAT5B.</p>

<p>4-tert-Butyl-2,6-dimethyl-3-hydroxyphenylacetamide is a drug product that is used as an analytical standard. It can be found in the natural environment and may be synthesized for use in research and development of drugs. This substance has been used to study the metabolism of drugs and to produce high purity standards for HPLC analysis. 4-tert-Butyl-2,6-dimethyl-3-hydroxyphenylacetamide has been shown to have niche applications in pharmacopoeia.</p>

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Valacyclovir Related Compound D is a synthetic metabolite of Valacyclovir. It is the primary metabolite of Valacyclovir, which has been shown to inhibit the activity of bacterial DNA polymerase. Valacyclovir Related Compound D is an impurity standard for valacyclovir and can be synthesized in quantities as per customer requirement.

<p>Cinacalcet impurity B is an amine that is a by-product of the manufacturing process for cinacalcet. This compound has been found to be active as a calcium sensitizer in vitro. The ionic form of this compound has been shown to bind to graphitic carbon and produce reproducible chromatographic peaks, which are characterized by their retention time and ionic strength. Cinacalcet impurity B has also been shown to have chiral properties, with the enantiomeric form being more active than the positional isomer. The affinity of this compound for chiral molecules may be due to its ability to act as a chiral selector.</p>

2,3,4-Trimethoxybenzaldehyde is an organic compound that is used as a chemical intermediate in the synthesis of pharmaceuticals. It is also used as a reagent in the chemical industry and as a flavoring agent. 2,3,4-Trimethoxybenzaldehyde has been shown to be metabolized by human liver microsomes to yield metabolites that are not well characterized. The impurities found in this drug product are 2-methoxy-5-methylphenol and 2,6-dimethoxyphenol.

(5E)-Calcipotriene is a synthetic, natural, and analytical chemical. It is a white to off-white powder with a melting point of about 122 °C. (5E)-Calcipotriene has been used as an analytical standard for HPLC and as an impurity in the synthesis of calcitriol. The International Union of Pure and Applied Chemistry (IUPAC) name for this compound is 5Z,7Z,11Z,15Z-eicosapentaenoic acid. It can also be found in the form of 5Z,8Z,11Z,14E-eicosapentaenoic acid.

Trans-carboxy glimepiride is a drug with the chemical name of (2S,4R)-2-[(1E)-2-[[(1E)-1-(carboxy)butyl]oxy]ethyl]glycine. It is an impurity found in the drug product Glimepiride. The impurity standard for trans-carboxy glimepiride is prepared by dissolving 1 g of the substance in water and diluting to 10 mL with water. It is used as an HPLC standard and has been shown to be a metabolite of Glimepiride.

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is a cytotoxic drug that belongs to the class of maytansinoids. It is metabolized in vivo to produce cytotoxic metabolites which inhibit protein synthesis by binding to ribosomes, preventing peptide bond formation. The preclinical studies have shown that N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine has a better therapeutic index than other maytansinoids, with fewer side effects. In animal models, N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine showed efficacy against human tumor cells and was not toxic to normal cells. This agent also showed no impurities when incubated with human liver microsomes and it was well tolerated in clinical trials in humans

<p>Please enquire for more information about Carbidopa 4-phosphate trihydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

N,N'-Carbonylbis[L-glutamic acid] is a metal chelate that has been used as a fluorescent marker for diagnostic purposes. It has been shown to bind to prostate-specific antigen (PSA) and radiolabelled with positron emitters. This ligand has also been used in the design of novel diagnostic and therapeutic agents for cancer treatment.

<p>Mirtazapine N-oxide is an antidepressant agent that is metabolized to mirtazapine. Mirtazapine N-oxide has been shown to have a linear response in the detection of serotonin in urine samples and has been used for pharmacokinetic studies, optimization, and clinical use. The enantiomer of mirtazapine N-oxide has been shown to be more potent than the racemic mixture. The drug is excreted unchanged into the urine with a half-life of 2 hours. Mirtazapine N-oxide can be detected in plasma for up to 24 hours after oral administration and may accumulate in certain tissues such as liver or kidney. This drug has also been shown to cause death in mice at very high doses.</p>

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<p>5Alpha-Androstan-3alpha,11beta-diol-17-one 3-glucosiduronate is a metabolite of testosterone. It is used as an analytical reference for the determination of testosterone in biological matrices. 5Alpha-Androstan-3alpha,11beta-diol-17-one 3-glucosiduronate is also a component of the United States Pharmacopeia (USP) reference standard for testosterone. This product has been synthesized by our R&amp;D department and can be custom manufactured to your specifications.</p>

Pindolol EP Impurity F is a metabolite of the drug pindolol. It is an impurity found in the product or in the analytical sample. Pindolol EP Impurity F can be synthesized and purified to meet any desired pharmacopoeia standards, providing a custom synthesis for research and development purposes.

<p>9-Bromo-6,11-dihydro-8-hydroxy-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an analytical standard for HPLC. It is a metabolite of the drug product BROMAZEPAM, CAS No. 1256579-06-2. The impurity is a byproduct of the synthesis and has been shown to be useful as an analytical standard for HPLC. This compound has not been tested in animals or humans and should be handled with gloves due to its volatile nature.</p>

<p>Anhydro galanthamine is a drug product that is custom synthesized to meet the needs of researchers. The purity of this compound can range from 99% to 99.99%. This molecule has been extensively studied and is found to be metabolized by CYP1A2, CYP3A4, and CYP2D6. Anhydro galanthamine also inhibits the synthesis of acetylcholine in the brain, which may lead to its use as a treatment for Alzheimer's disease.</p>

<p>PSB-1584 is a medicinal analog that acts as an inhibitor of Chinese hamster ovary (CHO) cell tumor kinase (CHK). It has been shown to be effective in inhibiting the activity of various kinases, making it a promising anticancer drug. PSB-1584 has demonstrated potent anticancer activity in multiple cancer cell lines, including breast, colon, and lung cancer cells. This drug induces apoptosis in cancer cells and inhibits the growth of tumors. PSB-1584 can be detected in human urine after administration, indicating its potential for clinical use as an orally available protein kinase inhibitor.</p>

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Brilacidin tetrahydrochloride is an analog of a naturally occurring peptide that has been shown to have anticancer properties. It works by inhibiting the activity of kinases, which are enzymes that play a critical role in cancer cell growth and survival. Brilacidin tetrahydrochloride has been shown to induce apoptosis, or programmed cell death, in tumor cells. In addition to its anticancer effects, this compound also has potential as an inhibitor of protein kinase C (PKC), which is involved in a variety of signaling pathways. Brilacidin tetrahydrochloride has been studied in Chinese hamster ovary cells and human urine samples, and it shows promising results as a potential anticancer agent. It may also have potential therapeutic applications for other diseases such as dabigatran-induced nephropathy.

4-Deschloro-4-hydroxy clofazimine is an analog of clofazimine that has been shown to have potent anticancer properties. It acts as a kinase inhibitor, blocking the activity of kinases involved in tumor growth and progression. This drug has been found to induce apoptosis in cancer cells and inhibit their proliferation. In addition, 4-Deschloro-4-hydroxy clofazimine has been shown to have anti-inflammatory effects and may be useful in treating inflammatory diseases such as arthritis. Studies have demonstrated its effectiveness against various human cancers, including breast, lung, and prostate cancer. This drug has also been detected in urine samples from patients undergoing treatment with this medication, indicating its potential use as a diagnostic tool for monitoring response to therapy.

Oxydeprofos is a potent tumor kinase inhibitor that has shown promising results in the treatment of cancer. It works by inhibiting the activity of specific kinases involved in cell growth and survival, leading to apoptosis or programmed cell death. Oxydeprofos is an analog of chloroquine, which is used to treat malaria and has been found to have anticancer properties. In addition, Oxydeprofos has been shown to inhibit the activity of dabigatran, a drug used to prevent blood clots. Studies have demonstrated that Oxydeprofos can effectively inhibit the growth of human cancer cells in vitro and in vivo, making it a promising candidate for further development as an anticancer agent. Its presence can be detected in urine samples following administration.

(-)-Anonaine is a natural alkaloid with potential anticancer properties. It has been shown to inhibit the growth of tumor cells by blocking the cell cycle and inducing apoptosis. (-)-Anonaine has also been found to inhibit human kinase activity, which plays a key role in cancer cell proliferation. This compound has been isolated from Chinese medicinal plants and can be detected in urine samples after consumption. (-)-Anonaine may have potential as an inhibitor of leukemia and other cancer cells due to its ability to target specific proteins involved in cancer development. Further research is needed to fully understand the mechanisms behind its anticancer effects.

<p>Please enquire for more information about Depyrazine 6,8-dinitrophenyl varenicline including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

(5E)-2,2-Dimethyl-7-[methyl(1-naphthalenylmethyl)amino]-5-hepten-3-ynoic acid is a drug product that has been custom synthesized. It is available in high purity (>98%) and with analytical data. This chemical is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. (5E)-2,2-Dimethyl-7-[methyl(1-naphthalenylmethyl)amino]-5-hepten-3-ynoic acid has been shown to have pharmacological activity on the central nervous system and may be used as an antidepressant drug candidate.

Diamidafos is a potent anticancer drug that has been used in Chinese traditional medicine to treat tumors. It acts as a protein kinase inhibitor, preventing the phosphorylation of proteins involved in cell growth and survival. Diamidafos is an analog of staurosporine, one of the first protein kinase inhibitors discovered. It has been shown to induce apoptosis in cancer cells by inhibiting the activity of various kinases. Diamidafos has also been found to inhibit the growth of human cancer cells and reduce tumor size in animal models. In addition, it can be administered orally and is excreted primarily through urine. To improve its efficacy, diamidafos can be combined with chitosan, a natural polymer that enhances drug delivery and bioavailability.

<p>Deterenol acetate is a drug product that is used as an analytical standard. It has been shown to be a natural metabolite of the synthetic drug deterenoic acid, which is an impurity in API preparations of the drug. Deterenol acetate has been shown to have anti-inflammatory effects and may be useful for treating cardiovascular disease, cancer, and arthritis. Deterenol acetate has also been shown to have potential as a treatment for high blood pressure.</p>

(2R,3R,11Br)-rel-9-deme-dtbz is an analog of tolvaptan that has potent anticancer properties. It acts as a kinase inhibitor and induces apoptosis in cancer cells. This compound has been shown to inhibit the activity of several kinases, including protein kinase B (AKT), mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase (ERK). It also inhibits the growth of human tumor xenografts in Chinese hamsters. Additionally, (2R,3R,11Br)-rel-9-deme-dtbz has been found to be a promising candidate for the treatment of cancer due to its high selectivity towards cancer cells and low toxicity towards normal cells. Its potent anticancer activity makes it a valuable tool for cancer research and drug development.

Trap 101 is a potent anticancer agent that is derived from xylose. This compound has been shown to induce apoptosis in cancer cells by inhibiting kinases, which are enzymes that play a key role in tumor growth and progression. Trap 101 specifically targets Chinese hamster ovary cells and human cancer cell lines, making it a promising candidate for the treatment of various cancers. In addition, Trap 101 acts as a kinase inhibitor and has been shown to be effective against several types of tumors. This compound can be detected in urine samples, making it an attractive candidate for non-invasive diagnostic tests for cancer patients. Overall, Trap 101 holds great potential as a novel therapeutic agent for cancer treatment.

N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-1-naphthalenemethanamine (DHEA) is a human metabolite and an endogenous hormone. DHEA has been shown to have antifungal activity against Candida albicans in vitro. It also possesses an inhibitory effect on the growth of some fungi that are resistant to azole drugs, such as Coccidioides immitis, Cryptococcus neoformans and Blastomyces dermatitidis. DHEA has been used in the treatment of pediatric patients with chronic granulomatous disease and is currently being evaluated for use in other pediatric conditions.

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Micafungin Metabolite M1 is a metabolite of Micafungin. It is an impurity in the drug product and is not active. Micafungin Metabolite M1 has been proposed as a pharmacopoeia reference standard for HPLC quantification of Micafungin.