APIs pour la recherche et les impuretés

Acyclovir is an antiviral drug that inhibits the replication of herpes viruses by selectively inhibiting viral DNA polymerase. The drug is active against a broad range of herpes viruses, including both types of herpes simplex virus (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir has also been shown to be effective against aciclovir-resistant mutants. This drug can be used as a prophylaxis or in combination with other antiviral agents for the treatment of active infections. Acyclovir can cause headaches, nausea, vomiting, and diarrhea when taken orally. It should not be taken with certain medicines such as aminoglycosides or high doses of aspirin because this may increase the risk for kidney problems.

Remdesivir is a nucleoside monophosphate that inhibits the HIV-1 reverse transcriptase and HIV-1 protease. This drug is used to treat human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS). Remdesivir blocks the viral life cycle by preventing the production of new viruses. It also has an affinity for polymerase and phosphatase, which are enzymes necessary for viral replication. Remdesivir is uncharged, so it can be taken orally.
Remdesivir does not work against all strains of HIV, but it does inhibit some strains more than others.

Rifaximin Impurity 2 is a custom synthesis that is made to the customer's specifications. This compound is used as an impurity standard for drug product. It has a high purity and follows the pharmacopoeia standards. Rifaximin Impurity 2 is used in research and development of new drugs, which includes drug metabolism studies. This compound can be synthesized with natural or synthetic methods, and can be analyzed using HPLC.

Isoribavirin is a ribonucleoside monophosphate analog that inhibits viral RNA polymerase. Isoribavirin has been shown to be active against influenza virus, herpes simplex virus, and vesicular stomatitis virus in cell culture. Isoribavirin is stable in an acetonitrile solution in the presence of phosphoric acid at pH 3-4 or in the presence of sulfate ions at pH 9-10. It can be purified by chromatography on a silica gel column using an acetonitrile/water mobile phase gradient. The impurities of isoribavirin are not detectable by liquid chromatography and have no significant effect on its sensitivity. Isoribavirin elutes from the silica gel column with the impurities.

Atorvastatin impurity F is an impurity that can be found in atorvastatin. It is a white to off-white crystalline solid with a melting point of 142°C. It has a molecular weight of 273.5 and chemical formula of C14H13N3O2. This impurity can be found in atorvastatin as an API impurity, which may have an effect on the efficacy or toxicity of the drug product. Impurities are present in all pharmaceutical products and should be identified, characterized, and quantified for quality control purposes. Impurities are often unavoidable byproducts of the manufacturing process and can lead to potential safety concerns if they are not detected early on during drug development. The presence of impurities may also affect the pharmacological effects or therapeutic efficacy of the drug product.

The following is a description of an impurity standard for the metabolite 2-(3-Hydroxy-2,2-Dimethylpropoxy)-1-(6-Hydroxy-2-Naphthyl)Propan-1-One:

Tirzepatide Impurity