APIs pour la recherche et les impuretés

Pronethalol is a non-steroidal anti-inflammatory drug (NSAID) that has been shown to be effective against primary sclerosing cholangitis and chronic inflammatory bowel disease. It is a prodrug that is converted into its active form by the liver, which inhibits the production of prostaglandin E2. Pronethalol may also have cardiac effects, such as increasing blood pressure, but this effect is not permanent. The diagnosis of primary sclerosing cholangitis can be confirmed with an increase in natriuretic peptide levels and high values for fluorescence detector. Long-term efficacy of pronethalol has been demonstrated in some cases. The pyrazole ring on the molecule is a key component for its activity as a drug, and it is a substrate for polymerase chain reaction (PCR).

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2-Methoxy-5-methyl-gamma-phenylbenzenepropanol is a synthetic compound that is used as an intermediate in the synthesis of coumarin derivatives. Reaction with sulfonating agents produces sulfones, and reaction with borohydride reagents produces boronates. The synthesis of 2-methoxy-5-methyl-gamma-phenylbenzenepropanol can be accomplished by the reduction of diphenyl ethers with lithium aluminum hydride or borohydride. The reduction can also be carried out using lanthanum oxide and potassium borohydride. The reaction proceeds smoothly at room temperature in nonpolar solvents.
2-Methoxy-5-methyl-gamma-phenylbenzenepropanol reacts with chloride to produce the corresponding chlorides, which are useful intermediates for the synthesis of tolterodine tartrate, a drug used to treat urinary inc

2-Demethoxy-4-methoxy urapidil is a drug product that is used in the development of new drugs. It is a synthetic compound that is metabolized to form its natural metabolite, 2-demethoxyurapidil. This impurity standard has been shown to have anti-inflammatory effects and can be used as an API impurity for pharmacopoeia. 2DMO4MU has been shown to be useful in the study of metabolism and has been found to inhibit prostaglandin synthesis.

Alverine EP Impurity C is a by-product of the synthesis of alverine, which is an ammonium salt. The process involves the use of high yield, high purity triflic acid, and organic solvents. The reaction system is typically carried out in a solvent such as toluene or dichloromethane. The organic solvent is then removed by filtration and the desired product can be obtained by crystallization or recrystallization. Alverine EP Impurity C has been shown to have insecticidal properties when applied externally, due to its interaction with insect stereoisomers. It also has anticancer activity and may be used in cancer therapy treatments that involve decompressing tumours and increasing blood supply to the area. Alverine EP Impurity C also has a citric acid binding property that makes it insoluble in water.

Montelukast Bis-sulfide is a drug product that is custom synthesized with high purity. It has been studied for its metabolism, analytical properties, and natural sources. The metabolite of montelukast bis-sulfide has been extensively researched for pharmacopoeia as well as for drug development. Montelukast bis-sulfide is a synthetic compound that is not found in nature, but it has niche applications in research and development. CAS No.: 1242260-05-4

Descyclopropyl-2-oxopropyl prasugrel is a metabolite of the prodrug prasugrel. It is a synthetic compound that has been shown to have pharmacological activity similar to its parent drug. Descyclopropyl-2-oxopropyl prasugrel has a purity of >98% and is available as an API standard in impurity grade and as custom synthesis. The chemical name for descyclopropyl-2-oxopropyl prasugrel is 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2- yl)butoxy]-N-(3S)-(3aR*,8aS*)-octahydroindole-1,3(2H)-dione.

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N2-Methyl carvedilol is a drug product that is used for the treatment of hypertension. It belongs to the class of beta blockers and it has been shown to be metabolized in vitro by both human hepatic and intestinal cytochrome P450 enzymes. N2-Methyl carvedilol is an impurity standard for HPLC analysis. This compound is also synthesized from natural sources, but can also be synthetically reproduced.

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the production of prostaglandins, which are produced by inflammatory cells in response to tissue injury. It is used to treat pain and inflammation. Aceclofenac is absorbed quickly from the gastrointestinal tract and has a high bioavailability. The maximum plasma concentration is reached within 1 hour after oral administration. Aceclofenac has a short half-life of about 2 hours. This drug binds to fatty acids and hepatoprotective substances, such as polymers, pyruvic transaminase, acetate extract, and humans. It also inhibits the transcription of cyclooxygenase-2 (COX-2), which produces prostaglandins that are involved in various aspects of inflammation.

Amlodipine besilate impurity A is a low-energy impurity that is formed in the crystallization process. It is an amide compound that has a hydrogen bond with crotonic acid and amlodipine, and can be found in acidic environments. The structural formula for this impurity is C8H14NO2S·C4H6O4·CH3OH.

Apigenin 5-o-β-D-glucuronide is a natural compound derived from the Chinese herb scutellaria baicalensis. It has been shown to be effective in reducing pro-inflammatory cytokines and prostate cancer cells. Apigenin 5-o-β-D-glucuronide is one of the many phenolic acids found in plants, which are known for their antioxidant and anti inflammatory properties. The plant metabolizes apigenin 5-o-β-D-glucuronide by conjugating it with glucuronic acid, forming the glucuronide conjugate. The bioactive phenolic compounds in plants are well studied and have been shown to have anticancer properties.

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Desmethylnortriptyline is a tricyclic antidepressant drug that has been shown to have anti-inflammatory properties. It inhibits the production of inflammatory cytokines in the intestine, which may be due to its effect on the induction of apoptosis by inhibiting protein synthesis. Desmethylnortriptyline also has a beneficial effect on bowel diseases, such as colitis and ileitis. This drug inhibits the uptake of serotonin in rat brains and can lead to decreased levels of serotonin in the brain and spinal cord, which may be responsible for its clinical response. Desmethylnortriptyline is metabolized by demethylation and deamination. It undergoes oxidative deamination by cytochrome P450 enzymes found in human liver microsomes and isolated heart tissue, generating an inactive product. The drug also undergoes oxidation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) to form an active metabolite.

Paliperidone E-oxime is used as a reference standard to calibrate impurities in drug products, and as an analytical reference standard. Paliperidone E-oxime is also used in the synthesis of other drugs. Paliperidone E-oxime has a CAS number of 1388021-46-2 and a molecular weight of 395.37 g/mol.

4’-Chloro clomiphene citrate is a drug product that is used as an analytical standard and impurity in the pharmaceutical industry. This compound is a natural metabolite of clomiphene, and is found in urine, serum, liver, and brain tissue. 4’-Chloro clomiphene citrate has been shown to have anti-inflammatory properties.

Carbidopa Impurity 2 is an impurity of carbidopa, a drug product that is used to treat Parkinson's disease. Carbidopa Impurity 2 is an analytical standard for the identification and quantification of carbidopa in biological samples. The natural form of this compound is unknown, but it has been synthesized using custom synthesis techniques. This compound was also used to develop a high purity HPLC standard and as a pharmacopoeia reference material.