APIs pour la recherche et les impuretés

<p>Trans-4-(6,8-Dibromo-3(4H)-quinazolinyl)cyclohexanol hydrochloride is a potent kinase inhibitor that has shown promising results in anticancer research. It specifically targets human kinases and induces apoptosis in cancer cells. This compound has been identified as a potential therapeutic agent for the treatment of various types of tumors, including those found in breast, lung, and prostate cancers. In addition to its medicinal properties, trans-4-(6,8-Dibromo-3(4H)-quinazolinyl)cyclohexanol hydrochloride can be detected in urine samples and serves as an important tool for researchers studying protein kinases and their inhibitors. This analog of Chinese medicine is a valuable addition to any laboratory seeking to advance cancer research through the development of new therapies.</p>

<p>(S)-2-Amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl propanoic acid is a synthetic compound that is used as an impurity standard. It has been shown to be metabolized by cytochrome P450 enzyme system and its metabolites are excreted in the urine. This chemical can also act as an analytical reference for HPLC analysis of other compounds.</p>

<p>Cefixime Impurity A is a drug product that is used for analytical purposes. It is an impurity of cefixime.</p>

<p>Please enquire for more information about NSC 37553 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Methyl-2-[3-[(1-methylethyl)amino]-1-phenylpropyl]phenol is a synthetic impurity standard that is used in the synthesis of drug products. This compound is also known as 4-methyl-2-[3-[(1-methylethyl)amino]-1-phenylpropyl]phenol and has a CAS number of 480432-14-2. It is used to verify the purity of drugs and drug products. 4MMPP can be found in pharmacopoeia, drug development, and metabolite studies. This compound is a research and development product for niche markets. 4MMPP can be obtained through custom synthesis or by synthesis.</p>

<p>(S)-3-((R)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a drug product of the drug development industry. It is a metabolite of 3-(1,2,4-triazol-1-ylmethyl)thiazolidine-4-carboxylic acid and has been used as an analytical standard for HPLC methods. The compound has been shown to be naturally occurring in humans. (S)-3-(1,2,4-Triazol-1ylmethyl)thiazolidine 4 carboxylic acid is also used as the impurity standard for the API 3-(1,2,4 triazol 1ylmethyl)thiazolidine 4 carboxylic acid.</p>

<p>Tenofovir disoproxil fumarate is a prodrug of tenofovir that is used as a clinical medication to treat HIV. Tenofovir works by inhibiting reverse transcriptase, an enzyme required for the production of viral DNA. The flow rate of this drug is high and it has a sensitivity of less than 1 ng/mL. Tenofovir disoproxil fumarate contains impurities such as methoxy, which can affect the chiral purity and sensitivity of the drug. It also contains tenofovir, which is used as an intermediate in its synthesis. This drug can be detected using chromatographic methods, which use n-hexane and a wavelength below 220 nm for liquid chromatography analysis.</p>

<p>1,3-bis(1,1-Dimethylpropyl) benzene is a synthetic compound that is used in drug product formulation. It is also used as an analytical standard for the determination of 1,3-bis(1,1-dimethylethyl)benzene in drug products and as a natural impurity in API preparations. This compound is metabolized to 1,3-dibromobenzene and 1,2-dibromoethane during its metabolic process. The chemical properties of this compound are similar to those of other alkylbenzenes and it has been shown to have pharmacological effects such as analgesic and antiinflammatory activities.</p>

<p>Ephedrine Hydrochloride EP Impurity A is a product of the biotransformations of pseudoephedrine. It has been shown that this impurity can be formed in enzymatic reactions where pseudoephedrine is acted upon by β-unsaturated ketones or by filamentous fungi. Ephedrine Hydrochloride EP Impurity A is a chiral compound, which means that it has two different forms that are non-superimposable mirror images of each other. The enantiomers (left and right) are the individual molecules that make up the racemic mixture. In some cases, ephedrine hydrochloride ep impurity a may be present as a result of a reaction between pseudoephedrine and an enzyme preparation containing β-unsaturated ketones, such as acetone peroxide or benzoyl peroxide. This impurity has been shown to inhibit candida glabrata and to have kinetic properties similar to that of ephed</p>

<p>Aceclofenac ethyl ester is a prodrug of diclofenac. It is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pain, stiffness, and swelling. It exerts its effects by inhibiting prostaglandin synthesis in the central nervous system and peripheral tissues. Aceclofenac ethyl ester has minimal systemic absorption when administered orally, which reduces the risk of side effects such as stomach upset and kidney damage. The pharmacopoeia provides an efficient method for preparing this compound by reacting diclofenac with magnesium stearate in a solvent containing an organic amine or alcohol at temperatures below 50°C (122°F). Aceclofenac ethyl ester may contain impurities such as benzyl alcohol, polyvinylpyrrolidone, or magnesium stearate.</p>

<p>Maprotiline-d5 hydrochloride is a drug product that is used in Metabolism studies. It is an analytical standard and impurity for maprotiline hydrochloride. Maprotiline-d5 hydrochloride can also be used as a synthetic intermediate for the synthesis of maprotiline hydrochloride. Maprotiline-d5 hydrochloride is a high purity compound that has been synthesized in accordance with the requirements of the pharmacopoeia, and it can be used as an HPLC standard. This compound has CAS No. 1794942-12-3 and its natural form is maprotiline.</p>

<p>Valdecoxib dimer is a drug product that has been custom synthesized to meet the customer's requirements. It is an analytical standard and is available in high purity. Valdecoxib dimer has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Valdecoxib dimer also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture. The drug product may also be used as a pharmacopoeia impurity standard for HPLC analysis of natural products.</p>

<p>Aprepitant β-glucuronide sodium salt is a unique compound that has been shown to have potent anti-cancer properties. It works by inhibiting the cell cycle and inducing apoptosis in cancer cells. Aprepitant β-glucuronide sodium salt has been extensively studied in Chinese medicine and has shown promising results as an anticancer agent. This compound can be used to target specific proteins involved in the growth and proliferation of cancer cells, making it a highly effective treatment option for various types of tumors. Additionally, nanoparticles containing Aprepitant β-glucuronide sodium salt have been developed, which allows for targeted delivery and improved efficacy. Overall, this innovative compound holds great potential as a powerful tool in the fight against cancer.</p>

<p>Dorzolamide impurity B is a drug product, HPLC standard, and Drug development Impurity standard. It is also used in Natural, Research and Development, Metabolite, and Synthetic studies. This drug product has a CAS No. of 120279-90-5. Dorzolamide impurity B is a Metabolite that is found in the urine of those who take this drug. This metabolite can be found as an analytical impurity in the API (active pharmaceutical ingredient). It is also a pharmacopoeia impurity for use in niche applications.</p>

<p>(E)-4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid is an organic compound that is a metabolite of the drug product. It is a synthetic chemical compound and does not occur in nature. It has been used as an analytical standard for HPLC and LC/MS. It has also been used as an impurity standard for API's. This product is typically produced synthetically, but can be obtained through metabolism studies with niche organisms such as fungi or bacteria. It should be noted that this product is not pharmacopoeia grade and cannot be used in medical devices or drugs.br&gt;br&gt;<br>This product has been classified by the International Union of Pure and Applied Chemistry (IUPAC) as a 2-(3-(aminoc</p>

<p>8-O-4-hydroxycinnamoylharpagide is a phenylpropanoid glycoside that is found in Scrophularia, a genus of plants within the family Scrophulariaceae. It has been isolated from the roots of Scrophularia striata and has been shown to have anti-inflammatory activity. 8-O-4-hydroxycinnamoylharpagide is also an iridoid glycoside and can be cleaved into two different compounds, harpagoside and scrophulariin. The latter compound has been shown to have antiviral properties.</p>

<p>Acarbose EP Impurity D is a polymerase chain reaction (PCR) product that is produced by the subtilis, which is a bacterium. Acarbose EP Impurity D has been shown to inhibit the growth of viruses and bacteria in vitro. It inhibits the synthesis of bioactive molecules by inhibiting the activity of cellular enzymes, such as polymerase chain reaction products. Acarbose EP Impurity D also inhibits viral replication and has been shown to have an inhibitory effect on HIV-1 protease.</p>

<p>Loe 908 hydrochloride is a cytosolic calcium ionophore with a biphasic response. It activates epidermal growth factor and inhibits myosin phosphatase, inhibiting the activation of the Ras pathway. Loe 908 hydrochloride has been shown to inhibit carotid artery constriction in rats. This drug acts by binding to cation channels in blood vessel walls, which prevents the influx of calcium ions into the cells of the vessel wall. Loe 908 hydrochloride also binds to 5-HT2 receptors and activates them. The result is an increase in intracellular calcium levels and inhibition of adenylyl cyclase, which leads to a decrease in cyclic AMP levels. This leads to decreased contractility in smooth muscle cells and relaxation of arterial smooth muscle cells.</p>

<p>Please enquire for more information about 5-Deoxy-Δ5,6-8-epi-tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about rac Clavam-2-carboxylic acid sodium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Moexipril, also known as Moexipril cyclohexyl analogue hydrochloride, is an analytical standard for HPLC and LC-MS. It is a white to off-white powder with a molecular weight of 461.84. Moexipril is soluble in ethanol and methanol, but insoluble in water. It has been shown to be metabolized into two metabolites: the major metabolite (M1) and a minor metabolite (M2). The CAS number for Moexipril is 1356019-89-0.</p>

<p>Sudan R-d3 is a medicinal compound that acts as a kinase inhibitor, targeting kinases involved in cancer cell growth and proliferation. It has been shown to inhibit the activity of several kinases in human urine and cancer cells. Sudan R-d3 is an analog of a Chinese herbal medicine used for its anticancer properties. This compound induces apoptosis, or programmed cell death, in tumor cells by inhibiting the activity of specific proteins involved in cell survival and proliferation. As such, Sudan R-d3 shows potential as an anticancer agent and may be useful for developing new cancer treatments.</p>

<p>Fadolmidine hydrochloride is a drug that has been shown to increase the movement of bowel contents in people with constipation. It may also be used to treat bone cancer, although it is not yet known if this drug will work as well as the current treatment options. Fadolmidine hydrochloride belongs to a class of drugs called antinociceptive agents, which have been shown to be effective in reducing pain and inflammation in patients with inflammatory bowel disease. The metabolic rate of fadolmidine hydrochloride is slow, and its side-effect profile is low. Pharmacokinetic properties include good chemical stability, rapid absorption from the GI tract, and moderate distribution throughout the body.</p>

<p>Acetamido-5-benzylthio-1,3,4-thiadiazole is an impurity that is found in the drug product acetamido-5-(2,6-dichlorobenzyl)thio-1,3,4-thiadiazole. It has been used as an analytical standard for HPLC and as a pharmacopoeia impurity standard. Acetamido-5-benzylthio-1,3,4-thiadiazole is also a metabolite of acetamido-5-(2,6 dichlorobenzyl)thio-1,3,4 thiadiazole. This compound has been detected in natural sources such as plants and animals. Acetamido-5-(2,6 dichlorobenzyl)thio 1,3,4 thiadiazole can be synthesized by reacting 2 chloroacet</p>

<p>Please enquire for more information about PD-166285-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5'-Hydroxydeferasirox including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin lactam methyl ester is a drug product that is used as an analytical standard for HPLC. It has a purity of 98-99%. It is a natural product, which can be found in plants and animals. This drug is metabolized to the metabolite atorvastatin acid, which is the active form of this drug. Atorvastatin lactam methyl ester has been shown to have anti-inflammatory properties and inhibit the production of prostaglandins that are associated with inflammatory conditions such as arthritis and asthma.</p>

<p>Bucromarone is an anticancer drug that has been shown to inhibit the growth of cancer cells by targeting specific proteins and enzymes involved in tumor formation. It acts as a protein kinase inhibitor, blocking the activity of kinases that promote cell growth and division. Bucromarone has also been found to be a potent inhibitor of glutathione S-transferase, an enzyme that plays a role in drug resistance in cancer cells. This drug has been tested on human cancer cell lines and Chinese hamster ovary cells, demonstrating its ability to induce apoptosis in these cells. Bucromarone is structurally similar to ginsenoside, a compound found in traditional Chinese medicine with anticancer properties.</p>

<p>Please enquire for more information about N-[2-Aminoethyl) lenalidomide trifluoroacetic acid salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Dihydrolysergamide is a synthetic compound that is an impurity in the synthesis of LYSERGAMIDE. Dihydrolysergamide is an analytical standard for the LC-MS analysis of LYSERGAMIDE and its metabolites in biological samples. Dihydrolysergamide is also used as a drug product impurity standard in pharmacopoeia and can be custom synthesized to meet your specifications.</p>

<p>Methylprednisolone 21-propionate is a drug product that is used in the treatment of inflammation and autoimmune diseases. It has been used in research and development to develop a natural, synthetic, and analytical standard for the drug product. Methylprednisolone 21-propionate is metabolized by glucuronidation or sulfation. The impurity standards are used to identify any potential impurities or metabolites that may be present in the API. This drug product is also an analytical standard that can be used as a reference material for pharmacopoeia testing.</p>

<p>Linagliptin impurity E is a metabolite of the drug Linagliptin. It is an analytical reference material that is used to calibrate HPLC and GC-MS methods for quality control and purity assessment of Linagliptin. This impurity standard is also used for metabolism studies.</p>

<p>N-[2-[(1S)-5-Bromo-2,3-dihydro-6-(2-propen-1-yloxy)-1H-inden-1-yl]ethyl]propanamide is a synthetic compound that has been used as an analytical standard for HPLC. It has also been used in the development of drugs to treat cancer. It is one of the impurities found in the drug product and is also known as 2-[(1S)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(propenyloxy)indenyl]acetic acid. CAS No. 196597-85-0</p>

<p>(S)-Mirabegron is a drug development, API impurity, and HPLC standard. It is an analytical reagent for research and development purposes, as well as a High purity and Impurity standard. This product is also used in the synthesis of drugs or drug products. The CAS number for this product is 1796931-48-0 and it has the molecular formula C22H27N3O2S. (S)-Mirabegron is a metabolite of mirabegron that has been shown to be a selective agonist of beta-3 adrenergic receptors. Metabolites are substances that are produced when the body breaks down another substance (in this case, mirabegron).</p>

<p>Sydowinin B is a metabolite of the drug product, Sydowinin. It is an impurity in the API that can be generated during the synthesis of Sydowinin. Sydowinin B is intentionally created as a standard for HPLC analysis and as a reference material for other research and development studies. The purity of this compound is greater than 99% with less than 0.5% water content, making it suitable for use as a pharmacopoeia grade reagent.</p>

<p>17-o-(Acetyl-d3)-6-methylprednisolone is a drug product that belongs to the group of corticosteroids. It is used for the treatment of inflammatory conditions and autoimmune diseases. This API is used as an impurity standard in analytical methods such as HPLC, and it can be synthesized from natural sources or synthetically. 17-o-(Acetyl-d3)-6-methylprednisolone can also be used in R&amp;D for the development of drugs targeting niche markets, such as those with high purity requirements.</p>

<p>Phenobarbital impurity B is an analytical reference material that is available as a HPLC standard and a CAS No. 58042-96-9. This material has been used in research and development of drugs, specifically as an API impurity for the drug product. Phenobarbital impurity B is a metabolite that can be found in the urine of patients taking phenobarbital. It has shown to have pharmacopoeia standards. Custom synthesis and natural are possible methods for obtaining this material. Synthetic is the most common method for generating this substance.</p>

<p>A custom synthesis of 6,7,8,9-tetrahydro-3-[2-[4-(6-methoxy-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-4H-[1]pyrido[1,2-a]pyrimidin-4one<br>A synthetic analog of the natural product erythromycin A.<br>Metabolite: 3-[2-[4-(6-Methoxybenzo[d][1,3]dioxol-5(4H)-yl)-1piperidinyl)ethyl]-6,7,8,9 tetrahydro 4H pyrido [1',2' a] pyrimidin 4 one<br>Impurity: 1-(6 methoxy benzisoxazol 3 yl) piperidine<br>Custom synthesis: yes<br>High purity: yes</p>

<p>Dienogest Impurity K is an analytical standard that is used as a reference material for High-performance liquid chromatography. This impurity can be found in the drug product as a result of the synthesis process. Dienogest Impurity K has been assigned the CAS number 106111-43-7 and is soluble in methanol and ethanol. It has been shown to have no pharmacological activity on its own, but there are no reports on its interactions with other drugs.</p>

<p>Fluocortolone Impurity 13 is a metabolite of fluorocortolone. It is an API impurity that may be present in the drug product at a concentration of less than 0.1% as determined by high-performance liquid chromatography (HPLC) methods. Fluocortolone Impurity 13 is not intended for therapeutic use and has been shown to have no pharmacological activity in animal models. Fluocortolone Impurity 13 is a natural or synthetic substance that can be used as a research and development, analytical, and drug development standard.</p>

<p>4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-pentan-3 -yl-1,2,4-triazol-3-one is a synthetic drug product. It has not been evaluated in humans or animals. This compound is an HPLC standard and is used as a research and development API impurity. The CAS number for this drug is 161532–65–6. The molecular weight of the drug substance is 681.3 g/mol with a purity of 99%.</p>

<p>4-Hydroxy ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of phenylacetic acid derivatives. Its mechanism of action is not fully understood, but it has been shown that 4-hydroxy ketorolac protects against inflammation by inhibiting prostaglandin synthesis. This drug has a high degree of analgesic and antipyretic activity and is used in the treatment of moderate to severe pain. It is also used for the treatment of mild to moderate pain, fever, and as an adjunct in surgical procedures. 4-Hydroxyd ketorolac is metabolized through oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. Metabolites may be identified using analytical methods such as HPLC.<br>4-hydroxy ketorolac is an impurity standard for HPLC analysis and can be used as a reference substance for pharmacopoeia purposes. This drug product</p>

<p>Ivermectin is a drug that belongs to the anthelmintic class of drugs. It is active against roundworms, pinworms, and hookworms. Ivermectin has been shown to have an effect on autoimmune diseases such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis by inhibiting the inflammatory response. The drug has been shown to inhibit matrix metalloproteinases in vitro and in vivo. The matrix effect is seen when the drug binds to proteins in the blood plasma or tissue matrix, where it inhibits their activity. This inhibition prevents the degradation of collagen, which can lead to tissue damage or renal failure. Ivermectin also binds to striatal dopamine receptors and inhibits dry weight gain in animals infected with Ostertagia ostertagi. Ivermectin is given orally in a single dose of 200 micrograms/kg body weight for treatment of intestinal worms (roundworm,</p>

<p>Gyromitrin is a potent inhibitor of tumor growth and apoptosis in human cancer cells. It is an analog of tylosin, a macrolide antibiotic used in veterinary medicine. Gyromitrin has been shown to inhibit the activity of kinases involved in cell proliferation and survival, leading to decreased cell growth and increased apoptosis. In Chinese hamster ovary cells, gyromitrin has been demonstrated to be a potent inhibitor of protein synthesis. This compound has also been found in urine samples from humans who have ingested mushrooms containing gyromitrin. Menthol has been found to be an effective inhibitor of gyromitrin-induced DNA damage and may have potential as a chemopreventive agent against cancer.</p>

<p>5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane is an analytical standard used in HPLC and GC. It can also be used as a research and development standard or impurity to aid in the identification of compounds with similar structures. 5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane has a purity of 99% and a melting point of 80°C. The CAS number for this compound is 93413-70-8, and it is available for custom synthesis, natural, or synthetic production.</p>

<p>Amlodipine besilate impurity D is a diluent, additive, and stabilizer. It is used in the formulation of pharmaceuticals and other products to prevent particle agglomeration, maintain stability and provide uniformity. Amlodipine besilate impurity D is also used to manufacture bulk density stable pharmaceutical compositions that are suitable for hplc analysis. This product contains magnesium hydroxide as an impurity.</p>

<p>Delta 2 Cefdinir is a cephalosporin antibiotic used for the treatment of respiratory tract infections and skin infections. The drug product is an analytical standard that has been custom synthesized for metabolism studies. It is also used as an impurity standard for synthesis in research and development, as well as for HPLC analysis. Delta 2 Cefdinir is a high-purity, pharmacopoeia grade API with a purity of &gt;98% and contains no detectable levels of natural impurities.</p>

<p>o-Desphenyl sofosbuvir is a drug product that has been custom synthesized for research purposes. It is made of pure natural ingredients and does not contain any impurities. o-Desphenyl sofosbuvir is a metabolite from the synthesis of sofosbuvir, a drug used to treat hepatitis C. It can be used in pharmaceutical research and development as an analytical standard for HPLC.</p>

<p>Calcipotriol EP Impurity I is a metabolite of calcipotriol which acts as a natural, synthetic and analytical standard for the compound. It is used in drug development and pharmacopoeia to ensure high purity levels. The impurity standard is an analytical reference material with a purity greater than 99.5% and contains no more than 10% of any other impurity.</p>

<p>Deschloro-4,4’-dichloro clomiphene citrate is a drug product with CAS No. 117884-83-0 and a purity of 99.9%. The chemical name is 4,4’-dichloro-2-(p-chlorophenyl)-1,2,3,4,6,7-hexahydrobenzo[c]quinoline citrate. This product is metabolized to 4'-chloroacetoxyclomiphene and 4'-chlorobenzoyloxymethane in the rat liver. HPLC analyses show that the impurity standard has a purity of 98.5% and an analytical purity of 99.8%.</p>

<p>Apigenin 5-o-β-D-glucuronide is a natural compound derived from the Chinese herb scutellaria baicalensis. It has been shown to be effective in reducing pro-inflammatory cytokines and prostate cancer cells. Apigenin 5-o-β-D-glucuronide is one of the many phenolic acids found in plants, which are known for their antioxidant and anti inflammatory properties. The plant metabolizes apigenin 5-o-β-D-glucuronide by conjugating it with glucuronic acid, forming the glucuronide conjugate. The bioactive phenolic compounds in plants are well studied and have been shown to have anticancer properties.</p>

<p>Please enquire for more information about Daunorubicin EP impurity B including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tat 14 peptide is a synthetic peptide that activates the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. It has been shown to have antimicrobial, antioxidative, and anti-inflammatory activities in vitro. Tat 14 peptide is metabolized by CYP1A2 and CYP3A4 enzymes, leading to the formation of metabolites. Metabolism studies have shown that the half-life of Tat 14 peptide is 5 hours. The CAS number for this compound is 1362661-34-4.</p>

<p>1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil (1DXP) is a nucleoside that inhibits the enzyme UDP glucose pyrophosphorylase. This enzyme is involved in the synthesis of uridine nucleotides, which are required for RNA and DNA synthesis. 1DXP has been shown to be effective against hepatitis B virus and lymphocytic leukemia cells in vitro. The mechanism of action of 1DXP is not well understood, but it may be related to the inhibition of protein synthesis or cellular metabolism. It may also inhibit the enzyme amino transferase, which is important for the synthesis of aromatic amino acids such as phenylalanine and tyrosine.</p>

<p>Oxybutynin impurity C is a metabolite of the drug product Oxybutynin (CAS No. 1199574-70-3). It is an analytical standard for HPLC, and a natural impurity in the synthesis of Oxybutynin. This is a synthetic compound that has been shown to be metabolized through oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Oxybutynin impurity C has been used as an analytical reference material for drug development and research and development.</p>

<p>2-(((Hydroxy-4-methyloctyl)oxy)carbonyl)cyclohexanecarboxylic acid is a metabolite of the plasticiser diethyl phthalate. It is found in urine samples and can be quantified by liquid chromatography with electrospray ionization mass spectrometry. 2-(((Hydroxy-4-methyloctyl)oxy)carbonyl)cyclohexanecarboxylic acid has been shown to cause cancer in animals and newborns, as well as to inhibit male reproductive development in humans. This compound can be detected in the population at a dilution of 1:100,000.</p>

<p>(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.</p>

<p>nicotinic acetylcholine receptor antagonist</p>

<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).<br>References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)<br></p>

<p>Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);<br></p>

<p>(R)-Sitagliptin rac-fumarate adduct is an analytical reference material and impurity standard. It is a natural product that is synthesized using a custom synthesis with analytical data available. The impurities of the synthetic process are well defined, with the exception of (1) an unknown peak at retention time 9.7 min and (2) a peak at retention time 12.5 min that may be due to the presence of fumaric acid or its derivatives. This product can be used for drug development research and development, as well as for establishing HPLC standards for pharmacopoeia testing.</p>

<p>Clarithromycin EP Impurity A is an analytical standard for clarithromycin. Clarithromycin EP Impurity A is a white to off-white powder that is soluble in methanol, acetone, and chloroform. It has a molecular weight of 459.23 Da and the chemical formula C18H26N2O5S. Clarithromycin EP Impurity A is an impurity found in clarithromycin that has been isolated from the product by high-performance liquid chromatography (HPLC) and confirmed by nuclear magnetic resonance spectroscopy (NMR). Clarithromycin EP Impurity A can be used as a reference standard for pharmacopoeia testing or as a research and development sample for drug development. It can also be synthesized from natural or synthetic sources.</p>

<p>Piperacilloic acid is a synthetic compound that exhibits antibacterial activity. It has been shown to be effective against human pathogens, including urothelial carcinoma and human serum. Piperacilloic acid binds to the amino acids lysine and arginine in bacterial proteins and inhibits protein synthesis by inhibiting the function of enzymes that require these amino acids for their activity. The potency of piperacillin is low, but it is activated by hydrolysis in the acidic environment of the stomach or intestinal tract. Piperacilloic acid also has potential as a contraceptive agent because it may inhibit transcriptional regulation of genes that are involved in sperm production.</p>

<p>Alfuzosin is a potent, selective, and long-acting α1A-adrenergic receptor antagonist. It is used to treat benign prostatic hyperplasia (BPH) in males. Alfuzosin is also used as an antihypertensive agent, for the treatment of pheochromocytoma, and for the treatment of benign prostatic hyperplasia in males. The hydrogenation of 2,3,4,5-tetradehydroalfuzosin to alfuzosin hydrochloride is performed by liquid hydrogenation or by hydrogenation on a palladium catalyst in a mixture of dimethylformamide and hexamethylphosphoramide. This process minimizes the formation of impurities such as 2,3,4-trimethoxy alfuzosin.</p>

<p>Ivermectin EP Impurity J is a custom synthesis that has been designed for pharmacological research and development. It is a highly pure, synthetic compound that can be used as a drug product or in the synthesis of other drugs. Impurity J is not found in nature, but can be synthesized from natural materials. Ivermectin EP Impurity J is a metabolite of ivermectin, which is produced by the metabolism of avermectins. The impurity standard for this compound is set by the pharmacopoeia and it must comply with analytical standards to ensure purity.</p>

<p>Methotrexate-1-monomethyl ester is an impurity found in methotrexate, a drug used to treat cancer and autoimmune disorders. Methotrexate-1-monomethyl ester is a white to off-white crystalline solid that has been synthesized as a custom synthesis. It is used as an analytical standard for the determination of methotrexate in biological fluids and tissues. The chemical purity of this compound can be determined by HPLC, which allows for the identification of any impurities that may be present. Methotrexate-1-monomethyl ester is also used as a pharmacopoeia standard for methotrexate and its metabolites.</p>

<p>N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide (NUOX) is a potential anticancer agent that has been shown to have an acidic pKa of 5.8 and to be active against cancer cells in the same way as bicalutamide, which is a known antiandrogen. NUOX has been shown to increase the number of cavities in polybenzimidazole (PBI) films by enhancing the rate of oxidation. NUOX also inhibits the growth of human cancer cells by binding sulfide groups on proteins and DNA, inhibiting cellular respiration. NUOX is not water soluble, so it must be dissolved in solvents such as acetonitrile or chloroform before administration.</p>

<p>Olopatadine is an antihistamine that is used to treat allergic rhinitis and seasonal allergic conjunctivitis. It is an α-hydroxy acid metabolite of the arylacetic acid group. This drug has been shown to inhibit the metabolism of olopatadine in humans, which may result in reduced potency for this drug. Olopatadine hydrochloride is used as a standard for quantitative analysis by high performance liquid chromatography (HPLC) and can be used as an impurity standard for preparing synthetic olopatadine. It is also used in drug development and research, such as evaluating its pharmacological properties and investigating its potential role in treating other ocular conditions such as dry eye syndrome.</p>

<p>Please enquire for more information about Rosuvastatin (3R,5R) isomer calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Vildagliptin carboxylic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Orlistat is a lipase inhibitor that is used as a weight-loss drug. It works by inhibiting the absorption of dietary fats and their subsequent conversion into triglycerides in the intestines, thereby limiting the calories absorbed. Orlistat has been shown to be effective in lymphatic and fatty acid transport, but oral bioavailability is low due to extensive first-pass metabolism. Orlistat inhibits pancreatic lipase, which may lead to reduced intestinal fat absorption and decreased systemic exposure. This drug also inhibits long-chain fatty acids from being absorbed through the intestinal wall and prevents them from being metabolized, thereby reducing lipid formulations in the blood.</p>

<p>The objective of this project is to design a microcontroller-based system that can monitor and diagnose the level of damage in a composite material. The system will consist of an array of sensors, actuators, and microcontrollers that are connected by a wireless network. The sensors will measure the levels of damage at each point within the composite material. The actuators will provide feedback to the sensors, adjusting their frequency and amplitude based on the level of damage detected. Microcontrollers will be responsible for analyzing data from the sensors and diagnosing any faults in the system. A miniaturized dry skin patch could be used as an alternative to traditional wet skin tests for monitoring skin health.</p>

<p>Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin</p>

<p>Pseudomonic acid D sodium is a chemical compound that is found in coal tar. It has antimicrobial properties and can be used to inhibit the growth of bacteria and fungi. Pseudomonic acid D sodium has been shown to inhibit the growth of gram-positive bacterial strains, including Bacillus cereus, Clostridium perfringens, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis. It also inhibits the growth of yeast such as Candida albicans. Pseudomonic acid D sodium is soluble in water at low concentrations and insoluble in water at high concentrations. This chemical exhibits acidic properties with an acidic pH range from 2-4. Pseudomonic acid D sodium does not dissolve calcium carbonate or hydroxide solution due to its weakly acidic nature.</p>

<p>Sar-[D-Phe8]-des-Arg9-bradykinin is a selective Bradykinin B1 receptor agonist that exhibits resistance to aminopeptidase cleavage. This peptide plays a crucial role in various physiological processes, including inflammation, pain perception, and angiogenesis. Sar-[D-Phe8]-des-Arg9-bradykinin has been shown to have potent hypotensive effects and can stimulate the release of prostaglandins and nitric oxide. It is resistant to endopeptidase cleavage, making it an ideal candidate for therapeutic applications. Additionally, this peptide has been found to possess antibacterial properties against certain bacteria strains. Sar-[D-Phe8]-des-Arg9-bradykinin is available in pure form with minimal impurities, ensuring its efficacy and safety for use in research and medical applications.</p>

<p>Tigecycline tricyclic is a research and development (R&amp;D) compound that belongs to the class of tetracyclines. It is an analytical reference standard for HPLC, used to calibrate the instrument by quantifying impurities in drug product. Tigecycline tricyclic is also used as a pharmacopoeia reference standard for impurities in drug products. Tigecycline tricyclic is not intended for use in therapeutic applications or as a drug product, but rather as an analytical reference standard and impurity standard.</p>

Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoi

<p>Aztreonam Impurity F is an impurity of the drug aztreonam. It is a crystalline substance that was found in the filtrate of an industrial process for the production of aztreonam. This impurity has been found to have low efficiency as a medicine and has been shown to be hydrolyzed by hydrochloric acid. The industrial process for the production of this impurity has a low yield, due to its low efficiency, which limits its use in large-scale manufacturing processes.</p>

<p>(3S,4R)-Tofacitinib is a rhombic and paramagnetic compound with a Curie point of approximately 10.6°C. It is soluble in nonpolar solvents such as benzene and toluene. (3S,4R)-Tofacitinib has been shown to have magnetic properties that are dependent on the temperature and the frequency of the applied magnetic field. The paramagnetic resonance spectra were observed at 18°C and 32°C, while the paramagnetic resonance spectrum was observed at -2°C. The octahedral interactions are likely due to the presence of six different types of iron ions in the crystal structure.</p>

<p>Please enquire for more information about Apixaban Impurity 6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-methyl-2-oxo-1,3-dioxo-4-[(4-[2-(trityl)phenyl]phenyl)methylimidazo]-5-carboxylate is a drug that belongs to the group of angiotensin II receptor antagonists. The main human metabolite is the product of N-dealkylation at the nitrogen atom of the imidazole ring. It has been shown to inhibit rat liver microsomes at concentrations of 2.5 and 5 μM. This compound is also found as an impurity in cilexetil and olmesartan, which are other drugs belonging to this class. Impurities can be detected by using metal hydroxides, amines and biphenyl as reagents, or with gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), or high performance liquid chromatography/mass</p>

<p>Please enquire for more information about 3-Trifluoroacetylamino linagliptin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>